KR930016379A - 아릴사이클로알킬 유도체, 이의 제조방법 및 용도 - Google Patents
아릴사이클로알킬 유도체, 이의 제조방법 및 용도 Download PDFInfo
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- KR930016379A KR930016379A KR1019930000507A KR930000507A KR930016379A KR 930016379 A KR930016379 A KR 930016379A KR 1019930000507 A KR1019930000507 A KR 1019930000507A KR 930000507 A KR930000507 A KR 930000507A KR 930016379 A KR930016379 A KR 930016379A
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Abstract
본 발명은 염중 상태에 대한 활성을 나타내는 일반식(I)의 화합물을 관한 것이다.
상기식에서 R1은 C1-C6-알킬, 치환된 C1-C6-알킬, C(O)0-C1-C4- 알킬 또는 O(O)OH) 이거나
[여기서, R5는 서로 독립적으로H, C1-C6-알킬, 치환된 C1-C6-알킬, 하이드록시, 카복시, 시아노, -NHC(O)C1-C3-알킬, -O-C1-C3-알킬페닐, -CCH2-O, C1-C6-알콕시, C1-C4-알킬-O-C1-C4-알킬, O-C(O)-C1-C4-알킬, -C(O)-O-C1-C4-알킬, 할로겐, 아미노, 니트로, -NH-C1-C4-알킬, -N-(C1-C4-알킬)2및 -C1-C4- 알킬-R6(여기서, R6은
로부터 선택된 잔기이다)으로부터 선택된 1,2,3 또는 4개의 잔기이며, X는 O,S,N-H 또는 N-C1-C6- 알킬이다]로부터 선택된 잔기이고; R2는 H, C1-C6-알킬 또는 -C(O)-C1-C6-알킬이며; R2은 서로 독립적으로 H, C1-C6-알킬, -C(O)-C1-C6-알킬, -C(O)-O-C1-C6- 알킬, OH, O-C1-C6-알킬, -O-C(O)-C1-C6-알킬 및 할로겐으로부터 선택된 1,2 또는 3개의 잔기이고, R4는 H, -OH, -O-C1-C6-알킬, -O-(CO)-C1-C6-알킬, -C(O)-OH, -C(O) -O-C1-C6알킬,,또는
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 LPS 자극된 IL-1알파(약IC50=200 내지 300nmoℓ/ℓ의 억제제로서의 화합물(4)의 효과를 나타내었다.
Claims (9)
- 하기 일반식(I)의 화합물상기식에서 R1은 C1-C6-알킬, 치환된 C1-C6-알킬, C(O)O-C1-C4-알킬 또는 O(O)OH이거나,[여기서, R5는 서로 독립적으로 H, C1-C6-알킬, 치환된 C1-C6- 알킬, 하이드록시, 카복시, 시아노, -NHC(O)C1-C3-알킬, -O-C1-C3-알킬페닐, -COH2-O-, C1-C6-알콕시, C1-C4-알킬-O-C1-C4-알킬, O-C(O)-C1-C4-알킬, -C(O)-O-C1-C4-알킬, 할로겐, 아미노 , 니트로, -NH-C1-C4-알킬, -N-(C1-C4-알킬)2및 -C1-C4-알킬-R6(여기서,R6은로부터 선택된 잔기이다)으로부터 선택된 1,2,3 또는 4개의 잔기이며, X는 O, S, N-H 또는 N-C1-C6-알킬이다]로부터 선택된 잔기이고; R2는 H, C1-C6-알킬 또는 -C(O)-C1-C6-알킬이며; R3은 서로 독립적으로 H, C1-C6-알킬, -C(O)-C1-C6-알킬,-C(O)-O-C1-C6-알킬, OH, O-C1-C6-알킬,-O-C(O)-C1-C6- 알킬 및 할로겐으로부터 선택된 1, 2 또는 3개의 잔기이고, R4는 H, -OH, -O-C1-C4-알킬,-O-(C0)-C1-C6-알킬, -C(O)-O-C1-C6-알킬,,이며; n은 0, 1 또는 2이고 ; 'a'는 임의의 추가의 단일결합을 타나낸다.
- 제1항에 있어서, 하기 일반식(Ⅱ)의 화합물.상기식에서, R1, R2, R3, R4및 a는 제1항에서 정의한 바와같다.
- 제1항 또는 제2항에 있어서, R1이[여기서, R5는 H, C1-C6-알킬, 치환된 C1-C6-알킬, 하이드록시, C1-C3-알콕시, 할로겐 또는 C1-C4-알킬-R6(여기서, R6은이다)이며, X는O,NH,S 또는N-C1-C6- 알킬이다)이며;a가 임의의 추가의 결합인 일반식(I)의 화합물.
- 제1항 내지 제3항중의 어느 한 항에 있어서, 하기 일반식(Ⅲ)의 화합물.상기식에서, R3는 H 또는 C1-C3-알킬이고, R5는 1 또는 2개의 할로겐 또는 1 또는 2개의 C1-C6-알킬 또는 C1-C3-알콕시 그룹이며, a는 임의의 추가의 단일결합이다
- A) 일반식(V)의 화합물을 보란-용매-착물로 처리한 다음, 산화시켜, R4가 OH 인 하기 일반식(Ⅵ)의 화합물로 전환시키거나, B) 일반식(V)의 화합물을 과산 및 에폭사이드로 처리한 다음, 수소화물 제제로 처리하여, 일반식(Ⅵ)의 화합물을 수득하거나, C) 적합한 아렌을 산 촉매의 존재하에 사이클로헥센옥사이드와 축합시켜 일반식(Ⅵ)의 화합물을 수득하고, D) 일반식(Ⅵ)의 화합물을 아세트산 무수물과 무기산으로 처리하여, R2가 메틸이고 R4가 O-C(O)-Me인 일반식(Ⅶ)의 화합물을 수득하며, E) D) 에서 기술한 바와같은 일반식(Ⅶ)의 화합물을 루이스산 또는 탈메틸화제로 처리하여 탈메틸화시켜, R2가 H이고 R4가 OC(O)Me인 일반식(Ⅶ)의 화합물을 수득하고, F) E)에서 제조한 화합물을 묽은 알칼리로 처리하여, R2가 H이고 R4가 OH인 일반식(Ⅶ)의 화합물을 수득하며, G) 일반식(Ⅷ)의 화합물을 염기의 존재하에 적절한 알데하이드로 처리하여 a가 추가의 결합인 일반식(Ⅰ)의 화합물로 전환시키고, 이를 수소화시켜 a가 추가의 결합이 아닌 일반식(Ⅰ)의 화합물을 제조함을 특징으로 하여, 일반식(Ⅰ)의 화합물을 제조하는 방법.상기식에서 R1, R2, n 및 R은 제1항에 정의한 바와 같다.
- 제1항 내지 제4항 중의 어느 한 항에서 청구한 하나 이상의 화합물을 활성 양으로 함유하는 약제.
- 염증상태, 특히 만성 염증 상태를 예방하고/거나 치료하기 위한, 제1항 내지 제4항중의 어느 한 항에서 청구한 화합물의 용도.
- 염증 상태, 특히 만성 염증 상태에 대해 작용하는 약제를 제조하기 위한, 제1항 내지 제4항 중의 어느 한항에서 청구한 화합물의 용도.
- 제1항 내지 제4항 중의 어느 한 항에서 청구한 하나 이상의 화합물을 임의의 약제학적 보조제 및/또는 부형제와 함께 적합한 투여 형태로 제조함을 특징으로 하는, 제6항에서 청구한 약제의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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Application Number | Priority Date | Filing Date | Title |
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EP92100664 | 1992-01-16 | ||
EP92-100664.9 | 1992-01-16 |
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KR930016379A true KR930016379A (ko) | 1993-08-26 |
KR100276933B1 KR100276933B1 (ko) | 2001-02-01 |
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US (2) | US5589514A (ko) |
EP (1) | EP0551849B1 (ko) |
JP (1) | JP2949000B2 (ko) |
KR (1) | KR100276933B1 (ko) |
CN (1) | CN1036779C (ko) |
AT (1) | ATE143935T1 (ko) |
AU (1) | AU662382B2 (ko) |
CA (1) | CA2087414C (ko) |
CZ (1) | CZ285937B6 (ko) |
DE (1) | DE69305189T2 (ko) |
DK (1) | DK0551849T3 (ko) |
ES (1) | ES2093860T3 (ko) |
GR (1) | GR3021338T3 (ko) |
HU (1) | HU221007B1 (ko) |
MX (1) | MX9300222A (ko) |
RU (1) | RU2125553C1 (ko) |
SK (1) | SK280617B6 (ko) |
TW (1) | TW376382B (ko) |
ZA (1) | ZA93267B (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US6159988A (en) * | 1992-01-16 | 2000-12-12 | Hoeschst Aktiengesellschaft | Arylcycloalkyl derivatives, their production and their use |
HRP950558A2 (en) * | 1994-11-15 | 1997-12-31 | Scott M. Wilhelm | Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
ATE298566T1 (de) | 1995-09-11 | 2005-07-15 | Osteoarthritis Sciences Inc | Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis |
BR9803596A (pt) * | 1997-09-23 | 2000-04-25 | Pfizer Prod Inc | Derivados do resorcinol. |
US6878381B2 (en) | 1999-03-22 | 2005-04-12 | Pfizer, Inc | Resorcinol composition |
US6828460B2 (en) | 1999-03-22 | 2004-12-07 | Pfizer Inc. | Resorcinol derivatives |
GB0021776D0 (en) * | 2000-09-05 | 2000-10-18 | Arakis Ltd | The treatment of inflammatory disorders |
UA82827C2 (en) | 2000-12-18 | 2008-05-26 | Inhibitors against the production and release of inflammatory cytokines | |
DE10222895A1 (de) * | 2002-05-23 | 2003-12-11 | Bosch Gmbh Robert | Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil |
TWI280876B (en) * | 2002-06-05 | 2007-05-11 | Inst Med Molecular Design Inc | Therapeutic drug for diabetes |
TW200410671A (en) * | 2002-06-05 | 2004-07-01 | Inst Med Molecular Design Inc | Medicines for inhibiting the activation of AP-1 |
EA008622B1 (ru) * | 2002-06-05 | 2007-06-29 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | Ингибиторы ассоциированной с иммунитетом протеинкиназы |
KR101054562B1 (ko) | 2002-06-06 | 2011-08-04 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 항알레르기약 |
JP4743382B2 (ja) | 2002-06-06 | 2011-08-10 | 株式会社医薬分子設計研究所 | O−置換ヒドロキシアリール誘導体 |
TW200307535A (en) * | 2002-06-10 | 2003-12-16 | Inst Med Molecular Design Inc | Therapeutic agent for cancer |
TW200410675A (en) * | 2002-06-10 | 2004-07-01 | Inst Med Molecular Design Inc | An NF-κB activation inhibitor |
CA2488979A1 (en) * | 2002-06-11 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Medicament for treatment of neurodegenerative diseases |
KR20050074949A (ko) * | 2002-11-12 | 2005-07-19 | 엔오케이 가부시키가이샤 | 고무형상 탄성부품 |
CA2794676A1 (en) | 2010-03-29 | 2011-10-06 | Piramal Enterprises Limited | Cytokine inhibitors |
EA023852B1 (ru) * | 2014-02-12 | 2016-07-29 | Институт Нефтехимических Процессов Им. Академика Ю. Мамедалиева, Нан Азербайджана | 2-гидрокси-5-(1-метилциклоалкил)ацетофеноны - стабилизаторы полистирола |
EP3386500B1 (en) | 2015-12-09 | 2022-09-07 | The Board of Trustees of the University of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
MX2019008158A (es) | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2616479C2 (de) * | 1976-04-14 | 1986-12-04 | Brickl, Rolf, Dr., 7951 Warthausen | Substituierte Fluoracylresorcine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel und Kosmetika |
MA19680A1 (fr) * | 1982-01-11 | 1983-10-01 | Novartis Ag | N- arylsulfonyl - n' - pyrimidinylurees. |
SE8400239D0 (sv) * | 1984-01-19 | 1984-01-19 | Pharmacia Ab | Nya arylettiksyraderivat |
JPS6126775A (ja) * | 1984-07-16 | 1986-02-06 | Canon Inc | 堆積膜形成方法 |
JPS61144717A (ja) * | 1984-12-18 | 1986-07-02 | Canon Electronics Inc | ヘツド装置 |
JPH0683475B2 (ja) * | 1985-01-21 | 1994-10-19 | 株式会社日立製作所 | ビデオテ−プレコ−ダ |
JPS61248389A (ja) * | 1985-04-24 | 1986-11-05 | 松下電工株式会社 | 照明灯点灯装置 |
IN164232B (ko) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
JPS62281022A (ja) * | 1986-05-30 | 1987-12-05 | Mitsubishi Electric Corp | 計算機システムの履歴管理装置 |
FR2602228A1 (en) * | 1986-07-30 | 1988-02-05 | Kirkiacharian Serge | New phenoxyisobutyric acids, their derivatives and processes for producing them |
HU203515B (en) * | 1986-12-12 | 1991-08-28 | Tsumura & Co | Process for producing new calcon derivatives and pharmaceutical compositions containing them as active components |
-
1992
- 1992-12-31 SK SK4036-92A patent/SK280617B6/sk unknown
- 1992-12-31 CZ CS924036A patent/CZ285937B6/cs unknown
-
1993
- 1993-01-11 EP EP93100279A patent/EP0551849B1/en not_active Expired - Lifetime
- 1993-01-11 DE DE69305189T patent/DE69305189T2/de not_active Expired - Lifetime
- 1993-01-11 DK DK93100279.4T patent/DK0551849T3/da active
- 1993-01-11 ES ES93100279T patent/ES2093860T3/es not_active Expired - Lifetime
- 1993-01-11 AT AT93100279T patent/ATE143935T1/de not_active IP Right Cessation
- 1993-01-14 JP JP5004720A patent/JP2949000B2/ja not_active Expired - Lifetime
- 1993-01-15 ZA ZA93267A patent/ZA93267B/xx unknown
- 1993-01-15 CN CN93100484A patent/CN1036779C/zh not_active Expired - Fee Related
- 1993-01-15 RU RU93004417A patent/RU2125553C1/ru active
- 1993-01-15 CA CA002087414A patent/CA2087414C/en not_active Expired - Fee Related
- 1993-01-15 MX MX9300222A patent/MX9300222A/es not_active IP Right Cessation
- 1993-01-15 AU AU31847/93A patent/AU662382B2/en not_active Ceased
- 1993-01-15 HU HU9300110A patent/HU221007B1/hu not_active IP Right Cessation
- 1993-01-16 KR KR1019930000507A patent/KR100276933B1/ko not_active IP Right Cessation
- 1993-02-04 TW TW082100737A patent/TW376382B/zh active
-
1995
- 1995-05-19 US US08/444,518 patent/US5589514A/en not_active Expired - Lifetime
-
1996
- 1996-08-05 US US08/692,129 patent/US5776977A/en not_active Expired - Lifetime
- 1996-10-11 GR GR960402708T patent/GR3021338T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
RU2125553C1 (ru) | 1999-01-27 |
ATE143935T1 (de) | 1996-10-15 |
HU221007B1 (hu) | 2002-07-29 |
JPH069476A (ja) | 1994-01-18 |
EP0551849B1 (en) | 1996-10-09 |
SK280617B6 (sk) | 2000-05-16 |
SK403692A3 (en) | 1995-03-08 |
ES2093860T3 (es) | 1997-01-01 |
HU9300110D0 (en) | 1993-04-28 |
KR100276933B1 (ko) | 2001-02-01 |
CN1076186A (zh) | 1993-09-15 |
CZ403692A3 (en) | 1993-09-15 |
AU3184793A (en) | 1993-07-22 |
CN1036779C (zh) | 1997-12-24 |
MX9300222A (es) | 1993-07-01 |
DE69305189T2 (de) | 1997-03-13 |
CA2087414A1 (en) | 1993-07-17 |
GR3021338T3 (en) | 1997-01-31 |
DK0551849T3 (da) | 1997-03-10 |
DE69305189D1 (de) | 1996-11-14 |
US5589514A (en) | 1996-12-31 |
TW376382B (en) | 1999-12-11 |
EP0551849A1 (en) | 1993-07-21 |
CA2087414C (en) | 2002-04-16 |
HUT63598A (en) | 1993-09-28 |
CZ285937B6 (cs) | 1999-12-15 |
JP2949000B2 (ja) | 1999-09-13 |
AU662382B2 (en) | 1995-08-31 |
US5776977A (en) | 1998-07-07 |
ZA93267B (en) | 1993-08-23 |
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