TW300888B - - Google Patents

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Publication number
TW300888B
TW300888B TW084112820A TW84112820A TW300888B TW 300888 B TW300888 B TW 300888B TW 084112820 A TW084112820 A TW 084112820A TW 84112820 A TW84112820 A TW 84112820A TW 300888 B TW300888 B TW 300888B
Authority
TW
Taiwan
Prior art keywords
methyl
group
phenyl
amino
carbonyl
Prior art date
Application number
TW084112820A
Other languages
English (en)
Chinese (zh)
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of TW300888B publication Critical patent/TW300888B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW084112820A 1994-12-02 1995-12-01 TW300888B (index.php)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP19881695 1995-08-03

Publications (1)

Publication Number Publication Date
TW300888B true TW300888B (index.php) 1997-03-21

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084112820A TW300888B (index.php) 1994-12-02 1995-12-01

Country Status (20)

Country Link
US (1) US5869501A (index.php)
EP (1) EP0798295B1 (index.php)
JP (1) JP3004362B2 (index.php)
KR (1) KR100383161B1 (index.php)
CN (1) CN1087736C (index.php)
AT (1) ATE233240T1 (index.php)
AU (1) AU688628B2 (index.php)
CA (1) CA2206532C (index.php)
DE (1) DE69529770T2 (index.php)
ES (1) ES2193202T3 (index.php)
FI (1) FI115051B (index.php)
HU (1) HUT77313A (index.php)
MX (1) MX9704059A (index.php)
NO (1) NO309566B1 (index.php)
NZ (1) NZ296210A (index.php)
PL (1) PL184824B1 (index.php)
PT (1) PT798295E (index.php)
RU (1) RU2154633C2 (index.php)
TW (1) TW300888B (index.php)
WO (1) WO1996016940A1 (index.php)

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US6653340B1 (en) 1997-06-03 2003-11-25 Biocryst Pharmaceuticals, Inc. Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
WO1998057934A1 (en) * 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
ZA986594B (en) * 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
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US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1048652A4 (en) * 1997-12-26 2001-05-09 Mochida Pharm Co Ltd AROMATIC COMPOUNDS WITH A CYCLIC AMINO GROUP OR THEIR SALTS
AU2074699A (en) * 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
NZ508101A (en) * 1998-04-10 2002-12-20 Japan Tobacco Inc Amidine compounds useful as factor Xa inhibitors and as anticoagulants
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
EP1140862A4 (en) 1998-12-23 2004-07-28 Bristol Myers Squibb Pharma Co THROMBIN OR Xa FACTOR INHIBITORS
AU771776B2 (en) 1999-01-13 2004-04-01 Genentech Inc. Serine protease inhibitors
JP4599714B2 (ja) * 1999-01-22 2010-12-15 アステラス製薬株式会社 経口吸収改善医薬用組成物
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
FR2793247B1 (fr) * 1999-05-04 2001-06-22 Synthelabo Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) * 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
AU5570900A (en) * 1999-07-01 2001-01-22 Sankyo Company Limited Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
CN1572882A (zh) * 1999-10-28 2005-02-02 三共株式会社 苯甲脒衍生物
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
US6376515B2 (en) 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
EP1272483A2 (en) * 2000-03-24 2003-01-08 Millenium Pharmaceuticals, Inc. OXINDOLE INHIBITORS OF FACTOR Xa
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
US6410733B1 (en) 2000-09-11 2002-06-25 Genentech, Inc. Amidine inhibitors of serine proteases
CN1283626C (zh) 2000-11-22 2006-11-08 安斯泰来制药有限公司 取代苯衍生物或其盐
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
CA2440389A1 (en) 2001-03-09 2002-10-03 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
PL363961A1 (en) 2001-04-05 2004-11-29 Sankyo Company, Limited Benzamidine derivative
PL207295B1 (pl) * 2002-01-29 2010-11-30 Serono Lab Podstawione pochodne metylenoamidowe , ich zastosowanie i sposób ich wytwarzania oraz kompozycja farmaceutyczna
RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов
AU2003284596A1 (en) 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
WO2004058728A1 (ja) * 2002-12-24 2004-07-15 Daiichi Pharmaceutical Co., Ltd. 新規なエチレンジアミン誘導体
US7250447B2 (en) 2003-05-20 2007-07-31 Genentech, Inc. Acylsulfamide inhibitors of factor VIIa
JP2007500221A (ja) 2003-05-20 2007-01-11 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のベンゾフラン阻害剤
CN1886398A (zh) 2003-10-09 2006-12-27 米伦纽姆医药公司 作为Xa因子抑制剂的经硫醚取代的苯甲酰胺
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
JP5020073B2 (ja) 2004-06-18 2012-09-05 ミレニアム ファーマシューティカルズ インク． 第Ｘａ因子阻害剤
WO2006055951A2 (en) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
US7678913B2 (en) 2004-12-07 2010-03-16 Portola Pharmaceuticals, Inc. Ureas as factor Xa inhibitors
WO2006063293A2 (en) * 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. THIOUREAS AS FACTOR Xa INHIBITORS
JP4900238B2 (ja) 2005-02-02 2012-03-21 味の素株式会社 新規ベンズアミジン化合物
US7598276B2 (en) 2005-11-08 2009-10-06 Millenium Pharmaceuticals, Inc. Pharmaceutical salts and polymorphs of a factor Xa inhibitor
JP2009531364A (ja) * 2006-03-28 2009-09-03 ノバルティス アクチエンゲゼルシャフト アミド誘導体およびｇタンパク質関連疾患の処置のためのそれらの使用
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WO2019241213A1 (en) * 2018-06-11 2019-12-19 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
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Also Published As

Publication number Publication date
EP0798295A1 (en) 1997-10-01
PL320486A1 (en) 1997-09-29
EP0798295B1 (en) 2003-02-26
WO1996016940A1 (en) 1996-06-06
CN1087736C (zh) 2002-07-17
DE69529770T2 (de) 2003-12-24
CN1167484A (zh) 1997-12-10
ATE233240T1 (de) 2003-03-15
NZ296210A (en) 1998-05-27
PT798295E (pt) 2003-07-31
PL184824B1 (pl) 2002-12-31
FI972326A0 (fi) 1997-06-02
NO309566B1 (no) 2001-02-19
NO972482L (no) 1997-08-01
HUT77313A (hu) 1998-03-30
CA2206532C (en) 2006-07-11
RU2154633C2 (ru) 2000-08-20
FI115051B (fi) 2005-02-28
MX9704059A (es) 1997-08-30
DE69529770D1 (de) 2003-04-03
AU688628B2 (en) 1998-03-12
EP0798295A4 (en) 1998-03-04
NO972482D0 (no) 1997-05-30
AU3994295A (en) 1996-06-19
CA2206532A1 (en) 1996-06-06
US5869501A (en) 1999-02-09
JP3004362B2 (ja) 2000-01-31
ES2193202T3 (es) 2003-11-01
FI972326A7 (fi) 1997-06-02
KR100383161B1 (ko) 2003-12-24

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