SG163559A1 - Il-12/p40 binding proteins - Google Patents

Il-12/p40 binding proteins

Info

Publication number
SG163559A1
SG163559A1 SG201004756-1A SG2010047561A SG163559A1 SG 163559 A1 SG163559 A1 SG 163559A1 SG 2010047561 A SG2010047561 A SG 2010047561A SG 163559 A1 SG163559 A1 SG 163559A1
Authority
SG
Singapore
Prior art keywords
hil
antibodies
activity
antibody
binding proteins
Prior art date
Application number
SG201004756-1A
Inventor
Susan E Lacy
Emma Fung
Jonathan P Belk
Richard W Dixon
Michael Roguska
Paul R Hinton
Shankar Kumar
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of SG163559A1 publication Critical patent/SG163559A1/en

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  • Peptides Or Proteins (AREA)

Abstract

The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL- 23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL- 23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
SG201004756-1A 2005-06-30 2006-06-29 Il-12/p40 binding proteins SG163559A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69567905P 2005-06-30 2005-06-30
SG200718236 2006-06-29

Publications (1)

Publication Number Publication Date
SG163559A1 true SG163559A1 (en) 2010-08-30

Family

ID=43064937

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201004756-1A SG163559A1 (en) 2005-06-30 2006-06-29 Il-12/p40 binding proteins

Country Status (1)

Country Link
SG (1) SG163559A1 (en)

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