EP1067930A4 - Antagonists of gonadotropin releasing hormone - Google Patents

Antagonists of gonadotropin releasing hormone

Info

Publication number
EP1067930A4
EP1067930A4 EP99912924A EP99912924A EP1067930A4 EP 1067930 A4 EP1067930 A4 EP 1067930A4 EP 99912924 A EP99912924 A EP 99912924A EP 99912924 A EP99912924 A EP 99912924A EP 1067930 A4 EP1067930 A4 EP 1067930A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
releasing hormone
gonadotropin releasing
gonadotropin
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99912924A
Other languages
German (de)
French (fr)
Other versions
EP1067930A1 (en
Inventor
Thomas F Walsh
Feroze Ujjainwalla
Mark T Goulet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815854.6A external-priority patent/GB9815854D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1067930A1 publication Critical patent/EP1067930A1/en
Publication of EP1067930A4 publication Critical patent/EP1067930A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
EP99912924A 1998-04-02 1999-03-29 Antagonists of gonadotropin releasing hormone Withdrawn EP1067930A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8040598P 1998-04-02 1998-04-02
US80405P 1998-04-02
GBGB9815854.6A GB9815854D0 (en) 1998-07-21 1998-07-21 Antagonists of gonadotropin releasing hormone
GB9815854 1998-07-21
PCT/US1999/006726 WO1999051232A1 (en) 1998-04-02 1999-03-29 Antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number Publication Date
EP1067930A1 EP1067930A1 (en) 2001-01-17
EP1067930A4 true EP1067930A4 (en) 2002-09-18

Family

ID=26314082

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99912924A Withdrawn EP1067930A4 (en) 1998-04-02 1999-03-29 Antagonists of gonadotropin releasing hormone

Country Status (5)

Country Link
EP (1) EP1067930A4 (en)
JP (1) JP2002510629A (en)
AU (1) AU3118399A (en)
CA (1) CA2326143A1 (en)
WO (1) WO1999051232A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534189B1 (en) 1994-07-15 2003-03-18 Exxonmobil Oil Corporation Uniaxially shrinkable biaxially oriented polypropylene film and method for use as tobacco pack overwrap
US6346534B1 (en) 1998-09-23 2002-02-12 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
WO2000069859A1 (en) * 1999-05-14 2000-11-23 Neurocrine Biosciences, Inc. Imidazo- and pyrrolo[1,2-a]pyrimid-4-ones as gonadotropin-releasing hormone receptor antagonists
EP1220857B1 (en) * 1999-10-15 2005-09-21 Neurocrine Biosciences, Inc. Gonadotropin releasing hormone receptor antagonists and their related methods of use
US6537998B1 (en) 1999-10-15 2003-03-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
CA2395593C (en) 1999-12-24 2011-08-02 Aventis Pharma Limited Azaindoles
KR100814269B1 (en) 2000-01-25 2008-03-18 뉴로크린 바이오사이언시즈 인코퍼레이티드 Gonadotropin-releasing hormone receptor antagonists and a pharmaceutical composition comprising them
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (en) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (en) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
JP2006501231A (en) 2002-08-21 2006-01-12 アストラゼネカ アクチボラグ Pyrazole derivatives as GNRH inhibitors
US7317010B2 (en) 2002-08-21 2008-01-08 Astrazeneca Ab Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
SE0300908D0 (en) 2003-03-31 2003-03-31 Astrazeneca Ab Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
BRPI0814423B1 (en) 2007-07-17 2022-04-19 Plexxikon, Inc Kinase modulating compounds and pharmaceutical composition comprising the same
NZ594398A (en) 2009-04-03 2014-03-28 Plexxikon Inc Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof
AU2010315126B2 (en) 2009-11-06 2015-06-25 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
DK2672967T3 (en) 2011-02-07 2019-01-02 Plexxikon Inc RELATIONSHIPS AND METHODS FOR CHINESE MODULATION AND INDICATIONS THEREOF
AR085279A1 (en) 2011-02-21 2013-09-18 Plexxikon Inc SOLID FORMS OF {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDE OF PROPANE ACID-1- SULFONIC
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021704A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051233A1 (en) * 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732969B1 (en) * 1995-04-14 1997-05-16 Adir NOVEL PYRIDINIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2229201A1 (en) * 1995-10-19 1997-04-24 Satoshi Sasaki Quinoline derivatives, their production and use
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021704A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051233A1 (en) * 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9951232A1 *

Also Published As

Publication number Publication date
EP1067930A1 (en) 2001-01-17
WO1999051232A1 (en) 1999-10-14
CA2326143A1 (en) 1999-10-14
JP2002510629A (en) 2002-04-09
AU3118399A (en) 1999-10-25

Similar Documents

Publication Publication Date Title
EP0986385A4 (en) Antagonists of gonadotropin releasing hormone
EP1067930A4 (en) Antagonists of gonadotropin releasing hormone
EP0986557A4 (en) Antagonists of gonadotropin releasing hormone
EP0918522A4 (en) Antagonists of gonadotropin releasing hormone
IL124554A0 (en) Antagonists of gonadotropin releasing hormone
IL124613A0 (en) Antagonists of gonadotropin releasing hormone
AU3008997A (en) Antagonists of gonadotropin releasing hormone
EP0868178A4 (en) Antagonists of gonadotropin releasing hormone
ZA9610535B (en) Antagonists of gonadotropin releasing hormone.
ZA9610536B (en) Antagonists of gonadotropin releasing hormone.
EP1011667A4 (en) Antagonists of gonadotropin releasing hormone
EP1027046A4 (en) Antagonists of gonadotropin releasing hormone
EP0901471A4 (en) Antagonists of gonadotropin releasing hormone
EP0920319A4 (en) Antagonists of gonadotropin releasing hormone
EP1049472A4 (en) Antagonists of gonadotropin releasing hormone
AU4834900A (en) Antagonists of gonadotropin releasing hormone
EP1062215A4 (en) Antagonists of gonadotropin releasing hormone
AU4742101A (en) Antagonists of gonadotropin releasing hormone
AU4738101A (en) Antagonists of gonadotropin releasing hormone
GB9809789D0 (en) Antagonists of gonadotropin releasing hormone
GB9812217D0 (en) Antagonists of gonadotropin releasing hormone
GB9815847D0 (en) Antagonists of gonadotropin releasing hormone
GB9800451D0 (en) Antagonists of gonadotropin releasing hormone
GB9805717D0 (en) Antagonists of gonadotropin releasing hormone
GB9823087D0 (en) Antagonists of gonadotropin releasing hormone

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20001102

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20001102;LT PAYMENT 20001102;LV PAYMENT 20001102;MK PAYMENT 20001102;RO PAYMENT 20001102;SI PAYMENT 20001102

A4 Supplementary search report drawn up and despatched

Effective date: 20020802

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/445 A, 7A 61K 31/495 B, 7A 61K 31/50 B, 7A 61K 31/52 B, 7A 61K 31/54 B, 7A 61K 31/505 B, 7A 61K 31/535 B, 7C 07D 401/12 B, 7C 07D 401/14 B, 7C 07D 403/12 B, 7C 07D 519/00 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20021001