KR910000775A - 무라밀 디펩티드 유도체 - Google Patents

무라밀 디펩티드 유도체 Download PDF

Info

Publication number
KR910000775A
KR910000775A KR1019900009637A KR900009637A KR910000775A KR 910000775 A KR910000775 A KR 910000775A KR 1019900009637 A KR1019900009637 A KR 1019900009637A KR 900009637 A KR900009637 A KR 900009637A KR 910000775 A KR910000775 A KR 910000775A
Authority
KR
South Korea
Prior art keywords
asterisk
carbon atom
compound according
formula
configuration
Prior art date
Application number
KR1019900009637A
Other languages
English (en)
Inventor
쉐다 루이
듀코 피터
르프랑시에 피에르
스튜에쯔 피터
Original Assignee
쟝 크라머, 한스 루돌프 하우스
산도즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쟝 크라머, 한스 루돌프 하우스, 산도즈 리미티드 filed Critical 쟝 크라머, 한스 루돌프 하우스
Publication of KR910000775A publication Critical patent/KR910000775A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

무라밀 디펩티드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
0일째에 CY로, -1일째에 MDP-GDP(300㎍) 또는 물질A(300㎍)로 처리한 마우스로부터 수득한 골육 세포의 증식 반응도.

Claims (10)

  1. 하기 구조식(Ⅰ)의 화합물 :
    (상기식에서, 별표 *로 표시한 탄소 원자는 각각 R 또는 S배위를 갖는다)
  2. 제1항에 있어서, 별표 *로 표시한 탄소 원자가 R 배위를 갖는 화합물.
  3. 제1항에 있어서, 별표 *로 표시한 탄소 원자가 S 배위를 갖는 화합물.
  4. 상응하는 하기 일반식(Ⅱ)의 화합물을 탈보호시킴을 포함하는, 제1항에 따른 화합물의 제조방법.
    상기식에서, 별표 *로 표시한 탄소 원자는 제1항에서 정의한 바와 같고, R1내지 R4는 독립적으로 하이드록시-보호 그룹이다.
  5. 제4항에 있어서, 수소화 반응에 의해 탈보호시킴을 포함하는 방법.
  6. 제4항에 있어서, 상기 일반식(Ⅱ)에서 R1및 R2가 함께 벤질리덴이고, R3가 벨질이며, R3가 벤질 또는 3급-부틸 디메틸실릴인 방법.
  7. 최소한 하나의 약학적으로 허용가능한 담체 또는 희석제와 함께 제1항 내지 3항중 어느 한 항에 따른 화합물을 함유하는 약한 조성물.
  8. 제7항에 있어서, 리포솜형인 약학 조성물.
  9. 제7항에 있어서, 혼합 미셀형인 약학 조성물.
  10. 제7항에 있어서, 제1항에 따른 화합물이 백신중의 보조제 형인 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900009637A 1989-06-29 1990-06-28 무라밀 디펩티드 유도체 KR910000775A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE3921246 1989-06-29
DEP3921246.7 1989-06-29
DE3921248 1989-06-29
DEP3921248.3 1989-06-29
DE3924874 1989-07-27
DEP3924875.5 1989-07-27
DE3924875 1989-07-27
DEP3924874.7 1989-07-27

Publications (1)

Publication Number Publication Date
KR910000775A true KR910000775A (ko) 1991-01-30

Family

ID=27434666

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900009637A KR910000775A (ko) 1989-06-29 1990-06-28 무라밀 디펩티드 유도체

Country Status (17)

Country Link
US (1) US5210072A (ko)
EP (1) EP0406175B1 (ko)
JP (1) JPH0737479B2 (ko)
KR (1) KR910000775A (ko)
AT (1) ATE130313T1 (ko)
AU (1) AU636150B2 (ko)
CA (1) CA2019922A1 (ko)
DE (1) DE69023559T2 (ko)
ES (1) ES2079464T3 (ko)
FI (1) FI903232A0 (ko)
HU (1) HU205147B (ko)
IE (1) IE902345A1 (ko)
IL (1) IL94885A (ko)
MY (1) MY105727A (ko)
NZ (1) NZ234270A (ko)
PL (1) PL163888B1 (ko)
PT (1) PT94517A (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2054228A1 (en) * 1990-10-30 1992-05-01 Masaharu Oki Muramyldipeptide derivatives and influenza vaccine comprising the derivatives
US5919466A (en) * 1993-10-01 1999-07-06 Gerbu Biotechnik Gmbh Method for improving the yield of immunoantibodies in the vaccination of animals and humans
GB9320820D0 (en) * 1993-10-08 1993-12-01 Biokine Tech Ltd Compounds for medicinal use
GB9326518D0 (en) * 1993-12-29 1994-03-02 Sandoz Ltd Organic compounds
GB9413935D0 (en) * 1994-07-11 1994-08-31 Peptech Uk Ltd Use of maramyl peptide compounds
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
ES2930246T3 (es) 2015-12-10 2022-12-09 Bharat Biotech Int Ltd Nuevo compuesto derivado del péptido muramilo, síntesis y utilizaciones del mismo
CN108883080B (zh) 2015-12-15 2021-12-21 巴拉特生物技术国际有限公司 胞壁酰肽衍生物化合物、其合成及其用途
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897308A (en) * 1975-06-30 1990-01-30 L'oreal Compositions comprising aqueous dispersions of lipid spheres
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
US4315913A (en) * 1980-06-09 1982-02-16 Merck & Co. Inc. Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
JPS58172399A (ja) * 1982-04-05 1983-10-11 Dai Ichi Seiyaku Co Ltd ムラミルトリペプチド誘導体
JPS6078997A (ja) * 1983-10-07 1985-05-04 Dai Ichi Seiyaku Co Ltd ムラミルペプチド誘導体
FR2564096B1 (fr) * 1984-05-11 1988-02-19 Anvar Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir

Also Published As

Publication number Publication date
PL163888B1 (pl) 1994-05-31
IE902345L (en) 1990-12-29
EP0406175A2 (en) 1991-01-02
IL94885A (en) 1994-07-31
JPH0737479B2 (ja) 1995-04-26
AU636150B2 (en) 1993-04-22
CA2019922A1 (en) 1990-12-29
IE902345A1 (en) 1991-01-16
PL285842A1 (en) 1991-03-11
NZ234270A (en) 1993-02-25
IL94885A0 (en) 1991-04-15
HUT54180A (en) 1991-01-28
ES2079464T3 (es) 1996-01-16
US5210072A (en) 1993-05-11
ATE130313T1 (de) 1995-12-15
PT94517A (pt) 1991-02-08
JPH03135998A (ja) 1991-06-10
HU205147B (en) 1992-03-30
AU5787590A (en) 1991-01-03
DE69023559D1 (de) 1995-12-21
MY105727A (en) 1994-11-30
FI903232A0 (fi) 1990-06-27
HU903880D0 (en) 1990-11-28
DE69023559T2 (de) 1996-06-27
EP0406175A3 (en) 1992-04-01
EP0406175B1 (en) 1995-11-15

Similar Documents

Publication Publication Date Title
AU591310B2 (en) Process for the preparation of taxol and 10-deacetyltaxol
KR950017957A (ko) 3, 4, 4-삼치환-피페리디닐-n-알킬카르복실레이트의 제법 및 중간체
ATE195740T1 (de) Glucosamin-disaccharide, verfahren zu deren herstellung, pharmazeutische präparate davon und ihre verwendung
WO1990004918A3 (en) Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
HUT61555A (en) Process for producing 2,8-dioxa-bicyclo/3.2.1/octane derivatives and pharmaceutical compositions comprising same
ZA931473B (en) Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
KR910000775A (ko) 무라밀 디펩티드 유도체
FI101376B1 (fi) Menetelmä 3-bentsyyliamino-2-fenyylipiperidiinijohdannaisten valmistamiseksi
PL305457A1 (en) Galantamine derivatives, method of obtaining them and their application as drugs
UA27108A1 (uk) Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя
KR890009962A (ko) 매뉴마이신 유도체, 이의 제조방법 및 용도
HRP930014A2 (en) 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
NZ232207A (en) Dihydrobenz(c)acridine derivatives and pharmaceutical compositions
KR950032183A (ko) 글루코피라노사이드 벤조티오펜
ATE3046T1 (de) Ein amino-zucker enthaltende polyen-makrolidantibiotika-derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ZA903111B (en) 2-hydroxy-3-phenoxypropylamino compounds and pharmaceutical compositions containing them
HUT70761A (en) Alkyl derivatives of trazodone having action for central nervous system, pharmaceutical compositions for preparing thereof
NO903291D0 (no) Renin-hemmende aminooligohydroksy-derivater.
KR930023328A (ko) N-메틸데아세틸콜히세인아미드 유도체
KR940021524A (ko) 1,2,5,6-테트라하이드로피리딘 유도체와 이의 제조 방법 및 치료시 이의 이용방법
KR920012011A (ko) 데아세틸콜히친 유도체
KR900014327A (ko) 1h-피라졸-1-아세트아미드 화합물, 그들의 제조방법 및 그들 포함한 심장 부정맥 치료를 위한 조성물
KR910000780A (ko) 신규 안트라사이클린 및 그 제조방법과 이것을 포함한 의약품
KR890006643A (ko) β-락탐 항생물질의 모노하이드레이트 및 용매화합물

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid