CZ327195A3 - Substituted 1h-imidazoles - Google Patents

Substituted 1h-imidazoles Download PDF

Info

Publication number
CZ327195A3
CZ327195A3 CZ953271A CZ327195A CZ327195A3 CZ 327195 A3 CZ327195 A3 CZ 327195A3 CZ 953271 A CZ953271 A CZ 953271A CZ 327195 A CZ327195 A CZ 327195A CZ 327195 A3 CZ327195 A3 CZ 327195A3
Authority
CZ
Czechia
Prior art keywords
imidazole
compound
tetrahydro
naphthalenyl
imidazol
Prior art date
Application number
CZ953271A
Other languages
Czech (cs)
English (en)
Inventor
Jean-Pierre Geerts
Genevieve Motte
Edmond Differding
Jean-Pierre Henichart
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of CZ327195A3 publication Critical patent/CZ327195A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CZ953271A 1994-12-14 1995-12-12 Substituted 1h-imidazoles CZ327195A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
CZ327195A3 true CZ327195A3 (en) 1996-07-17

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ953271A CZ327195A3 (en) 1994-12-14 1995-12-12 Substituted 1h-imidazoles

Country Status (26)

Country Link
US (1) US5658938A (cg-RX-API-DMAC7.html)
EP (1) EP0717037A1 (cg-RX-API-DMAC7.html)
JP (1) JPH08208622A (cg-RX-API-DMAC7.html)
KR (1) KR960022474A (cg-RX-API-DMAC7.html)
CN (1) CN1054376C (cg-RX-API-DMAC7.html)
AR (1) AR002257A1 (cg-RX-API-DMAC7.html)
AU (1) AU693614B2 (cg-RX-API-DMAC7.html)
BG (1) BG63043B1 (cg-RX-API-DMAC7.html)
BR (1) BR9505815A (cg-RX-API-DMAC7.html)
CA (1) CA2165133A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ327195A3 (cg-RX-API-DMAC7.html)
EE (1) EE9500064A (cg-RX-API-DMAC7.html)
FI (1) FI955927A7 (cg-RX-API-DMAC7.html)
GB (1) GB9425211D0 (cg-RX-API-DMAC7.html)
HU (1) HUT73980A (cg-RX-API-DMAC7.html)
IL (1) IL116325A (cg-RX-API-DMAC7.html)
IS (1) IS4311A (cg-RX-API-DMAC7.html)
MX (1) MX9505063A (cg-RX-API-DMAC7.html)
NO (1) NO305316B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ280646A (cg-RX-API-DMAC7.html)
PL (1) PL311736A1 (cg-RX-API-DMAC7.html)
RO (1) RO113346B1 (cg-RX-API-DMAC7.html)
RU (1) RU2156239C2 (cg-RX-API-DMAC7.html)
SK (1) SK155095A3 (cg-RX-API-DMAC7.html)
TW (1) TW303362B (cg-RX-API-DMAC7.html)
ZA (1) ZA9510554B (cg-RX-API-DMAC7.html)

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GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
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PT1280779E (pt) 2000-05-08 2005-11-30 Orion Corp Novos indanilimidazois policiclicos com actividade adrenergica alfa2
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FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
CN101374517A (zh) * 2006-01-27 2009-02-25 弗·哈夫曼-拉罗切有限公司 2-咪唑类化合物用于治疗cns病症的用途
ATE546437T1 (de) * 2006-10-19 2012-03-15 Hoffmann La Roche Aminomethyl-4-imidazole
AU2007312389B2 (en) * 2006-10-19 2012-02-23 F. Hoffmann-La Roche Ag Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
ATE533755T1 (de) * 2006-11-02 2011-12-15 Hoffmann La Roche Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren
AU2007321376A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
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US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
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MX2009008776A (es) * 2007-02-13 2009-08-25 Schering Corp Agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos.
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AU2008216797A1 (en) * 2007-02-13 2008-08-21 Pharmacopeia, Llc Functionally selective alpha2C adrenoreceptor agonists
ES2525229T3 (es) * 2007-02-15 2014-12-19 F. Hoffmann-La Roche Ag 2-aminooxazolinas como ligandos de TAAR1
EP2173720A2 (en) 2007-07-02 2010-04-14 F. Hoffmann-Roche AG 2-imidazolines having a good affinity to the trace amine associated receptors (taars)
JP2010531836A (ja) * 2007-07-03 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー ４−イミダゾリン及びそれらの抗うつ剤としての使用
CA2694362A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
EP2182935A1 (en) * 2007-08-02 2010-05-12 F. Hoffmann-Roche AG The use of benzamide derivatives for the treatment of cns disorders
BRPI0814758A2 (pt) * 2007-08-03 2015-03-03 Hoffmann La Roche Piridinacarboxamida e derivados de benzamida como ligantes taar1
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP2257546B1 (en) 2008-02-21 2012-08-15 Merck Sharp & Dohme Corp. Functionally selective alpha2c adrenoreceptor agonists
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
WO2010010014A1 (en) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag 4,5-dihydro-oxazol-2-yl derivatives
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
AR073628A1 (es) 2008-10-07 2010-11-17 Schering Corp Analogos de biaril espiroaminooxazolina y espiroaminodiazolina moduladores de receptores adrenergicos alfa2c, composiciones farmaceuticas que los comprenden y uso de los mismos en rinitis alergica,trastornos cardiacos y otras enfermedades
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
WO2013104591A1 (en) 2012-01-12 2013-07-18 F. Hoffmann-La Roche Ag Heterocyclic derivatives as trace amine associated receptors (taars)
UA113776C2 (xx) 2012-09-14 2017-03-10 Похідні піразолкарбоксаміду як модулятори рецепторів слідових амінів (taar) для застосування при лікуванні різних розладів, таких як депресія, діабет та хвороба паркінсона
KR101676208B1 (ko) * 2012-09-17 2016-11-14 에프. 호프만-라 로슈 아게 트라이아졸 카복스아미드 유도체
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
RU2017107521A (ru) 2014-08-27 2018-10-01 Ф. Хоффманн-Ля Рош Аг Замещенные производные азетидина в качестве лигандов рецепторов следовых аминов taar
JP6364122B2 (ja) 2014-08-27 2018-07-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ障害を処置するための置換ピラジノ［２，１−ａ］イソキノリン誘導体
ES2819830T3 (es) 2016-03-17 2021-04-19 Hoffmann La Roche Derivado de 5-etiol-4-metil-pirazol-3-carboxamida que tiene actividad como agonista de TAAR
EA039557B1 (ru) * 2016-03-17 2022-02-10 Фмк Корпорейшн Способ превращения s-энантиомера в его рацемическую форму
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
FI955927L (fi) 1996-06-15
KR960022474A (ko) 1996-07-18
NO305316B1 (no) 1999-05-10
JPH08208622A (ja) 1996-08-13
US5658938A (en) 1997-08-19
MX9505063A (es) 1997-01-31
AR002257A1 (es) 1998-03-11
BG100208A (bg) 1996-07-31
IL116325A (en) 1999-10-28
NZ280646A (en) 1996-08-27
IS4311A (is) 1996-06-15
ZA9510554B (en) 1996-06-13
FI955927A7 (fi) 1996-06-15
RU2156239C2 (ru) 2000-09-20
PL311736A1 (en) 1996-06-24
HUT73980A (en) 1996-10-28
AU693614B2 (en) 1998-07-02
EP0717037A1 (fr) 1996-06-19
BR9505815A (pt) 1998-01-06
CN1054376C (zh) 2000-07-12
SK155095A3 (en) 1997-02-05
IL116325A0 (en) 1996-03-31
GB9425211D0 (en) 1995-02-15
TW303362B (cg-RX-API-DMAC7.html) 1997-04-21
AU4036895A (en) 1996-06-20
CA2165133A1 (en) 1996-06-15
NO955034D0 (no) 1995-12-12
BG63043B1 (bg) 2001-02-28
EE9500064A (et) 1996-06-17
NO955034L (no) 1996-06-17
HU9503549D0 (en) 1996-02-28
FI955927A0 (fi) 1995-12-11
CN1133837A (zh) 1996-10-23
RO113346B1 (ro) 1998-06-30

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic