DE60327606D1 - Mutiertes immunoglobulinbindendes protein - Google Patents
Mutiertes immunoglobulinbindendes proteinInfo
- Publication number
- DE60327606D1 DE60327606D1 DE60327606T DE60327606T DE60327606D1 DE 60327606 D1 DE60327606 D1 DE 60327606D1 DE 60327606 T DE60327606 T DE 60327606T DE 60327606 T DE60327606 T DE 60327606T DE 60327606 D1 DE60327606 D1 DE 60327606D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- binding protein
- immunoglobulin
- mutated
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/44—Materials comprising a mixture of organic materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/52—Sorbents specially adapted for preparative chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0200943A SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Mutant protein |
PCT/SE2003/000475 WO2003080655A1 (en) | 2002-03-25 | 2003-03-20 | A mutated immunoglobulin-binding protein |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60327606D1 true DE60327606D1 (de) | 2009-06-25 |
Family
ID=20287415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60327606T Expired - Lifetime DE60327606D1 (de) | 2002-03-25 | 2003-03-20 | Mutiertes immunoglobulinbindendes protein |
Country Status (13)
Country | Link |
---|---|
US (9) | US7834158B2 (de) |
EP (3) | EP1485407B2 (de) |
JP (1) | JP4391830B2 (de) |
KR (4) | KR101307714B1 (de) |
CN (6) | CN102558317A (de) |
AT (1) | ATE431360T1 (de) |
AU (1) | AU2003217119B2 (de) |
CA (1) | CA2479896C (de) |
DE (1) | DE60327606D1 (de) |
DK (2) | DK1972689T3 (de) |
ES (3) | ES2783876T3 (de) |
SE (1) | SE0200943D0 (de) |
WO (1) | WO2003080655A1 (de) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
SE0301936D0 (sv) * | 2003-06-30 | 2003-06-30 | Affibody Ab | New polypeptide |
SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
US8597908B2 (en) * | 2004-07-06 | 2013-12-03 | Kaneka Corporation | Process for producing protein A-like protein with use of Brevibacillus genus bacterium |
CA2586803C (en) * | 2004-12-14 | 2012-12-11 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
US8728828B2 (en) | 2004-12-22 | 2014-05-20 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
DK1869071T3 (da) | 2005-03-01 | 2011-02-28 | Affibody Ab | TNF-alfa-bindende polypeptid, anvendelser deraf og fremgangsmåder, der gør brug deraf |
EP1992692B1 (de) * | 2006-02-21 | 2013-01-09 | Protenova Co., Ltd. | Immunglobulin-affinitätsligand |
JP5345539B2 (ja) | 2006-09-29 | 2013-11-20 | ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー | 抗体単離のためのスタフィロコッカスアウレウス由来のドメインcを含むクロマトグラフィーリガンド |
WO2008127457A2 (en) | 2006-12-06 | 2008-10-23 | Repligen Corporation | Nucleic acids encoding recombinant protein a |
WO2008143199A1 (ja) | 2007-05-21 | 2008-11-27 | Nomadic Bioscience Co., Ltd. | 新規ポリペプチド,アフィニティークロマトグラフィー用材,及びイムノグロブリンの分離及び/又は精製方法 |
SG149759A1 (en) | 2007-07-10 | 2009-02-27 | Millipore Corp | Media for affinity chromatography |
GB2452301A (en) | 2007-08-30 | 2009-03-04 | Ge Healthcare Bio Sciences Ab | Sterilization Method |
KR101104417B1 (ko) * | 2008-05-09 | 2012-01-16 | 한국생명공학연구원 | 단백질 g 변형체를 이용한 항체의 특이적 공유결합 커플링방법 |
JP2011523408A (ja) * | 2008-05-15 | 2011-08-11 | ノボ・ノルデイスク・エー/エス | 抗体精製方法 |
JP5677943B2 (ja) * | 2008-06-05 | 2015-02-25 | アフィボディ・アーベーAffibody Ab | ポリペプチド |
US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
EP2339339A4 (de) * | 2008-09-25 | 2016-10-12 | Jsr Corp | Füllmittel für affinitätschromatographie |
JP5229888B2 (ja) * | 2008-09-30 | 2013-07-03 | 独立行政法人産業技術総合研究所 | 弱酸性域での易解離性を向上したプロテインa変異型タンパク質及び抗体捕捉剤 |
CA2739352C (en) * | 2008-10-29 | 2021-07-13 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
SG162687A1 (en) * | 2008-12-24 | 2010-07-29 | Millipore Corp | Caustic stable chromatography ligands |
US20120149875A1 (en) * | 2009-01-12 | 2012-06-14 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
EP2412809B1 (de) | 2009-03-24 | 2017-08-09 | Kaneka Corporation | Protein mit immunglobulinaffinität und ligand mit affinität für immunglobulinbindung |
AU2011230313B2 (en) | 2010-03-24 | 2015-01-22 | Kaneka Corporation | Protein capable of binding specifically to immunoglobulin, and immunoglobulin-binding affinity ligand |
KR102006097B1 (ko) | 2010-03-31 | 2019-07-31 | 제이에스알 가부시끼가이샤 | 친화성 크로마토그래피용 충전제 |
US20130052209A1 (en) * | 2010-04-23 | 2013-02-28 | Purdue Research Foundation | Protein drug formulations and packages |
WO2012001142A1 (en) | 2010-07-02 | 2012-01-05 | Novo Nordisk A/S | Improved antibody binding affinity ligands |
DK2632948T3 (en) * | 2010-10-27 | 2017-02-27 | Spiber Tech Ab | SPIDER SILK FUSION PROTEIN INSTRUCTIONS FOR BINDING TO AN ORGANIC GOAL. |
JP2014502272A (ja) * | 2010-11-29 | 2014-01-30 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | アフィニティークロマトグラフィーマトリックス |
WO2012087230A1 (en) | 2010-12-20 | 2012-06-28 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
US9187555B2 (en) | 2010-12-20 | 2015-11-17 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
CN103403020A (zh) * | 2010-12-21 | 2013-11-20 | Jsr株式会社 | 蛋白a的新型耐碱变体及其在亲和色谱中的用途 |
WO2012086660A1 (ja) | 2010-12-21 | 2012-06-28 | Jsr株式会社 | アフィニティークロマトグラフィー用担体およびイムノグロブリンを単離する方法 |
JPWO2012086837A1 (ja) * | 2010-12-24 | 2014-06-05 | 旭化成メディカル株式会社 | 温度応答性プロテインaの固定化方法 |
WO2012099521A1 (en) | 2011-01-20 | 2012-07-26 | Applied Precision, Inc. | Light-scanning systems |
WO2012124145A1 (ja) | 2011-03-15 | 2012-09-20 | オムロン株式会社 | 演算ユニット、支援装置、支援プログラム、支援プログラムを格納した記憶媒体、および、支援装置における動作方法 |
JP6038774B2 (ja) | 2011-03-24 | 2016-12-07 | 株式会社カネカ | タンパク性物質結合性低分子化合物 |
EP2690108B1 (de) * | 2011-03-25 | 2018-07-25 | Kaneka Corporation | Neuartiges immunoglobulinbindendes polypeptid |
WO2012170446A2 (en) * | 2011-06-05 | 2012-12-13 | Apple Inc. | Systems and methods for displaying notifications received from multiple applications |
SG10201604554WA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
US9657055B2 (en) * | 2011-11-30 | 2017-05-23 | Ge Healthcare Bioprocess R&D Ab | Affinity chromatography matrix |
WO2013147691A1 (en) * | 2012-03-28 | 2013-10-03 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
CA2872305A1 (en) * | 2012-05-02 | 2013-11-07 | Spiber Technologies Ab | Spider silk fusion protein structures incorporating immunoglobulin fragments as affinity ligands |
JP6335785B2 (ja) | 2012-09-03 | 2018-05-30 | 株式会社カネカ | ミックスモード抗体アフィニティー分離マトリックスとそれを用いた精製方法および標的分子 |
EP2904393B1 (de) | 2012-10-03 | 2018-11-28 | Gyros Patent Ab | Verfahren und kit zur analytbestimmung unter sauren bedingungen |
CN104837536B (zh) | 2012-12-14 | 2018-01-02 | 通用电气医疗集团生物工艺研发股份公司 | 清洁填充床层析柱的方法 |
CN104059133B (zh) * | 2013-03-18 | 2019-03-15 | 南京金斯瑞生物科技有限公司 | 一类突变的具有高耐碱特性的蛋白a及其应用 |
CN103214563B (zh) * | 2013-03-26 | 2015-09-30 | 江南大学 | 一种性能改进的重组金黄色葡萄球菌蛋白a亲和配基及其构建方法 |
WO2015005859A1 (en) | 2013-07-10 | 2015-01-15 | Ge Healthcare Bio-Sciences Ab | Mutated immunoglobulin-binding polypeptides |
JP6456831B2 (ja) * | 2013-09-04 | 2019-01-23 | プロテノバ株式会社 | イムノグロブリン結合ドメイン多量体 |
EP3042954A4 (de) * | 2013-09-06 | 2017-03-22 | Kaneka Corporation | Ligand mit verstärkter dissoziationskapazität für eine affinitätsdissoziationsmatrix |
KR20160054597A (ko) | 2013-09-17 | 2016-05-16 | 가부시키가이샤 가네카 | 신규 항체 정제 방법 및 그로부터 얻어지는 항체, 및 양이온 교환기를 사용한 신규 항체 정제법 및 그로부터 얻어지는 항체 |
CN103540588B (zh) * | 2013-10-08 | 2016-06-08 | 杨波 | 一种基因工程改造的免疫球蛋白-亲和蛋白 |
JP6440320B2 (ja) | 2013-10-15 | 2018-12-19 | 株式会社カネカ | 多孔質セルロースビーズの製造方法およびそれを用いた吸着体 |
JP6517145B2 (ja) | 2013-10-15 | 2019-05-22 | 株式会社カネカ | 多孔質セルロースビーズの製造方法及びそれを用いた吸着体 |
JP6442409B2 (ja) | 2013-10-15 | 2018-12-19 | 株式会社カネカ | 多孔質セルロースビーズの製造方法 |
CN104945488B (zh) * | 2014-03-27 | 2020-02-18 | 迈格生物医药(上海)有限公司 | 一种具有免疫球蛋白结合能力的多肽 |
CN105481954B (zh) * | 2014-09-16 | 2021-03-26 | 亿一生物制药(北京)有限公司 | 一种重组蛋白a及其应用 |
JP6369807B2 (ja) * | 2014-10-21 | 2018-08-08 | 株式会社プロテイン・エクスプレス | プロテインl変異体 |
US11566082B2 (en) * | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
US10208091B2 (en) | 2014-12-17 | 2019-02-19 | Ge Healthcare Bioprocess R&D Ab | Modified kappa light chain-binding polypeptides |
CN108064286A (zh) | 2015-01-26 | 2018-05-22 | 株式会社钟化 | 突变型免疫球蛋白κ链可变区结合性肽 |
WO2016121701A1 (ja) | 2015-01-26 | 2016-08-04 | 株式会社カネカ | 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス |
JP6805831B2 (ja) | 2015-02-05 | 2020-12-23 | 三菱ケミカル株式会社 | 免疫グロブリンに親和性を有するタンパク質、およびそれを用いたアフィニティ分離剤、液体クロマトグラフィー用カラム |
CN107429244A (zh) * | 2015-03-26 | 2017-12-01 | Jsr株式会社 | 免疫球蛋白结合蛋白质和使用其的亲和载体 |
CN106188251B (zh) * | 2015-05-06 | 2020-07-31 | 上海迈泰君奥生物技术有限公司 | 一种免疫球蛋白结合蛋白突变体及其用途 |
JPWO2017014261A1 (ja) * | 2015-07-22 | 2018-04-26 | 株式会社カネカ | 抗体様タンパク質の精製方法 |
EP3327029A4 (de) * | 2015-07-22 | 2018-10-31 | Kaneka Corporation | Antikörperbindendes protein mit reduzierter antikörperbindungskapazität in regionen mit saurem ph-wert |
GB201515339D0 (en) | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
KR101993845B1 (ko) * | 2016-02-18 | 2019-06-28 | (주)에이피테크놀로지 | 알칼리 저항성이 증대된 항체 친화성 리간드 |
WO2017191748A1 (ja) * | 2016-05-02 | 2017-11-09 | 株式会社カネカ | 改変型免疫グロブリンκ鎖可変領域結合性ペプチド |
WO2017195638A1 (ja) | 2016-05-09 | 2017-11-16 | 株式会社カネカ | 抗体またはκ鎖可変領域含有抗体断片の精製方法 |
CN109071613A (zh) * | 2016-05-11 | 2018-12-21 | 通用电气医疗集团生物工艺研发股份公司 | 分离基质 |
WO2017194593A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
CN109311949B (zh) * | 2016-05-11 | 2022-09-16 | 思拓凡生物工艺研发有限公司 | 储存分离基质的方法 |
US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
KR101857953B1 (ko) * | 2016-07-06 | 2018-05-16 | 아미코젠주식회사 | 알칼리 내성이 증가된 변이 면역글로불린 결합 단백질 |
CN106117324A (zh) * | 2016-07-29 | 2016-11-16 | 湖北爱晟生物科技有限公司 | 重组蛋白a及其编码基因和应用 |
CN109476712B (zh) * | 2016-08-11 | 2022-08-02 | 纳维格蛋白质有限公司 | 新型对碱稳定的免疫球蛋白结合蛋白 |
WO2018048941A2 (en) * | 2016-09-08 | 2018-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Use of high affinity monoclonal antibody product binders to increase the duration of action of therapeutic monoclonal antibody products in a biologic tissue |
CN106543274B (zh) * | 2016-10-18 | 2020-10-27 | 天津大学 | 一种对抗体具有特异性结合作用的a蛋白结构域z的衍生物及其应用 |
BR112019011921A2 (pt) | 2016-12-12 | 2019-11-05 | Hurrah S A R L | polipeptídeo engenheirado que liga imunoglobulinas ou compostos contendo imunoglobulina, matriz de separação, composição, proteína, meio cromatográfico e método de purificação de uma imunoglobulina |
GB201703116D0 (en) | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
GB201708277D0 (en) | 2017-05-24 | 2017-07-05 | Ge Healthcare | A Recombinant protein |
CN111132994B (zh) | 2017-08-07 | 2024-05-31 | 瑞普利金公司 | 在c末端螺旋区中具有半胱氨酸的fc结合蛋白 |
CN109721645A (zh) * | 2017-12-29 | 2019-05-07 | 兆生生物科技南京有限公司 | 一种基因突变的蛋白a及其应用 |
CN111902720A (zh) | 2018-03-21 | 2020-11-06 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
WO2020040307A1 (ja) * | 2018-08-24 | 2020-02-27 | Jsr株式会社 | イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体 |
JP7117741B2 (ja) * | 2018-10-10 | 2022-08-15 | 国立大学法人 鹿児島大学 | IgG結合性ペプチドを含む固相担体及びIgGの分離方法 |
CA3123498A1 (en) * | 2019-02-01 | 2020-08-06 | Navigo Proteins Gmbh | Immunoglobulin binding proteins for affinity purification |
WO2020196938A1 (ko) * | 2019-03-25 | 2020-10-01 | 아미코젠주식회사 | 불순물 제거능이 우수한 항체 정제용 레진 |
GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
JP2022530852A (ja) * | 2019-04-17 | 2022-07-04 | ブリストル-マイヤーズ スクイブ カンパニー | クロマトグラフィー樹脂の再生方法 |
ES2945795T3 (es) | 2019-04-29 | 2023-07-07 | Cytiva Bioprocess R & D Ab | Método de separación de anticuerpos o fragmentos de anticuerpo que están desprovistos de una región Fc capaz de unirse a la proteína A |
CN112210013A (zh) * | 2019-07-03 | 2021-01-12 | 拜奥普罗塞亚科技有限责任公司 | 碱耐受性亲和色谱配体 |
TW202128230A (zh) | 2019-10-18 | 2021-08-01 | 日商日本醫事物理股份有限公司 | 具有經ri標定之人類化抗體的複合體、放射性醫藥 |
CN111057153B (zh) * | 2019-12-06 | 2021-09-07 | 广州康盛生物科技股份有限公司 | 一种免疫球蛋白结合蛋白及其制备方法和应用 |
CN112461943A (zh) * | 2020-10-12 | 2021-03-09 | 河南省奶牛生产性能测定有限公司 | 一种牛乳中免疫球蛋白igG高效液相色谱检测方法 |
JP2023551353A (ja) | 2020-10-13 | 2023-12-08 | アヴィタイド エルエルシー | 3へリックスバンドルタンパク質の親和性リガンドライブラリー及びその使用 |
GB202018588D0 (en) | 2020-11-26 | 2021-01-13 | Cytiva Bioprocess R & D Ab | Separation matrix |
WO2022136440A1 (en) | 2020-12-21 | 2022-06-30 | Syngenta Crop Protection Ag | Pesticidal hexatoxin polypeptides and methods of use thereof |
CN117241866A (zh) | 2021-02-19 | 2023-12-15 | 艾维泰有限责任公司 | Aav2亲和剂 |
JPWO2022225006A1 (de) | 2021-04-21 | 2022-10-27 | ||
EP4327833A1 (de) | 2021-04-21 | 2024-02-28 | Nihon Medi-Physics Co., Ltd. | Radioaktives antitumormittel |
GB2609185A (en) | 2021-05-24 | 2023-02-01 | Astrea Uk Services Ltd | Scaffold for isolation of a biomolecule |
GB202109246D0 (en) | 2021-06-28 | 2021-08-11 | Cytiva Bioprocess R & D Ab | A method of separating bispecific antibodies |
GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
CN114315996B (zh) * | 2021-12-31 | 2023-01-17 | 博格隆(浙江)生物技术有限公司 | 一种重组ProteinA蛋白及亲和层析介质的制备方法 |
CN114409748A (zh) | 2022-01-28 | 2022-04-29 | 博格隆(浙江)生物技术有限公司 | 蛋白a的b结构域和z结构域突变体及其应用 |
GB202203478D0 (en) | 2022-03-14 | 2022-04-27 | Cytiva Bioprocess R & D Ab | Vh3 binding polypeptides |
CN114605508B (zh) * | 2022-05-11 | 2022-07-29 | 北京达成生物科技有限公司 | 能够结合于抗体分子Fc区域的抗体结合蛋白及其应用 |
CN117700501A (zh) * | 2022-09-13 | 2024-03-15 | 普米斯生物技术(珠海)有限公司 | 免疫球蛋白结合蛋白及其应用 |
CN117024529B (zh) * | 2023-07-17 | 2024-01-26 | 北京达成生物科技有限公司 | 抗体结合蛋白及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
DE69230061T2 (de) | 1991-07-25 | 2000-01-05 | Oriental Yeast Co. Ltd., Tokio/Tokyo | Künstliches immunoglobulin-bindendes protein |
SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
US5834597A (en) * | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
GB9823071D0 (en) * | 1998-10-21 | 1998-12-16 | Affibody Technology Ab | A method |
US7709209B2 (en) * | 2002-03-25 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Protein ligands |
SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
US7993650B2 (en) * | 2003-07-04 | 2011-08-09 | Affibody Ab | Polypeptides having binding affinity for HER2 |
US8728828B2 (en) * | 2004-12-22 | 2014-05-20 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
DK1869071T3 (da) * | 2005-03-01 | 2011-02-28 | Affibody Ab | TNF-alfa-bindende polypeptid, anvendelser deraf og fremgangsmåder, der gør brug deraf |
US20120149875A1 (en) * | 2009-01-12 | 2012-06-14 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
CN103403020A (zh) * | 2010-12-21 | 2013-11-20 | Jsr株式会社 | 蛋白a的新型耐碱变体及其在亲和色谱中的用途 |
WO2015005859A1 (en) * | 2013-07-10 | 2015-01-15 | Ge Healthcare Bio-Sciences Ab | Mutated immunoglobulin-binding polypeptides |
US11566082B2 (en) * | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
US10730908B2 (en) * | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US10654887B2 (en) * | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
US10703774B2 (en) * | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
-
2002
- 2002-03-25 SE SE0200943A patent/SE0200943D0/xx unknown
-
2003
- 2003-03-20 JP JP2003578408A patent/JP4391830B2/ja not_active Expired - Lifetime
- 2003-03-20 ES ES17166519T patent/ES2783876T3/es not_active Expired - Lifetime
- 2003-03-20 CN CN2011104134571A patent/CN102558317A/zh active Pending
- 2003-03-20 KR KR1020127028735A patent/KR101307714B1/ko active IP Right Grant
- 2003-03-20 DE DE60327606T patent/DE60327606D1/de not_active Expired - Lifetime
- 2003-03-20 KR KR1020047015303A patent/KR101067181B1/ko active IP Right Grant
- 2003-03-20 DK DK08004374.8T patent/DK1972689T3/en active
- 2003-03-20 EP EP03713152A patent/EP1485407B2/de not_active Expired - Lifetime
- 2003-03-20 CN CN2011104078321A patent/CN102516371A/zh active Pending
- 2003-03-20 CN CN2011104078514A patent/CN102516372A/zh active Pending
- 2003-03-20 CN CN2011104134586A patent/CN102558318A/zh active Pending
- 2003-03-20 KR KR1020107026798A patent/KR101307700B1/ko active IP Right Grant
- 2003-03-20 ES ES08004374.8T patent/ES2634145T3/es not_active Expired - Lifetime
- 2003-03-20 AU AU2003217119A patent/AU2003217119B2/en not_active Expired
- 2003-03-20 EP EP17166519.3A patent/EP3249047B1/de not_active Expired - Lifetime
- 2003-03-20 EP EP08004374.8A patent/EP1972689B1/de not_active Expired - Lifetime
- 2003-03-20 US US10/508,625 patent/US7834158B2/en active Active
- 2003-03-20 KR KR1020127028734A patent/KR101307651B1/ko active IP Right Grant
- 2003-03-20 AT AT03713152T patent/ATE431360T1/de not_active IP Right Cessation
- 2003-03-20 WO PCT/SE2003/000475 patent/WO2003080655A1/en active Application Filing
- 2003-03-20 CN CN038067935A patent/CN1642976B/zh not_active Expired - Lifetime
- 2003-03-20 DK DK17166519.3T patent/DK3249047T3/da active
- 2003-03-20 CA CA2479896A patent/CA2479896C/en not_active Expired - Lifetime
- 2003-03-20 CN CN201110407855.2A patent/CN102532284B/zh not_active Expired - Lifetime
- 2003-03-20 ES ES03713152T patent/ES2325362T5/es not_active Expired - Lifetime
-
2006
- 2006-03-13 US US11/374,532 patent/US20060194950A1/en not_active Abandoned
-
2009
- 2009-09-29 US US12/568,854 patent/US8354510B2/en not_active Expired - Lifetime
-
2010
- 2010-10-08 US US12/900,958 patent/US8198404B2/en not_active Expired - Fee Related
-
2012
- 2012-06-05 US US13/488,662 patent/US9156892B2/en not_active Expired - Lifetime
-
2013
- 2013-01-14 US US13/740,793 patent/US9296791B2/en not_active Expired - Fee Related
-
2015
- 2015-09-04 US US14/845,817 patent/US9534023B2/en not_active Expired - Lifetime
-
2016
- 2016-12-02 US US15/367,640 patent/US10918971B2/en not_active Expired - Lifetime
-
2021
- 2021-01-20 US US17/153,015 patent/US20210162319A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE431360T1 (de) | Mutiertes immunoglobulinbindendes protein | |
Lund et al. | Novel peptide ligand with high binding capacity for antibody purification | |
DK1562972T3 (da) | Modifikation af FcRn-bindingsaffiniteter eller serumhalveringstider for antistoffer ved mutagenese | |
WO2005123780A3 (en) | Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis | |
AU2002367839A8 (en) | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | |
BRPI0409269A (pt) | anticorpo modificado da classe igg e método de produção do mesmo | |
WO2004035170A3 (en) | Composition for separating molecules | |
ATE441715T1 (de) | Streptococcus pyogenes antigene | |
JP2008506960A5 (de) | ||
WO2005037867B1 (en) | ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG | |
CN101704879A (zh) | 具有改进的特异性的新型免疫球蛋白结合蛋白 | |
WO2004074310A8 (en) | Mycobacterial diagnostics | |
EP2346900A1 (de) | Verfahren zur aufreinigung von einzeldomänantigenbindenden molekülen | |
WO2006130834A3 (en) | IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF | |
WO2004067779A3 (en) | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof | |
WO2004081186A3 (en) | Single nucleotide polymorphisms associated with stenosis, methods of detection and uses thereof | |
McCue et al. | Validation of the manufacturing process used to produce long‐acting recombinant factor IX Fc fusion protein | |
RU2010125489A (ru) | Способ характеризации рекомбинантного поликлонального белка | |
ATE428728T1 (de) | Verfahren zur reinigung von erythropoietin | |
JPWO2006001300A1 (ja) | 高耐久性液体クロマトグラフィー用充填剤 | |
Yoshida et al. | Characterization of an apparently lower molecular weight gamma-chain variant in fibrinogen Kyoto I. The replacement of gamma-asparagine 308 by lysine which causes accelerated cleavage of fragment D1 by plasmin and the generation of a new plasmin cleavage site. | |
EP1960427A4 (de) | Multimere fc-rezeptor-polypeptide | |
WO2004106367A3 (en) | Enterococcus antigens | |
WO2004083403A3 (en) | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof | |
WO2002029094A3 (de) | Verfahren zur selektion hochaffin an ein target bindender nukleinsäuren durch zweidimensionale auftrennung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: HAMMONDS LLP, LONDON, GB |
|
R102 | Epo decision maintaining patent in amended form now final |
Ref document number: 1485407 Country of ref document: EP Effective date: 20120926 |
|
R082 | Change of representative |
Ref document number: 1485407 Country of ref document: EP Representative=s name: J D REYNOLDS & CO., GB |