BR9916053B1 - composições contendo um peptìdeo e um ácido glicólico poliláctico, adequadas para preparação de implantes subcutáneos com perìodo de liberação prolongado. - Google Patents

composições contendo um peptìdeo e um ácido glicólico poliláctico, adequadas para preparação de implantes subcutáneos com perìodo de liberação prolongado.

Info

Publication number
BR9916053B1
BR9916053B1 BRPI9916053-6A BR9916053A BR9916053B1 BR 9916053 B1 BR9916053 B1 BR 9916053B1 BR 9916053 A BR9916053 A BR 9916053A BR 9916053 B1 BR9916053 B1 BR 9916053B1
Authority
BR
Brazil
Prior art keywords
peptide
preparation
glycolic acid
compositions containing
subcutaneous implants
Prior art date
Application number
BRPI9916053-6A
Other languages
English (en)
Other versions
BR9916053A (pt
Inventor
Alain Maquin
Patrice Mauriac
Pierre Marion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9916053A publication Critical patent/BR9916053A/pt
Publication of BR9916053B1 publication Critical patent/BR9916053B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
BRPI9916053-6A 1998-12-10 1999-12-06 composições contendo um peptìdeo e um ácido glicólico poliláctico, adequadas para preparação de implantes subcutáneos com perìodo de liberação prolongado. BR9916053B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002655A IT1304152B1 (it) 1998-12-10 1998-12-10 Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
PCT/EP1999/009536 WO2000033809A1 (en) 1998-12-10 1999-12-06 Compositions containing a peptide and polylactic-glycolic acid suitable for preparing subcutaneous implants with an extended release period

Publications (2)

Publication Number Publication Date
BR9916053A BR9916053A (pt) 2001-09-04
BR9916053B1 true BR9916053B1 (pt) 2011-04-19

Family

ID=11381206

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9916053-6A BR9916053B1 (pt) 1998-12-10 1999-12-06 composições contendo um peptìdeo e um ácido glicólico poliláctico, adequadas para preparação de implantes subcutáneos com perìodo de liberação prolongado.

Country Status (16)

Country Link
US (1) US6620422B1 (pt)
EP (1) EP1137400B1 (pt)
JP (1) JP4607329B2 (pt)
KR (1) KR100676844B1 (pt)
CN (1) CN1149975C (pt)
AT (1) ATE253893T1 (pt)
AU (1) AU757898C (pt)
BR (1) BR9916053B1 (pt)
CA (1) CA2354034C (pt)
DE (1) DE69912836T2 (pt)
DK (1) DK1137400T3 (pt)
ES (1) ES2211211T3 (pt)
IT (1) IT1304152B1 (pt)
PT (1) PT1137400E (pt)
TW (1) TW561053B (pt)
WO (1) WO2000033809A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004535431A (ja) 2001-06-22 2004-11-25 サザン バイオシステムズ， インコーポレイテッド ゼロ次長期放出同軸インプラント
ES2385030T3 (es) 2001-06-29 2012-07-17 Medgraft Microtech, Inc. Implantes inyectables biodegradables y procedimientos relacionados con su fabricación y uso
KR100885070B1 (ko) * 2002-05-08 2009-02-25 재단법인서울대학교산학협력재단 Ｐｌｇａ에 특이적으로 부착하는 올리고 펩타이드
DK1532985T3 (en) 2002-06-25 2016-12-05 Takeda Pharmaceuticals Co PROCEDURE FOR PREPARING A COMPOSITION WITH LONG-TERM RELEASE
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
NZ541595A (en) 2003-01-28 2008-08-29 Microbia Inc Methods and compositions for the treatment of gastrointestinal disorders
GB0304726D0 (en) * 2003-03-01 2003-04-02 Ardana Bioscience Ltd New Process
ES2291893T3 (es) * 2003-06-26 2008-03-01 Mediolanum Pharmaceuticals Limited Implantes subcutaneos con liberacion inicial limitada del principio activo y posterior liberacion prolongada linealmente variable de los mismos.
ITMI20031302A1 (it) * 2003-06-26 2004-12-27 Mediolanum Pharmaceuticals Ltd Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
JP5105578B2 (ja) 2003-11-05 2012-12-26 サーコード バイオサイエンス インコーポレイテッド 細胞接着のモジュレーター
EP1711159B1 (en) * 2003-12-30 2013-03-20 Durect Corporation Solid implants containing a block copolymer for controlled release of a gnrh compound
FR2865938B1 (fr) 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
US20080254086A1 (en) * 2004-12-23 2008-10-16 Brown James E Controlled Release Compositions
SI2444079T1 (sl) 2005-05-17 2017-05-31 Sarcode Bioscience Inc. Sestavki in postopki za zdravljenje očesnih motenj
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
CN101209238B (zh) * 2006-12-27 2012-05-09 辽宁省计划生育科学研究院 含孕二烯酮的生物降解型长效皮下避孕埋植剂及其制备
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
CA2958665C (en) 2007-10-19 2021-03-02 Sarcode Bioscience Inc. Compositions and methods for treatment of diabetic retinopathy
JP5502751B2 (ja) 2007-12-20 2014-05-28 エボニック コーポレイション 低残留溶媒濃度を有する微粒子を調製するためのプロセス
US20090258069A1 (en) * 2008-04-15 2009-10-15 John Burnier Delivery of LFA-1 antagonists to the gastrointestinal system
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2246063A1 (en) * 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9364518B2 (en) 2010-06-24 2016-06-14 Torrent Pharmaceuticals Limited Pharmaceutical composition containing goserelin for in-situ implant
JP6092849B2 (ja) 2011-05-04 2017-03-08 バランス セラピューティックス, インコーポレイテッドBalance Therapeutics, Inc. ペンチレンテトラゾール誘導体
DE102011114864A1 (de) 2011-10-05 2013-04-11 Acino Ag Verfahren zur Herstellung einer homogenen Pulvermischung und Verfahren zur Herstellung eines Implantats sowie Implantat
EP2877465A4 (en) 2012-07-25 2016-05-11 Sarcode Bioscience Inc LFA-1 HEMMER AND POLYMORPH THEREOF
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CN103446041B (zh) * 2013-08-27 2015-06-10 青岛东辉医药科技发展有限公司 一种亮丙瑞林缓控释药棒及其制备方法
EP3054969B1 (en) 2013-10-10 2021-03-10 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
CN105287390A (zh) * 2015-11-20 2016-02-03 北京博恩特药业有限公司 一种长效醋酸亮丙瑞林微球及其制备方法
CN105267153B (zh) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 一种曲普瑞林缓释微粒及其制备方法
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
CN105878174B (zh) * 2016-04-26 2021-06-29 广州帝奇医药技术有限公司 一种固体分散体及其制备方法与应用
CN107281493A (zh) * 2017-06-20 2017-10-24 苏州乔纳森新材料科技有限公司 一种聚乳酸‑聚乙醇酸共聚复合材料及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
CH679207A5 (pt) * 1989-07-28 1992-01-15 Debiopharm Sa
JPH07503700A (ja) * 1991-01-03 1995-04-20 アルカーメス　コントロールド　セラピューティックス，　インコーポレイテッド カチオン生体ポリマーによるタンパク質の安定化
WO1992011843A1 (en) * 1991-01-09 1992-07-23 Alza Corporation Bioerodible devices and compositions for diffusional release of agents
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
EP0948321B1 (de) * 1996-12-12 2003-10-22 Dds Drug Delivery Service Gesellschaft Zur Förderung Der Forschung In Pharmazeutischer Technologie Und Biopharmazie Mbh Zubereitung in form eines wahlweise wirkstoffhaltigen matrixmaterial-hilfsstoff compounds

Also Published As

Publication number Publication date
DK1137400T3 (da) 2004-03-22
US6620422B1 (en) 2003-09-16
DE69912836T2 (de) 2004-11-11
DE69912836D1 (de) 2003-12-18
IT1304152B1 (it) 2001-03-08
CN1329485A (zh) 2002-01-02
EP1137400A1 (en) 2001-10-04
BR9916053A (pt) 2001-09-04
JP2002531486A (ja) 2002-09-24
AU757898B2 (en) 2003-03-13
ITMI982655A1 (it) 2000-06-10
KR20010082310A (ko) 2001-08-29
AU1971100A (en) 2000-06-26
PT1137400E (pt) 2004-03-31
TW561053B (en) 2003-11-11
CA2354034C (en) 2009-01-27
AU757898C (en) 2003-12-18
CN1149975C (zh) 2004-05-19
WO2000033809A1 (en) 2000-06-15
CA2354034A1 (en) 2000-06-15
KR100676844B1 (ko) 2007-01-31
JP4607329B2 (ja) 2011-01-05
ES2211211T3 (es) 2004-07-01
ATE253893T1 (de) 2003-11-15
EP1137400B1 (en) 2003-11-12

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: MEDIOLANUM PHARMACEUTICALS LIMITED (IE)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/04/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2259 DE 22-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.