RU2492166C2 - Соединения, подходящие для применения в качестве ингибиторов киназы raf - Google Patents
Соединения, подходящие для применения в качестве ингибиторов киназы raf Download PDFInfo
- Publication number
- RU2492166C2 RU2492166C2 RU2009149214/04A RU2009149214A RU2492166C2 RU 2492166 C2 RU2492166 C2 RU 2492166C2 RU 2009149214/04 A RU2009149214/04 A RU 2009149214/04A RU 2009149214 A RU2009149214 A RU 2009149214A RU 2492166 C2 RU2492166 C2 RU 2492166C2
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- Prior art keywords
- compound
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- independently selected
- nitrogen
- oxygen
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- 150000001875 compounds Chemical class 0.000 title claims abstract 66
- 102000009929 raf Kinases Human genes 0.000 title claims 2
- 108010077182 raf Kinases Proteins 0.000 title claims 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 6
- 230000000694 effects Effects 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 20
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 18
- 125000005842 heteroatom Chemical group 0.000 claims 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 18
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 18
- 229910052760 oxygen Inorganic materials 0.000 claims 18
- 239000001301 oxygen Chemical group 0.000 claims 18
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 13
- 229910052717 sulfur Chemical group 0.000 claims 13
- 239000011593 sulfur Chemical group 0.000 claims 13
- 229920006395 saturated elastomer Polymers 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000002619 bicyclic group Chemical group 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000001931 aliphatic group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- -1 tioksanila Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 2
- 125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000005306 thianaphthenyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004306 triazinyl group Chemical group 0.000 claims 2
- UWCWUCKPEYNDNV-LBPRGKRZSA-N 2,6-dimethyl-n-[[(2s)-pyrrolidin-2-yl]methyl]aniline Chemical compound CC1=CC=CC(C)=C1NC[C@H]1NCCC1 UWCWUCKPEYNDNV-LBPRGKRZSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 208000020446 Cardiac disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- QXNDZONIWRINJR-UHFFFAOYSA-N azocane Chemical compound C1CCCNCCC1 QXNDZONIWRINJR-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 125000005411 dithiolanyl group Chemical group S1SC(CC1)* 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004324 lymphatic system Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 125000005880 oxathiolanyl group Chemical group 0.000 claims 1
- 125000003544 oxime group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 1
- 238000000053 physical method Methods 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 claims 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 claims 1
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 abstract 1
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 0 Cc1c(C)ncnc1C(N(*)CC(CCCC1)CCCC1C(NC1CCCCCCC1)=O)=O Chemical compound Cc1c(C)ncnc1C(N(*)CC(CCCC1)CCCC1C(NC1CCCCCCC1)=O)=O 0.000 description 57
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- MFRNAWCDLBNWQM-UHFFFAOYSA-N CC(C(CCC1)CCCC1C(NC1CCCCCCCC1)=O)N Chemical compound CC(C(CCC1)CCCC1C(NC1CCCCCCCC1)=O)N MFRNAWCDLBNWQM-UHFFFAOYSA-N 0.000 description 1
- PMTJZHGPXWJTNZ-UHFFFAOYSA-N CC(c1ncc(C(CNc(cc2C(C)(C)C)nnc2Cl)=O)[s]1)NC(c1ncnc(Nc2ccncc2)c1Cl)=O Chemical compound CC(c1ncc(C(CNc(cc2C(C)(C)C)nnc2Cl)=O)[s]1)NC(c1ncnc(Nc2ccncc2)c1Cl)=O PMTJZHGPXWJTNZ-UHFFFAOYSA-N 0.000 description 1
- BDVVYTPJKFVGDN-UHFFFAOYSA-N CC(c1ncc(C(CNc(nc2)nc(C(C)(C)C)c2Cl)=O)[s]1)NC(c1ncnc(C#CCCO)c1)=O Chemical compound CC(c1ncc(C(CNc(nc2)nc(C(C)(C)C)c2Cl)=O)[s]1)NC(c1ncnc(C#CCCO)c1)=O BDVVYTPJKFVGDN-UHFFFAOYSA-N 0.000 description 1
- JMULLEWPYVDDDN-UHFFFAOYSA-N CC(c1ncc(C(Nc(nc2)cc(C(F)(F)F)c2Cl)=O)[s]1)NC(c1ncnc(NC)c1)=O Chemical compound CC(c1ncc(C(Nc(nc2)cc(C(F)(F)F)c2Cl)=O)[s]1)NC(c1ncnc(NC)c1)=O JMULLEWPYVDDDN-UHFFFAOYSA-N 0.000 description 1
- LUZDWHZGVGRDDF-UHFFFAOYSA-N CC(c1ncc(C(Nc(nc2)nc(C(C)(C)C)c2Cl)=O)[s]1)NC(c1ncnc(N)c1C)=O Chemical compound CC(c1ncc(C(Nc(nc2)nc(C(C)(C)C)c2Cl)=O)[s]1)NC(c1ncnc(N)c1C)=O LUZDWHZGVGRDDF-UHFFFAOYSA-N 0.000 description 1
- WZZRXYNJWWSZDG-UHFFFAOYSA-N CC(c1ncc(C(Nc2ncnc(C(C)(C)C)c2)=O)[s]1)NC(c1c(CN)c(N)ncn1)=O Chemical compound CC(c1ncc(C(Nc2ncnc(C(C)(C)C)c2)=O)[s]1)NC(c1c(CN)c(N)ncn1)=O WZZRXYNJWWSZDG-UHFFFAOYSA-N 0.000 description 1
- GXMNYZJOOGVEOO-UHFFFAOYSA-N CC(c1ncc(C(Nc2ncnc(C(C)(C)C)c2)=O)[s]1)NC(c1ncnc(-c2ncc[nH]2)c1Cl)=O Chemical compound CC(c1ncc(C(Nc2ncnc(C(C)(C)C)c2)=O)[s]1)NC(c1ncnc(-c2ncc[nH]2)c1Cl)=O GXMNYZJOOGVEOO-UHFFFAOYSA-N 0.000 description 1
- WJJCSRIZIZNOJG-SECBINFHSA-N C[C@H](c1cc(-c([nH]2)nc3c2nc(C(C)(C)C)nc3)n[o]1)NC(c1ncnc(N)c1)=O Chemical compound C[C@H](c1cc(-c([nH]2)nc3c2nc(C(C)(C)C)nc3)n[o]1)NC(c1ncnc(N)c1)=O WJJCSRIZIZNOJG-SECBINFHSA-N 0.000 description 1
- VQQWTVFKUIPRNQ-LLVKDONJSA-N C[C@H](c1cc(-c([nH]2)nc3c2nc(C2(C)CC2)cc3)n[o]1)NC(c1ncnc(N)c1CNC)=O Chemical compound C[C@H](c1cc(-c([nH]2)nc3c2nc(C2(C)CC2)cc3)n[o]1)NC(c1ncnc(N)c1CNC)=O VQQWTVFKUIPRNQ-LLVKDONJSA-N 0.000 description 1
- SCNBGARDALTPFI-UHFFFAOYSA-N O=C(c1cnc(CNC(c2ncnc(-c3ncc[nH]3)c2Cl)=O)[s]1)Nc(nc1)cc(C(F)(F)F)c1Cl Chemical compound O=C(c1cnc(CNC(c2ncnc(-c3ncc[nH]3)c2Cl)=O)[s]1)Nc(nc1)cc(C(F)(F)F)c1Cl SCNBGARDALTPFI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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| TWI444379B (zh) | 2007-06-29 | 2014-07-11 | Sunesis Pharmaceuticals Inc | 有用於作為Raf激酶抑制劑之化合物 |
| NZ582349A (en) * | 2007-06-29 | 2012-06-29 | Sunesis Pharmaceuticals Inc | Heterocyclic compounds useful as raf kinase inhibitors |
| JP5485884B2 (ja) * | 2007-07-26 | 2014-05-07 | ノバルティス アーゲー | 炎症性またはアレルギー性状態の処置に有用なピリミジン誘導体 |
| BRPI0814975A2 (pt) * | 2007-08-08 | 2015-02-03 | Merck Serono Sa | Derivados de 6-amino-pirimidina-4-carboxamida e compostos relacionados que se ligam ao receptor de 1-fosfato de esfingosina (s1p) para o tratamento de esclerose múltipla |
| FR2934265B1 (fr) * | 2008-07-23 | 2010-07-30 | Sanofi Aventis | Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique |
| NZ590887A (en) * | 2008-08-04 | 2012-09-28 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP2012514044A (ja) * | 2008-12-30 | 2012-06-21 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | Rafキナーゼ阻害剤として有用なヘテロアリール化合物 |
| JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| JP2012521425A (ja) * | 2009-03-23 | 2012-09-13 | Msd株式会社 | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
| EP2411011A4 (en) * | 2009-03-24 | 2012-08-15 | Msd Kk | NEW AMINO-PYRIDINE DERIVATIVES WITH SELECTIVE AURORA A INHIBITION |
| CA2765044A1 (en) | 2009-06-09 | 2010-12-16 | California Capital Equity, Llc | Benzyl substituted triazine derivatives and their therapeutical applications |
| CN102573473B (zh) | 2009-06-09 | 2015-05-27 | 加利福尼亚资本权益有限责任公司 | 用作hedgehog 信号转导抑制剂的异喹啉、喹啉和喹唑啉衍生物 |
| CN102573480B (zh) | 2009-06-09 | 2015-06-10 | 加利福尼亚资本权益有限责任公司 | 三嗪衍生物及其治疗应用 |
| BR112012005616A2 (pt) * | 2009-09-21 | 2016-06-21 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| WO2011091153A1 (en) | 2010-01-25 | 2011-07-28 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| US9296722B2 (en) | 2010-05-27 | 2016-03-29 | Ambit Biosciences Corporation | Azolyl urea compounds and methods of use thereof |
| CN102406646B (zh) * | 2010-09-20 | 2015-09-09 | 北大方正集团有限公司 | 芳基脲衍生物用于制备治疗移植排斥药物的用途 |
| CN102153515B (zh) * | 2011-02-24 | 2013-02-27 | 中国药科大学 | N,N′-双取代脲类Raf激酶抑制剂及其制备方法和用途 |
| EA027451B1 (ru) | 2011-08-30 | 2017-07-31 | Схди Фаундейшн, Инк. | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и их применение |
| SG2014011654A (en) | 2011-08-30 | 2014-08-28 | Chdi Foundation Inc | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| JP2015511632A (ja) * | 2012-03-30 | 2015-04-20 | 武田薬品工業株式会社 | メラノーマの治療におけるraf阻害剤およびmek阻害剤の投与 |
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| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9186361B2 (en) | 2013-03-15 | 2015-11-17 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| MY175865A (en) | 2013-12-19 | 2020-07-14 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis |
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| CN114588157A (zh) | 2014-07-17 | 2022-06-07 | Chdi基金会股份有限公司 | 用于治疗hiv相关病症的方法和组合物 |
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