FR2679450B1 - Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques. - Google Patents

Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques.

Info

Publication number
FR2679450B1
FR2679450B1 FR9208991A FR9208991A FR2679450B1 FR 2679450 B1 FR2679450 B1 FR 2679450B1 FR 9208991 A FR9208991 A FR 9208991A FR 9208991 A FR9208991 A FR 9208991A FR 2679450 B1 FR2679450 B1 FR 2679450B1
Authority
FR
France
Prior art keywords
microspheres
preparation
polymeric material
controlled release
drug substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9208991A
Other languages
English (en)
Other versions
FR2679450A1 (fr
Inventor
Orsolini Dr Piero
Heimgartner Dr Frederic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Original Assignee
Debio Recherche Pharmaceutique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Recherche Pharmaceutique SA filed Critical Debio Recherche Pharmaceutique SA
Publication of FR2679450A1 publication Critical patent/FR2679450A1/fr
Application granted granted Critical
Publication of FR2679450B1 publication Critical patent/FR2679450B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2257—Prolactin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
FR9208991A 1991-07-22 1992-07-21 Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques. Expired - Lifetime FR2679450B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2178/91A CH683149A5 (fr) 1991-07-22 1991-07-22 Procédé pour la préparation de microsphères en matériau polymère biodégradable.

Publications (2)

Publication Number Publication Date
FR2679450A1 FR2679450A1 (fr) 1993-01-29
FR2679450B1 true FR2679450B1 (fr) 1995-06-09

Family

ID=4227716

Family Applications (2)

Application Number Title Priority Date Filing Date
FR9208991A Expired - Lifetime FR2679450B1 (fr) 1991-07-22 1992-07-21 Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques.
FR929208992A Expired - Fee Related FR2680109B1 (fr) 1991-07-22 1992-07-21 Composition pour la liberation prolongee et controlee et controlee d'une substance medicamenteuse peptidique et procede pour sa preparation.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR929208992A Expired - Fee Related FR2680109B1 (fr) 1991-07-22 1992-07-21 Composition pour la liberation prolongee et controlee et controlee d'une substance medicamenteuse peptidique et procede pour sa preparation.

Country Status (40)

Country Link
US (2) US5445832A (fr)
JP (2) JP2842736B2 (fr)
KR (1) KR930702018A (fr)
CN (1) CN1054543C (fr)
AT (2) AT408609B (fr)
AU (2) AU651711B2 (fr)
BE (2) BE1005696A3 (fr)
BR (1) BR9205375A (fr)
CA (2) CA2074322C (fr)
CH (2) CH683149A5 (fr)
CZ (1) CZ287585B6 (fr)
DE (3) DE4223284C2 (fr)
DK (2) DK176219B1 (fr)
EE (1) EE03014B1 (fr)
ES (2) ES2037621B1 (fr)
FI (2) FI106925B (fr)
FR (2) FR2679450B1 (fr)
GB (2) GB2257909B (fr)
GR (2) GR1002548B (fr)
HR (1) HRP920229A2 (fr)
HU (1) HU218203B (fr)
IE (2) IE71199B1 (fr)
IL (2) IL102591A (fr)
IT (2) IT1259891B (fr)
LU (2) LU88151A1 (fr)
MX (1) MX9204268A (fr)
NL (2) NL194576C (fr)
NO (2) NO304136B1 (fr)
NZ (1) NZ243643A (fr)
PH (1) PH31564A (fr)
PL (1) PL169387B1 (fr)
PT (2) PT100712B (fr)
RU (1) RU2103994C1 (fr)
SE (2) SE512609C2 (fr)
SI (1) SI9200152B (fr)
SK (1) SK280612B6 (fr)
TW (1) TW260610B (fr)
UA (1) UA35569C2 (fr)
WO (1) WO1993001802A1 (fr)
ZA (2) ZA925486B (fr)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6191105B1 (en) 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
DE4342092B4 (de) * 1993-12-09 2007-01-11 Zentaris Gmbh Langwirkende Injektionssuspension und Verfahren zur Herstellung
AU6242096A (en) 1995-06-27 1997-01-30 Takeda Chemical Industries Ltd. Method of producing sustained-release preparation
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
KR0162872B1 (ko) * 1996-04-01 1998-12-01 김은영 용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법
US20020111603A1 (en) * 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
WO1998032423A1 (fr) * 1997-01-29 1998-07-30 Takeda Chemical Industries, Ltd. Microspheres a liberation prolongee, leur production et utilisation
MY118835A (en) * 1997-04-18 2005-01-31 Ipsen Pharma Biotech Sustained release compositions and the process for their preparation
AU3108299A (en) * 1998-03-18 1999-10-11 University Technology Corporation Sustained-release composition including amorphous polymer
US6613358B2 (en) 1998-03-18 2003-09-02 Theodore W. Randolph Sustained-release composition including amorphous polymer
SE9801288D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and metod of production
EP1240896A3 (fr) * 1998-07-23 2003-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Encapsulation de peptides hydrosolubles
US6270700B1 (en) 1998-07-23 2001-08-07 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Encapsulation of water soluble peptides
WO2000004916A1 (fr) * 1998-07-23 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Encapsulation de peptides hydrosolubles
US20070009605A1 (en) * 1998-07-23 2007-01-11 Ignatious Francis X Encapsulation of water soluble peptides
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
GB2344519B (en) * 1998-12-07 2004-05-19 Johnson & Johnson Medical Ltd Sterile therapeutic compositions
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
US6682724B2 (en) 1999-02-23 2004-01-27 Arch Chemcials, Inc. Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
US6317623B1 (en) * 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
EP1161257A2 (fr) 1999-03-17 2001-12-12 Novartis AG Compositions pharmaceutiques
EP1044683A1 (fr) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. Procédé de dispersion à une étape pour la microencapsulation de substances solubles dans l'eau
ES2169980B1 (es) * 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
US6309454B1 (en) 2000-05-12 2001-10-30 Johnson & Johnson Medical Limited Freeze-dried composite materials and processes for the production thereof
ES2292634T3 (es) 2000-12-21 2008-03-16 Alrise Biosystems Gmbh Procedimiento de transicion de fase inducida para la produccion de microparticulas que contienen agentes hidrofilos activos.
MXPA04002446A (es) * 2001-09-26 2004-07-23 Baxter Int Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
KR100885070B1 (ko) * 2002-05-08 2009-02-25 재단법인서울대학교산학협력재단 Ｐｌｇａ에 특이적으로 부착하는 올리고 펩타이드
NZ541365A (en) * 2002-12-27 2009-09-25 Diobex Inc Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en) 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
PT1911763E (pt) 2003-01-28 2010-11-18 Ironwood Pharmaceuticals Inc Composições para o tratamento de desordens gastrointestinais
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004078147A2 (fr) * 2003-03-05 2004-09-16 Pr Pharmaceuticals Preparations a base d'oxytocine a liberation controlee et leurs procedes d'utilisation
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
EP1682537B1 (fr) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulateurs de l'adhesion cellulaire
US7875700B2 (en) 2004-07-19 2011-01-25 Biocon Limited Cation complexes of insulin compound conjugates, formulation and uses thereof
WO2006078320A2 (fr) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Procede de production de systemes d'administration, et systemes d'administration
ES2255426B1 (es) * 2004-10-19 2007-08-16 Gp Pharm, S.A. Formulacion farmaceutica que comprende microcapsulas de estatinas suspendidas en ester alquilicos de acidos grasos poliinsaturados (pufa).
EP1674082A1 (fr) 2004-12-22 2006-06-28 Zentaris GmbH Procédé pour la manufacture des suspensions ou lyophilisates steriles des complexes mal-soluble de peptides basic, des formulations pharmaceutiques avec ces complexes et leur utilisation comme medicament
US7608612B2 (en) * 2005-01-21 2009-10-27 Richard H. Matthews Radiosensitizer formulations and methods for use
US20080095849A1 (en) * 2005-04-25 2008-04-24 Amgen Inc. Peptide sustained release compositions and uses thereof
EP2444079B1 (fr) 2005-05-17 2016-11-30 SARcode Bioscience Inc. Compositions et procédés pour le traitement des troubles de l'oeil
JP2008543842A (ja) * 2005-06-14 2008-12-04 バクスター インターナショナル インコーポレイテッド 薬物−薬物相互作用を最小にするための薬学的処方物
CN101309669A (zh) * 2005-11-15 2008-11-19 巴克斯特国际公司 脂氧合酶抑制剂的组合物
KR20140133968A (ko) * 2005-12-22 2014-11-20 노파르티스 아게 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
EP1983917B1 (fr) * 2006-01-27 2014-06-25 Spinal Ventures, LLC Système à basse pression pour l'administration d'un mélange de solide et de liquide dans un site cible en vue d'un traitement médical
KR100722607B1 (ko) 2006-05-11 2007-05-28 주식회사 펩트론 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
US7403325B2 (en) * 2006-05-19 2008-07-22 Xerox Corporation Electrophoretic display device
US8039461B1 (en) 2006-11-10 2011-10-18 Pisgah Laboratories, Inc. Physical states of a pharmaceutical drug substance
US7858663B1 (en) 2007-10-31 2010-12-28 Pisgah Laboratories, Inc. Physical and chemical properties of thyroid hormone organic acid addition salts
US8211905B1 (en) 2007-05-22 2012-07-03 Pisgah Laboratories, Inc. Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties
US20080293695A1 (en) * 2007-05-22 2008-11-27 David William Bristol Salts of physiologically active and psychoactive alkaloids and amines simultaneously exhibiting bioavailability and abuse resistance
US7718649B1 (en) 2006-11-10 2010-05-18 Pisgah Labs, Inc. Physical states of a pharmaceutical drug substance
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8329720B1 (en) 2007-05-22 2012-12-11 Pisgah Laboratories, Inc. Opioid salts and formulations exhibiting abuse deterrent and anti-dose dumping properties
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US9421266B2 (en) 2007-05-22 2016-08-23 Pisgah Laboratories, Inc. Safety of pseudoephedrine drug products
US10183001B1 (en) 2007-05-22 2019-01-22 Pisgah Laboratories, Inc. Opioid and attention deficit hyperactivity disorder medications possessing abuse deterrent and anti-dose dumping safety features
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2998314B1 (fr) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
ES2694401T3 (es) * 2007-06-06 2018-12-20 Debiopharm International Sa Composición farmacéutica de liberación lenta hecha de micropartículas
MX2010003979A (es) 2007-10-16 2010-06-02 Biocon Ltd Composicion farmaceutica oralmente administrable y proceso para su preparacion.
CN101873797A (zh) 2007-10-19 2010-10-27 萨可德公司 用于治疗糖尿病性视网膜病的组合物和方法
WO2009085952A1 (fr) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Procédé pour préparer des microparticules ayant un faible volume de solvant résiduel
US8883863B1 (en) 2008-04-03 2014-11-11 Pisgah Laboratories, Inc. Safety of psuedoephedrine drug products
US8080562B2 (en) * 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US20090258069A1 (en) * 2008-04-15 2009-10-15 John Burnier Delivery of LFA-1 antagonists to the gastrointestinal system
WO2009149279A2 (fr) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
WO2010009319A2 (fr) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US20100062057A1 (en) * 2008-09-10 2010-03-11 Pronova BioPharma Norge AS. Formulation
WO2010119319A1 (fr) 2009-03-09 2010-10-21 Pronova Biopharma Norge As Compositions comprenant un mélange oléagineux à base d'acides gras et d'un acide gras libre, et procédés et utilisations associés
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
ES2363965B1 (es) 2009-11-20 2013-01-24 Gp Pharm S.A. Cápsulas de principios activos betabloqueantes y ésteres de ácidos grasos poliinsaturados.
ES2363964B1 (es) 2009-11-20 2012-08-22 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
CA2785296A1 (fr) 2009-12-23 2011-06-30 Claudio Cavazza Composition de combinaison utile pour le traitement de maladies cardiovasculaires
ES2385240B1 (es) 2010-07-26 2013-09-23 Gp-Pharm, S.A. Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata.
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9453020B2 (en) 2011-05-04 2016-09-27 Balance Therapeutics, Inc. Substituted pentylenetetrazoles as GABA receptor activity modulators
WO2013072767A1 (fr) 2011-11-18 2013-05-23 Pronova Biopharma Norge As Compositions et préconcentrés comprenant au moins un salicylate et un mélange huileux d'acide gras oméga-3
EP2833881A1 (fr) 2012-04-04 2015-02-11 Pronova BioPharma Norge AS Compositions comprenant des acides gras oméga-3 et de la vitamine d destinées à lutter contre le psoriasis, et méthodes et utilisations associées
ES2606392T3 (es) 2012-04-04 2017-03-23 Pronova Biopharma Norge As Composiciones que comprenden ácidos grasos omega-3 y vitamina D para acné vulgar y/o eccema, y procedimientos y usos de las mismas
PL2851085T3 (pl) 2012-05-14 2019-12-31 Teijin Limited Kompozycja białka sterylizowana promieniowaniem
CN104797574B (zh) 2012-07-25 2019-11-22 原生质生物科学股份有限公司 Lfa-1抑制剂及其多晶型物
EP3718557A3 (fr) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Agoniste du récepteur de la guanylate cyclase sp-333 à utiliser lors du nettoyage du côlon
CN105120842B (zh) 2013-02-28 2020-12-01 普罗诺瓦生物医药挪威公司 包含脂质化合物、甘油三酯和表面活性剂的组合物以及使用它们的方法
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EA201690732A1 (ru) 2013-10-10 2016-12-30 Синерджи Фармасьютикалз, Инк. Агонисты гуанилатциклазы, используемые для лечения индуцированных опиоидами дисфункций
US20160151511A1 (en) * 2014-12-02 2016-06-02 Antriabio, Inc. Proteins and protein conjugates with increased hydrophobicity
BR112017023164A2 (pt) 2015-04-28 2018-07-24 Pronova Biopharma Norge As composto, e, método de prevenir e/ou tratar a esteato-hepatite não alcoólica em um indivíduo em necessidade do mesmo
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
WO2019066649A1 (fr) 2017-09-26 2019-04-04 Nanomi B.V. Procédé de préparation de microparticules par une technique de double émulsion
IL308604A (en) 2017-12-06 2024-01-01 Basf As Fatty acid antecedents for the treatment of nonalcoholic fatty liver disease

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2010115A1 (de) * 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
JPS523342B2 (fr) * 1972-01-26 1977-01-27
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
EP0190833B1 (fr) * 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Procédé de préparation de microcapsules
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
IL79134A (en) * 1985-07-29 1991-06-10 American Cyanamid Co Continuous release peptide implants for parenteral administration
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5000886A (en) * 1987-05-26 1991-03-19 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules and process of making the same
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
CH672887A5 (fr) * 1987-10-14 1990-01-15 Debiopharm Sa
US5187150A (en) * 1987-10-14 1993-02-16 Debiopharm S.A. Polyester-based composition for the controlled release of polypeptide medicinal substances
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
ATE133087T1 (de) * 1989-05-04 1996-02-15 Southern Res Inst Einkapselungsverfahren
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
CH679207A5 (fr) * 1989-07-28 1992-01-15 Debiopharm Sa
CH681425A5 (fr) * 1990-11-14 1993-03-31 Debio Rech Pharma Sa
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.

Also Published As

Publication number Publication date
BE1005696A3 (fr) 1993-12-21
CA2074320C (fr) 1999-04-06
NO922885D0 (no) 1992-07-21
LU88151A1 (fr) 1993-02-15
IL102590A0 (en) 1993-01-14
FR2680109A1 (fr) 1993-02-12
GR1001446B (el) 1993-12-30
FI923320A0 (fi) 1992-07-21
IT1259891B (it) 1996-03-28
FR2680109B1 (fr) 1994-09-02
AU652844B2 (en) 1994-09-08
BE1005697A5 (fr) 1993-12-21
RU2103994C1 (ru) 1998-02-10
GB2257909A (en) 1993-01-27
WO1993001802A1 (fr) 1993-02-04
IE69967B1 (en) 1996-10-16
DK176218B1 (da) 2007-02-26
FI106925B (fi) 2001-05-15
DE4223282A1 (de) 1993-01-28
HU218203B (hu) 2000-06-28
JPH06172208A (ja) 1994-06-21
DK176219B1 (da) 2007-02-26
CA2074320A1 (fr) 1993-01-23
NO922886L (no) 1993-01-25
IE71199B1 (en) 1997-02-12
SE512609C2 (sv) 2000-04-10
NO304057B1 (no) 1998-10-19
FI923321A0 (fi) 1992-07-21
ITBS920093A1 (it) 1994-01-21
FI923320A (fi) 1993-01-23
DK93892D0 (da) 1992-07-21
NL194576B (nl) 2002-04-02
FI923321A (fi) 1993-01-23
NL194577C (nl) 2002-08-05
CN1054543C (zh) 2000-07-19
CZ287585B6 (cs) 2000-12-13
NL194576C (nl) 2002-08-05
HRP920229A2 (en) 1996-04-30
ITBS920093A0 (it) 1992-07-21
HU9301186D0 (en) 1993-07-28
SI9200152B (sl) 1998-06-30
PL169387B1 (pl) 1996-07-31
DK93892A (da) 1993-01-23
PT100712B (pt) 1999-07-30
CH683149A5 (fr) 1994-01-31
US5445832A (en) 1995-08-29
UA35569C2 (uk) 2001-04-16
JP3600252B2 (ja) 2004-12-15
ZA925486B (en) 1993-04-28
SE9202212L (sv) 1993-01-23
IL102591A (en) 1997-06-10
HUT64234A (en) 1993-12-28
PT100713B (pt) 1999-07-30
SI9200152A (en) 1993-03-31
GB9215480D0 (en) 1992-09-02
EE03014B1 (et) 1997-08-15
AU2043792A (en) 1993-01-28
MX9204268A (es) 1994-03-31
DE4223284A1 (de) 1993-01-28
US5637568A (en) 1997-06-10
ES2037621A1 (es) 1993-06-16
NO922886D0 (no) 1992-07-21
ITBS920092A0 (it) 1992-07-21
AT408609B (de) 2002-01-25
IE922366A1 (en) 1993-01-27
NL9201309A (nl) 1993-02-16
GB9215479D0 (en) 1992-09-02
IL102591A0 (en) 1993-01-14
ATA148892A (de) 2001-06-15
DE9219084U1 (de) 1997-09-25
BR9205375A (pt) 1994-03-08
ZA925485B (en) 1993-04-28
NL9201310A (nl) 1993-02-16
CN1070344A (zh) 1993-03-31
ES2050070A1 (es) 1994-05-01
NZ243643A (en) 1993-10-26
CH683592A5 (fr) 1994-04-15
IT1259892B (it) 1996-03-28
GR920100323A (el) 1993-05-24
SE9202212D0 (sv) 1992-07-21
SE9202213D0 (sv) 1992-07-21
CZ66093A3 (en) 1994-01-19
PT100712A (pt) 1993-10-29
DK93992A (da) 1993-01-23
KR930702018A (ko) 1993-09-08
PL298504A1 (en) 1994-01-10
AU651711B2 (en) 1994-07-28
FR2679450A1 (fr) 1993-01-29
JP2842736B2 (ja) 1999-01-06
PT100713A (pt) 1993-08-31
DE4223284C2 (de) 1997-07-31
CA2074322C (fr) 2003-04-08
JPH05221855A (ja) 1993-08-31
ATA148992A (de) 1997-06-15
NO304136B1 (no) 1998-11-02
IL102590A (en) 1997-07-13
ES2037621B1 (es) 1994-02-01
PH31564A (en) 1998-11-03
AU2043692A (en) 1993-01-28
NO922885L (no) 1993-01-25
SE9202213L (sv) 1993-01-23
ITBS920092A1 (it) 1994-01-21
GB2257909B (en) 1996-01-10
ES2050070B1 (es) 1994-10-01
GB2257973A (en) 1993-01-27
FI105318B (fi) 2000-07-31
IE922367A1 (en) 1993-01-27
SE512670C2 (sv) 2000-04-17
NL194577B (nl) 2002-04-02
CA2074322A1 (fr) 1993-01-23
LU88150A1 (fr) 1993-02-15
AT403348B (de) 1998-01-26
GB2257973B (en) 1996-02-28
SK280612B6 (sk) 2000-05-16
SK38293A3 (en) 1993-08-11
TW260610B (fr) 1995-10-21
GR1002548B (el) 1997-01-28
DK93992D0 (da) 1992-07-21

Similar Documents

Publication Publication Date Title
FR2679450B1 (fr) Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques.
MA26415A1 (fr) Composes heterocycliques, procede pour la preparation et compositions pharmaceutiques les contenant
NO973229D0 (no) Biologisk nedbrytbare polymerer, fremgangsmåte for fremstilling av disse, samt anvendelse av polymerene for fremstilling av biologisk nedbrytbare formlegemer
FR2732685B1 (fr) Polysilane, procede pour le preparer et matiere premiere correspondante
NO973767L (no) Biologisk nedbrytbare polymerer, fremgangsmåte for fremstilling, samt anvendelse av polymerene for fremstilling av biologisk nedbrytbare formlegemer
HUP9802994A3 (en) Polymer material, process for its production and use thereof
IT8448836A0 (it) Idrogeli polimerici separati in microfase per il rilascio controllato di materiali bioattivi, quali medicinali, antibiotici, contraccettivi e simili
DE69019817T3 (de) Trägermaterial zur Arzneimittelverabreichung.
TR26866A (tr) Düsük yogunluklu,gözenekli,capraz baglanmis polimerik malzemelerin hazirlanmasi icin islem.
HUP9903387A3 (en) Polymer particles and process for the preparation thereof, foamed product, and using that polymer particles
DE59001372D1 (de) Schuettfaehiges packmaterial, daraus hergestellte packeinheit und verfahren und einrichtung zu dessen bzw. deren herstellung.
EP0584228A4 (fr) Nouveau materiau polymere thermoplastique et procede de fabrication associe.
FR2740132B1 (fr) Procede pour la preparation de 1,1,1,3,3-pentafluoropropane
ITRE970056A0 (it) Sistema di caricamento degli stampi delle presse per la formatura di p iastrelle e relativi mezzi di attuazione.
DE69023927D1 (de) Thermoplastisches copolymer, dessen herstellungsverfahren und dieses enthaltende thermoplastische harzmischung.
ITRE960061A0 (it) Sistema di caricamento degli stampi delle presse ceramiche per la formatura di piastrelle pressosmaltate, e relativi mezzi di attuazione
FI942843A (fi) Aminohappojen erotus, aminohappoperustainen monomeeri, ja menetelmä sen valmistamiseksi, sekä polymeerimateriaali ja menetelmä sen valmistamiseksi
ES1017765Y (es) Contenedor para material granular.
FR2734580B1 (fr) Procede pour la preparation de particules de polymere metallisees, materiau polymere prepare par le procede et son utilisation
HUP9901715A3 (en) Layered tablet for the controlled release of active substances
FR2649983B1 (fr) Procede de preparation de perles de polymere expansibles et materiaux en derivant
DE69002091T2 (de) System zur kontinuierlichen Freisetzung von Vitamin A im Speisewasser.
FR2674129B1 (fr) Matiere desodorisante et son procede de production.
EP0421216A3 (en) Process for the preparation of 2,4, resp. 2,6 dihalo-aniline
FR2655280B1 (fr) Dispositif de preparation, sous forme de charges, d'un produit en vrac.