SK279249B6 - Ľudské monoklonálne protilátky a spôsob ich výroby - Google Patents
Ľudské monoklonálne protilátky a spôsob ich výroby Download PDFInfo
- Publication number
- SK279249B6 SK279249B6 SK3566-83A SK356683A SK279249B6 SK 279249 B6 SK279249 B6 SK 279249B6 SK 356683 A SK356683 A SK 356683A SK 279249 B6 SK279249 B6 SK 279249B6
- Authority
- SK
- Slovakia
- Prior art keywords
- human
- monoclonal antibodies
- fusion
- cells
- hybridomas
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 7
- 230000004927 fusion Effects 0.000 claims abstract description 33
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 22
- 210000003719 b-lymphocyte Anatomy 0.000 claims abstract description 13
- 210000004881 tumor cell Anatomy 0.000 claims description 10
- 210000004408 hybridoma Anatomy 0.000 abstract description 33
- 210000004027 cell Anatomy 0.000 abstract description 28
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 238000010367 cloning Methods 0.000 abstract description 5
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- 230000016784 immunoglobulin production Effects 0.000 abstract description 3
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- 210000001165 lymph node Anatomy 0.000 description 12
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 9
- 201000011510 cancer Diseases 0.000 description 9
- 210000004698 lymphocyte Anatomy 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 8
- 239000000427 antigen Substances 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 206010008342 Cervix carcinoma Diseases 0.000 description 6
- 201000010881 cervical cancer Diseases 0.000 description 6
- 230000009257 reactivity Effects 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 5
- 102000018358 immunoglobulin Human genes 0.000 description 5
- 229940072221 immunoglobulins Drugs 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
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- 108090000623 proteins and genes Proteins 0.000 description 4
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 210000005260 human cell Anatomy 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 208000019065 cervical carcinoma Diseases 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
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- 239000012894 fetal calf serum Substances 0.000 description 2
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- 238000003018 immunoassay Methods 0.000 description 2
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- 230000001225 therapeutic effect Effects 0.000 description 2
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- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000000799 fusogenic effect Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 125000003712 glycosamine group Chemical group 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical group 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 210000001082 somatic cell Anatomy 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57084843A JPS58201994A (ja) | 1982-05-21 | 1982-05-21 | 抗原特異的ヒト免疫グロブリンの生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK356683A3 SK356683A3 (en) | 1998-08-05 |
| SK279249B6 true SK279249B6 (sk) | 1998-08-05 |
Family
ID=13842073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK3566-83A SK279249B6 (sk) | 1982-05-21 | 1983-05-19 | Ľudské monoklonálne protilátky a spôsob ich výroby |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0109441B1 (cs) |
| JP (2) | JPS58201994A (cs) |
| AT (1) | ATE114189T1 (cs) |
| AU (1) | AU560595B2 (cs) |
| CZ (1) | CZ280677B6 (cs) |
| DE (1) | DE3382764T2 (cs) |
| DK (1) | DK164510C (cs) |
| FI (1) | FI86077C (cs) |
| HU (1) | HU190908B (cs) |
| IN (1) | IN157982B (cs) |
| SK (1) | SK279249B6 (cs) |
| WO (1) | WO1983004313A1 (cs) |
| ZA (1) | ZA833686B (cs) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247538A (en) * | 1982-05-21 | 1988-12-28 | Mark C. Glassy | Human-human hybridomas for solid tumors |
| US4618577A (en) * | 1983-02-09 | 1986-10-21 | The Regents Of The University Of California | Human-human hybridoma, CLNH5 |
| US4939240A (en) * | 1983-03-04 | 1990-07-03 | Health Research, Inc. | Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy |
| CA1215331A (en) * | 1983-03-04 | 1986-12-16 | Tsann M. Chu | Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy |
| US4613576A (en) * | 1983-03-09 | 1986-09-23 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies to cancer cells |
| US4693966A (en) * | 1983-03-11 | 1987-09-15 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies from lymphocytes of patients with malignant melanoma |
| SE8401945L (sv) * | 1983-04-08 | 1984-11-13 | Kureha Chemical Ind Co Ltd | Antikropp mot cancer i urinblasan hos menniska |
| EP0162070A1 (en) * | 1983-11-25 | 1985-11-27 | The University Of Melbourne | Cell line and monoclonal antibody |
| NZ210867A (en) * | 1984-01-31 | 1989-01-06 | Litton Bionetics Inc | Tumour-specific monoclonal antibodies, production thereof and use |
| US4886745A (en) * | 1984-03-30 | 1989-12-12 | Syntex Inc. | Monoclonal antibody specific for human basal cell surface antigen |
| CA1320689C (en) * | 1984-03-30 | 1993-07-27 | Alain Schreiber | Monoclonal antibody specific for human basal cell surface antigen |
| JPS6133125A (ja) * | 1984-07-25 | 1986-02-17 | Morinaga & Co Ltd | ヒト単クロ−ン性抗肺ガン細胞抗体 |
| US4761377A (en) * | 1984-10-15 | 1988-08-02 | The Regents Of The University Of California | Human-human hybrid cell lines that produce antibodies against antigenic determinants on cancer cells |
| EP0183876A1 (en) * | 1984-11-27 | 1986-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Monoclonal antibodies for endotoxin core and their use |
| US5106746A (en) * | 1985-05-22 | 1992-04-21 | E. I. Du Pont De Nemours And Company | Process for the in vitro immunization of human splenocytes against tumor associated antigens |
| US5776093A (en) * | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| JPH0655680B2 (ja) * | 1985-10-26 | 1994-07-27 | 萩原 義秀 | 悪性腫瘍用ヒトモノクロナル抗体複合剤 |
| EP0222360A3 (en) * | 1985-11-12 | 1989-03-15 | Biotherapeutics Inc. | A method of producing a patient-specific cytotoxic reagent and composition |
| JPH0767388B2 (ja) * | 1986-01-13 | 1995-07-26 | 三菱化学株式会社 | 抗体産生細胞株の樹立方法 |
| WO1991009135A1 (en) * | 1989-12-18 | 1991-06-27 | Board Of Regents, The University Of Texas System | Tumor-specific, cell surface-binding monoclonal antibodies |
| US5281710A (en) * | 1990-08-01 | 1994-01-25 | The Scripps Research Institute | Dynemicin analogs: synthesis, methods of preparation and use |
| JPH04346792A (ja) * | 1991-05-22 | 1992-12-02 | Hagiwara Yoshihide | 抗癌ヒトモノクローナル抗体のアミノ酸配列及びそれをコードするｄｎａ塩基配列 |
| EP0528663B1 (en) * | 1991-08-16 | 1997-10-29 | Kabushiki Kaisha Toshiba | Monoclonal antibody to a synaptophysin |
| ATE395933T1 (de) | 1997-08-15 | 2008-06-15 | Chugai Pharmaceutical Co Ltd | Präventiva oder arzneien enthaltend neutralisierende anti-il6-rezeptor antikörper zur reduktion urinären proteins bei systemischen lupus erythematosus |
| ES2307526T3 (es) | 1999-08-23 | 2008-12-01 | Chugai Seiyaku Kabushiki Kaisha | Potenciadores de la expresion del antigeno hm1.24. |
| CZ20021035A3 (cs) | 1999-10-01 | 2002-08-14 | Chugai Seiyaku Kabushiki Kaisha | Prevence a léčba nemocí souvisejících s poruchami krevní sráľlivosti |
| US7931897B2 (en) | 2001-02-07 | 2011-04-26 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for hematopoietic tumors |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| MXPA04007924A (es) | 2002-02-14 | 2005-05-17 | Chugai Pharmaceutical Co Ltd | Formulaciones en solucion que contienen anticuerpo. |
| US20060058511A1 (en) | 2002-08-27 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | Method for stabilizing protein solution preparation |
| EP2261230B1 (en) | 2002-09-11 | 2017-05-10 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| US7863042B2 (en) | 2003-06-18 | 2011-01-04 | Chugai Seiyaku Kabushiki Kaisha | Fucose transporter |
| JP4643450B2 (ja) | 2003-08-08 | 2011-03-02 | 株式会社ペルセウスプロテオミクス | 癌高発現遺伝子 |
| ATE512232T1 (de) | 2003-12-03 | 2011-06-15 | Chugai Pharmaceutical Co Ltd | Expressionssystem mit einem säuger-beta-actin- promotor |
| WO2005056605A1 (ja) | 2003-12-12 | 2005-06-23 | Chugai Seiyaku Kabushiki Kaisha | ３量体以上の受容体を認識する改変抗体 |
| EP1674111B1 (en) | 2004-07-09 | 2010-11-03 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican 3 antibody |
| EP2208783A1 (en) | 2004-12-22 | 2010-07-21 | Chugai Seiyaku Kabushiki Kaisha | Method of producing an antibody using a cell in which the function of fucose transporter is inhibited |
| US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| CN101237890A (zh) | 2005-06-10 | 2008-08-06 | 中外制药株式会社 | 含有葡甲胺的蛋白质制剂的稳定剂及其利用 |
| RU2446826C2 (ru) | 2005-10-14 | 2012-04-10 | Фукуока Юниверсити | Агенты для подавления повреждения трансплантированных островков после трансплантации островков |
| EP1964574B1 (en) | 2005-11-14 | 2016-09-07 | Cellmid Limited | Method for treatment or prevention of disease associated with functional disorder of regulatory t cell |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| WO2007061029A1 (ja) | 2005-11-25 | 2007-05-31 | Keio University | 前立腺癌治療剤 |
| AR059213A1 (es) | 2006-01-27 | 2008-03-19 | Univ Keio | Agentes terapeuticos para enfermedades que involucran neovascularizacion coroidal |
| WO2007114319A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 抗体の血中動態を制御する方法 |
| EP4218801A3 (en) | 2006-03-31 | 2023-08-23 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| EP2011870A4 (en) | 2006-04-14 | 2010-09-15 | Medical & Biol Lab Co Ltd | MUTANT POLYPEPTIDE WITH EFFECTOR FUNCTION |
| KR20090024243A (ko) | 2006-06-08 | 2009-03-06 | 추가이 세이야쿠 가부시키가이샤 | 염증성 질환의 예방 또는 치료제 |
| MX2008015975A (es) | 2006-06-14 | 2009-03-26 | Chugai Pharmaceutical Co Ltd | Agentes para promocionar el crecimiento de celulas de vastago hematopoyeticas. |
| JPWO2008007755A1 (ja) | 2006-07-13 | 2009-12-10 | 中外製薬株式会社 | 細胞死誘導剤 |
| WO2008010556A1 (fr) | 2006-07-21 | 2008-01-24 | Chugai Seiyaku Kabushiki Kaisha | Médicament agissant contre une maladie rénale |
| ATE465179T1 (de) | 2006-07-24 | 2010-05-15 | Pasteur Institut | Antikörper, antikörperfragmente und scfv die an posttranslational modifizierte neurotrophine binden |
| WO2008020586A1 (fr) | 2006-08-14 | 2008-02-21 | Forerunner Pharma Research Co., Ltd. | diagnostic et traitement du cancer à l'aide de l'anticorps anti-desmogléine-3 |
| EP2083017A4 (en) | 2006-09-14 | 2011-01-12 | Med & Biological Lab Co Ltd | ANTIBODIES HAVING INCREASED ADCC ACTIVITY AND METHOD FOR PRODUCING THE SAME |
| NZ601022A (en) | 2006-10-12 | 2014-09-26 | Chugai Pharmaceutical Co Ltd | Diagnosis and treatment of cancer using anti-ereg antibody |
| US20100061933A1 (en) | 2006-10-20 | 2010-03-11 | Naoki Kimura | Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient |
| EP2123676A4 (en) | 2007-01-05 | 2011-01-05 | Univ Tokyo | DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-PRG-3 ANTIBODIES |
| CA2679266A1 (en) | 2007-02-27 | 2008-09-04 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-grp78 antibody as active ingredient |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001461A1 (en) * | 1980-07-18 | 1982-05-13 | Leland Stanford Junior Univ | Human hybridomas,precursors and products |
| NZ198851A (en) * | 1980-11-07 | 1984-07-31 | Wistar Inst | Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line |
-
1982
- 1982-05-21 JP JP57084843A patent/JPS58201994A/ja active Granted
-
1983
- 1983-05-19 CZ CS833566A patent/CZ280677B6/cs not_active IP Right Cessation
- 1983-05-19 SK SK3566-83A patent/SK279249B6/sk unknown
- 1983-05-20 EP EP83902157A patent/EP0109441B1/en not_active Expired - Lifetime
- 1983-05-20 JP JP58502264A patent/JPS60501359A/ja active Pending
- 1983-05-20 WO PCT/US1983/000781 patent/WO1983004313A1/en not_active Ceased
- 1983-05-20 DE DE3382764T patent/DE3382764T2/de not_active Expired - Lifetime
- 1983-05-20 AU AU17729/83A patent/AU560595B2/en not_active Expired
- 1983-05-20 HU HU832697A patent/HU190908B/hu not_active IP Right Cessation
- 1983-05-20 AT AT83902157T patent/ATE114189T1/de not_active IP Right Cessation
- 1983-05-23 ZA ZA833686A patent/ZA833686B/xx unknown
- 1983-05-31 IN IN683/CAL/83A patent/IN157982B/en unknown
-
1984
- 1984-01-19 FI FI840219A patent/FI86077C/fi not_active IP Right Cessation
- 1984-01-20 DK DK025084A patent/DK164510C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3382764D1 (de) | 1994-12-22 |
| DK164510C (da) | 1992-11-23 |
| EP0109441A4 (en) | 1986-09-22 |
| SK356683A3 (en) | 1998-08-05 |
| ATE114189T1 (de) | 1994-12-15 |
| IN157982B (cs) | 1986-08-09 |
| DK25084A (da) | 1984-01-20 |
| WO1983004313A1 (en) | 1983-12-08 |
| JPS58201994A (ja) | 1983-11-25 |
| DK25084D0 (da) | 1984-01-20 |
| JPH0159878B2 (cs) | 1989-12-20 |
| HU190908B (en) | 1986-12-28 |
| ZA833686B (en) | 1984-09-26 |
| CZ356683A3 (en) | 1995-11-15 |
| AU560595B2 (en) | 1987-04-09 |
| FI840219L (fi) | 1984-01-19 |
| EP0109441B1 (en) | 1994-11-17 |
| EP0109441A1 (en) | 1984-05-30 |
| AU1772983A (en) | 1983-12-16 |
| DK164510B (da) | 1992-07-06 |
| JPS60501359A (ja) | 1985-08-22 |
| FI840219A0 (fi) | 1984-01-19 |
| FI86077C (fi) | 1992-07-10 |
| CZ280677B6 (cs) | 1996-04-17 |
| DE3382764T2 (de) | 1995-03-16 |
| FI86077B (fi) | 1992-03-31 |
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