NO20025656D0 - Opplöselige CTLA4 mutantmolekyler og anvendelser derav - Google Patents

Opplöselige CTLA4 mutantmolekyler og anvendelser derav

Info

Publication number
NO20025656D0
NO20025656D0 NO20025656A NO20025656A NO20025656D0 NO 20025656 D0 NO20025656 D0 NO 20025656D0 NO 20025656 A NO20025656 A NO 20025656A NO 20025656 A NO20025656 A NO 20025656A NO 20025656 D0 NO20025656 D0 NO 20025656D0
Authority
NO
Norway
Prior art keywords
soluble ctla4
mutant molecules
applications
amino acid
ctla4
Prior art date
Application number
NO20025656A
Other languages
English (en)
Other versions
NO20025656L (no
NO330797B1 (no
Inventor
Robert J Peach
Joseph Roy Naemura
Peter S Linsley
Jurgen Bajorath
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20025656L publication Critical patent/NO20025656L/no
Publication of NO20025656D0 publication Critical patent/NO20025656D0/no
Publication of NO330797B1 publication Critical patent/NO330797B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20025656A 2000-05-26 2002-11-25 CTLA4-mutantmolekyler, anvendelse og fremstilling derav, samt nukleinsyremolekyl, vektor, vertsvektorsystem, vertscelle, opploslig CTLA-4 mutantprotein og farmasoytisk sammensetning NO330797B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (3)

Publication Number Publication Date
NO20025656L NO20025656L (no) 2002-11-25
NO20025656D0 true NO20025656D0 (no) 2002-11-25
NO330797B1 NO330797B1 (no) 2011-07-18

Family

ID=26908652

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20025656A NO330797B1 (no) 2000-05-26 2002-11-25 CTLA4-mutantmolekyler, anvendelse og fremstilling derav, samt nukleinsyremolekyl, vektor, vertsvektorsystem, vertscelle, opploslig CTLA-4 mutantprotein og farmasoytisk sammensetning
NO2011027C NO2011027I1 (no) 2000-05-26 2011-12-15 Belatacept

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2011027C NO2011027I1 (no) 2000-05-26 2011-12-15 Belatacept

Country Status (41)

Country Link
EP (3) EP1248802B9 (no)
JP (1) JP4328525B2 (no)
KR (2) KR100889887B1 (no)
CN (2) CN1309735C (no)
AR (1) AR031699A1 (no)
AT (1) ATE271066T1 (no)
AU (2) AU2001263466C1 (no)
BE (1) BE2011C041I2 (no)
BR (1) BRPI0111191B8 (no)
CA (1) CA2409748C (no)
CY (2) CY2011019I1 (no)
CZ (1) CZ304451B6 (no)
DE (2) DE60104282T2 (no)
DK (1) DK1248802T3 (no)
EC (1) ECSP024365A (no)
EE (2) EE05458B1 (no)
EG (1) EG24459A (no)
ES (2) ES2571852T3 (no)
FR (1) FR11C0053I2 (no)
GE (1) GEP20053658B (no)
HK (2) HK1048126B (no)
HU (2) HU228137B1 (no)
IL (1) IL152315A (no)
LT (1) LT5133B (no)
LU (1) LU91902I2 (no)
LV (1) LV12994B (no)
MX (1) MXPA02011534A (no)
MY (1) MY136113A (no)
NO (2) NO330797B1 (no)
PE (1) PE20011338A1 (no)
PL (1) PL206267B1 (no)
PT (1) PT1248802E (no)
RU (1) RU2283847C2 (no)
SI (1) SI1248802T1 (no)
SK (1) SK288131B6 (no)
TR (1) TR200402703T4 (no)
TW (2) TWI314933B (no)
UA (1) UA87432C2 (no)
UY (1) UY26723A1 (no)
WO (1) WO2001092337A2 (no)
ZA (1) ZA200208944B (no)

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DE60225914T2 (de) 2001-05-23 2009-07-23 Bristol-Myers Squibb Co. Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4-mutationsmolekülen
WO2003088991A1 (en) * 2002-04-19 2003-10-30 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
WO2004058800A2 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
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WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
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KR20170091801A (ko) * 2008-10-02 2017-08-09 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Ｃｄ86 길항제 다중-표적 결합 단백질
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
TW201134481A (en) * 2010-03-12 2011-10-16 Abbott Biotherapeutics Corp CTLA4 proteins and their uses
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US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
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US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
KR20150033703A (ko) * 2012-06-27 2015-04-01 오르반 바이오테크 엘엘씨 당뇨병 치료를 위한 ctla4 융합 단백질
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
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GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
PL3152317T3 (pl) 2014-06-04 2019-08-30 Amgen Inc. Sposoby zbierania hodowli ssaczych komórek
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KR20180073693A (ko) 2015-11-09 2018-07-02 브리스톨-마이어스 스큅 컴퍼니 Cho 세포에서 생산되는 폴리펩티드의 품질 속성을 조작하는 방법
EP3515489A4 (en) * 2016-09-19 2020-05-06 Oncoimmune, Inc. CD80 AND CD86 BINDING PROTEIN COMPOSITIONS AND USES THEREOF
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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Also Published As

Publication number Publication date
HUS1300012I1 (hu) 2016-08-29
PL206267B1 (pl) 2010-07-30
HUP0302201A3 (en) 2010-01-28
UY26723A1 (es) 2001-12-28
MY136113A (en) 2008-08-29
CZ20023892A3 (cs) 2003-09-17
UA87432C2 (uk) 2009-07-27
ECSP024365A (es) 2003-03-31
EP1536234A3 (en) 2009-06-03
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
EE05557B1 (et) 2012-08-15
BRPI0111191B8 (pt) 2021-05-25
BE2011C041I2 (no) 2020-08-20
HUP0302201A2 (hu) 2003-10-28
EP1248802B9 (en) 2005-05-11
NO20025656L (no) 2002-11-25
HK1071931A1 (zh) 2005-08-05
FR11C0053I2 (fr) 2013-01-11
LV12994B (en) 2003-08-20
CY1117625T1 (el) 2017-04-26
EE05458B1 (et) 2011-08-15
PL366231A1 (en) 2005-01-24
CA2409748C (en) 2008-09-16
ES2225549T3 (es) 2005-03-16
TWI319405B (en) 2010-01-11
EG24459A (en) 2009-07-16
EP1536234B1 (en) 2016-03-16
NO330797B1 (no) 2011-07-18
MXPA02011534A (es) 2004-08-12
WO2001092337A2 (en) 2001-12-06
JP2004511213A (ja) 2004-04-15
NO2011027I1 (no) 2012-01-09
TW200906857A (en) 2009-02-16
KR100895134B1 (ko) 2009-05-04
DE122011100063I1 (de) 2012-06-14
ZA200208944B (en) 2004-02-13
HK1048126A1 (en) 2003-03-21
AU6346601A (en) 2001-12-11
EP1248802B1 (en) 2004-07-14
PT1248802E (pt) 2004-11-30
PE20011338A1 (es) 2002-01-13
JP4328525B2 (ja) 2009-09-09
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
BR0111191A (pt) 2004-07-06
AU2001263466C1 (en) 2006-10-26
CZ304451B6 (cs) 2014-05-14
EE201100050A (et) 2011-10-17
ES2571852T3 (es) 2016-05-27
SI1248802T1 (en) 2005-02-28
IL152315A (en) 2010-04-15
KR20030009502A (ko) 2003-01-29
RU2283847C2 (ru) 2006-09-20
CN101255192A (zh) 2008-09-03
CN1441810A (zh) 2003-09-10
ATE271066T1 (de) 2004-07-15
AR031699A1 (es) 2003-10-01
TWI314933B (en) 2009-09-21
AU2001263466B2 (en) 2006-04-27
IL152315A0 (en) 2003-05-29
DK1248802T3 (da) 2004-11-15
KR100889887B1 (ko) 2009-03-24
TR200402703T4 (tr) 2004-11-22
LT2002114A (en) 2003-12-29
CN1309735C (zh) 2007-04-11
EE200200659A (et) 2004-06-15
DE60104282D1 (de) 2004-08-19
EP3029062A1 (en) 2016-06-08
GEP20053658B (en) 2005-11-10
SK288131B6 (sk) 2013-10-02
WO2001092337A3 (en) 2002-05-10
SK15702002A3 (sk) 2004-01-08
CA2409748A1 (en) 2001-12-06
HK1048126B (zh) 2005-03-04
CY2011019I1 (el) 2016-12-14
BRPI0111191B1 (pt) 2019-12-31
FR11C0053I1 (no) 2012-01-13
NO2011027I2 (no) 2011-12-15
LT5133B (lt) 2004-05-25
DE60104282T2 (de) 2005-10-13
EP1536234A2 (en) 2005-06-01
HU228137B1 (en) 2012-12-28

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