UY26723A1 - Moléculas mutantes de ctla4 solubles y usos de las mismas - Google Patents

Moléculas mutantes de ctla4 solubles y usos de las mismas

Info

Publication number
UY26723A1
UY26723A1 UY26723A UY26723A UY26723A1 UY 26723 A1 UY26723 A1 UY 26723A1 UY 26723 A UY26723 A UY 26723A UY 26723 A UY26723 A UY 26723A UY 26723 A1 UY26723 A1 UY 26723A1
Authority
UY
Uruguay
Prior art keywords
soluble ctla4
mutant molecules
amino acid
molecules
ctla4 mutant
Prior art date
Application number
UY26723A
Other languages
English (en)
Inventor
Peter S Linsley
Bajorath Jurgen
Robert J Peach
Joseph R Naemura
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of UY26723A1 publication Critical patent/UY26723A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona las moléculas mutantes de CTLA4 solubles que se enlazan con mayor silvestre o CTLA4Ig no mutada. Las moléculas de CTLA4 solubles tienen una primera secuencia de aminoácidos que comprende el dominio extracelular de CTLA4, donde ciertos residuos de aminoácidos dentro de la región S25-R33 y la región M97-G107 están mutados. Las moléculas mutantes de la invención pueden también incluir una segunda secuencia de aminoácidos que incrementa la solubilidad de la molécula mutante.
UY26723A 2000-05-26 2001-05-23 Moléculas mutantes de ctla4 solubles y usos de las mismas UY26723A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26

Publications (1)

Publication Number Publication Date
UY26723A1 true UY26723A1 (es) 2001-12-28

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26723A UY26723A1 (es) 2000-05-26 2001-05-23 Moléculas mutantes de ctla4 solubles y usos de las mismas

Country Status (41)

Country Link
EP (3) EP1536234B1 (es)
JP (1) JP4328525B2 (es)
KR (2) KR100889887B1 (es)
CN (2) CN101255192A (es)
AR (1) AR031699A1 (es)
AT (1) ATE271066T1 (es)
AU (2) AU6346601A (es)
BE (1) BE2011C041I2 (es)
BR (1) BRPI0111191B8 (es)
CA (1) CA2409748C (es)
CY (2) CY2011019I2 (es)
CZ (1) CZ304451B6 (es)
DE (2) DE60104282T2 (es)
DK (1) DK1248802T3 (es)
EC (1) ECSP024365A (es)
EE (2) EE05458B1 (es)
EG (1) EG24459A (es)
ES (2) ES2225549T3 (es)
FR (1) FR11C0053I2 (es)
GE (1) GEP20053658B (es)
HK (2) HK1048126B (es)
HU (2) HU228137B1 (es)
IL (1) IL152315A (es)
LT (1) LT5133B (es)
LU (1) LU91902I2 (es)
LV (1) LV12994B (es)
MX (1) MXPA02011534A (es)
MY (1) MY136113A (es)
NO (2) NO330797B1 (es)
PE (1) PE20011338A1 (es)
PL (1) PL206267B1 (es)
PT (1) PT1248802E (es)
RU (1) RU2283847C2 (es)
SI (1) SI1248802T1 (es)
SK (1) SK288131B6 (es)
TR (1) TR200402703T4 (es)
TW (2) TWI319405B (es)
UA (1) UA87432C2 (es)
UY (1) UY26723A1 (es)
WO (1) WO2001092337A2 (es)
ZA (1) ZA200208944B (es)

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EP1536234A2 (en) 2005-06-01
HK1071931A1 (zh) 2005-08-05
NO2011027I1 (no) 2012-01-09
PL366231A1 (en) 2005-01-24
BRPI0111191B1 (pt) 2019-12-31
SK15702002A3 (sk) 2004-01-08
AU2001263466C1 (en) 2006-10-26
BE2011C041I2 (es) 2020-08-20
CY2011019I1 (el) 2016-12-14
SK288131B6 (sk) 2013-10-02
HUP0302201A3 (en) 2010-01-28
EE05458B1 (et) 2011-08-15
EE200200659A (et) 2004-06-15
HUS1300012I1 (hu) 2016-08-29
EP1248802B9 (en) 2005-05-11
DE122011100063I1 (de) 2012-06-14
UA87432C2 (uk) 2009-07-27
TWI319405B (en) 2010-01-11
TWI314933B (en) 2009-09-21
ATE271066T1 (de) 2004-07-15
FR11C0053I2 (fr) 2013-01-11
CY1117625T1 (el) 2017-04-26
DE60104282D1 (de) 2004-08-19
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
RU2283847C2 (ru) 2006-09-20
CZ304451B6 (cs) 2014-05-14
KR100889887B1 (ko) 2009-03-24
TW200906857A (en) 2009-02-16
LT2002114A (en) 2003-12-29
MXPA02011534A (es) 2004-08-12
AU2001263466B2 (en) 2006-04-27
GEP20053658B (en) 2005-11-10
KR20030009502A (ko) 2003-01-29
PL206267B1 (pl) 2010-07-30
BRPI0111191B8 (pt) 2021-05-25
CN101255192A (zh) 2008-09-03
ES2225549T3 (es) 2005-03-16
HU228137B1 (en) 2012-12-28
MY136113A (en) 2008-08-29
EP1536234B1 (en) 2016-03-16
CA2409748C (en) 2008-09-16
NO330797B1 (no) 2011-07-18
AR031699A1 (es) 2003-10-01
PE20011338A1 (es) 2002-01-13
JP4328525B2 (ja) 2009-09-09
IL152315A0 (en) 2003-05-29
WO2001092337A3 (en) 2002-05-10
PT1248802E (pt) 2004-11-30
EP1536234A3 (en) 2009-06-03
EE201100050A (et) 2011-10-17
AU6346601A (en) 2001-12-11
LV12994B (en) 2003-08-20
EP1248802B1 (en) 2004-07-14
CA2409748A1 (en) 2001-12-06
EG24459A (en) 2009-07-16
NO2011027I2 (es) 2011-12-15
NO20025656D0 (no) 2002-11-25
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
LT5133B (lt) 2004-05-25
EP3029062A1 (en) 2016-06-08
CN1309735C (zh) 2007-04-11
HUP0302201A2 (hu) 2003-10-28
EE05557B1 (et) 2012-08-15
ECSP024365A (es) 2003-03-31
ZA200208944B (en) 2004-02-13
NO20025656L (no) 2002-11-25
FR11C0053I1 (es) 2012-01-13
SI1248802T1 (en) 2005-02-28
KR100895134B1 (ko) 2009-05-04
CN1441810A (zh) 2003-09-10
HK1048126B (zh) 2005-03-04
BR0111191A (pt) 2004-07-06
WO2001092337A2 (en) 2001-12-06
ES2571852T3 (es) 2016-05-27
CZ20023892A3 (cs) 2003-09-17
HK1048126A1 (en) 2003-03-21
DE60104282T2 (de) 2005-10-13
IL152315A (en) 2010-04-15
JP2004511213A (ja) 2004-04-15
TR200402703T4 (tr) 2004-11-22
DK1248802T3 (da) 2004-11-15

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