MX2009006740A - Anticuerpos humanos que se unen a la il-12 humana y metodos para producirlos. - Google Patents

Anticuerpos humanos que se unen a la il-12 humana y metodos para producirlos.

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Publication number
MX2009006740A
MX2009006740A MX2009006740A MX2009006740A MX2009006740A MX 2009006740 A MX2009006740 A MX 2009006740A MX 2009006740 A MX2009006740 A MX 2009006740A MX 2009006740 A MX2009006740 A MX 2009006740A MX 2009006740 A MX2009006740 A MX 2009006740A
Authority
MX
Mexico
Prior art keywords
hil
antibodies
human antibodies
human
activity
Prior art date
Application number
MX2009006740A
Other languages
English (en)
Inventor
Zehra Kaymakcalan
Michael Roguska
Michael Paskind
Michael White
Paul Sakorafas
Angela Myles
Amy Venturini
Nicholas W Warne
Elaine J Derbyshire
Alexander Robert Duncan
Jochen G Salfeld
Subhashis Banerjee
Daniel Edward Tracey
Boris Lbkovsky
Geertruida M Veldman
Angela Widom
Stuart Friedrich
John Gawain Elvin
Thor Las Holtet
Sara Carmen
Sarah Leila Du Fou
Stephen Smith
Original Assignee
Abbot Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbot Gmbh & Co Kg filed Critical Abbot Gmbh & Co Kg
Publication of MX2009006740A publication Critical patent/MX2009006740A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Biophysics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
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Abstract

La presente invención se refiere a anticuerpos humanos, de preferencia anticuerpos humanos recombinantes, que se unen específicamente a la interleucina-12 humana (hlL-12). Los anticuerpos preferidos tienen una alta afinidad por la hlL-12 y neutralizan la actividad de la misma in vitro e in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa, o una porción de unión al antígeno del mismo. Los anticuerpos o porciones de unión al antígeno de los mismos, de la invención, son útiles para detectar la hlL-12 y para inhibir la actividad de la hlL-12, por ejemplo, en un sujeto humano que padece un trastorno en el cual la actividad de la hlL-12 es dañina. En la presente invención también se incluyen ácidos nucleicos, vectores y células huésped para expresar los anticuerpos humanos recombinantes de la invención, y métodos para sintetizar dichos anticuerpos.
MX2009006740A 2006-12-22 2007-12-21 Anticuerpos humanos que se unen a la il-12 humana y metodos para producirlos. MX2009006740A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/645,287 US7883704B2 (en) 1999-03-25 2006-12-22 Methods for inhibiting the activity of the P40 subunit of human IL-12
PCT/US2007/026212 WO2008079359A2 (en) 2006-12-22 2007-12-21 Human antibodies that bind human il-12 and methods for producing

Publications (1)

Publication Number Publication Date
MX2009006740A true MX2009006740A (es) 2009-10-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006740A MX2009006740A (es) 2006-12-22 2007-12-21 Anticuerpos humanos que se unen a la il-12 humana y metodos para producirlos.

Country Status (14)

Country Link
US (3) US7883704B2 (es)
EP (1) EP2099414A4 (es)
JP (1) JP2010513529A (es)
KR (1) KR20090114368A (es)
CN (1) CN101616653A (es)
AU (1) AU2007338677B2 (es)
BR (1) BRPI0721125A2 (es)
CA (1) CA2673639A1 (es)
MX (1) MX2009006740A (es)
NZ (1) NZ577828A (es)
RU (2) RU2009128215A (es)
SG (1) SG177921A1 (es)
WO (1) WO2008079359A2 (es)
ZA (1) ZA201308087B (es)

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US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
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