ES2049617A1 - Procedimiento de preparacion de una composicion farmaceutica. - Google Patents

Procedimiento de preparacion de una composicion farmaceutica.

Info

Publication number
ES2049617A1
ES2049617A1 ES9102518A ES9102518A ES2049617A1 ES 2049617 A1 ES2049617 A1 ES 2049617A1 ES 9102518 A ES9102518 A ES 9102518A ES 9102518 A ES9102518 A ES 9102518A ES 2049617 A1 ES2049617 A1 ES 2049617A1
Authority
ES
Spain
Prior art keywords
poly
extrusion
containing insoluble
implant containing
biodegradable microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9102518A
Other languages
English (en)
Other versions
ES2049617B1 (es
Inventor
Orsolini
Heimgartner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Original Assignee
Debio Recherche Pharmaceutique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Recherche Pharmaceutique SA filed Critical Debio Recherche Pharmaceutique SA
Publication of ES2049617A1 publication Critical patent/ES2049617A1/es
Application granted granted Critical
Publication of ES2049617B1 publication Critical patent/ES2049617B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UNA COMPOSICION FARMACEUTICA EN FORMA DE MICROPARTICULAS O DE UNA IMPLANTACION QUE COMPRENDE UN POLIMERO BIODEGRADABLE ESCOGIDO DE ENTRE POLI-1,4-BUTILENSUCCINATO, POLI-2,3-BUTILENSUCCINATO, POLI-1,4-BUTILENFUMARATO Y POLI-2,3-BUTILENFUMARATO, INCORPORANDO COMO SUBSTANCIA ACTIVA EL PAMOATO, TANNATO, ESTEARATO O PALMITATO DE UN PEPTIDO NATURAL O SINTETICO QUE COMPRENDE DE 3 A 45 AMINOACIDOS, TALES COMO LH-RH, SOMATOSTATINA, GH-RH O CALCITONINA, O UNO DE SUS ANALOGOS U HOMOLOGOS SINTETICOS. LA PREPARACION COMPRENDE MEZCLAR EN SECO LOS INGREDIENTES EN FORMA DE POLVO, PRECOMPRIMIR Y PRECALENTAR LA MEZCLA Y LUEGO EXTRUIR LA MEZCLA PRECOMPRIMIDA Y PRECALENTADA. EL PRODUCTO RESULTANTE DE LA ETAPA DE EXTRUSION PUEDE TRITURARSE A CONTINUACION Y FINALMENTE CRIBARSE.
ES09102518A 1990-11-14 1991-11-13 Procedimiento de preparacion de una composicion farmaceutica. Expired - Lifetime ES2049617B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3616/90A CH681425A5 (es) 1990-11-14 1990-11-14

Publications (2)

Publication Number Publication Date
ES2049617A1 true ES2049617A1 (es) 1994-04-16
ES2049617B1 ES2049617B1 (es) 1997-03-16

Family

ID=4259807

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09102518A Expired - Lifetime ES2049617B1 (es) 1990-11-14 1991-11-13 Procedimiento de preparacion de una composicion farmaceutica.

Country Status (12)

Country Link
JP (1) JPH04288021A (es)
AT (1) AT397198B (es)
BE (1) BE1004923A5 (es)
CA (1) CA2055115A1 (es)
CH (1) CH681425A5 (es)
DE (1) DE4136930A1 (es)
ES (1) ES2049617B1 (es)
FR (1) FR2668707B1 (es)
GB (1) GB2249725B (es)
IT (1) IT1252870B (es)
NL (1) NL9101877A (es)
SE (1) SE506448C2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
WO2004096178A1 (en) * 2003-05-02 2004-11-11 The University Of Nottingham Nano and microparticle drug delivery systems comprising polyesters containing aliphatic dicarboxylate residues and residues of aliphatic polyols

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211091A (en) * 1987-10-14 1989-06-28 Debiopharm Sa Biodegradable polyester-based sustained release composition
ES2009346A6 (es) * 1987-09-21 1989-09-16 Debiopharm Sa Procedimiento de preparacion de composiciones farmaceuticas que contienen polipeptidos hidroinsolubles.
EP0486959A1 (en) * 1990-11-22 1992-05-27 Vectorpharma International S.P.A. Pharmaceutical composition of microparticles with controlled release and process of preparing it

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978203A (en) * 1974-07-12 1976-08-31 Dynatech Corporation Sustained release of pharmaceuticals from polyester matrices
US4481353A (en) * 1983-10-07 1984-11-06 The Children's Medical Center Corporation Bioresorbable polyesters and polyester composites
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
CH679207A5 (es) * 1989-07-28 1992-01-15 Debiopharm Sa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2009346A6 (es) * 1987-09-21 1989-09-16 Debiopharm Sa Procedimiento de preparacion de composiciones farmaceuticas que contienen polipeptidos hidroinsolubles.
GB2211091A (en) * 1987-10-14 1989-06-28 Debiopharm Sa Biodegradable polyester-based sustained release composition
EP0486959A1 (en) * 1990-11-22 1992-05-27 Vectorpharma International S.P.A. Pharmaceutical composition of microparticles with controlled release and process of preparing it

Also Published As

Publication number Publication date
ATA223591A (de) 1993-07-15
SE9103348D0 (sv) 1991-11-13
FR2668707B1 (fr) 1995-05-24
CA2055115A1 (en) 1992-05-15
ES2049617B1 (es) 1997-03-16
GB9123241D0 (en) 1991-12-18
SE506448C2 (sv) 1997-12-15
GB2249725B (en) 1994-08-10
IT1252870B (it) 1995-06-28
BE1004923A5 (fr) 1993-02-23
NL9101877A (nl) 1992-06-01
ITBS910119A1 (it) 1993-05-08
CH681425A5 (es) 1993-03-31
FR2668707A1 (fr) 1992-05-07
JPH04288021A (ja) 1992-10-13
ITBS910119A0 (it) 1991-11-08
GB2249725A (en) 1992-05-20
SE9103348L (sv) 1992-05-15
DE4136930A1 (de) 1992-08-20
AT397198B (de) 1994-02-25

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