ATE304709T1 - Substanzen mit verzweigten linkermolekülen - Google Patents
Substanzen mit verzweigten linkermolekülenInfo
- Publication number
- ATE304709T1 ATE304709T1 AT01985752T AT01985752T ATE304709T1 AT E304709 T1 ATE304709 T1 AT E304709T1 AT 01985752 T AT01985752 T AT 01985752T AT 01985752 T AT01985752 T AT 01985752T AT E304709 T1 ATE304709 T1 AT E304709T1
- Authority
- AT
- Austria
- Prior art keywords
- substances
- linker molecules
- branched linker
- branched linkers
- branched
- Prior art date
Links
- 239000000126 substance Substances 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10048417A DE10048417A1 (de) | 2000-09-29 | 2000-09-29 | Verbindungen mit verzweigtem Linker |
| PCT/EP2001/011118 WO2002027315A2 (en) | 2000-09-29 | 2001-09-26 | Compounds with a branched linker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE304709T1 true ATE304709T1 (de) | 2005-09-15 |
Family
ID=7658168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01985752T ATE304709T1 (de) | 2000-09-29 | 2001-09-26 | Substanzen mit verzweigten linkermolekülen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040086943A1 (de) |
| EP (1) | EP1327146B1 (de) |
| JP (1) | JP3647845B2 (de) |
| AT (1) | ATE304709T1 (de) |
| AU (1) | AU2002215904A1 (de) |
| CA (1) | CA2423916C (de) |
| DE (2) | DE10048417A1 (de) |
| DK (1) | DK1327146T3 (de) |
| ES (1) | ES2248405T3 (de) |
| WO (1) | WO2002027315A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| CN1434726A (zh) | 2000-06-08 | 2003-08-06 | 拉卓拉药物公司 | 包含高分子量聚环氧乙烷的多价平台分子 |
| DE60234094D1 (de) | 2001-05-11 | 2009-12-03 | Ludwig Inst For Cancer Res Ltd | Spezifische bindungsproteine und ihre verwendung |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US8114418B2 (en) | 2001-06-21 | 2012-02-14 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—IV |
| DE10227599B4 (de) * | 2002-06-20 | 2005-04-28 | Proteome Factory Ag | Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe |
| DE10393455D2 (de) * | 2002-07-19 | 2005-06-16 | Mologen Ag | DNA-Expressionskonstrukt zur multiplen Genexpression |
| GB0329825D0 (en) * | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
| KR101158271B1 (ko) * | 2004-07-30 | 2012-06-19 | 가부시끼가이샤 센단세메이가가꾸겐큐죠 | 프로브 복합체 |
| BRPI0618907A2 (pt) | 2005-11-25 | 2012-04-17 | Mologen Ag | c0nstructo de expressão de dna, método de produção de vetores, kit para produção de vetores e para produção de constructo de expressão |
| GB0607479D0 (en) * | 2006-04-13 | 2006-05-24 | Johnson Matthey Plc | Adhesion promoting compound |
| CA2676244C (en) | 2007-01-25 | 2017-01-17 | Kwok-Kin Wong | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| CN101688229B (zh) | 2007-03-15 | 2013-06-12 | 路德维格癌症研究所 | 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途 |
| CA2696360C (en) | 2007-08-14 | 2018-11-20 | Ludwig Institute For Cancer Research | Monoclonal antibody targeting the egfr receptor and uses thereof |
| EP2318051A4 (de) * | 2008-07-14 | 2012-12-26 | Andrew Metters | In-vitro-diagnosekmarker mit kohlenstoffnanopartikeln und kits |
| CN103588801A (zh) * | 2013-12-02 | 2014-02-19 | 天津大港油田圣达科技有限公司 | 一种微量元素井间示踪剂的使用方法 |
| EP3897734A4 (de) * | 2018-12-21 | 2022-12-07 | Seagen Inc. | Adcs mit thiol-multiplex-linkern |
| EP3903103B1 (de) | 2018-12-28 | 2024-05-15 | Abbott Laboratories | Direkte detektion von einzelmolekülen auf mikropartikeln |
| JP7646667B2 (ja) * | 2019-12-18 | 2025-03-17 | スタンダード バイオツールズ カナダ インコーポレイテッド | シグナル増幅のためのマスサイトメトリー試薬および方法 |
| CN119775256B (zh) * | 2024-12-31 | 2025-09-19 | 英科新创（苏州）生物科技有限公司 | 吖啶磺酰胺衍生物、制备方法、其应用及试剂盒 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK365785A (da) * | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
| US5075447A (en) * | 1984-09-17 | 1991-12-24 | Hoffmann-La Roche Inc. | Ruthenium complexes useful as carriers for immunologically active materials |
| FR2579224B1 (fr) * | 1985-03-25 | 1987-05-22 | Genetica | Procede de preparation microbiologique de la serum-albumine humaine |
| US5750409A (en) * | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
| GB9215780D0 (en) * | 1992-07-24 | 1992-09-09 | Univ London Pharmacy | Peptide compounds |
| DE4310141A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Homobidentale trifunktionelle Linker |
| GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
| EP0720614B1 (de) * | 1994-07-25 | 2000-05-24 | Roche Diagnostics GmbH | Metallkomplexe mit geladenem linker |
| CN1148578C (zh) * | 1994-07-25 | 2004-05-05 | 罗切诊断学有限公司 | 免疫测定特异抗体的方法、所用试剂、抗原及其用途 |
| DE59507438D1 (de) * | 1994-07-25 | 2000-01-20 | Roche Diagnostics Gmbh | Hydrophile metallkomplexe |
| WO1996003423A1 (de) * | 1994-07-25 | 1996-02-08 | Boehringer Mannheim Gmbh | Hapten-markierte peptide |
| CA2195648A1 (en) * | 1994-07-25 | 1996-02-08 | Christoph Seidel | Metal chelate-labelled peptides |
| US5718915A (en) * | 1994-10-31 | 1998-02-17 | Burstein Laboratories, Inc. | Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme |
| DE19519973A1 (de) * | 1995-05-31 | 1996-12-05 | Boehringer Mannheim Gmbh | Entstörungsreagenz für die Bestimmung eines Analyten mit einem lumineszenzfähigen Metallkomplex |
| US5714360A (en) * | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
| EP0941120A4 (de) * | 1996-11-05 | 2004-08-18 | Bristol Myers Squibb Co | Verzweigte peptidlinker |
| ATE268609T1 (de) * | 1998-03-12 | 2004-06-15 | Nektar Therapeutics Al Corp | Polyethylenglycolderivate mit benachbarten reaktiven gruppen |
| DE19811582A1 (de) * | 1998-03-17 | 1999-09-23 | Roche Diagnostics Gmbh | Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| WO2000018583A1 (en) * | 1998-09-29 | 2000-04-06 | Hewlett-Packard Company | Method and apparatus for making booklets |
| GB2413081A (en) * | 2004-04-13 | 2005-10-19 | Sca Hygiene Prod Ab | Absorbant article with folded side flap portions and method of manufacture |
-
2000
- 2000-09-29 DE DE10048417A patent/DE10048417A1/de not_active Withdrawn
-
2001
- 2001-09-26 JP JP2002530643A patent/JP3647845B2/ja not_active Expired - Lifetime
- 2001-09-26 DE DE60113445T patent/DE60113445T2/de not_active Expired - Lifetime
- 2001-09-26 CA CA002423916A patent/CA2423916C/en not_active Expired - Lifetime
- 2001-09-26 DK DK01985752T patent/DK1327146T3/da active
- 2001-09-26 AT AT01985752T patent/ATE304709T1/de active
- 2001-09-26 WO PCT/EP2001/011118 patent/WO2002027315A2/en not_active Ceased
- 2001-09-26 ES ES01985752T patent/ES2248405T3/es not_active Expired - Lifetime
- 2001-09-26 EP EP01985752A patent/EP1327146B1/de not_active Expired - Lifetime
- 2001-09-26 US US10/381,944 patent/US20040086943A1/en not_active Abandoned
- 2001-09-26 AU AU2002215904A patent/AU2002215904A1/en not_active Abandoned
-
2009
- 2009-02-13 US US12/370,886 patent/US20090264618A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2423916C (en) | 2009-02-03 |
| EP1327146A2 (de) | 2003-07-16 |
| JP2004510160A (ja) | 2004-04-02 |
| DK1327146T3 (da) | 2006-01-23 |
| DE10048417A1 (de) | 2002-04-11 |
| WO2002027315A2 (en) | 2002-04-04 |
| DE60113445T2 (de) | 2006-06-29 |
| WO2002027315A3 (en) | 2002-07-11 |
| US20040086943A1 (en) | 2004-05-06 |
| AU2002215904A1 (en) | 2002-04-08 |
| DE60113445D1 (de) | 2005-10-20 |
| JP3647845B2 (ja) | 2005-05-18 |
| US20090264618A1 (en) | 2009-10-22 |
| ES2248405T3 (es) | 2006-03-16 |
| EP1327146B1 (de) | 2005-09-14 |
| CA2423916A1 (en) | 2002-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE304709T1 (de) | Substanzen mit verzweigten linkermolekülen | |
| EP2357006A3 (de) | Arzneimittelkonjugate und deren Verwendung zur Behandlung von Krebs, einer Autoimmunerkrankung oder einer Infektionskrankheit | |
| EA200800657A1 (ru) | Способ приготовления очищенных конъюгатов лекарственных средств | |
| EA200800952A1 (ru) | Конъюгаты антитело-лекарство и способы применения | |
| PT1144459E (pt) | Acidos hialuronicos reticulados e as suas utilizacoes em medicina | |
| MA26886A1 (fr) | Acides malonamiques et leurs derives, utiles comme ligands de recepteurs thyroidiens. | |
| TW200505942A (en) | Antibody molecules having specificity for human IL-1β | |
| CY1114922T1 (el) | Κυτταροτοξικοι παραγοντες οι οποιοι περιλαμβανουν νεα παραγωγα τομαϋμυκινης και τη θεραπευτικη τους χρηση | |
| ATE368054T1 (de) | Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität | |
| DE60042369D1 (de) | Chemisch programmierbare immunität | |
| ATE296105T1 (de) | Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel | |
| AU1922902A (en) | Novel means for the diagnosis and therapy of CTCL | |
| WO2004013307A3 (en) | Compounds for targeting hepatocytes | |
| WO2006002895A3 (en) | Conjugates of antibody and duoarmycin derivatives as antitumor agents | |
| SE0003476D0 (sv) | Compounds | |
| DE69921486D1 (de) | Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren | |
| DE69840673D1 (de) | Modifizierte polysaccharide mit veränderter biologischer erkennung | |
| ATE507844T1 (de) | Verfahren zur herstellung eines homogenen doxorubicin-transferrin kojugates | |
| AU2002360350A1 (en) | Peptides that home to tumor lymphatic vasculature and methods of using same | |
| DE59813469D1 (de) | Linker-nucleosid, seine herstellung und verwendung | |
| UY26170A1 (es) | Antigeno (c42) asociados a tumores | |
| NO20021429L (no) | 1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner | |
| TR200103405T2 (tr) | İkiişlevli antikorlar ve bunların tümör-önleyici amilleri hedeflemede kullanımı. | |
| AR023794A1 (es) | Antigeno asociado con tumores | |
| ATE307838T1 (de) | Klebstoffzubereitungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1327146 Country of ref document: EP |