SE0200943D0 - Mutant protein - Google Patents
Mutant proteinInfo
- Publication number
- SE0200943D0 SE0200943D0 SE0200943A SE0200943A SE0200943D0 SE 0200943 D0 SE0200943 D0 SE 0200943D0 SE 0200943 A SE0200943 A SE 0200943A SE 0200943 A SE0200943 A SE 0200943A SE 0200943 D0 SE0200943 D0 SE 0200943D0
- Authority
- SE
- Sweden
- Prior art keywords
- protein
- immunoglobulin
- binding
- mutated
- glutamine
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/44—Materials comprising a mixture of organic materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/52—Sorbents specially adapted for preparative chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (35)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0200943A SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Mutant protein |
CN2011104134586A CN102558318A (zh) | 2002-03-25 | 2003-03-20 | 一种突变的免疫球蛋白-结合蛋白 |
DE60327606T DE60327606D1 (de) | 2002-03-25 | 2003-03-20 | Mutiertes immunoglobulinbindendes protein |
EP08004374.8A EP1972689B1 (de) | 2002-03-25 | 2003-03-20 | Mutiertes immunglobulinbindendes Protein |
CN2011104078321A CN102516371A (zh) | 2002-03-25 | 2003-03-20 | 一种突变的免疫球蛋白-结合蛋白 |
PCT/SE2003/000475 WO2003080655A1 (en) | 2002-03-25 | 2003-03-20 | A mutated immunoglobulin-binding protein |
ES08004374.8T ES2634145T3 (es) | 2002-03-25 | 2003-03-20 | Proteína de unión a inmunoglobulinas mutada |
CN038067935A CN1642976B (zh) | 2002-03-25 | 2003-03-20 | 一种突变的免疫球蛋白-结合蛋白 |
AU2003217119A AU2003217119B2 (en) | 2002-03-25 | 2003-03-20 | A mutated immunoglobulin-binding protein |
CN2011104134571A CN102558317A (zh) | 2002-03-25 | 2003-03-20 | 一种突变的免疫球蛋白-结合蛋白 |
CN201110407855.2A CN102532284B (zh) | 2002-03-25 | 2003-03-20 | 一种突变的免疫球蛋白-结合蛋白 |
DK17166519.3T DK3249047T3 (en) | 2002-03-25 | 2003-03-20 | Mutantprotein |
AT03713152T ATE431360T1 (de) | 2002-03-25 | 2003-03-20 | Mutiertes immunoglobulinbindendes protein |
CA2479896A CA2479896C (en) | 2002-03-25 | 2003-03-20 | A mutated immunoglobulin-binding protein |
EP03713152A EP1485407B2 (de) | 2002-03-25 | 2003-03-20 | Mutiertes immunoglobulinbindendes protein |
JP2003578408A JP4391830B2 (ja) | 2002-03-25 | 2003-03-20 | 変異免疫グロブリン結合タンパク質 |
US10/508,625 US7834158B2 (en) | 2002-03-25 | 2003-03-20 | Mutated immunoglobulin-binding protein |
KR1020127028734A KR101307651B1 (ko) | 2002-03-25 | 2003-03-20 | 돌연변이된 면역글로불린-결합 단백질 |
KR1020047015303A KR101067181B1 (ko) | 2002-03-25 | 2003-03-20 | 돌연변이된 면역글로불린-결합 단백질 |
DK08004374.8T DK1972689T3 (en) | 2002-03-25 | 2003-03-20 | A mutated immunoglobulin-binding protein |
EP17166519.3A EP3249047B1 (de) | 2002-03-25 | 2003-03-20 | Mutantes protein |
KR1020127028735A KR101307714B1 (ko) | 2002-03-25 | 2003-03-20 | 돌연변이된 면역글로불린-결합 단백질 |
CN2011104078514A CN102516372A (zh) | 2002-03-25 | 2003-03-20 | 一种突变的免疫球蛋白-结合蛋白 |
ES17166519T ES2783876T3 (es) | 2002-03-25 | 2003-03-20 | Proteína mutante |
ES03713152T ES2325362T5 (es) | 2002-03-25 | 2003-03-20 | Una proteína de unión a inmunoglobulina mutada |
KR1020107026798A KR101307700B1 (ko) | 2002-03-25 | 2003-03-20 | 돌연변이된 면역글로불린-결합 단백질 |
US11/363,078 US7709209B2 (en) | 2002-03-25 | 2006-02-27 | Protein ligands |
US11/374,532 US20060194950A1 (en) | 2002-03-25 | 2006-03-13 | Mutant protein |
US12/568,854 US8354510B2 (en) | 2002-03-25 | 2009-09-29 | Mutant protein |
US12/900,958 US8198404B2 (en) | 2002-03-25 | 2010-10-08 | Mutated immunoglobulin-binding protein |
US13/488,662 US9156892B2 (en) | 2002-03-25 | 2012-06-05 | Mutated immunoglobulin-binding protein |
US13/740,793 US9296791B2 (en) | 2002-03-25 | 2013-01-14 | Mutant protein |
US14/845,817 US9534023B2 (en) | 2002-03-25 | 2015-09-04 | Mutated immunoglobulin-binding protein |
US15/367,640 US10918971B2 (en) | 2002-03-25 | 2016-12-02 | Mutated immunoglobulin-binding protein |
US17/153,015 US20210162319A1 (en) | 2002-03-25 | 2021-01-20 | Mutated Immunoglobulin-Binding Polypeptides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0200943A SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Mutant protein |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0200943D0 true SE0200943D0 (sv) | 2002-03-25 |
Family
ID=20287415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0200943A SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Mutant protein |
Country Status (13)
Country | Link |
---|---|
US (9) | US7834158B2 (de) |
EP (3) | EP1972689B1 (de) |
JP (1) | JP4391830B2 (de) |
KR (4) | KR101067181B1 (de) |
CN (6) | CN102558318A (de) |
AT (1) | ATE431360T1 (de) |
AU (1) | AU2003217119B2 (de) |
CA (1) | CA2479896C (de) |
DE (1) | DE60327606D1 (de) |
DK (2) | DK3249047T3 (de) |
ES (3) | ES2634145T3 (de) |
SE (1) | SE0200943D0 (de) |
WO (1) | WO2003080655A1 (de) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
SE0301936D0 (sv) * | 2003-06-30 | 2003-06-30 | Affibody Ab | New polypeptide |
SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
CA2570253A1 (en) * | 2004-07-06 | 2006-01-12 | Kaneka Corporation | Process for producing protein a-like protein with use of brevibacillus genus bacaterium |
WO2006065208A1 (en) * | 2004-12-14 | 2006-06-22 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
US8728828B2 (en) | 2004-12-22 | 2014-05-20 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
DK1869071T3 (da) | 2005-03-01 | 2011-02-28 | Affibody Ab | TNF-alfa-bindende polypeptid, anvendelser deraf og fremgangsmåder, der gør brug deraf |
WO2007097361A1 (ja) | 2006-02-21 | 2007-08-30 | Protenova Co., Ltd. | イムノグロブリン親和性リガンド |
CN106422418B (zh) | 2006-09-29 | 2022-03-01 | 思拓凡生物工艺研发有限公司 | 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体 |
WO2008127457A2 (en) | 2006-12-06 | 2008-10-23 | Repligen Corporation | Nucleic acids encoding recombinant protein a |
WO2008143199A1 (ja) * | 2007-05-21 | 2008-11-27 | Nomadic Bioscience Co., Ltd. | 新規ポリペプチド,アフィニティークロマトグラフィー用材,及びイムノグロブリンの分離及び/又は精製方法 |
SG149759A1 (en) * | 2007-07-10 | 2009-02-27 | Millipore Corp | Media for affinity chromatography |
GB2452301A (en) | 2007-08-30 | 2009-03-04 | Ge Healthcare Bio Sciences Ab | Sterilization Method |
KR101104417B1 (ko) * | 2008-05-09 | 2012-01-16 | 한국생명공학연구원 | 단백질 g 변형체를 이용한 항체의 특이적 공유결합 커플링방법 |
CN103396480A (zh) * | 2008-05-15 | 2013-11-20 | 诺沃—诺迪斯克有限公司 | 抗体纯化方法 |
US9238810B2 (en) | 2008-06-05 | 2016-01-19 | Affibody Ab | Polypeptide |
US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
EP2339339A4 (de) * | 2008-09-25 | 2016-10-12 | Jsr Corp | Füllmittel für affinitätschromatographie |
JP5229888B2 (ja) * | 2008-09-30 | 2013-07-03 | 独立行政法人産業技術総合研究所 | 弱酸性域での易解離性を向上したプロテインa変異型タンパク質及び抗体捕捉剤 |
JP6113404B2 (ja) * | 2008-10-29 | 2017-04-12 | アブリンクス エン.ヴェー. | 単一ドメイン抗原結合分子の精製方法 |
SG195555A1 (en) | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
WO2010080065A1 (en) * | 2009-01-12 | 2010-07-15 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
EP2412809B1 (de) * | 2009-03-24 | 2017-08-09 | Kaneka Corporation | Protein mit immunglobulinaffinität und ligand mit affinität für immunglobulinbindung |
CN102844432A (zh) * | 2010-03-24 | 2012-12-26 | 株式会社钟化 | 特异性结合免疫球蛋白的蛋白质以及免疫球蛋白结合性亲和配体 |
JP5354094B2 (ja) | 2010-03-31 | 2013-11-27 | Jsr株式会社 | アフィニティークロマトグラフィー用充填剤 |
US20130052209A1 (en) * | 2010-04-23 | 2013-02-28 | Purdue Research Foundation | Protein drug formulations and packages |
WO2012001142A1 (en) | 2010-07-02 | 2012-01-05 | Novo Nordisk A/S | Improved antibody binding affinity ligands |
US9115204B2 (en) | 2010-10-27 | 2015-08-25 | Spiber Technologies Ab | Spider silk fusion protein structures for binding to an organic target |
WO2012074463A1 (en) * | 2010-11-29 | 2012-06-07 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
JP5974342B2 (ja) * | 2010-12-20 | 2016-08-23 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | アフィニティークロマトグラフィーマトリックス |
WO2012087231A1 (en) | 2010-12-20 | 2012-06-28 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
KR101461772B1 (ko) | 2010-12-21 | 2014-12-03 | 제이에스알 가부시끼가이샤 | 친화성 크로마토그래피용 담체 및 면역 글로불린을 단리하는 방법 |
US9051375B2 (en) | 2010-12-21 | 2015-06-09 | The University Of Western Ontario | Alkali-resistant variants of protein A and their use in affinity chromatography |
US20130317172A1 (en) * | 2010-12-24 | 2013-11-28 | Nomadic Bioscience Co., Ltd. | Method for immobilizing temperature responsive protein a |
EP2666049B1 (de) | 2011-01-20 | 2018-02-28 | GE Healthcare Bio-Sciences Corp. | Lichtabtastsysteme |
WO2012124145A1 (ja) | 2011-03-15 | 2012-09-20 | オムロン株式会社 | 演算ユニット、支援装置、支援プログラム、支援プログラムを格納した記憶媒体、および、支援装置における動作方法 |
JP6038774B2 (ja) | 2011-03-24 | 2016-12-07 | 株式会社カネカ | タンパク性物質結合性低分子化合物 |
JP5933526B2 (ja) | 2011-03-25 | 2016-06-08 | 株式会社カネカ | 免疫グロブリン結合性新規ポリペプチド |
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JP6420756B2 (ja) * | 2012-03-28 | 2018-11-07 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | アフィニティークロマトグラフィーマトリックス |
JP6302895B2 (ja) * | 2012-05-02 | 2018-03-28 | スパイバー テクノロジーズ アーベーSpiber Technologies Ab | 親和性リガンドとして免疫グロブリン断片を組み込んだクモ糸融合タンパク質の構造 |
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US10036745B2 (en) | 2012-10-03 | 2018-07-31 | Gyros Patent Ab | Method and kit for analyte determination at acidic conditions |
WO2014092636A1 (en) | 2012-12-14 | 2014-06-19 | Ge Healthcare Bio-Sciences Ab | Method for cleaning of packed bed chromatography columns |
CN104059133B (zh) | 2013-03-18 | 2019-03-15 | 南京金斯瑞生物科技有限公司 | 一类突变的具有高耐碱特性的蛋白a及其应用 |
CN103214563B (zh) * | 2013-03-26 | 2015-09-30 | 江南大学 | 一种性能改进的重组金黄色葡萄球菌蛋白a亲和配基及其构建方法 |
EP3019520B1 (de) | 2013-07-10 | 2019-12-11 | GE Healthcare BioProcess R&D AB | Mutierte immunglobulinbindende polypeptide |
US10208094B2 (en) | 2013-09-04 | 2019-02-19 | Protenova Co., Ltd. | Multimeric immunoglobulin-binding domain |
WO2015034056A1 (ja) * | 2013-09-06 | 2015-03-12 | 株式会社カネカ | アフィニティー分離マトリックス用分離能強化リガンド |
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CN103540588B (zh) * | 2013-10-08 | 2016-06-08 | 杨波 | 一种基因工程改造的免疫球蛋白-亲和蛋白 |
US10189007B2 (en) | 2013-10-15 | 2019-01-29 | Kaneka Corporation | Method for producing porous cellulose beads and adsorbent employing same |
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