SI9300648B - Z N-oksikarbonilom substituirani 5'-deoksi-5-fluorocitidini - Google Patents
Z N-oksikarbonilom substituirani 5'-deoksi-5-fluorocitidini Download PDFInfo
- Publication number
- SI9300648B SI9300648B SI9300648A SI9300648A SI9300648B SI 9300648 B SI9300648 B SI 9300648B SI 9300648 A SI9300648 A SI 9300648A SI 9300648 A SI9300648 A SI 9300648A SI 9300648 B SI9300648 B SI 9300648B
- Authority
- SI
- Slovenia
- Prior art keywords
- deoxy
- cytidine
- fluoro
- fluorocytidine
- acetyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92121538 | 1992-12-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9300648A SI9300648A (en) | 1994-09-30 |
SI9300648B true SI9300648B (sl) | 2000-06-30 |
Family
ID=8210304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9300648A SI9300648B (sl) | 1992-12-18 | 1993-12-10 | Z N-oksikarbonilom substituirani 5'-deoksi-5-fluorocitidini |
Country Status (41)
Country | Link |
---|---|
US (1) | US5472949A (de) |
EP (1) | EP0602454B1 (de) |
JP (1) | JP2501297B2 (de) |
KR (1) | KR100347218B1 (de) |
CN (1) | CN1035617C (de) |
AT (1) | ATE137244T1 (de) |
AU (1) | AU671491B2 (de) |
BG (1) | BG61485B1 (de) |
BR (1) | BR9305089A (de) |
CA (1) | CA2103324C (de) |
CZ (1) | CZ284788B6 (de) |
DE (1) | DE69302360T2 (de) |
DK (1) | DK0602454T3 (de) |
EE (1) | EE03086B1 (de) |
ES (1) | ES2086856T3 (de) |
FI (1) | FI112365B (de) |
GE (1) | GEP20074251B (de) |
GR (1) | GR3020286T3 (de) |
HK (1) | HK1005875A1 (de) |
HR (1) | HRP931430B1 (de) |
HU (2) | HU218291B (de) |
IL (1) | IL108000A0 (de) |
IS (1) | IS4108A (de) |
LT (1) | LT3115B (de) |
LV (1) | LV10625B (de) |
MY (1) | MY109282A (de) |
NO (1) | NO300066B1 (de) |
NZ (1) | NZ250414A (de) |
PH (1) | PH30168A (de) |
PL (1) | PL174100B1 (de) |
RO (1) | RO112619B1 (de) |
RU (2) | RU2458932C2 (de) |
SA (1) | SA93140409B1 (de) |
SI (1) | SI9300648B (de) |
SK (1) | SK281403B6 (de) |
SV (1) | SV1993000080A (de) |
TW (1) | TW372239B (de) |
UA (1) | UA39158C2 (de) |
UY (1) | UY23697A1 (de) |
YU (1) | YU49411B (de) |
ZA (1) | ZA939293B (de) |
Families Citing this family (84)
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US5476932A (en) * | 1994-08-26 | 1995-12-19 | Hoffmann-La Roche Inc. | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
EP0882734B1 (de) * | 1997-06-02 | 2009-08-26 | F. Hoffmann-La Roche Ag | 5-Deoxy-Cytidin-Derivate |
NZ330360A (en) * | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
US6005098A (en) * | 1998-02-06 | 1999-12-21 | Hoffmann-La Roche Inc. | 5'deoxycytidine derivatives |
AU762079B2 (en) * | 1998-09-25 | 2003-06-19 | Warner-Lambert Company | Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin |
US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
US20070122481A1 (en) * | 1998-11-02 | 2007-05-31 | Elan Corporation Plc | Modified Release Compositions Comprising a Fluorocytidine Derivative for the Treatment of Cancer |
WO2001062235A2 (en) * | 2000-02-28 | 2001-08-30 | Aventis Pharma S.A. | A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer |
AU2001246863A1 (en) * | 2000-04-11 | 2001-10-23 | Sayuri Yamada | Curcumin compositions |
KR100631754B1 (ko) * | 2000-08-09 | 2006-10-09 | 주식회사 코오롱 | N-알킬옥시카르보닐-5-플루오로사이토신 유도체 및 그의제조방법 |
KR100730768B1 (ko) * | 2000-08-09 | 2007-06-21 | 코오롱생명과학 주식회사 | 5'-데옥시-n-알킬옥시카르보닐-5-플루오로사이토신-5'-카르복실산 및 그 유도체와 이들의 제조방법 |
GB0113374D0 (en) * | 2001-06-04 | 2001-07-25 | Jerram Clare | Washing line umbrella |
CA2471509A1 (en) * | 2002-01-14 | 2003-07-17 | Novartis Ag | Combinations comprising epothilones and anti-metabolites |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
AU2003274576A1 (en) * | 2002-11-15 | 2004-06-15 | Warner-Lambert Company Llc | Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer |
WO2004105747A1 (en) * | 2003-05-20 | 2004-12-09 | Aronex Pharmaceuticals, Inc | Combination chemotherapy comprising capecitabine and a liposomal platinum complex |
ATE406897T1 (de) * | 2003-11-13 | 2008-09-15 | Pharma Mar Sau | Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs |
EP1706414B1 (de) * | 2003-12-22 | 2008-07-23 | F.Hoffmann-La Roche Ag | Verfahren für fluorcytidinderivate |
AU2006210572B2 (en) | 2005-02-03 | 2011-08-04 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
AU2006228581A1 (en) * | 2005-04-01 | 2006-10-05 | F. Hoffmann-La Roche Ag | Method for administration of capecitabine |
CN101242822B (zh) | 2005-07-18 | 2011-08-24 | 彼帕科学公司 | 治疗卵巢癌的药物 |
CA2616008A1 (en) | 2005-07-21 | 2007-01-25 | Stefan Meuer | Stabilized chlorite solutions in combination with fluoropyrimidines for cancer treatment. |
CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
MY159449A (en) | 2005-12-13 | 2017-01-13 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
US20080085310A1 (en) * | 2006-10-06 | 2008-04-10 | Maria Oksana Bachynsky | Capecitabine rapidly disintegrating tablets |
CN100425617C (zh) * | 2006-10-31 | 2008-10-15 | 浙江海正药业股份有限公司 | 一种含氟嘧啶类化合物烷氧羰酰化的方法 |
ITMI20070435A1 (it) | 2007-03-05 | 2008-09-06 | Innovate Biotechnology Srl | 2',3'-di-o-acil-5-fluoronucleosidi |
BRPI0810067A2 (pt) * | 2007-04-20 | 2014-10-21 | Reddys Lab Ltd Dr | Processo para a preparação de capecitabina |
WO2008145403A1 (en) * | 2007-06-01 | 2008-12-04 | Synthon B.V. | Processes related to making capecitabine |
TR201903488T4 (tr) | 2007-06-13 | 2019-04-22 | Incyte Holdings Corp | Janus kinaz inhibitörü (r)-3-(4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-siklopentilpropannitril tuzlarının kullanımı. |
US7842675B2 (en) * | 2007-09-15 | 2010-11-30 | Protia, Llc | Deuterium-enriched capecitabine |
WO2009042064A2 (en) | 2007-09-21 | 2009-04-02 | Nektar Therapeutics Al, Corporation | Oligomer-nucleoside phosphate conjugates |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
KR101013312B1 (ko) * | 2007-11-19 | 2011-02-09 | 한미홀딩스 주식회사 | 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법 |
AR064165A1 (es) | 2007-12-06 | 2009-03-18 | Richmond Sa Com Ind Y Financie | Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento |
WO2009088989A1 (en) * | 2008-01-03 | 2009-07-16 | Plus Chemicals, S.A. | Process for the preparation of capecitabine |
US20090311335A1 (en) * | 2008-06-12 | 2009-12-17 | Scott Jenkins | Combination of a triptan and an nsaid |
CA2725598C (en) | 2008-06-17 | 2013-10-08 | Wyeth Llc | Antineoplastic combinations containing hki-272 and vinorelbine |
WO2010017163A1 (en) | 2008-08-04 | 2010-02-11 | Wyeth | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
EP2370414A4 (de) * | 2008-12-02 | 2012-11-14 | Reddys Lab Ltd Dr | Herstellung von capecitabin |
US8603999B2 (en) | 2008-12-05 | 2013-12-10 | Commonwealth Scientific And Industrial Research Organisation | Amphiphile prodrugs |
KR20140036332A (ko) | 2009-04-06 | 2014-03-25 | 와이어쓰 엘엘씨 | 네라티닙을 이용한 유방암의 치료법 |
FR2945211A1 (fr) | 2009-05-06 | 2010-11-12 | Sanofi Aventis | Combinaison antitumorale comprenant la cabazitaxel et la capecitabine |
AR076920A1 (es) | 2009-05-22 | 2011-07-20 | Incyte Corp | 3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)octano-o heptano--nitrilo como inhibidores de jak |
EP2456778A4 (de) * | 2009-07-23 | 2013-05-29 | Scinopharm Taiwan Ltd | Verfahren zur herstellung von fluorcytidinderivaten |
WO2011067588A1 (en) | 2009-12-04 | 2011-06-09 | Generics [Uk] Limited | Cyclic sulphinyl esters of cytidine |
WO2011104540A1 (en) * | 2010-02-24 | 2011-09-01 | Generics [Uk] Limited | One step process for the preparation of capecitabine |
PT3050882T (pt) | 2010-03-10 | 2018-04-16 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
EP3117709B1 (de) | 2010-03-12 | 2018-08-01 | Genzyme Corporation | Kombinationstherapie zur behandlung von brustkrebs |
EP2574168B9 (de) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topische formulierung für einen jak-hemmer |
CN102260309B (zh) * | 2010-05-24 | 2014-10-22 | 重庆福安药业(集团)股份有限公司 | 一种高纯度卡培他滨的制备方法 |
AU2011329734B2 (en) | 2010-11-19 | 2015-05-28 | Incyte Holdings Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
CN102558262A (zh) * | 2010-12-23 | 2012-07-11 | 天津泰普药品科技发展有限公司 | 一种高纯度卡培他滨的制备方法 |
ES2560611T3 (es) | 2011-06-20 | 2016-02-22 | Incyte Holdings Corporation | Derivados de fenil de azetidinilo, carboxamida de piridilo o pirazinilo como inhibidores de JAK |
CN102266303A (zh) * | 2011-07-07 | 2011-12-07 | 程雪翔 | 一种卡培他滨药用组合物及其制备方法 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
CN102516338B (zh) * | 2011-12-09 | 2014-04-02 | 海南锦瑞制药股份有限公司 | 一种卡培他滨化合物、其药物组合物及其制备方法 |
TWI560195B (en) * | 2012-01-13 | 2016-12-01 | Pharmaessentia Corp | Novel synthesis of 5-deoxy-5'-fluorocytidine compounds |
BR112015010663B1 (pt) | 2012-11-15 | 2022-12-06 | Incyte Holdings Corporation | Formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo |
UA121532C2 (uk) | 2013-03-06 | 2020-06-10 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки при отриманні інгібітора jak |
EP3721873A1 (de) | 2013-08-07 | 2020-10-14 | Incyte Corporation | Darreichungsformen für einen jak1-inhibitor mit verzögerter freisetzung |
CA2921568A1 (en) * | 2013-08-20 | 2015-02-25 | Incyte Corporation | Survival benefit in patients with solid tumors with elevated c-reactive protein levels |
EP2883959A1 (de) | 2013-12-13 | 2015-06-17 | Plasmia Biotech, S.L. | Enzymatische Herstellung von Cytosin-Nukleosidanaloga |
CN103897006A (zh) * | 2013-12-18 | 2014-07-02 | 吉林修正药业新药开发有限公司 | 一种卡培他滨异构体的制备方法 |
WO2015191576A1 (en) | 2014-06-09 | 2015-12-17 | Lipomedix Pharmaceuticals Ltd. | Combination therapy comprising a liposomal prodrug of mitomycin c and radiotherapy |
CN104530164A (zh) * | 2014-12-31 | 2015-04-22 | 辰欣药业股份有限公司 | 一种卡培他滨的合成工艺 |
KR20160117060A (ko) | 2015-03-31 | 2016-10-10 | 이승주 | 유아용 탁자 |
CN105646625B (zh) * | 2015-12-29 | 2019-06-11 | 江苏吴中医药集团有限公司 | 一种卡培他滨的制备方法 |
US11034667B2 (en) | 2017-01-09 | 2021-06-15 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
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TR201702500A2 (tr) * | 2017-02-20 | 2017-07-21 | Anadolu Ueniversitesi | Serani̇b-2?ni̇n akci̇ğer kanseri̇ ve meme kanseri̇ni̇n tedavi̇si̇nde kullanimi |
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EA202091830A1 (ru) | 2018-01-30 | 2020-12-29 | Инсайт Корпорейшн | Способы и промежуточные соединения для получения ингибитора jak |
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WO2020144657A1 (en) | 2019-01-11 | 2020-07-16 | Lipomedix Pharmaceuticals Ltd. | Liposome composition comprising liposomal prodrug of mitomycin c and method of manufacture |
CN115605492A (zh) | 2020-04-21 | 2023-01-13 | 配体制药股份有限公司(Us) | 核苷酸前药化合物 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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CA1135258A (en) * | 1979-06-15 | 1982-11-09 | Richard D'souza | Process for the preparation of 5'deoxy-5-fluorouridine |
IL77133A (en) * | 1984-12-04 | 1991-01-31 | Lilly Co Eli | Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation |
CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
-
1993
- 1993-11-12 AU AU50690/93A patent/AU671491B2/en not_active Expired
- 1993-11-15 TW TW082109533A patent/TW372239B/zh not_active IP Right Cessation
- 1993-11-17 CA CA002103324A patent/CA2103324C/en not_active Expired - Lifetime
- 1993-11-23 HR HR92121538.0A patent/HRP931430B1/xx not_active IP Right Cessation
- 1993-12-01 EP EP93119349A patent/EP0602454B1/de not_active Expired - Lifetime
- 1993-12-01 DE DE69302360T patent/DE69302360T2/de not_active Expired - Lifetime
- 1993-12-01 ES ES93119349T patent/ES2086856T3/es not_active Expired - Lifetime
- 1993-12-01 DK DK93119349.4T patent/DK0602454T3/da active
- 1993-12-01 AT AT93119349T patent/ATE137244T1/de active
- 1993-12-07 SA SA93140409A patent/SA93140409B1/ar unknown
- 1993-12-10 SI SI9300648A patent/SI9300648B/sl unknown
- 1993-12-10 NZ NZ250414A patent/NZ250414A/en not_active IP Right Cessation
- 1993-12-10 ZA ZA939293A patent/ZA939293B/xx unknown
- 1993-12-10 HU HU9303525A patent/HU218291B/hu active Protection Beyond IP Right Term
- 1993-12-13 CZ CZ932731A patent/CZ284788B6/cs not_active IP Right Cessation
- 1993-12-13 IL IL10800093A patent/IL108000A0/xx not_active IP Right Cessation
- 1993-12-14 FI FI935616A patent/FI112365B/fi not_active IP Right Cessation
- 1993-12-14 US US08/167,392 patent/US5472949A/en not_active Expired - Lifetime
- 1993-12-15 YU YU77993A patent/YU49411B/sh unknown
- 1993-12-15 RO RO93-01706A patent/RO112619B1/ro unknown
- 1993-12-15 PH PH47455A patent/PH30168A/en unknown
- 1993-12-16 RU RU93056196/04A patent/RU2458932C2/ru active Protection Beyond IP Right Term
- 1993-12-16 KR KR1019930027962A patent/KR100347218B1/ko not_active IP Right Cessation
- 1993-12-16 RU RU2012134029/04A patent/RU2493162C1/ru not_active IP Right Cessation
- 1993-12-16 MY MYPI93002726A patent/MY109282A/en unknown
- 1993-12-16 BG BG98304A patent/BG61485B1/bg unknown
- 1993-12-16 JP JP5342812A patent/JP2501297B2/ja not_active Expired - Fee Related
- 1993-12-16 BR BR9305089A patent/BR9305089A/pt not_active Application Discontinuation
- 1993-12-17 LV LVP-93-1347A patent/LV10625B/en unknown
- 1993-12-17 NO NO934671A patent/NO300066B1/no not_active IP Right Cessation
- 1993-12-17 SV SV1993000080A patent/SV1993000080A/es not_active Application Discontinuation
- 1993-12-17 SK SK1444-93A patent/SK281403B6/sk not_active IP Right Cessation
- 1993-12-17 UA UA93004687A patent/UA39158C2/uk unknown
- 1993-12-17 CN CN93112838A patent/CN1035617C/zh not_active Expired - Lifetime
- 1993-12-17 UY UY23697A patent/UY23697A1/es not_active IP Right Cessation
- 1993-12-17 LT LTIP1627A patent/LT3115B/lt not_active IP Right Cessation
- 1993-12-17 PL PL93301541A patent/PL174100B1/pl unknown
- 1993-12-17 IS IS4108A patent/IS4108A/is unknown
-
1994
- 1994-11-18 EE EE9400154A patent/EE03086B1/xx not_active IP Right Cessation
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1995
- 1995-06-19 HU HU95P/P00255P patent/HU211965A9/hu unknown
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1996
- 1996-06-19 GR GR960401668T patent/GR3020286T3/el unknown
-
1998
- 1998-06-05 HK HK98105008A patent/HK1005875A1/xx not_active IP Right Cessation
-
2006
- 2006-07-17 GE GEAP20069525A patent/GEP20074251B/en unknown
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