RU2154633C2 - Производные амидинонафтила и фармацевтическая композиция - Google Patents

Производные амидинонафтила и фармацевтическая композиция Download PDF

Info

Publication number
RU2154633C2
RU2154633C2 RU97108576/04A RU97108576A RU2154633C2 RU 2154633 C2 RU2154633 C2 RU 2154633C2 RU 97108576/04 A RU97108576/04 A RU 97108576/04A RU 97108576 A RU97108576 A RU 97108576A RU 2154633 C2 RU2154633 C2 RU 2154633C2
Authority
RU
Russia
Prior art keywords
methyl
piperidyl
phenyl
oxy
naphthyl
Prior art date
Application number
RU97108576/04A
Other languages
English (en)
Russian (ru)
Other versions
RU97108576A (ru
Inventor
ма Фукуси Хира (JP)
Фукуси ХИРАЯМА
Хироюки Косио (JP)
Хироюки Косио
Юзо Матсумото (JP)
Юзо Матсумото
Томихиса КАВАСАКИ (JP)
Томихиса Кавасаки
Сейдзи Каку (JP)
Сейдзи Каку
Исао ЯНАГИСАВА (JP)
Исао Янагисава
Original Assignee
Яманоути Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Яманоути Фармасьютикал Ко., Лтд. filed Critical Яманоути Фармасьютикал Ко., Лтд.
Publication of RU97108576A publication Critical patent/RU97108576A/ru
Application granted granted Critical
Publication of RU2154633C2 publication Critical patent/RU2154633C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU97108576/04A 1994-12-02 1995-12-01 Производные амидинонафтила и фармацевтическая композиция RU2154633C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP7-105205 1995-08-03
JP7-198816 1995-08-03
JP19881695 1995-08-03
JP6-299963 1995-08-03

Publications (2)

Publication Number Publication Date
RU97108576A RU97108576A (ru) 1999-05-20
RU2154633C2 true RU2154633C2 (ru) 2000-08-20

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97108576/04A RU2154633C2 (ru) 1994-12-02 1995-12-01 Производные амидинонафтила и фармацевтическая композиция

Country Status (20)

Country Link
US (1) US5869501A (index.php)
EP (1) EP0798295B1 (index.php)
JP (1) JP3004362B2 (index.php)
KR (1) KR100383161B1 (index.php)
CN (1) CN1087736C (index.php)
AT (1) ATE233240T1 (index.php)
AU (1) AU688628B2 (index.php)
CA (1) CA2206532C (index.php)
DE (1) DE69529770T2 (index.php)
ES (1) ES2193202T3 (index.php)
FI (1) FI115051B (index.php)
HU (1) HUT77313A (index.php)
MX (1) MX9704059A (index.php)
NO (1) NO309566B1 (index.php)
NZ (1) NZ296210A (index.php)
PL (1) PL184824B1 (index.php)
PT (1) PT798295E (index.php)
RU (1) RU2154633C2 (index.php)
TW (1) TW300888B (index.php)
WO (1) WO1996016940A1 (index.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028427A1 (en) 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
HUP9904363A3 (en) 1996-08-15 2000-12-28 Schering Corp Piperidine ether muscarinic antagonists and pharmaceutical compositions containing them
EP0842941A1 (de) * 1996-11-16 1998-05-20 Roche Diagnostics GmbH Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel
US6653340B1 (en) 1997-06-03 2003-11-25 Biocryst Pharmaceuticals, Inc. Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
WO1998057934A1 (en) * 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
ZA986594B (en) * 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
WO1999011617A1 (en) * 1997-09-01 1999-03-11 Yamanouchi Pharmaceutical Co., Ltd. Novel naphthamide derivatives or salts thereof
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1048652A4 (en) * 1997-12-26 2001-05-09 Mochida Pharm Co Ltd AROMATIC COMPOUNDS WITH A CYCLIC AMINO GROUP OR THEIR SALTS
AU2074699A (en) * 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
NZ508101A (en) * 1998-04-10 2002-12-20 Japan Tobacco Inc Amidine compounds useful as factor Xa inhibitors and as anticoagulants
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
EP1140862A4 (en) 1998-12-23 2004-07-28 Bristol Myers Squibb Pharma Co THROMBIN OR Xa FACTOR INHIBITORS
AU771776B2 (en) 1999-01-13 2004-04-01 Genentech Inc. Serine protease inhibitors
JP4599714B2 (ja) * 1999-01-22 2010-12-15 アステラス製薬株式会社 経口吸収改善医薬用組成物
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
FR2793247B1 (fr) * 1999-05-04 2001-06-22 Synthelabo Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) * 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
AU5570900A (en) * 1999-07-01 2001-01-22 Sankyo Company Limited Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
CN1572882A (zh) * 1999-10-28 2005-02-02 三共株式会社 苯甲脒衍生物
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
US6376515B2 (en) 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
EP1272483A2 (en) * 2000-03-24 2003-01-08 Millenium Pharmaceuticals, Inc. OXINDOLE INHIBITORS OF FACTOR Xa
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
US6410733B1 (en) 2000-09-11 2002-06-25 Genentech, Inc. Amidine inhibitors of serine proteases
CN1283626C (zh) 2000-11-22 2006-11-08 安斯泰来制药有限公司 取代苯衍生物或其盐
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
CA2440389A1 (en) 2001-03-09 2002-10-03 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
PL363961A1 (en) 2001-04-05 2004-11-29 Sankyo Company, Limited Benzamidine derivative
PL207295B1 (pl) * 2002-01-29 2010-11-30 Serono Lab Podstawione pochodne metylenoamidowe , ich zastosowanie i sposób ich wytwarzania oraz kompozycja farmaceutyczna
AU2003284596A1 (en) 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
WO2004058728A1 (ja) * 2002-12-24 2004-07-15 Daiichi Pharmaceutical Co., Ltd. 新規なエチレンジアミン誘導体
US7250447B2 (en) 2003-05-20 2007-07-31 Genentech, Inc. Acylsulfamide inhibitors of factor VIIa
JP2007500221A (ja) 2003-05-20 2007-01-11 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のベンゾフラン阻害剤
CN1886398A (zh) 2003-10-09 2006-12-27 米伦纽姆医药公司 作为Xa因子抑制剂的经硫醚取代的苯甲酰胺
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
JP5020073B2 (ja) 2004-06-18 2012-09-05 ミレニアム ファーマシューティカルズ インク． 第Ｘａ因子阻害剤
WO2006055951A2 (en) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
US7678913B2 (en) 2004-12-07 2010-03-16 Portola Pharmaceuticals, Inc. Ureas as factor Xa inhibitors
WO2006063293A2 (en) * 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. THIOUREAS AS FACTOR Xa INHIBITORS
JP4900238B2 (ja) 2005-02-02 2012-03-21 味の素株式会社 新規ベンズアミジン化合物
US7598276B2 (en) 2005-11-08 2009-10-06 Millenium Pharmaceuticals, Inc. Pharmaceutical salts and polymorphs of a factor Xa inhibitor
JP2009531364A (ja) * 2006-03-28 2009-09-03 ノバルティス アクチエンゲゼルシャフト アミド誘導体およびｇタンパク質関連疾患の処置のためのそれらの使用
WO2008044731A1 (en) * 2006-10-12 2008-04-17 Institute Of Medicinal Molecular Design. Inc. N-phenyloxamidic acid derivative
ES2382055T3 (es) 2006-11-02 2012-06-04 Millennium Pharmaceuticals, Inc. Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa
WO2008066102A1 (en) 2006-11-30 2008-06-05 Takeda Pharmaceutical Company Limited Sustained release preparation
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
WO2010005087A1 (ja) 2008-07-11 2010-01-14 味の素株式会社 アミジン誘導体
EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
WO2019241213A1 (en) * 2018-06-11 2019-12-19 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
CN117304076B (zh) * 2023-11-28 2024-02-20 苏州大学 一种n-磺酰基脒化合物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов

Also Published As

Publication number Publication date
EP0798295A1 (en) 1997-10-01
PL320486A1 (en) 1997-09-29
EP0798295B1 (en) 2003-02-26
WO1996016940A1 (en) 1996-06-06
CN1087736C (zh) 2002-07-17
TW300888B (index.php) 1997-03-21
DE69529770T2 (de) 2003-12-24
CN1167484A (zh) 1997-12-10
ATE233240T1 (de) 2003-03-15
NZ296210A (en) 1998-05-27
PT798295E (pt) 2003-07-31
PL184824B1 (pl) 2002-12-31
FI972326A0 (fi) 1997-06-02
NO309566B1 (no) 2001-02-19
NO972482L (no) 1997-08-01
HUT77313A (hu) 1998-03-30
CA2206532C (en) 2006-07-11
FI115051B (fi) 2005-02-28
MX9704059A (es) 1997-08-30
DE69529770D1 (de) 2003-04-03
AU688628B2 (en) 1998-03-12
EP0798295A4 (en) 1998-03-04
NO972482D0 (no) 1997-05-30
AU3994295A (en) 1996-06-19
CA2206532A1 (en) 1996-06-06
US5869501A (en) 1999-02-09
JP3004362B2 (ja) 2000-01-31
ES2193202T3 (es) 2003-11-01
FI972326A7 (fi) 1997-06-02
KR100383161B1 (ko) 2003-12-24

Similar Documents

Publication Publication Date Title
RU2154633C2 (ru) Производные амидинонафтила и фармацевтическая композиция
JPWO1996016940A1 (ja) 新規なアミジノナフチル誘導体又はその塩
EP1308439B1 (en) Proline derivatives and use thereof as drugs
JP4199309B2 (ja) 新規アセトアミド誘導体およびプロテアーゼ阻害
EP1605752B1 (en) Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
WO2002006234A1 (en) Sulfone derivatives, process for their production and use thereof
JPWO1998009949A1 (ja) 新規アセトアミド誘導体およびプロテアーゼ阻害剤
US11807605B2 (en) Human plasma kallikrein inhibitors
CA3007280A1 (en) Apelin receptor agonists and methods of use
WO2004048363A1 (ja) イミダゾール誘導体、その製造法および用途
CA2936886A1 (en) Heterocyclic compounds as nav channel inhibitors and uses thereof
KR20010095174A (ko) 디아제판 유도체 또는 이의 염
EA006096B1 (ru) Ингибиторы протеазы вич широкого спектра действия на основе сульфонамидов 2-(замещенных-амино)бензотиазолов
WO2004056766A1 (en) Inhibitors of tace
ES2314632T3 (es) Nuevos derivados de pirrolidina-3,4-dicarboxamida.
WO2002096892A1 (en) Oxadiazole derivative compounds and drugs containing these compounds as the active ingredient
JP2002201178A (ja) スルホン誘導体、その製造法及び用途
TWI740903B (zh) 新穎吡咯啶衍生物
HK40075971B (en) Human plasma kallikrein inhibitors
HK40075971A (en) Human plasma kallikrein inhibitors
US5675011A (en) Process for producing pyrrolidine derivative and salt thereof
JP2004155774A (ja) イミダゾピリジン誘導体、その製造法および用途
KR19990015206A (ko) 선택적 트롬빈 억제활성을 갖는 치환된 방향족 유도체
HK1101856B (en) Pyrrolidine-3,4-dicarboxamide derivatives
JP2000503634A (ja) トロンビン阻害剤としてのベンズアミド誘導体

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20041202