PT1137400E - Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado - Google Patents

Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado

Info

Publication number
PT1137400E
PT1137400E PT99963398T PT99963398T PT1137400E PT 1137400 E PT1137400 E PT 1137400E PT 99963398 T PT99963398 T PT 99963398T PT 99963398 T PT99963398 T PT 99963398T PT 1137400 E PT1137400 E PT 1137400E
Authority
PT
Portugal
Prior art keywords
peptide
polylactic
glycolic acid
implants
subscutaneous
Prior art date
Application number
PT99963398T
Other languages
English (en)
Inventor
Alain Maquin
Patrice Mauriac
Pierre Marion
Original Assignee
Mediolanum Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Pharmaceuticals Ltd filed Critical Mediolanum Pharmaceuticals Ltd
Publication of PT1137400E publication Critical patent/PT1137400E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT99963398T 1998-12-10 1999-12-06 Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado PT1137400E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002655A IT1304152B1 (it) 1998-12-10 1998-12-10 Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato

Publications (1)

Publication Number Publication Date
PT1137400E true PT1137400E (pt) 2004-03-31

Family

ID=11381206

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99963398T PT1137400E (pt) 1998-12-10 1999-12-06 Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado

Country Status (16)

Country Link
US (1) US6620422B1 (pt)
EP (1) EP1137400B1 (pt)
JP (1) JP4607329B2 (pt)
KR (1) KR100676844B1 (pt)
CN (1) CN1149975C (pt)
AT (1) ATE253893T1 (pt)
AU (1) AU757898C (pt)
BR (1) BR9916053B1 (pt)
CA (1) CA2354034C (pt)
DE (1) DE69912836T2 (pt)
DK (1) DK1137400T3 (pt)
ES (1) ES2211211T3 (pt)
IT (1) IT1304152B1 (pt)
PT (1) PT1137400E (pt)
TW (1) TW561053B (pt)
WO (1) WO2000033809A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004535431A (ja) 2001-06-22 2004-11-25 サザン バイオシステムズ， インコーポレイテッド ゼロ次長期放出同軸インプラント
US7314636B2 (en) 2001-06-29 2008-01-01 Medgraft Microtech, Inc. Biodegradable injectable implants containing glycolic acid
KR100885070B1 (ko) * 2002-05-08 2009-02-25 재단법인서울대학교산학협력재단 Ｐｌｇａ에 특이적으로 부착하는 올리고 펩타이드
AU2003244157A1 (en) * 2002-06-25 2004-01-06 Takeda Pharmaceutical Company Limited Process for producing sustained-release composition
ATE365174T1 (de) 2003-01-28 2007-07-15 Microbia Inc Zusammensetzungen zur behandlung von gastrointestinalen störungen
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0304726D0 (en) * 2003-03-01 2003-04-02 Ardana Bioscience Ltd New Process
ITMI20031302A1 (it) 2003-06-26 2004-12-27 Mediolanum Pharmaceuticals Ltd Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.
KR20060027353A (ko) * 2003-06-26 2006-03-27 메디올라늄 파마슈티컬즈 리미티드 활성 성분의 초기 방출이 제한되고 후속의 연장된 방출이선형적으로 변화하는 피하 삽입물
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
EP1682537B1 (en) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulators of cellular adhesion
AU2004313245B2 (en) * 2003-12-30 2011-04-14 Durect Corporation Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
US8541028B2 (en) 2004-08-04 2013-09-24 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
WO2006071208A1 (en) * 2004-12-23 2006-07-06 Durect Corporation Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of a gnrh
SI1881823T1 (sl) 2005-05-17 2015-04-30 Sarcode Bioscience Inc. Sestavki in postopki za zdravljenje bolezni oäśesa
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
CN101209238B (zh) * 2006-12-27 2012-05-09 辽宁省计划生育科学研究院 含孕二烯酮的生物降解型长效皮下避孕埋植剂及其制备
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
CN101873797A (zh) 2007-10-19 2010-10-27 萨可德公司 用于治疗糖尿病性视网膜病的组合物和方法
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
EP2276508A4 (en) * 2008-04-15 2011-12-28 Sarcode Bioscience Inc RELEASE OF LFA-1 ANTAGONISTS AGAINST THE GAS-DARM SYSTEM
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2246063A1 (en) * 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011161531A1 (en) 2010-06-24 2011-12-29 Torrent Pharmaceuticals Limited Pharmaceutical composition containing goserelin for in-situ implant
JP6092849B2 (ja) 2011-05-04 2017-03-08 バランス セラピューティックス, インコーポレイテッドBalance Therapeutics, Inc. ペンチレンテトラゾール誘導体
DE102011114864A1 (de) 2011-10-05 2013-04-11 Acino Ag Verfahren zur Herstellung einer homogenen Pulvermischung und Verfahren zur Herstellung eines Implantats sowie Implantat
CN104797574B (zh) 2012-07-25 2019-11-22 原生质生物科学股份有限公司 Lfa-1抑制剂及其多晶型物
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CN103446041B (zh) * 2013-08-27 2015-06-10 青岛东辉医药科技发展有限公司 一种亮丙瑞林缓控释药棒及其制备方法
US20160220630A1 (en) 2013-10-10 2016-08-04 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
CN105287390A (zh) * 2015-11-20 2016-02-03 北京博恩特药业有限公司 一种长效醋酸亮丙瑞林微球及其制备方法
CN105267153B (zh) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 一种曲普瑞林缓释微粒及其制备方法
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
CN105878174B (zh) * 2016-04-26 2021-06-29 广州帝奇医药技术有限公司 一种固体分散体及其制备方法与应用
CN107281493A (zh) * 2017-06-20 2017-10-24 苏州乔纳森新材料科技有限公司 一种聚乳酸‑聚乙醇酸共聚复合材料及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
CH679207A5 (pt) * 1989-07-28 1992-01-15 Debiopharm Sa
JPH07503700A (ja) * 1991-01-03 1995-04-20 アルカーメス　コントロールド　セラピューティックス，　インコーポレイテッド カチオン生体ポリマーによるタンパク質の安定化
WO1992011843A1 (en) 1991-01-09 1992-07-23 Alza Corporation Bioerodible devices and compositions for diffusional release of agents
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
WO1998025590A2 (de) * 1996-12-12 1998-06-18 Dds Drug Delivery Service Gesellschaft Zur Förderung Der Forschung In Pharmazeutischer Technologie Und Biopharmazie Mbh Zubereitung in form eines wahlweise wirkstoffhaltigen matrixmaterial-hilfsstoff compounds

Also Published As

Publication number Publication date
EP1137400B1 (en) 2003-11-12
CA2354034A1 (en) 2000-06-15
KR100676844B1 (ko) 2007-01-31
AU757898B2 (en) 2003-03-13
BR9916053B1 (pt) 2011-04-19
CA2354034C (en) 2009-01-27
ITMI982655A1 (it) 2000-06-10
IT1304152B1 (it) 2001-03-08
US6620422B1 (en) 2003-09-16
ATE253893T1 (de) 2003-11-15
CN1329485A (zh) 2002-01-02
JP2002531486A (ja) 2002-09-24
WO2000033809A1 (en) 2000-06-15
TW561053B (en) 2003-11-11
DE69912836T2 (de) 2004-11-11
KR20010082310A (ko) 2001-08-29
JP4607329B2 (ja) 2011-01-05
AU757898C (en) 2003-12-18
EP1137400A1 (en) 2001-10-04
AU1971100A (en) 2000-06-26
BR9916053A (pt) 2001-09-04
DE69912836D1 (de) 2003-12-18
ES2211211T3 (es) 2004-07-01
DK1137400T3 (da) 2004-03-22
CN1149975C (zh) 2004-05-19

Similar Documents

Publication Publication Date Title
PT1137400E (pt) Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado
MX9705710A (es) Compuestos con propiedades de liberacion de la hormona del crecimiento.
BR9808933A (pt) Composição sob forma de microcápsulas ou de implantes, processo de preparação de uma substância hidrossolúvel, substância ativa, acetato de triptorelina, acetato de lanreotìdeo, ou acetato de octreotìdeo, e rna de filamento duplo
EP1015008A4 (en) COMPOUNDS AND COMPOSITIONS FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES
HK1036970A1 (en) Compounds and compositions for delivering active agents.
EP0783299A4 (en) COMPOUNDS AND COMPOSITIONS FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES
PL347671A1 (en) Compounds and compositions for delivering active agents
BR8801242A (pt) Processo de preparar uma composicao para fornecer uma quantidade efetiva de uma dose constante de um ingrediente ativo a um animal e a respectiva composicao
FI962154A (fi) Koostumus terapeuttisten tuotteiden in vivo valmistusta varten
HK1040623A1 (en) The use of fumaric acid derivatives in transplantation medicine.
ATE146360T1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
HUP0104195A3 (en) Vitamin d analogues, preparation thereof, pharmaceutical and cosmetic compositions containing them
GR3029791T3 (en) Improved immunogenic compositions against human gastrin 17
PT975334E (pt) Microparticulas biodegradaveis para a libertacao sustentada de farmacos terapeuticos
BG105570A (en) Pharmaceutical compositions for modified release insulin sensitiser
ES2179375T3 (es) Composiciones farmaceuticas estabilizadas, a base de quinupristina y de dalfopristina y su preparacion.
ATE208627T1 (de) Orale zusammensetzungen mit niedrigdosierten zytotoxischen proteinen
ATE247961T1 (de) Sufentanilhaltige arzneimittel mit verzögerter wirkstoffabgabe