EP1161431A4 - 6-azaindole compounds as antagonists of gonadotropin releasing hormone - Google Patents

6-azaindole compounds as antagonists of gonadotropin releasing hormone

Info

Publication number
EP1161431A4
EP1161431A4 EP00917757A EP00917757A EP1161431A4 EP 1161431 A4 EP1161431 A4 EP 1161431A4 EP 00917757 A EP00917757 A EP 00917757A EP 00917757 A EP00917757 A EP 00917757A EP 1161431 A4 EP1161431 A4 EP 1161431A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
releasing hormone
gonadotropin releasing
azaindole compounds
azaindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00917757A
Other languages
German (de)
French (fr)
Other versions
EP1161431A1 (en
Inventor
Thomas F Walsh
Feroze Ujjainwalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1161431A1 publication Critical patent/EP1161431A1/en
Publication of EP1161431A4 publication Critical patent/EP1161431A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP00917757A 1999-03-10 2000-03-06 6-azaindole compounds as antagonists of gonadotropin releasing hormone Withdrawn EP1161431A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12362099P 1999-03-10 1999-03-10
US123620P 1999-03-10
PCT/US2000/005799 WO2000053602A1 (en) 1999-03-10 2000-03-06 6-azaindole compounds as antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number Publication Date
EP1161431A1 EP1161431A1 (en) 2001-12-12
EP1161431A4 true EP1161431A4 (en) 2002-04-24

Family

ID=22409767

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00917757A Withdrawn EP1161431A4 (en) 1999-03-10 2000-03-06 6-azaindole compounds as antagonists of gonadotropin releasing hormone

Country Status (5)

Country Link
EP (1) EP1161431A4 (en)
JP (1) JP2002539124A (en)
AU (1) AU3868500A (en)
CA (1) CA2366615A1 (en)
WO (1) WO2000053602A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1171135A4 (en) * 1999-03-10 2002-05-15 Merck & Co Inc 6-azaindole compounds as antagonists of gonadotropin releasing hormone
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
TWI262920B (en) * 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
SE0100566D0 (en) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (en) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
TW200413351A (en) * 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
EP1539743B1 (en) 2002-08-21 2007-05-30 Astrazeneca AB Pyrazole derivatives as gnrh inhibitors
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
US7317010B2 (en) 2002-08-21 2008-01-08 Astrazeneca Ab Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
US20070167428A1 (en) * 2004-02-20 2007-07-19 Astrazeneca Ab Thienopyrroles as antagonists of gnrh
BRPI0511874A (en) 2004-06-09 2008-01-15 Glaxo Group Ltd pyrrolopyridine derivatives
DE102004033902A1 (en) 2004-07-14 2006-02-16 Zentaris Gmbh New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease
EP1768984B1 (en) 2004-07-16 2010-10-20 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors
AU2006272876A1 (en) 2005-07-22 2007-02-01 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
TWI444379B (en) 2007-06-29 2014-07-11 Sunesis Pharmaceuticals Inc Compounds useful as raf kinase inhibitors
EP2167497A2 (en) 2007-06-29 2010-03-31 Sunesis Pharmaceuticals, Inc. Heterocyclic compounds useful as raf kinase inhibitors
EP2095818A1 (en) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
MX2021011302A (en) 2019-03-19 2022-01-19 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic aza-benzothiophene and aza-benzofuran compounds.
PE20231205A1 (en) 2020-05-29 2023-08-17 Boehringer Ingelheim Animal Health Usa Inc HETEROCYCLIC COMPOUNDS AS ANTHELMINTICS
WO2022076975A1 (en) 2020-10-05 2022-04-14 Enliven Therapeutics, Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
AU2022377394A1 (en) 2021-11-01 2024-06-13 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic pyrrolopyridazine compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021703A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021707A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
ATE258934T1 (en) * 1998-10-30 2004-02-15 Lilly Co Eli AZAINDOLE DERIVATIVES AND THEIR USE AS ANTITHRBOTIC AGENTS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021703A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021707A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0053602A1 *

Also Published As

Publication number Publication date
EP1161431A1 (en) 2001-12-12
JP2002539124A (en) 2002-11-19
CA2366615A1 (en) 2000-09-14
AU3868500A (en) 2000-09-28
WO2000053602A1 (en) 2000-09-14

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