SK288064B6 - Peptide compounds, pharmaceutical compositions comprising them and their use - Google Patents
Peptide compounds, pharmaceutical compositions comprising them and their use Download PDFInfo
- Publication number
- SK288064B6 SK288064B6 SK75-2003A SK752003A SK288064B6 SK 288064 B6 SK288064 B6 SK 288064B6 SK 752003 A SK752003 A SK 752003A SK 288064 B6 SK288064 B6 SK 288064B6
- Authority
- SK
- Slovakia
- Prior art keywords
- mmol
- solution
- alkyl
- absent
- compound
- Prior art date
Links
- 0 CCCC(C(C(**C(C(*I)=O)*1=CC(C)C=C1)=O)=O)NC(C(CCC1C)*1C([C@@]1NC(OCC(C)*)=*C1(*)*)=*C)=O Chemical compound CCCC(C(C(**C(C(*I)=O)*1=CC(C)C=C1)=O)=O)NC(C(CCC1C)*1C([C@@]1NC(OCC(C)*)=*C1(*)*)=*C)=O 0.000 description 50
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 3
- AHQZRFBZJSCKAV-UHFFFAOYSA-N CC1=CCC=C1 Chemical compound CC1=CCC=C1 AHQZRFBZJSCKAV-UHFFFAOYSA-N 0.000 description 2
- SSDZYLQUYMOSAK-UHFFFAOYSA-N C#CC1CCCCC1 Chemical compound C#CC1CCCCC1 SSDZYLQUYMOSAK-UHFFFAOYSA-N 0.000 description 1
- LBVFELYILXVJOW-HWOCKDDLSA-N CC(C(C1)N([C@@H](C)O)C11CCCC1)O Chemical compound CC(C(C1)N([C@@H](C)O)C11CCCC1)O LBVFELYILXVJOW-HWOCKDDLSA-N 0.000 description 1
- XPHVGKNBNZLSMG-AXAOJVOGSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)[C@H]11)C1C(NC(CC1CCC1)C(C(N)=O)=O)=O)=O)NC(NC1(C2)C(C3)CC2CC3C1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)[C@H]11)C1C(NC(CC1CCC1)C(C(N)=O)=O)=O)=O)NC(NC1(C2)C(C3)CC2CC3C1)=O XPHVGKNBNZLSMG-AXAOJVOGSA-N 0.000 description 1
- LKENTYLPIUIMFG-UHFFFAOYSA-N CC(C1CCCC1)=O Chemical compound CC(C1CCCC1)=O LKENTYLPIUIMFG-UHFFFAOYSA-N 0.000 description 1
- ONDBKLZMVCQRSS-UHFFFAOYSA-N CC1C2C=COC2BC1 Chemical compound CC1C2C=COC2BC1 ONDBKLZMVCQRSS-UHFFFAOYSA-N 0.000 description 1
- ZKCQLEUZFXIVIE-UHFFFAOYSA-N CCCCC(N(C)C(CC)CC)=O Chemical compound CCCCC(N(C)C(CC)CC)=O ZKCQLEUZFXIVIE-UHFFFAOYSA-N 0.000 description 1
- GSPAVZIEDMALNO-ULUSZKPHSA-N C[C@H](C1NCCCC1)O Chemical compound C[C@H](C1NCCCC1)O GSPAVZIEDMALNO-ULUSZKPHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22010800P | 2000-07-21 | 2000-07-21 | |
PCT/US2001/022678 WO2002008244A2 (en) | 2000-07-21 | 2001-07-19 | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
Publications (2)
Publication Number | Publication Date |
---|---|
SK752003A3 SK752003A3 (en) | 2003-08-05 |
SK288064B6 true SK288064B6 (sk) | 2013-04-03 |
Family
ID=22822095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK75-2003A SK288064B6 (sk) | 2000-07-21 | 2001-07-19 | Peptide compounds, pharmaceutical compositions comprising them and their use |
Country Status (32)
Country | Link |
---|---|
US (4) | US7012066B2 (pl) |
EP (1) | EP1385870B1 (pl) |
JP (3) | JP4298289B2 (pl) |
KR (2) | KR100939155B1 (pl) |
CN (3) | CN102206247B (pl) |
AR (2) | AR033985A1 (pl) |
AT (1) | ATE461207T1 (pl) |
AU (2) | AU7698801A (pl) |
BR (1) | BR0112540A (pl) |
CA (1) | CA2410662C (pl) |
CY (2) | CY1112267T1 (pl) |
CZ (1) | CZ303213B6 (pl) |
DE (2) | DE60141608D1 (pl) |
DK (1) | DK1385870T3 (pl) |
EC (1) | ECSP034438A (pl) |
ES (1) | ES2341534T3 (pl) |
HK (1) | HK1058047A1 (pl) |
HU (1) | HU229997B1 (pl) |
IL (2) | IL153670A0 (pl) |
LU (1) | LU91910I2 (pl) |
MX (1) | MXPA03000627A (pl) |
MY (2) | MY143322A (pl) |
NO (2) | NO332329B1 (pl) |
NZ (1) | NZ523782A (pl) |
PL (1) | PL206255B1 (pl) |
PT (1) | PT1385870E (pl) |
RU (2) | RU2355700C9 (pl) |
SI (1) | SI1385870T1 (pl) |
SK (1) | SK288064B6 (pl) |
TW (1) | TWI324611B (pl) |
WO (1) | WO2002008244A2 (pl) |
ZA (1) | ZA200210312B (pl) |
Families Citing this family (262)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA79749C2 (en) | 1996-10-18 | 2007-07-25 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
ATE461207T1 (de) * | 2000-07-21 | 2010-04-15 | Schering Corp | Peptide als inhibitoren der ns3-serinprotease des hepatitis c virus |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
AU2001291013A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
GB2367816A (en) * | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
AU2002236591B2 (en) * | 2000-12-12 | 2005-07-14 | Schering Corporation | Diaryl peptides as NS3-serine protease inhibitors of hepatits C virus |
EP1404704B9 (en) | 2001-07-11 | 2008-02-20 | Vertex Pharmaceuticals Incorporated | Bridged bicyclic serine protease inhibitors |
MXPA04003825A (es) * | 2001-10-24 | 2004-07-08 | Vertex Pharma | Inhibidores de serina proteasa, en particular la ns3-ns4a proteasa del virus de hepatitis c, que incorpora un sistema de anillo fusionado. |
MXPA04007163A (es) | 2002-01-23 | 2004-10-29 | Schering Corp | Compuestos de prolina como inhibidores de la proteasa serina ns3 para utilizarse en el tratamiento de la infeccion por el virus de la hepatitis c. |
US7119072B2 (en) | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
US6642204B2 (en) | 2002-02-01 | 2003-11-04 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
US7091184B2 (en) | 2002-02-01 | 2006-08-15 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
CN100381440C (zh) * | 2002-04-11 | 2008-04-16 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是丙型肝炎病毒ns3-ns4蛋白酶的抑制剂 |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
ES2381548T3 (es) * | 2003-04-11 | 2012-05-29 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas, particularmente de la proteasa VHC NS3-NS4A |
AU2011203054B2 (en) * | 2003-04-11 | 2012-04-26 | Vertex Pharmaceuticals, Incorporated | Inhibitors of Serine Proteases, Particularly HCV NS3-NS4A Protease |
UA83046C2 (ru) | 2003-05-21 | 2008-06-10 | Берингер Ингельхайм Интернациональ Гмбх | Соединения как ингибиторы вируса гепатита с, фармацевтическая композиция на их основе |
CN101823965B (zh) * | 2003-06-17 | 2012-12-19 | 默沙东公司 | 制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体 |
AR044694A1 (es) | 2003-06-17 | 2005-09-21 | Schering Corp | Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo |
US6992220B2 (en) | 2003-06-17 | 2006-01-31 | Schering Corporation | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof |
CN102020700A (zh) | 2003-07-18 | 2011-04-20 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
MXPA06002250A (es) * | 2003-08-26 | 2006-05-17 | Schering Corp | Inhibidores peptidomimeticos novedosos de la serina proteasa ns3 del virus de la hepatitis c. |
TW201127828A (en) | 2003-09-05 | 2011-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
CA2538791A1 (en) * | 2003-09-18 | 2005-03-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
BRPI0414814A (pt) * | 2003-09-26 | 2006-11-14 | Schering Corp | inibidores macrocìclicos de protease de serina ns3 de vìrus de hepatite c |
KR20120010278A (ko) | 2003-10-10 | 2012-02-02 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 hcv ns3-ns4a 프로테아제의 억제제 |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
EP1944042A1 (en) | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Combinations for HCV treatment |
US8187874B2 (en) | 2003-10-27 | 2012-05-29 | Vertex Pharmaceuticals Incorporated | Drug discovery method |
AU2004285019B9 (en) | 2003-10-27 | 2011-11-24 | Vertex Pharmaceuticals Incorporated | HCV NS3-NS4A protease resistance mutants |
JP2007532479A (ja) | 2003-11-20 | 2007-11-15 | シェーリング コーポレイション | C型肝炎ウイルスns3プロテアーゼの脱ペプチド化インヒビター |
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WO2005070955A1 (en) | 2004-01-21 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
ES2342944T3 (es) * | 2004-01-30 | 2010-07-19 | Medivir Ab | Inhibidores de ns-3 serina proteasa de vhc. |
CA2554999A1 (en) * | 2004-02-04 | 2005-08-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
JP4143669B2 (ja) | 2004-02-24 | 2008-09-03 | 日本たばこ産業株式会社 | 4環縮合複素環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
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US7635694B2 (en) | 2004-02-27 | 2009-12-22 | Schering Corporation | Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease |
US8067379B2 (en) * | 2004-02-27 | 2011-11-29 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
CN1946692A (zh) * | 2004-02-27 | 2007-04-11 | 先灵公司 | 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4-(环戊基)-稠合的脯氨酸化合物 |
US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
KR20070026394A (ko) | 2004-02-27 | 2007-03-08 | 쉐링 코포레이션 | C형 간염 바이러스의 ns3 세린 프로테아제 억제제로서사이클릭 p4's를 지닌 신규한 케토아미드 |
TW200602037A (en) * | 2004-02-27 | 2006-01-16 | Schering Corp | Novel compounds as inhibitors of hepatitis C virus NS3 serine protease |
WO2005085197A1 (en) * | 2004-02-27 | 2005-09-15 | Schering Corporation | Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease |
WO2005085275A1 (en) | 2004-02-27 | 2005-09-15 | Schering Corporation | Inhibitors of hepatitis c virus ns3 protease |
HUE024556T2 (hu) * | 2004-03-12 | 2016-02-29 | Vertex Pharma | Eljárások és intermedierek aszparagin acetál kapszáz inhibitorok elõállítására |
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DE602005015452D1 (de) * | 2004-05-20 | 2009-08-27 | Schering Corp | Substituierte proline als hemmer der ns3-serinprotease des hepatits-c-virus |
CA2573346C (en) | 2004-07-20 | 2011-09-20 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
MX2007002371A (es) | 2004-08-27 | 2007-04-23 | Schering Corp | Compuestos de acilsulfonamida como inhibidores de la serina proteasa ns3 del virus de la hepatitis c. |
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TWI449711B (zh) * | 2005-06-30 | 2014-08-21 | Virobay Inc | C型肝炎病毒(hcv)抑制劑 |
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US20090148407A1 (en) | 2005-07-25 | 2009-06-11 | Intermune, Inc. | Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication |
JP5230416B2 (ja) | 2005-07-29 | 2013-07-10 | テイボテク・フアーマシユーチカルズ | C型肝炎ウイルスの大員環状阻害剤 |
ATE524475T1 (de) | 2005-07-29 | 2011-09-15 | Tibotec Pharm Ltd | Makrocyclische inhibitoren des hepatitis-c-virus |
AU2006275413B2 (en) * | 2005-08-02 | 2012-07-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
CN102382170A (zh) | 2005-08-19 | 2012-03-21 | 弗特克斯药品有限公司 | 用于制备蛋白酶抑制剂的方法和中间体 |
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US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
WO2007041631A1 (en) * | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION |
CA2623865A1 (en) * | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection |
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