KR930023328A - N-메틸데아세틸콜히세인아미드 유도체 - Google Patents

N-메틸데아세틸콜히세인아미드 유도체 Download PDF

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Publication number
KR930023328A
KR930023328A KR1019930007332A KR930007332A KR930023328A KR 930023328 A KR930023328 A KR 930023328A KR 1019930007332 A KR1019930007332 A KR 1019930007332A KR 930007332 A KR930007332 A KR 930007332A KR 930023328 A KR930023328 A KR 930023328A
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KR
South Korea
Prior art keywords
methyldeacetylcol
hisinamide
derivative
formula
pharmaceutically acceptable
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KR1019930007332A
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English (en)
Inventor
기요시 아끼야마
Original Assignee
아끼야마 지아끼
유겐가이샤 오겐 겡뀨쇼
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Publication of KR930023328A publication Critical patent/KR930023328A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

하기 구조식의 N-메틸데아세틸콜히세인아미드 유도체
[상기식에서, R은 C3∼C7당 카르복실산으로부터 COOH를 제거하여 수득한 잔기를 나타내고, 이 잔기내에 존재하는 히드록실기는 히드록실기에 대한 보호기로 적절히 보호될 수 있다.]
상기 N-메틸데아세틸콜히세인아미드 유도체는 저독성을 가지며, 종양 세포의 중식을 저해하는 강한 작용을 가져서 제암제로서 사용될 수 있는 것으로 기대된다.

Description

N-메틸데아세틸콜히세인아미드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 구조식(Ⅰ)의 N-메틸데아세틸콜히세인아마드 유도체 및 그의 염;
    [상기식에서, R은 C C당 카르복실산으로부터 COOH를 제거하여 수득한 잔기를 나타내고, 이잔기내에 존재하는 히드록실기는 히드록실기에 대한 보호될 수 있다.]
  2. 제 1항에 있어서, R
    이고, 이들 기내에 존재하는 히드록실기는 아실기, 아세탈기 또는 케탈기로 보호될 수 있는 N-메틸데아세틸콜히세인아미드 유도체.
  3. N′-(O,O - 이소프로필리덴글리세로일)-N-메틸데아세틸콜히세인아미드.
  4. 하기 구조식(Ⅱ)의 N-메틸데아세틸콜히세인아미드를 하기 구조식(Ⅲ)의 당 카르복실산 또는 그의 반응성 유도체로 아미드화시키고, 생성 화합물을 염으로 전환시킬 수 있는 제 1항의 구조식(Ⅰ)의 N-메틸데아세틸콜히세인아미드 유도체의 제조방법.
    [상기 식에서, R은 제 1항에 정의한 바와 같다.]
  5. 하기 구조식(Ⅳ)의 데아세틸콜히친 유도체를 메틸아민과 반응시켜 10-위치의 메특시기를 메틸시기를 메틸아민화하고, 생성 화합물을 염으로 전환시킬 수 있는 제 1항의 구조식(Ⅰ)의 구조식(Ⅱ)의 N-메틸데아세틸콜히세인아미드 유도체 또는 그의 염의 제조방법.
    [상기 식에서, R은 제 1항에 정의한 바와 같다.]
  6. 제 1항의 구조식(Ⅰ)의 N-메틸데아세틸콜히세인아미드 유도체 또는 제약학적으로 허용가능한 그의 염을 함유하는 의약품.
  7. 제 1항의 구조식(Ⅰ)의 N-메틸데아세틸콜히세인아미드 유도체 또는 제약학적으로 허용가능한 그의 염을 함유하는 항종양제.
  8. 유효량의 제 1항의 구조식(Ⅰ)의 N-메틸데아세틸콜히세인아미드 유도체 또는 제약학적으로 허용가능한 그의 염과 제약학적으로 허용가능한 담체 또는 희석제를 포함하는 제약학적 제제.
  9. 항종양 유효량의 N-메틸데아세틸콜히세인아미드 유도체 또는 제약학적으로 허용가능한 그의 염을 투여하는 것으로 구성되는 종양의 치료방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930007332A 1993-01-20 1993-04-29 N-메틸데아세틸콜히세인아미드 유도체 KR930023328A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP93-24754 1993-01-20
JP5024754A JPH06211762A (ja) 1993-01-20 1993-01-20 Ｎ−メチルデアセチルコルヒセインアミド誘導体

Publications (1)

Publication Number Publication Date
KR930023328A true KR930023328A (ko) 1993-12-18

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ID=12146938

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930007332A KR930023328A (ko) 1993-01-20 1993-04-29 N-메틸데아세틸콜히세인아미드 유도체

Country Status (9)

Country Link
US (2) US5523320A (ko)
EP (1) EP0607647A1 (ko)
JP (1) JPH06211762A (ko)
KR (1) KR930023328A (ko)
CN (1) CN1090266A (ko)
AU (1) AU658728B2 (ko)
CA (1) CA2094796A1 (ko)
RU (1) RU2073006C1 (ko)
TW (1) TW251281B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5838631A (en) 1996-04-19 1998-11-17 Integrated Device Technology, Inc. Fully synchronous pipelined ram
US6115320A (en) 1998-02-23 2000-09-05 Integrated Device Technology, Inc. Separate byte control on fully synchronous pipelined SRAM
US7305928B2 (en) * 2005-10-12 2007-12-11 Brunswick Corporation Method for positioning a marine vessel
CN102126983B (zh) * 2010-01-13 2013-08-14 刘力 秋水仙碱衍生物及其制备方法和用途
CN113024400A (zh) * 2021-03-08 2021-06-25 沈阳药科大学 一种秋水仙碱衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6179690A (en) * 1989-08-09 1991-03-11 Michael Reese Hospital And Medical Center Method for detection and treatment of multiple drug-resistant tumor cells and useful colchicine derivative probes
AU634921B2 (en) * 1990-12-25 1993-03-04 Ohgen Research Laboratories Ltd. Deacetylcolchicine derivatives
IT1244660B (it) * 1991-03-06 1994-08-08 Giorgio Bonura Preparati farmaceutici per la terapia dei tumori contenenti colchicina come principio attivo e metodi per l'impiego degli stessi.
JPH06199749A (ja) * 1992-12-28 1994-07-19 Bigen Kenkyusho:Kk Ｎ−メチルデアセチルコルヒセインアミド誘導体

Also Published As

Publication number Publication date
CN1090266A (zh) 1994-08-03
EP0607647A1 (en) 1994-07-27
JPH06211762A (ja) 1994-08-02
US5523320A (en) 1996-06-04
US5672757A (en) 1997-09-30
AU3709593A (en) 1994-08-25
CA2094796A1 (en) 1994-07-21
TW251281B (ko) 1995-07-11
RU2073006C1 (ru) 1997-02-10
AU658728B2 (en) 1995-04-27

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