EE05458B1 - CTL4 lahustuvad mutantsed molekulid ja nende kasutamine - Google Patents

CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Info

Publication number
EE05458B1
EE05458B1 EEP200200659A EEP200200659A EE05458B1 EE 05458 B1 EE05458 B1 EE 05458B1 EE P200200659 A EEP200200659 A EE P200200659A EE P200200659 A EEP200200659 A EE P200200659A EE 05458 B1 EE05458 B1 EE 05458B1
Authority
EE
Estonia
Prior art keywords
mutant molecules
amino acid
ctla4
ctl4
molecules
Prior art date
Application number
EEP200200659A
Other languages
English (en)
Inventor
J. Peach Robert
R. Naemura Joseph
S. Linsley Peter
Bajorath Jurgen
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Priority to EEP201100050A priority Critical patent/EE05557B1/et
Publication of EE200200659A publication Critical patent/EE200200659A/et
Publication of EE05458B1 publication Critical patent/EE05458B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200200659A 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine EE05458B1 (et)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EEP201100050A EE05557B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (2)

Publication Number Publication Date
EE200200659A EE200200659A (et) 2004-06-15
EE05458B1 true EE05458B1 (et) 2011-08-15

Family

ID=26908652

Family Applications (2)

Application Number Title Priority Date Filing Date
EEP200200659A EE05458B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine
EEP201100050A EE05557B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Family Applications After (1)

Application Number Title Priority Date Filing Date
EEP201100050A EE05557B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Country Status (41)

Country Link
EP (3) EP3029062A1 (et)
JP (1) JP4328525B2 (et)
KR (2) KR100889887B1 (et)
CN (2) CN101255192A (et)
AR (1) AR031699A1 (et)
AT (1) ATE271066T1 (et)
AU (2) AU6346601A (et)
BE (1) BE2011C041I2 (et)
BR (1) BRPI0111191B8 (et)
CA (1) CA2409748C (et)
CY (2) CY2011019I2 (et)
CZ (1) CZ304451B6 (et)
DE (2) DE60104282T2 (et)
DK (1) DK1248802T3 (et)
EC (1) ECSP024365A (et)
EE (2) EE05458B1 (et)
EG (1) EG24459A (et)
ES (2) ES2225549T3 (et)
FR (1) FR11C0053I2 (et)
GE (1) GEP20053658B (et)
HK (2) HK1048126B (et)
HU (2) HU228137B1 (et)
IL (1) IL152315A (et)
LT (1) LT5133B (et)
LU (1) LU91902I2 (et)
LV (1) LV12994B (et)
MX (1) MXPA02011534A (et)
MY (1) MY136113A (et)
NO (2) NO330797B1 (et)
PE (1) PE20011338A1 (et)
PL (1) PL206267B1 (et)
PT (1) PT1248802E (et)
RU (1) RU2283847C2 (et)
SI (1) SI1248802T1 (et)
SK (1) SK288131B6 (et)
TR (1) TR200402703T4 (et)
TW (2) TWI319405B (et)
UA (1) UA87432C2 (et)
UY (1) UY26723A1 (et)
WO (1) WO2001092337A2 (et)
ZA (1) ZA200208944B (et)

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US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
KR100864120B1 (ko) * 2000-07-03 2008-10-16 브리스톨-마이어스스퀴브컴파니 가용성 ｃｔｌａ4 분자를 사용한 류마티스성 질환의 치료법
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
PT1397153E (pt) 2001-05-23 2008-06-12 Bristol Myers Squibb Co Métodos para proteger um transplante alogénico de ilhéus utilizando moléculas mutantes de ctla4 solúveis
EP1496931A4 (en) * 2002-04-19 2009-07-01 Bristol Myers Squibb Co METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
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AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US10508144B2 (en) 2005-12-20 2019-12-17 Bristol-Myers Squibb Company Carbohydrate content of CTLA4 molecules
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
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US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
CN106432474A (zh) * 2010-03-12 2017-02-22 艾伯维生物医疗股份有限公司 Ctla4蛋白和其用途
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US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
EP2866823A4 (en) 2012-06-27 2016-03-02 Orban Biotech Llc CTLA4 FUSION PROTEINS FOR THE TREATMENT OF DIABETES
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
EP3094735A1 (en) 2014-01-13 2016-11-23 Amgen Inc. Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
EA039148B1 (ru) 2014-06-04 2021-12-10 Эмджен Инк. Способ сбора рекомбинантного белка
HUE049201T2 (hu) 2014-12-01 2020-09-28 Amgen Inc Eljárás glikoprotein glikántartalmának befolyásolására
WO2016130734A1 (en) 2015-02-11 2016-08-18 Bristol-Myers Squibb Company Use of phenolic antioxidants in cell culture for the production of proteins
CN114773486A (zh) 2015-04-17 2022-07-22 高山免疫科学股份有限公司 具有可调的亲和力的免疫调节蛋白
WO2017044807A2 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
JP2018536404A (ja) 2015-11-09 2018-12-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃｈｏ細胞において産生したポリペプチドの品質特性を操作する方法
CN116942793A (zh) * 2016-09-19 2023-10-27 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
JP2020536552A (ja) 2017-10-10 2020-12-17 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｔｌａ−４変異型免疫調節タンパク質およびそれらの使用
CN115227824A (zh) * 2018-11-12 2022-10-25 中南大学湘雅二医院 免疫检查点的抑制剂在制备治疗青光眼和其他眼部免疫损伤机制相关疾病药物中的应用
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Also Published As

Publication number Publication date
EE201100050A (et) 2011-10-17
ES2225549T3 (es) 2005-03-16
CZ20023892A3 (cs) 2003-09-17
NO2011027I1 (no) 2012-01-09
KR20030009502A (ko) 2003-01-29
EE05557B1 (et) 2012-08-15
KR100895134B1 (ko) 2009-05-04
ATE271066T1 (de) 2004-07-15
UA87432C2 (uk) 2009-07-27
TW200906857A (en) 2009-02-16
PL366231A1 (en) 2005-01-24
PT1248802E (pt) 2004-11-30
FR11C0053I1 (et) 2012-01-13
JP2004511213A (ja) 2004-04-15
TWI319405B (en) 2010-01-11
AU2001263466C1 (en) 2006-10-26
CZ304451B6 (cs) 2014-05-14
ZA200208944B (en) 2004-02-13
ES2571852T3 (es) 2016-05-27
KR100889887B1 (ko) 2009-03-24
HK1071931A1 (zh) 2005-08-05
TR200402703T4 (tr) 2004-11-22
EE200200659A (et) 2004-06-15
HK1048126B (zh) 2005-03-04
EG24459A (en) 2009-07-16
HUS1300012I1 (hu) 2016-08-29
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
BE2011C041I2 (et) 2020-08-20
HUP0302201A3 (en) 2010-01-28
LT2002114A (en) 2003-12-29
EP1536234B1 (en) 2016-03-16
NO20025656L (no) 2002-11-25
DE60104282D1 (de) 2004-08-19
CN1309735C (zh) 2007-04-11
CA2409748A1 (en) 2001-12-06
TWI314933B (en) 2009-09-21
GEP20053658B (en) 2005-11-10
NO330797B1 (no) 2011-07-18
HU228137B1 (en) 2012-12-28
RU2283847C2 (ru) 2006-09-20
EP1536234A3 (en) 2009-06-03
CY2011019I1 (el) 2016-12-14
HK1048126A1 (en) 2003-03-21
AU2001263466B2 (en) 2006-04-27
EP1536234A2 (en) 2005-06-01
PL206267B1 (pl) 2010-07-30
FR11C0053I2 (fr) 2013-01-11
DE60104282T2 (de) 2005-10-13
NO2011027I2 (et) 2011-12-15
WO2001092337A3 (en) 2002-05-10
DE122011100063I1 (de) 2012-06-14
AU6346601A (en) 2001-12-11
SI1248802T1 (en) 2005-02-28
SK15702002A3 (sk) 2004-01-08
HUP0302201A2 (hu) 2003-10-28
UY26723A1 (es) 2001-12-28
NO20025656D0 (no) 2002-11-25
CA2409748C (en) 2008-09-16
WO2001092337A2 (en) 2001-12-06
LT5133B (lt) 2004-05-25
BR0111191A (pt) 2004-07-06
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
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AR031699A1 (es) 2003-10-01
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