MX351706B - Estabilizacion de inmunoglobulinas a traves de una formulacion acuosa con histidina a ph acido debil a neutro. - Google Patents

Estabilizacion de inmunoglobulinas a traves de una formulacion acuosa con histidina a ph acido debil a neutro.

Info

Publication number
MX351706B
MX351706B MX2013003018A MX2013003018A MX351706B MX 351706 B MX351706 B MX 351706B MX 2013003018 A MX2013003018 A MX 2013003018A MX 2013003018 A MX2013003018 A MX 2013003018A MX 351706 B MX351706 B MX 351706B
Authority
MX
Mexico
Prior art keywords
neutral
immunoglobulins
histidine
stabilization
aqueous formulation
Prior art date
Application number
MX2013003018A
Other languages
English (en)
Other versions
MX2013003018A (es
Inventor
Schwarz Hans-Peter
Teschner * Wolfgang
Arno Butterweck Harald
Kölbl Bernhard
Hofbauer Lucia
Original Assignee
Baxalta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc filed Critical Baxalta Inc
Publication of MX2013003018A publication Critical patent/MX2013003018A/es
Publication of MX351706B publication Critical patent/MX351706B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una composición acuosa de inmunoglobulina estable durante el almacenamiento, caracterizada porque comprende: (a) una inmunoglobulina; (b) de 100 mM a 500 mM de histidina; (c) de 0 mM a 10 mM de un catión de metal alcalino; y (d) un pH de 5.5 a 7.0, en donde la composición es estable durante al menos 6 meses cuando se almacena a partir de 28°C a 32°C, y en donde la composición se considera estable siempre y cuando el porcentaje de inmunoglobulina en el estado agregado se mantenga por debajo del 2%, y en donde la composición no contiene un tensioactivo o azúcar.
MX2013003018A 2010-09-17 2011-09-16 Estabilizacion de inmunoglobulinas a traves de una formulacion acuosa con histidina a ph acido debil a neutro. MX351706B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38420910P 2010-09-17 2010-09-17
PCT/US2011/052053 WO2012037534A1 (en) 2010-09-17 2011-09-16 Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph

Publications (2)

Publication Number Publication Date
MX2013003018A MX2013003018A (es) 2013-06-28
MX351706B true MX351706B (es) 2017-10-25

Family

ID=44721088

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003018A MX351706B (es) 2010-09-17 2011-09-16 Estabilizacion de inmunoglobulinas a traves de una formulacion acuosa con histidina a ph acido debil a neutro.

Country Status (23)

Country Link
US (4) US8795658B2 (es)
EP (3) EP2616091A1 (es)
JP (4) JP6055412B2 (es)
KR (1) KR101879885B1 (es)
CN (2) CN103282042B (es)
AR (3) AR083035A1 (es)
AU (2) AU2011301807C1 (es)
BR (1) BR112013006308B1 (es)
CA (2) CA2810734A1 (es)
CL (1) CL2013000724A1 (es)
CO (1) CO6660498A2 (es)
DK (1) DK2616090T3 (es)
EA (2) EA027353B1 (es)
ES (1) ES2959479T3 (es)
FI (1) FI2616090T3 (es)
IL (1) IL225093B (es)
MX (1) MX351706B (es)
MY (1) MY188828A (es)
PL (1) PL2616090T3 (es)
PT (1) PT2616090T (es)
SG (1) SG188487A1 (es)
TW (2) TWI621625B (es)
WO (2) WO2012037530A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI532498B (zh) 2008-03-17 2016-05-11 巴克斯特保健公司 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
MX2012003282A (es) * 2009-09-17 2012-04-30 Baxter Healthcare Sa Co-formulacion estable de hialuronidasa e inmunoglobulina, y metodos de su uso.
JP6055412B2 (ja) * 2010-09-17 2016-12-27 バクスアルタ ゲーエムベーハー 弱酸性〜中性のｐＨにおける、ヒスチジンを有する水性製剤を介した免疫グロブリンの安定化
BR112015004984A2 (pt) 2012-09-07 2017-07-04 Coherus Biosciences Inc formulações aquosas estáveis de adalimumab
PT2994160T (pt) * 2013-05-06 2019-08-07 Baxalta Inc Tratamento de sub-populações com doença de alzheimer com imunoglobulina g combinada
DK3177317T3 (en) 2014-08-04 2020-06-15 Csl Ltd Factor viii formulation
EP3233111B1 (en) * 2014-12-19 2024-08-07 Kedrion Biopharma Inc. Pharmaceutical composition comprising plasminogen and uses thereof
CN104826117B (zh) * 2015-05-05 2017-11-14 广东卫伦生物制药有限公司 用于人体血清免疫球蛋白溶液制剂的储存稳定剂
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
WO2017121867A1 (en) * 2016-01-13 2017-07-20 Genmab A/S Formulation for antibody and drug conjugate thereof
WO2017184880A1 (en) 2016-04-20 2017-10-26 Coherus Biosciences, Inc. A method of filling a container with no headspace
US20190282569A1 (en) * 2016-10-26 2019-09-19 Astellas Pharma Inc. Stable pharmaceutical composition
WO2018181876A1 (ja) * 2017-03-31 2018-10-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 水性製剤及び注射器入り水性製剤、並びに、抗体タンパク脱凝集剤及び抗体タンパク脱凝集方法
JP7465215B2 (ja) * 2018-04-12 2024-04-10 アムジェン インコーポレイテッド 安定なタンパク質組成物を製造する方法
WO2021001522A1 (en) 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
IL301681A (en) * 2020-09-27 2023-05-01 Emergent Biosolutions Canada Inc Hyperimmune globulin preparations
CN116322920A (zh) 2020-11-09 2023-06-23 武田药品工业株式会社 使用氧化硅吸附从血浆中纯化fviii

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK166763C (da) 1983-03-16 1993-07-12 Immuno Ag Immunoglobulin-g-holdig fraktion
DE3310150A1 (de) 1983-03-21 1984-09-27 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer nebenwirkungsfreien igg-immunglobulinloesung fuer die intravenoese applikation
DE3422000A1 (de) 1984-06-14 1985-12-19 Albert Schrem Werkzeugfabrik GmbH, 7928 Giengen Druckmittelbetaetigte spannvorrichtung zum spannen von werkzeugen oder werkstuecken
US4597966A (en) 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
AU5864086A (en) 1985-04-22 1986-11-18 Genetics Institute Inc. High yield production of active factor ix
US4786726A (en) 1986-01-06 1988-11-22 Blood Systems, Inc. Factor IX therapeutic blood product, means and methods of preparing same
CA1339946C (en) 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
FR2638643B1 (fr) 1988-11-09 1991-04-12 Transgene Sa Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants
JP2871709B2 (ja) 1988-11-21 1999-03-17 住友製薬株式会社 免疫グロブリンｇ結合活性を有する新規な蛋白質プロテインｈ、該蛋白質をコードする遺伝子及び該蛋白質の製造法
EP0448605A4 (en) * 1988-12-15 1991-11-21 Invitron Corporation Use of basic amino acids to solubilize immunoglobulins
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
AT402261B (de) 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
DE4111393A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JPH07503132A (ja) 1991-12-17 1995-04-06 ジェンファーム　インターナショナル，インコーポレイティド 異種抗体を産生することができるトランスジェニック非ヒト動物
EP0656941B1 (en) 1992-03-24 2005-06-01 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
AU690171B2 (en) 1993-12-03 1998-04-23 Medical Research Council Recombinant binding proteins and peptides
DK0659767T4 (da) * 1993-12-27 2003-02-10 Zlb Bioplasma Ag Fremgangsmåde til fremstilling af et koncentrat af anti-D-immunoglobulin G og et farmaceutisk præparat, som indeholder dette
GB9418092D0 (en) 1994-09-08 1994-10-26 Red Cross Found Cent Lab Blood Organic compounds
US7253262B2 (en) 1995-01-19 2007-08-07 Quandrant Drug Delivery Limited Dried blood factor composition comprising trehalose
DE69637481T2 (de) 1995-04-27 2009-04-09 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US5925738A (en) * 1995-12-01 1999-07-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
GB9610992D0 (en) 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
EP1029548B1 (en) * 1997-10-15 2007-04-04 Asahi Kasei Pharma Corporation Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution
DK1049480T3 (da) 1998-01-30 2003-01-27 Rhinopharma As Antiviralt middel af planteoprindelse
DE19803453A1 (de) * 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
DK1129186T4 (da) 1998-11-10 2017-02-06 Stichting Sanquin Bloedvoorziening Et faktor VIII-polypeptid med faktor VIII:C-aktivitet
JP5149470B2 (ja) * 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
TR200501367T2 (tr) 1999-03-25 2005-09-21 Abbott Gmbh & Co. Kg Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
ES2644275T3 (es) * 2000-08-11 2017-11-28 Chugai Seiyaku Kabushiki Kaisha Preparaciones estabilizadas que contienen anticuerpos
US6555391B1 (en) 2000-08-15 2003-04-29 Baxter International, Inc. Methods of conditioning an affinity resin after storage
EP1404813A4 (en) * 2001-06-13 2004-11-24 Genentech Inc METHOD FOR CULTIVATING ANIMAL CELLS AND POLYPEPTIDE PRODUCTION IN ANIMAL CELLS
US20060024346A1 (en) * 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
CA2466034C (en) * 2001-11-08 2012-12-18 Protein Design Labs, Inc. Stable aqueous pharmaceutical formulations of daclizumab antibodies
AU2003211991B2 (en) 2002-02-14 2008-08-21 Chugai Seiyaku Kabushiki Kaisha Antibody-containing solution formulations
WO2004001007A2 (en) 2002-06-21 2003-12-31 Idec Pharmaceuticals Corporation Buffered formulations for concentrating antibodies and methods of use thereof
EP1539212A4 (en) 2002-07-12 2007-05-02 Medarex Inc METHOD AND COMPOSITIONS FOR PREVENTING OXIDATIVE DEGRADATION OF PROTEINS
US7857828B2 (en) 2003-01-30 2010-12-28 Integrated Vascular Systems, Inc. Clip applier and methods of use
SI2236154T1 (en) * 2003-02-10 2018-08-31 Biogen Ma Inc. THE FORM OF IMUNOGLOBULIN AND THE METHOD OF ITS PREPARATION
PL1610820T5 (pl) 2003-04-04 2014-01-31 Genentech Inc Preparaty zawierające wysokoskoncentrowane przeciwciała i białka
EP2281577B1 (en) * 2003-05-14 2016-11-16 ImmunoGen, Inc. Drug conjugate composition
WO2004112828A1 (en) * 2003-06-25 2004-12-29 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
SI1698640T2 (sl) * 2003-10-01 2019-08-30 Kyowa Hakko Kirin Co., Ltd. Postopek za stabiliziranje protitelesa in stabiliziran pripravek protitelesa tipa raztopina
EP1532983A1 (en) * 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
CN1953768B (zh) 2004-02-12 2010-10-13 默克专利有限公司 抗-egfr抗体的高浓缩液体制剂
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
US20090047723A1 (en) 2005-01-14 2009-02-19 Bayer Healthcare Llc Method for purification of factor vii
GT200600031A (es) * 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
BRPI0614100A2 (pt) * 2005-08-03 2011-03-09 Immunogen Inc formulações de imunoconjugado lìquidas
KR100667860B1 (ko) 2005-10-18 2007-01-11 주식회사 녹십자 고순도 사람 혈액응고 제9인자의 정제 방법
CN101378782A (zh) * 2005-12-21 2009-03-04 惠氏公司 粘度降低的蛋白质制剂及其用途
WO2007074880A1 (ja) * 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha 抗体含有安定化製剤
PL3121266T3 (pl) 2006-01-04 2020-07-13 Baxalta Incorporated Wolne od oligopeptydów pożywki do hodowli komórkowej
JP2009525986A (ja) 2006-02-03 2009-07-16 メディミューン，エルエルシー タンパク質製剤
EP2094247B1 (en) * 2006-10-20 2022-06-29 Amgen Inc. Stable polypeptide formulations
CN101199845B (zh) * 2006-12-14 2012-05-23 上海国健生物技术研究院 一种稳定的抗IgE人源化单抗制剂
CA2673260A1 (en) * 2006-12-20 2008-07-03 Bayer Healthcare Llc Factor vii and viia compositions
EP2125866B1 (en) 2007-02-28 2013-05-22 Baxter International Inc. Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules
AU2008228823A1 (en) * 2007-03-22 2008-09-25 Imclone Llc Stable antibody formulations
MX2009010389A (es) * 2007-03-30 2010-01-20 Medimmune Llc Formulacion de anticuerpos.
US7598560B2 (en) 2007-03-30 2009-10-06 Kavalieros Jack T Hetero-bimos injection process for non-volatile flash memory
US20090208492A1 (en) * 2007-06-14 2009-08-20 Elan Pharmaceuticals, Inc. Lyophilized Immunoglobulin Formulations and Methods of Preparation
WO2009009406A1 (en) * 2007-07-06 2009-01-15 Smithkline Beecham Corporation Antibody formulations
EP2356247B2 (en) 2008-11-12 2019-05-15 Baxalta Incorporated Method of producing serum-free insulin-free factor vii
NZ606283A (en) * 2008-11-28 2014-08-29 Abbvie Inc Stable antibody compositions and methods for stabilizing same
EP2196476A1 (en) 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
RU2011140498A (ru) 2009-03-06 2013-04-20 Дженентек, Инк. Препарат антител
TWI445714B (zh) 2009-05-27 2014-07-21 Baxter Int 產製用於皮下使用之高濃度免疫球蛋白製備物之方法
GB0915480D0 (en) * 2009-09-04 2009-10-07 Arecor Ltd Stable formulation of factor viii
US8821879B2 (en) 2009-09-04 2014-09-02 Xoma Technology Ltd. Anti-botulism antibody coformulations
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
SG10201504808XA (en) 2010-03-17 2015-07-30 Abbott Res Bv Anti-Nerve Growth Factor (NGF) Antibody Compositions
JP6055412B2 (ja) 2010-09-17 2016-12-27 バクスアルタ ゲーエムベーハー 弱酸性〜中性のｐＨにおける、ヒスチジンを有する水性製剤を介した免疫グロブリンの安定化

Also Published As

Publication number Publication date
US20120076779A1 (en) 2012-03-29
CN104524566B (zh) 2018-08-07
CN103282042B (zh) 2014-12-10
AU2011301807A1 (en) 2013-03-28
US8795658B2 (en) 2014-08-05
FI2616090T3 (fi) 2023-09-21
EP2616091A1 (en) 2013-07-24
US20140370000A1 (en) 2014-12-18
EA032336B1 (ru) 2019-05-31
KR20130099956A (ko) 2013-09-06
MX2013003018A (es) 2013-06-28
EA027353B1 (ru) 2017-07-31
JP6055412B2 (ja) 2016-12-27
CL2013000724A1 (es) 2014-03-21
JP2013544762A (ja) 2013-12-19
AR122552A2 (es) 2022-09-21
KR101879885B1 (ko) 2018-07-18
TW201213342A (en) 2012-04-01
BR112013006308A2 (pt) 2016-06-07
AU2011301807C1 (en) 2016-02-11
CO6660498A2 (es) 2013-04-30
US20120076772A1 (en) 2012-03-29
AR083035A1 (es) 2013-01-30
TWI621625B (zh) 2018-04-21
TW201217395A (en) 2012-05-01
EP4289445A3 (en) 2024-02-21
ES2959479T3 (es) 2024-02-26
US9855331B2 (en) 2018-01-02
PT2616090T (pt) 2023-10-16
PL2616090T3 (pl) 2023-12-18
AR083034A1 (es) 2013-01-30
CN104524566A (zh) 2015-04-22
EA201390400A1 (ru) 2013-08-30
CA2810734A1 (en) 2012-03-22
EP2616090B8 (en) 2023-10-04
EP2616090A1 (en) 2013-07-24
AU2011301807B2 (en) 2015-07-30
JP2013544763A (ja) 2013-12-19
EP2616090B1 (en) 2023-08-23
DK2616090T3 (da) 2023-09-18
JP2017071631A (ja) 2017-04-13
EP4289445A2 (en) 2023-12-13
IL225093B (en) 2018-05-31
CA2810731A1 (en) 2012-03-22
WO2012037530A1 (en) 2012-03-22
MY188828A (en) 2022-01-06
JP2018203784A (ja) 2018-12-27
US20180250401A1 (en) 2018-09-06
SG188487A1 (en) 2013-05-31
CN103282042A (zh) 2013-09-04
WO2012037534A1 (en) 2012-03-22
AU2011301803A1 (en) 2013-03-21
BR112013006308B1 (pt) 2022-03-22
EA201692397A1 (ru) 2017-08-31

Similar Documents

Publication Publication Date Title
MY188828A (en) Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph
PH12015502013A1 (en) Pharmaceutical composition of s-ketamine hydrochloride
WO2014039903A3 (en) Stable aqueous formulations of adalimumab
PH12015501957A1 (en) Pharmaceutical composition of s-ketamine hydrochloride
NZ716840A (en) Combination formulation of two antiviral compounds
PH12015502041B1 (en) Heteroaryl compounds and uses thereof
MX362655B (es) Composiciones cosmeticas.
JO3452B1 (ar) بنزاميدات أمينو اريل مغاير كمثبطات كيناز
NZ704584A (en) Liquid stable virus vaccines
AU2012265219A8 (en) Compounds containing hydrido-tricyano-borate anions
EA201692104A1 (ru) Ингибиторы асс и их применения
HK1221653A1 (zh) 用於呼吸遞送三種或更多種活性劑的組合物、方法和系統
MX348823B (es) Formulaciones estables de linaclotida.
EA201590887A1 (ru) Композиция
WO2014195978A3 (en) PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS
MX2015008766A (es) Compuestos cbd fluorados, composiciones y usos de los mismos.
WO2014086982A3 (en) Stable metal compounds, their compositions and methods of their use
EP2557919A4 (en) STABILIZED FORMULATIONS OF STATIN
UA115357C2 (uk) Похідні піридин-4-ілу
MX2015015051A (es) Formulaciones alternativas para polipeptidos de fusion tnfr:fc.
MX2016001422A (es) Composicion farmaceutica de fingolimod.
EP3082417A4 (en) Additive package compositions for pesticide suspension concentrate formulations
WO2014166836A8 (en) Growth hormone compound formulation
WO2014194053A3 (en) Carbohydrate compounds for nutritional and therapeutic use
WO2012125552A3 (en) Methods of electric field induced delivery of compounds, compositions used in delivery, and system of delivery

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: BAXALTA INCORPORATED

FG Grant or registration