KR940014309A - 5,6,7,9-테트라히드로-1,2,3-트리메톡시-9-옥소벤조[α]헵탈렌유도체 - Google Patents
5,6,7,9-테트라히드로-1,2,3-트리메톡시-9-옥소벤조[α]헵탈렌유도체 Download PDFInfo
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- KR940014309A KR940014309A KR1019930007246A KR930007246A KR940014309A KR 940014309 A KR940014309 A KR 940014309A KR 1019930007246 A KR1019930007246 A KR 1019930007246A KR 930007246 A KR930007246 A KR 930007246A KR 940014309 A KR940014309 A KR 940014309A
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- KR
- South Korea
- Prior art keywords
- compound
- formula
- salt
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- pharmaceutically acceptable
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- YEKVYOOIQVZXSH-UHFFFAOYSA-N 2,3,4-trimethoxytricyclo[5.5.0.01,6]dodeca-2,4,6-trien-12-one Chemical class C1CCCC(=O)C2(C(OC)=C(C(OC)=C3)OC)C3=C21 YEKVYOOIQVZXSH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 125000006239 protecting group Chemical group 0.000 claims abstract 4
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 239000002246 antineoplastic agent Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 claims 1
- HFPMXDMZJUJZBX-AWEZNQCLSA-N Deacetylcolchicine Chemical compound C1([C@@H](N)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC HFPMXDMZJUJZBX-AWEZNQCLSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
하기 식(Ⅰ)의 화합물 :
[상기 식에서, R1및 R2는 각각 수소원자 또는 히드록실기에 대한 보호기를 나타내거나, 또는 R1및 R2가 결합하여 히드록실기에 대한 보호기를 나타내고, R3는 CH3O 또는 CH3NH-를 나타낸다]
상기 화합물은 암 세포의 증식을 억제하는 강력한 효과를 나타내며 제암제로서의 사용이 기대된다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 식으로 표시되는 화합물 및 그의 염 ;[상기 식에서, R1및 R2는 각각 수소원자 또는 히드록실기에 대한 보호기를 나타내거나, 또는 R1및 R2가 결합하여 히드록실기에 대한 보호기를 나타내고, R3는 CH3O 또는 CH3NH-를 나타낸다.]
- 제 1 항에 있어서, R1및 R2가 각각 수소원자, C1∼C10알카노일기 또는 아로일기를 나타내거나, 또는 R1및 R2가 결합하여 식(식중, R4는 수소원자 또는 C1∼C6알킬기를 나타내고, R5는 C1∼C6알킬 또는 페닐기를 나타낸다)로 표시되는 아세탈 또는 케탈기를 나타내는 화합물.
- 제 1 항에 있어서, N-(O, O-이소프로필레덴글리세릴) 데아세틸콜히친 및 N′-(O, O-디이소프로필리덴글리세릴)-N-메틸데아세틸콜히세인아미드에서 선택되는 화합물.
- 하기 식(Ⅱ)의 화합물을 하기 식(Ⅲ)의 글리세르알데히드와 반응시키고 ; 하기 식(Ⅳ)의 수득된 화합물을 환원시키고 ; 필요하다면 수득된 식(Ⅰ)의 화합물을 염으로 전환시킴을 특징으로 하는 제 1 항에 따른 화합물 또는 그의 염을 제조방법 :[상기 식에서, R1, R2및 R3는 제 1 항에 정의된 바와 같다]
- 하기식(Ⅰ-5)의 화합물을 메틸아미노화시키고, 필요하다면 수득된 화합물을 염으로 전환시킴을 특징으로 하는 하기식(Ⅰ-4)의 화합물 또는 그의 염의 제조방법 :[상기 식에서, R1및 R2는 제 1 항에 정의된 바와 같다]
- 제 1 항에 따른 식(Ⅰ)의 화합물 또는 약학적으로 허용 가능한 그의 염을 함유하는 약제.
- 제 1 항에 따른 식(Ⅰ)의 화합물 또는 약학적으로 허용 가능한 그의 염을 함유하는 항종양제.
- 제1항에 따른 식(Ⅰ)의 화합물 또는 약학적으로 허용 가능한 그의 염의 유효량 및 약학적으로 허용가능한 캐리어(들) 또는 희석제(들)를 함유하는 제약학적 제제.
- 제 1 항에 따른 식(Ⅰ)의 화합물 또는 약학적으로 허용가능한 그의 염의 항종양 유효량을 투여함을 특징으로 하는 종양의 치료방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP92-358,821 | 1992-12-28 | ||
| JP4358821A JPH06199749A (ja) | 1992-12-28 | 1992-12-28 | Ｎ−メチルデアセチルコルヒセインアミド誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR940014309A true KR940014309A (ko) | 1994-07-18 |
Family
ID=18461286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930007246A KR940014309A (ko) | 1992-12-28 | 1993-04-28 | 5,6,7,9-테트라히드로-1,2,3-트리메톡시-9-옥소벤조[α]헵탈렌유도체 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5326786A (ko) |
| EP (1) | EP0605078B1 (ko) |
| JP (1) | JPH06199749A (ko) |
| KR (1) | KR940014309A (ko) |
| CN (1) | CN1088911A (ko) |
| AT (1) | ATE148688T1 (ko) |
| AU (1) | AU658502B2 (ko) |
| CA (1) | CA2094753A1 (ko) |
| DE (1) | DE69308009T2 (ko) |
| DK (1) | DK0605078T3 (ko) |
| ES (1) | ES2101951T3 (ko) |
| GR (1) | GR3023322T3 (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06211762A (ja) * | 1993-01-20 | 1994-08-02 | Bigen Kenkyusho:Kk | Ｎ−メチルデアセチルコルヒセインアミド誘導体 |
| US7056055B1 (en) | 2005-08-04 | 2006-06-06 | Wen-Nan Kuo | Traffic cone (2) |
| CN113024400A (zh) * | 2021-03-08 | 2021-06-25 | 沈阳药科大学 | 一种秋水仙碱衍生物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6179690A (en) * | 1989-08-09 | 1991-03-11 | Michael Reese Hospital And Medical Center | Method for detection and treatment of multiple drug-resistant tumor cells and useful colchicine derivative probes |
| AU634921B2 (en) * | 1990-12-25 | 1993-03-04 | Ohgen Research Laboratories Ltd. | Deacetylcolchicine derivatives |
| IT1244660B (it) * | 1991-03-06 | 1994-08-08 | Giorgio Bonura | Preparati farmaceutici per la terapia dei tumori contenenti colchicina come principio attivo e metodi per l'impiego degli stessi. |
-
1992
- 1992-12-28 JP JP4358821A patent/JPH06199749A/ja active Pending
-
1993
- 1993-04-23 EP EP93303190A patent/EP0605078B1/en not_active Expired - Lifetime
- 1993-04-23 DE DE69308009T patent/DE69308009T2/de not_active Expired - Fee Related
- 1993-04-23 CA CA002094753A patent/CA2094753A1/en not_active Abandoned
- 1993-04-23 ES ES93303190T patent/ES2101951T3/es not_active Expired - Lifetime
- 1993-04-23 DK DK93303190.8T patent/DK0605078T3/da active
- 1993-04-23 AU AU37094/93A patent/AU658502B2/en not_active Ceased
- 1993-04-23 US US08/051,297 patent/US5326786A/en not_active Expired - Fee Related
- 1993-04-23 AT AT93303190T patent/ATE148688T1/de not_active IP Right Cessation
- 1993-04-28 KR KR1019930007246A patent/KR940014309A/ko not_active Application Discontinuation
- 1993-05-04 CN CN93104964A patent/CN1088911A/zh active Pending
-
1997
- 1997-05-02 GR GR970400980T patent/GR3023322T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69308009D1 (de) | 1997-03-20 |
| US5326786A (en) | 1994-07-05 |
| AU658502B2 (en) | 1995-04-13 |
| CN1088911A (zh) | 1994-07-06 |
| CA2094753A1 (en) | 1994-06-29 |
| JPH06199749A (ja) | 1994-07-19 |
| ATE148688T1 (de) | 1997-02-15 |
| EP0605078B1 (en) | 1997-02-05 |
| ES2101951T3 (es) | 1997-07-16 |
| GR3023322T3 (en) | 1997-08-29 |
| AU3709493A (en) | 1994-07-14 |
| DK0605078T3 (da) | 1997-08-18 |
| DE69308009T2 (de) | 1997-08-28 |
| EP0605078A1 (en) | 1994-07-06 |
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