LV12994B - Soluble ctla4 mutant molecules and uses thereof - Google Patents

Soluble ctla4 mutant molecules and uses thereof Download PDF

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Publication number
LV12994B
LV12994B LVP-02-214A LV020214A LV12994B LV 12994 B LV12994 B LV 12994B LV 020214 A LV020214 A LV 020214A LV 12994 B LV12994 B LV 12994B
Authority
LV
Latvia
Prior art keywords
ctla4
molecule
mutant
soluble
cell
Prior art date
Application number
LVP-02-214A
Other languages
English (en)
Latvian (lv)
Inventor
Robert J Peach
Joseph R Naemura
Peter S Linsley
Jurgen Bajorath
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of LV12994B publication Critical patent/LV12994B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LVP-02-214A 2000-05-26 2002-12-19 Soluble ctla4 mutant molecules and uses thereof LV12994B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26

Publications (1)

Publication Number Publication Date
LV12994B true LV12994B (en) 2003-08-20

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-02-214A LV12994B (en) 2000-05-26 2002-12-19 Soluble ctla4 mutant molecules and uses thereof

Country Status (41)

Country Link
EP (3) EP1248802B9 (no)
JP (1) JP4328525B2 (no)
KR (2) KR100889887B1 (no)
CN (2) CN101255192A (no)
AR (1) AR031699A1 (no)
AT (1) ATE271066T1 (no)
AU (2) AU6346601A (no)
BE (1) BE2011C041I2 (no)
BR (1) BRPI0111191B8 (no)
CA (1) CA2409748C (no)
CY (2) CY2011019I1 (no)
CZ (1) CZ304451B6 (no)
DE (2) DE60104282T2 (no)
DK (1) DK1248802T3 (no)
EC (1) ECSP024365A (no)
EE (2) EE05458B1 (no)
EG (1) EG24459A (no)
ES (2) ES2571852T3 (no)
FR (1) FR11C0053I2 (no)
GE (1) GEP20053658B (no)
HK (2) HK1048126B (no)
HU (2) HU228137B1 (no)
IL (1) IL152315A (no)
LT (1) LT5133B (no)
LU (1) LU91902I2 (no)
LV (1) LV12994B (no)
MX (1) MXPA02011534A (no)
MY (1) MY136113A (no)
NO (2) NO330797B1 (no)
PE (1) PE20011338A1 (no)
PL (1) PL206267B1 (no)
PT (1) PT1248802E (no)
RU (1) RU2283847C2 (no)
SI (1) SI1248802T1 (no)
SK (1) SK288131B6 (no)
TR (1) TR200402703T4 (no)
TW (2) TWI314933B (no)
UA (1) UA87432C2 (no)
UY (1) UY26723A1 (no)
WO (1) WO2001092337A2 (no)
ZA (1) ZA200208944B (no)

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US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
PL212205B1 (pl) * 2000-07-03 2012-08-31 Bristol Myers Squibb Co Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
MXPA03010568A (es) 2001-05-23 2005-03-07 Squibb Bristol Myers Co Metodos para proteger trasplantes alogenicos de celulas de isletas usando moleculas mutantes ctla4 solubles.
EP1496931A4 (en) * 2002-04-19 2009-07-01 Bristol Myers Squibb Co METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
MXPA05006522A (es) 2002-12-23 2006-02-17 Bristol Myers Squibb Co Mejora en la calidad de producto en procesos de cultivo en celulas de mamiferos para la produccion de proteina.
CN101044239B (zh) * 2002-12-23 2010-12-08 布里斯托尔-迈尔斯斯奎布公司 用于蛋白质生产的哺乳动物细胞培养方法
PL378879A1 (pl) 2002-12-30 2006-05-29 Amgen Inc. Terapia skojarzona z czynnikami kostymulującymi
AU2004287431B2 (en) 2003-10-27 2010-03-11 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
PL1969007T4 (pl) 2005-12-20 2014-04-30 Bristol Myers Squibb Co Kompozycje i sposoby wytwarzania kompozycji
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
GB0620934D0 (en) 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
CA2673725C (en) 2006-12-20 2016-01-12 Mmr Information Systems, Inc. Antibodies and methods for making and using them
EP2612868B1 (en) * 2007-11-01 2018-08-15 Astellas Pharma Inc. Immunosuppressive polypeptides and nucleic acids
DK2344540T3 (da) * 2008-10-02 2018-01-29 Aptevo Res & Development Llc Cd86-antagonist multimål bindingsproteiner
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
CN106432474A (zh) * 2010-03-12 2017-02-22 艾伯维生物医疗股份有限公司 Ctla4蛋白和其用途
EA201370187A1 (ru) 2011-02-23 2013-12-30 Амген Инк. Клеточная культуральная среда для уфс воздействия и относящиеся к ней способы
WO2013010537A1 (en) 2011-07-20 2013-01-24 Aarhus Universitet Method of treating morphea
WO2013148049A1 (en) * 2012-03-29 2013-10-03 The General Hospital Corporation Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4)
CA2868748C (en) 2012-05-11 2022-07-26 Medimmune, Llc Ctla-4 variants
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
CN113138279A (zh) 2012-06-27 2021-07-20 法姆制药有限责任公司 融合蛋白组合物的应用
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
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CA2997947A1 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
CN108350416A (zh) 2015-11-09 2018-07-31 百时美施贵宝公司 操纵在cho细胞中产生的多肽的品质属性的方法
WO2018053506A1 (en) * 2016-09-19 2018-03-22 Oncoimmune, Inc. Cd80 and cd86 binding protein compositions and uses thereof
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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CN111801347A (zh) * 2017-10-10 2020-10-20 高山免疫科学股份有限公司 Ctla-4变体免疫调节蛋白和其用途
CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
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Also Published As

Publication number Publication date
LT2002114A (en) 2003-12-29
NO20025656D0 (no) 2002-11-25
CN101255192A (zh) 2008-09-03
IL152315A0 (en) 2003-05-29
EE201100050A (et) 2011-10-17
HUS1300012I1 (hu) 2016-08-29
JP4328525B2 (ja) 2009-09-09
LT5133B (lt) 2004-05-25
DK1248802T3 (da) 2004-11-15
WO2001092337A2 (en) 2001-12-06
EP3029062A1 (en) 2016-06-08
FR11C0053I2 (fr) 2013-01-11
AU6346601A (en) 2001-12-11
EP1536234A2 (en) 2005-06-01
HK1048126A1 (en) 2003-03-21
BRPI0111191B8 (pt) 2021-05-25
CA2409748A1 (en) 2001-12-06
MXPA02011534A (es) 2004-08-12
EE05557B1 (et) 2012-08-15
AR031699A1 (es) 2003-10-01
PL366231A1 (en) 2005-01-24
ECSP024365A (es) 2003-03-31
SK15702002A3 (sk) 2004-01-08
CZ304451B6 (cs) 2014-05-14
HUP0302201A3 (en) 2010-01-28
EE200200659A (et) 2004-06-15
BE2011C041I2 (no) 2020-08-20
BRPI0111191B1 (pt) 2019-12-31
MY136113A (en) 2008-08-29
AU2001263466B2 (en) 2006-04-27
CN1441810A (zh) 2003-09-10
KR100889887B1 (ko) 2009-03-24
ES2225549T3 (es) 2005-03-16
EP1248802B1 (en) 2004-07-14
EP1536234A3 (en) 2009-06-03
DE122011100063I1 (de) 2012-06-14
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
EG24459A (en) 2009-07-16
BR0111191A (pt) 2004-07-06
ATE271066T1 (de) 2004-07-15
AU2001263466C1 (en) 2006-10-26
UA87432C2 (uk) 2009-07-27
NO2011027I2 (no) 2011-12-15
ZA200208944B (en) 2004-02-13
UY26723A1 (es) 2001-12-28
EP1536234B1 (en) 2016-03-16
CZ20023892A3 (cs) 2003-09-17
ES2571852T3 (es) 2016-05-27
HK1048126B (zh) 2005-03-04
HUP0302201A2 (hu) 2003-10-28
CA2409748C (en) 2008-09-16
KR100895134B1 (ko) 2009-05-04
EP1248802B9 (en) 2005-05-11
HU228137B1 (en) 2012-12-28
NO330797B1 (no) 2011-07-18
FR11C0053I1 (no) 2012-01-13
CY1117625T1 (el) 2017-04-26
GEP20053658B (en) 2005-11-10
KR20030009502A (ko) 2003-01-29
TR200402703T4 (tr) 2004-11-22
RU2283847C2 (ru) 2006-09-20
NO20025656L (no) 2002-11-25
DE60104282T2 (de) 2005-10-13
TW200906857A (en) 2009-02-16
PL206267B1 (pl) 2010-07-30
IL152315A (en) 2010-04-15
CY2011019I1 (el) 2016-12-14
JP2004511213A (ja) 2004-04-15
SK288131B6 (sk) 2013-10-02
WO2001092337A3 (en) 2002-05-10
EE05458B1 (et) 2011-08-15
PE20011338A1 (es) 2002-01-13
SI1248802T1 (en) 2005-02-28
TWI319405B (en) 2010-01-11
HK1071931A1 (zh) 2005-08-05
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
PT1248802E (pt) 2004-11-30
CN1309735C (zh) 2007-04-11
DE60104282D1 (de) 2004-08-19
TWI314933B (en) 2009-09-21
NO2011027I1 (no) 2012-01-09

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