SE9801992D0 - New 3-aryl-2-hydroxypropionic acid derivative I - Google Patents
New 3-aryl-2-hydroxypropionic acid derivative IInfo
- Publication number
- SE9801992D0 SE9801992D0 SE9801992A SE9801992A SE9801992D0 SE 9801992 D0 SE9801992 D0 SE 9801992D0 SE 9801992 A SE9801992 A SE 9801992A SE 9801992 A SE9801992 A SE 9801992A SE 9801992 D0 SE9801992 D0 SE 9801992D0
- Authority
- SE
- Sweden
- Prior art keywords
- aryl
- acid derivative
- hydroxypropionic acid
- new
- novel
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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- C07C271/06—Esters of carbamic acids
- C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C271/38—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
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- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
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- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
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- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
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- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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Priority Applications (84)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9801992A SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | New 3-aryl-2-hydroxypropionic acid derivative I |
MA25591A MA26634A1 (fr) | 1998-06-04 | 1999-05-20 | Nouveaux derives de l'acide 3-aryl propionique et analogues |
MA25592A MA26635A1 (fr) | 1998-06-04 | 1999-05-20 | Nouveau derive i de l'acide 3-aryl-2-hydroxypropionique |
DZ990099A DZ2799A1 (fr) | 1998-06-04 | 1999-05-23 | Nouveaux dérivés de l'acide 3-aryl propionique et analogues. |
DZ990100A DZ2800A1 (fr) | 1998-06-04 | 1999-05-23 | Nouveau dérivé de l'acide 3-aryl-2-hydroxypropionique. |
TW088108576A TW446696B (en) | 1998-06-04 | 1999-05-25 | New 3-aryl-2-hydroxypropionic acid derivative I |
TW088108577A TW548263B (en) | 1998-06-04 | 1999-05-25 | New 3-aryl propionic acid derivatives and analogs |
TR2000/03581T TR200003581T2 (tr) | 1998-06-04 | 1999-05-31 | Yeni 3-aril-2-hidroksipropiyonik asit türevi (I) |
AT99930059T ATE246674T1 (de) | 1998-06-04 | 1999-05-31 | Neue 3-aryl-2-hydroxypropionsäure-derivate |
PL99345205A PL195189B1 (pl) | 1998-06-04 | 1999-05-31 | Kwas (S)-2-etoksy-3-[4-(2-{4-metanosulfonyloksyfenylo}-etoksy)fenylo]propanowy, sposób jego wytwarzania, związki pośrednie, środek farmaceutyczny i zastosowanie kwasu (S)-2-etoksy-3-[4-(2-{4-metanosulfonyloksyfenylo}etoksy)fenylo]propanowego |
JP2000552084A JP3723739B2 (ja) | 1998-06-04 | 1999-05-31 | 新規3−アリールプロピオン酸誘導体および類似体 |
SI9930452T SI1084102T1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
UA2000116621A UA71912C2 (en) | 1998-06-04 | 1999-05-31 | 3-aryl-2-hydroxypropionic acid derivative, a process for its manufacture (variants), intermediate compound, a pharmaceutical composition (variants) and a method for prevention and/or treatment of clinical conditions associated with insulin resistance |
IL13963699A IL139636A (en) | 1998-06-04 | 1999-05-31 | (s)-2-ethoxy-3-[4-(2{4-methanesulfonyloxyphenyl} ethoxy) phenyl] propanoic acid, process for its preparation, pharmaceutical composition containing it and use thereof in the manufacture of medicament for the prophylaxis or treatment of clinical conditions associated with insulin resistance |
AT99930060T ATE251130T1 (de) | 1998-06-04 | 1999-05-31 | Neue 3-aryl-propionsäurederivate und analoge |
PT99930059T PT1084103E (pt) | 1998-06-04 | 1999-05-31 | Novo derivado do acido 3-aril-2-hidroxipropionico (i) |
ES99930059T ES2205844T3 (es) | 1998-06-04 | 1999-05-31 | Nuevo derivado (i) de acido 3-aril-2-hidroxipropionico. |
AU46671/99A AU752261B2 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative (I) |
RU2000130189/04A RU2214999C2 (ru) | 1998-06-04 | 1999-05-31 | Производное 3-арил-2-гидроксипропионовой кислоты, способ его получения(варианты), фармацевтический препарат, способ лечения и промежуточный продукт |
DE69911770T DE69911770T2 (de) | 1998-06-04 | 1999-05-31 | Neue 3-aryl-propionsäurederivate und analoge |
HU0103226A HUP0103226A3 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
BR9910928-0A BR9910928A (pt) | 1998-06-04 | 1999-05-31 | Composto, processo para a prepará-lo, uso do mesmo, formulação, e, processo para a profilaxia e/ou tratamento de condições clinicas associadas com resistência a insulina |
SK1768-2000A SK284642B6 (sk) | 1998-06-04 | 1999-05-31 | Deriváty kyseliny 3-aryl-2-hydroxypropiónovej, farmaceutický prípravok s ich obsahom a ich použitie |
DK99930059T DK1084103T3 (da) | 1998-06-04 | 1999-05-31 | Nyt 3-aryl-2-hydroxpropionsyrederivat (I) |
IDW20002652A ID28833A (id) | 1998-06-04 | 1999-05-31 | Turunan asam 3-aril-2-hidroksipropionat |
EEP200000725A EE04463B1 (et) | 1998-06-04 | 1999-05-31 | 3-arüülpropaanhappe derivaadid ja nende analoogid, nende valmistamise meetod, neid sisaldavad ravimkoostised ja ühendid kasutamiseks ravis |
KR1020007013662A KR100625152B1 (ko) | 1998-06-04 | 1999-05-31 | 신규한 3-아릴-2-히드록시프로피온산 유도체 (i) |
CA002333938A CA2333938C (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative (i) |
AU46672/99A AU752262B2 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
PT99930060T PT1084102E (pt) | 1998-06-04 | 1999-05-31 | Novos derivados do acido 3-aril-propionico e analogos |
US09/341,904 US6258850B1 (en) | 1998-06-04 | 1999-05-31 | 3-aryl-2-hydroxypropionic acid derivative (I) |
DK99930060T DK1084102T3 (da) | 1998-06-04 | 1999-05-31 | Nye 3-arylpropionsyrederivater og analoge |
PCT/SE1999/000942 WO1999062871A1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
UA2000116620A UA66852C2 (uk) | 1998-06-04 | 1999-05-31 | Похідні та аналоги 3-арилпропіонової кислоти, спосіб їх отримання, фармацевтична композиція (варіанти) та спосіб профілактики та/або лікування асоційованих з резистентністю до інсуліну клінічних станів |
TR2000/03583T TR200003583T2 (tr) | 1998-06-04 | 1999-05-31 | Yeni 3-aril propiyonik asit türevleri ve benzerleri. |
EP99930060A EP1084102B1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
IL13963599A IL139635A0 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
HU0103376A HUP0103376A3 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative, pharmaceutical compositions containing it, process for their preparation and their use |
CN99809340A CN1311772A (zh) | 1998-06-04 | 1999-05-31 | 新的3-芳基-2-羟基丙酸衍生物i |
CN99809354A CN1312795A (zh) | 1998-06-04 | 1999-05-31 | 新的3-芳基丙酸衍生物和其类似物 |
IDW20002669A ID29457A (id) | 1998-06-04 | 1999-05-31 | Turunan dan analog asam 3-aril propionat |
CA002334374A CA2334374A1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
EP99930059A EP1084103B1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative (i) |
BR9910921-2A BR9910921A (pt) | 1998-06-04 | 1999-05-31 | Composto, processo para preparar o mesmo, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com a resistência à insulina |
PCT/SE1999/000941 WO1999062872A1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative (i) |
JP2000552085A JP3554539B2 (ja) | 1998-06-04 | 1999-05-31 | 新規な3−アリール−2−ヒドロキシプロピオン酸誘導体i |
NZ508452A NZ508452A (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative (I) |
EEP200000720A EE04772B1 (et) | 1998-06-04 | 1999-05-31 | 3-arüül-2-hüdroksüpropaanhappe derivaat (I) |
US09/341,931 US6630600B1 (en) | 1998-06-04 | 1999-05-31 | 3-aryl propionic acid derivatives and analogs |
NZ508453A NZ508453A (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs and their use in the treatment of insulin resistance |
CZ20004484A CZ297424B6 (cs) | 1998-06-04 | 1999-05-31 | Kyselina (S)-2-ethoxy-3-{4-[2-(4-methansulfonyloxyfenyl)-ethoxy]fenyl}propanová, zpusob její prípravy, farmaceutický prostredek s jejím obsahem a její pouzití |
YUP-745/00A RS49688B (sr) | 1998-06-04 | 1999-05-31 | Novi derivat 3-aril-2- hidroksipropionske kiseline (i) |
SK1769-2000A SK284849B6 (sk) | 1998-06-04 | 1999-05-31 | Deriváty a analógy kyseliny 3-arylpropiónovej, spôsob ich prípravy, farmaceutické formulácie s ich obsahom a ich použitie |
CNB2005100687433A CN1310881C (zh) | 1998-06-04 | 1999-05-31 | 新的3-芳基-2-羟基丙酸衍生物i |
SI9930405T SI1084103T1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative (i) |
PL99344681A PL344681A1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl propionic acid derivatives and analogs |
ES99930060T ES2209457T3 (es) | 1998-06-04 | 1999-05-31 | Nuevos derivados del acido 3-aril-propionico, y analogos. |
KR1020007013673A KR20010052529A (ko) | 1998-06-04 | 1999-05-31 | 신규한 3-아릴 프로피온산 유도체 및 동족체 |
DE69910203T DE69910203T2 (de) | 1998-06-04 | 1999-05-31 | Neue 3-aryl-2-hydroxypropionsäure-derivate |
MYPI99002185A MY129581A (en) | 1998-06-04 | 1999-06-02 | New 3-aryl propionic acid derivatives and analogs |
TNTNSN99108A TNSN99108A1 (fr) | 1998-06-04 | 1999-06-02 | Nouveau derive i de l'acide 3-aryl-2-hydroxypropionique |
TNTNSN99103A TNSN99103A1 (fr) | 1998-06-04 | 1999-06-02 | Nouveaux derives de l'acide 3-aryl propionique et analogues |
MYPI99002209A MY117785A (en) | 1998-06-04 | 1999-06-02 | New 3-aryl-2-hydroxypropionic acid derivatives i |
ARP990102635A AR020875A1 (es) | 1998-06-04 | 1999-06-03 | Compuesto acido (s)-2-etoxi-3-[4-(2-(4-metansulfoniloxi fenil)etoxi)fenil]-propanoico, proceso para su preparacion formulaicon farmaceutica, uso de dicho compuesto en la elaboracion de medicamentos, y formulacion farmaceutica |
ARP990102634A AR035305A1 (es) | 1998-06-04 | 1999-06-03 | Derivados y analogos del acido 3-arilpropionico, proceso para su preparacion, formulaciones farmaceuticas, uso de los mismos en la elaboracion de medicamentos, y formulacion farmaceutica para usar en la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina |
EG65699A EG24140A (en) | 1998-06-04 | 1999-06-03 | New 3-aryl-2-hydroxypropionic acid derivative |
SA99200304A SA99200304B1 (ar) | 1998-06-04 | 1999-06-28 | مشتق جديد رقم 1 لـــ -2-aryl-3 hydroxypropionic acid |
ARP000102487A AR024061A2 (es) | 1998-06-04 | 2000-05-22 | Intermediario acido 2-etoxi-3(-(2[4-metansulfoniloxifenil*etoxi*fenil*propanoico |
HR20000782A HRP20000782B1 (en) | 1998-06-04 | 2000-11-16 | New 3-aryl-2-hydroxypropionic acid derivative (i) |
IS5714A IS2071B (is) | 1998-06-04 | 2000-11-17 | Ný 3-arýl-2-hýdroxýprópíonsýruafleiða (I) |
ZA200006774A ZA200006774B (en) | 1998-06-04 | 2000-11-20 | New 3-aryl-2-hydroxypropionic acid derivative (I). |
IS5744A IS5744A (is) | 1998-06-04 | 2000-11-29 | Nýjar 3-arýl-própíónsýruafleiður og -hliðstæður |
NO20006116A NO20006116L (no) | 1998-06-04 | 2000-12-01 | Nye 3-arylpropionsyrederivater og -analoger |
NO20006115A NO323426B1 (no) | 1998-06-04 | 2000-12-01 | Nytt 3-aryl-2-hydroksypropionsyrederivat, fremgangsmate for fremstilling derav samt anvendelse derav i terapi |
US09/861,163 US20010034371A1 (en) | 1998-06-04 | 2001-05-18 | New 3-aryl-2-hydroxypropionic acid derivative I |
HK01105768A HK1034957A1 (en) | 1998-06-04 | 2001-08-16 | New 3-aryl propionic acid derivatives and analogs |
HK01105811A HK1035711A1 (en) | 1998-06-04 | 2001-08-17 | New 3-aryl-2-hydroxypropionic acid derivative (i) |
US10/039,868 US6660879B2 (en) | 1998-06-04 | 2002-01-04 | 3-aryl-2-hydroxypropionic acid derivative I |
JP2003273428A JP2004043480A (ja) | 1998-06-04 | 2003-07-11 | 新規な3−アリール−2−ヒドロキシプロピオン酸誘導体iの中間体 |
US10/669,131 US20040229946A1 (en) | 1998-06-04 | 2003-09-22 | New 3-aryl-2-hydroxypropionic acid derivative I |
US10/678,739 US20040229949A1 (en) | 1998-06-04 | 2003-10-02 | New 3-aryl propionic acid derivatives and analogs |
JP2004183263A JP2004346079A (ja) | 1998-06-04 | 2004-06-22 | 新規3−アリールプロピオン酸誘導体および類似体 |
US11/078,201 US20060040979A1 (en) | 1998-06-04 | 2005-03-11 | 3-Aryl-2-hydroxypropionic acid derivative I |
US11/388,942 US20060173204A1 (en) | 1998-06-04 | 2006-03-24 | New 3-aryl propionic acid derivatives and analogs |
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SE9801992A SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | New 3-aryl-2-hydroxypropionic acid derivative I |
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JP (2) | JP3554539B2 (xx) |
KR (1) | KR100625152B1 (xx) |
CN (2) | CN1310881C (xx) |
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AT (1) | ATE246674T1 (xx) |
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CA (1) | CA2333938C (xx) |
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ES (1) | ES2205844T3 (xx) |
HK (1) | HK1035711A1 (xx) |
HR (1) | HRP20000782B1 (xx) |
HU (1) | HUP0103376A3 (xx) |
ID (1) | ID28833A (xx) |
IL (1) | IL139636A (xx) |
IS (1) | IS2071B (xx) |
MA (1) | MA26635A1 (xx) |
MY (1) | MY117785A (xx) |
NO (1) | NO323426B1 (xx) |
NZ (1) | NZ508452A (xx) |
PL (1) | PL195189B1 (xx) |
PT (1) | PT1084103E (xx) |
RS (1) | RS49688B (xx) |
RU (1) | RU2214999C2 (xx) |
SA (1) | SA99200304B1 (xx) |
SE (1) | SE9801992D0 (xx) |
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UA (1) | UA71912C2 (xx) |
WO (1) | WO1999062872A1 (xx) |
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US4114417A (en) * | 1977-06-27 | 1978-09-19 | Schmelzer Corporation | Method and apparatus for making metal parts |
US4479005A (en) * | 1982-12-16 | 1984-10-23 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
FR2653119B1 (fr) | 1989-10-18 | 1994-08-05 | Lipha | Nouveaux aryloxy alcoyl benzenes, leurs procedes de preparation et les compositions pharmaceutiques en renfermant. |
US5068345A (en) * | 1989-10-30 | 1991-11-26 | Eastman Kodak Company | Oxazolidinone aldol adduct |
US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
GB9114948D0 (en) * | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
ATE207470T1 (de) * | 1992-07-03 | 2001-11-15 | Smithkline Beecham Plc | Benzoxazol- und benzothiazol-derivate als arzneimittel |
US5232945A (en) | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
US5648541A (en) * | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
DE69725585T2 (de) * | 1996-04-04 | 2004-07-01 | Sankyo Co., Ltd. | Phenylalkylcarbonsäure-derivate |
CA2307820C (en) * | 1997-10-27 | 2007-04-24 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
MA26634A1 (fr) * | 1998-06-04 | 2004-12-20 | Astra Ab | Nouveaux derives de l'acide 3-aryl propionique et analogues |
SE9801990D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
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1998
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1999
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- 1999-05-31 CN CN99809340A patent/CN1311772A/zh active Pending
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