TR200802278T2 - Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. - Google Patents

Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

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Publication number
TR200802278T2
TR200802278T2 TR2008/02278T TR200802278T TR200802278T2 TR 200802278 T2 TR200802278 T2 TR 200802278T2 TR 2008/02278 T TR2008/02278 T TR 2008/02278T TR 200802278 T TR200802278 T TR 200802278T TR 200802278 T2 TR200802278 T2 TR 200802278T2
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Turkey
Prior art keywords
antibodies
human antibodies
human
htl
activity
Prior art date
Application number
TR2008/02278T
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English (en)
Inventor
G. Salfeld Jochen
L. Du Fou Sarah
Paskind Michael
Banerjee Subhashis
E. Tracey Dan�El
White Michael
Kaymak�Alan Zehra
Labkovsky Boris
Sakorafas Paul
Friedrich Stuart
Myles Angela
M. Veldman Geertruida
Venturini Amy
W. Warne Nicholas
Widom Angela
G. Elvin John
R. Duncan Alexander
J. Derbyshire Elaine
Carmen Sara
Smith Stephen
Las Holtet Thor
Roguska Michael
Original Assignee
Abbott Gmbh & Co. Kg
Genetics Institute, Llc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22425740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200802278(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co. Kg, Genetics Institute, Llc. filed Critical Abbott Gmbh & Co. Kg
Publication of TR200802278T2 publication Critical patent/TR200802278T2/tr

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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Abstract

Spesifik olarak beşeri interleukin-12'ye (hIL-12) bağlanan beşeri antikorlar, tercihen rekombinan beşeri antikorlar açıklanmaktadır Tercih edilen antikorlar hEL-12 için yüksek afiniteye sahiptir ve hTL-12 etkinliğini in vitro ve in vivo nötrleştirir. Buluşun bir antikoru tam uzunlukta bir antikor veya onun antijen bağlayıcı bir parçası olabilir Buluşun antikorları ve antikor parçalan, örneğin hTL-12 etkinliğinin zararlı olduğu bir bozukluğu olan bir insan denekte hIL-12'yi tespit etmek ve hTL-12 etkinliğini inhibe etmek için yararlıdır Buluşun rekombinan beşeri antikorlarını eksprese etmek için nükleik asitler, vektörler ve konak hücreler ve rekombinan beşeri antikorları sentezleme yöntemleri de buluşun çerçevesi içine girmektedir.Ş
TR2008/02278T 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. TR200802278T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12660399P 1999-03-25 1999-03-25

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TR200802278T2 true TR200802278T2 (tr) 2008-08-21

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ID=22425740

Family Applications (5)

Application Number Title Priority Date Filing Date
TR2005/03572T TR200503572T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2001/02715T TR200102715T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2006/03997T TR200603997T1 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/01367T TR200501367T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2008/02278T TR200802278T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
TR2005/03572T TR200503572T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2001/02715T TR200102715T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2006/03997T TR200603997T1 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/01367T TR200501367T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

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