SI9200152B - Sestavek za zadrževano in kontrolirano oddajanje zdravilnih snovi in postopek za njegovo pripravo - Google Patents
Sestavek za zadrževano in kontrolirano oddajanje zdravilnih snovi in postopek za njegovo pripravo Download PDFInfo
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- SI9200152B SI9200152B SI9200152A SI9200152A SI9200152B SI 9200152 B SI9200152 B SI 9200152B SI 9200152 A SI9200152 A SI 9200152A SI 9200152 A SI9200152 A SI 9200152A SI 9200152 B SI9200152 B SI 9200152B
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- 239000000126 substance Substances 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title claims abstract 4
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- 230000002459 sustained effect Effects 0.000 title claims abstract 3
- 238000013268 sustained release Methods 0.000 title claims abstract 3
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- 239000000463 material Substances 0.000 claims abstract 4
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- 238000000034 method Methods 0.000 claims 9
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 4
- 239000012736 aqueous medium Substances 0.000 claims 3
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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Claims (9)
- PATENTNI ZAHTEVKI 1. Postopek za pripravo sestavka za zadrževano in kontrolirano oddajanje zdravilnih snovi, ki nastopajo v obliki mikrosfer iz polimernega biološko razgradljivega materiala z vsebnostjo omenjene zdravilne substance, označen s tem, da: a) pretvorimo peptid ali v vodi topne peptidne soli v peptid, oziroma v peptidno sol, ki v vodi ni topna; b) damo omenjeni peptid v suspenzijo oz. peptidno sol, ki v vodi ni topna, v suspenzijo v organskem okolju, ki vsebuje biološko razgradljiv polimerni material v raztopljenem stanju; c) omenjeno organsko suspenzijo razpršimo v vodnem okolju, ki tvori neprekinjeno fazo tako nastale emulzije; d) omenjeno emulzijo prenesemo v odvečno vodno okolje in končno ločimo tako pridobljene mikrosfere od tekoče faze.
- 2. Postopek, po zahtevku 1, označen s tem, da pred prenosom oljne emulzije v odvečno vodno okolje izvršimo delno izparevanje organskega topila, ki tvori oljno fazo. 10
- 3. Postopek po zahtevku 1 in 2, označen s tem, da je zdravilna peptidna substanca naravni ali sintetični polipeptid, ki vsebuje 3 do 45 aminokislin.
- 4. Postopek po enem izmed zahtevkov, označen s tem, da je zdravilna substanca izbrana med snovmi kot so oksitocin, vasopresin, kortikotropin, kalcitonin, faktor rasti epiderma (EGF), prolaktin, inhibitin, interferon, somatostatin, insulin, glukagon, (ANF), endropin, inhibitor renina, hormon za sproščanje luteinostimulina io (LHRH), hormon za sproščanje hormona rasti (GHRH), peptid T ali ena izmed sintetičnih analognih ali homolognih substanc.
- 5. Postopek, po enem izmed zahtevkov od 1 do 4, označen s tem, da je zdravilna substanca LHRH ali somatostatin ali ena izmed is sintetičnih analognih ali homolognih substanc, izbranih med: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OH, D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Trp-NH2, D-Trp-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-NH2, D-Phe-Cys-T yr-D-T rp-Lys-Val-Cys-Thr-NH2, 20 D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2, AcPhe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-NH2, AcPhe-Cys-Tyr-D-T rp-Lys-Val-Cys-T rp-NH211 Ac-DNal-DpCI-Phe-DTrp-Ser-Tyr-DCit-Leu-Arg-Pro-DAIa-NH2, (pyro) Glu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2, (pyro) Glu-His-Trp-Ser-Tyr-D-Phe-Leu-Arg-Pro-Gly-NH2, (pyro) Glu-His-Trp-D-Ser-Tyr-D-Leu-Arg-Pro-Gly-NHR1, 5 ali (pyro) Glu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHr1, R1 = spodnji alki).
- 6. Postopek po zahtevku 5, označen s tem, da je v vodi netopna io peptidna sol pamoat, tanat, stearat ali palmitat. \
- 7. Postopek po zahtevkih od 1 do 6, označen s tem, da je polimerni, ; 'i biološko razgradljivi material, polilaktid, poliglikolid, kopolimer j mlečne in glikolne kisline, poliester, kot je polialkilni polialkilen f { l is fumarat ali sukcinat, ali pa poliortoester, poliacetal ali polianhidrid. /
- 8. Postopek po zahtevku 7, označen s tem, da je kopolimer mlečne in glikolne kisline kopolimer kislin L ali D, pri čemer L vsebuje od 45 do 90% (mol) mlečne kisline oz. od 55 do 10% (mol) glikolne kisline. 20
- 9. Postopek po zahtevku 8, označen s tem, da je polialkilen fumarat ali sukcinat poli-1, 4-butilen-sukcinat, poli-2,3-butilen-sukcinat, poli-1,4-butilen-fumarat ali poli-2,3-butilen-fumarat. Za:
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CH2178/91A CH683149A5 (fr) | 1991-07-22 | 1991-07-22 | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
Publications (2)
Publication Number | Publication Date |
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SI9200152A SI9200152A (en) | 1993-03-31 |
SI9200152B true SI9200152B (sl) | 1998-06-30 |
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ID=4227716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9200152A SI9200152B (sl) | 1991-07-22 | 1992-07-21 | Sestavek za zadrževano in kontrolirano oddajanje zdravilnih snovi in postopek za njegovo pripravo |
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CH (2) | CH683149A5 (sl) |
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