BRPI0813499B8 - compostos pirimidina carboxamidas úteis como inibidores da quinase raf, composição farmacêutica compreendendo os mesmos e método de preparação dos mesmos - Google Patents
compostos pirimidina carboxamidas úteis como inibidores da quinase raf, composição farmacêutica compreendendo os mesmos e método de preparação dos mesmosInfo
- Publication number
- BRPI0813499B8 BRPI0813499B8 BRPI0813499A BRPI0813499A BRPI0813499B8 BR PI0813499 B8 BRPI0813499 B8 BR PI0813499B8 BR PI0813499 A BRPI0813499 A BR PI0813499A BR PI0813499 A BRPI0813499 A BR PI0813499A BR PI0813499 B8 BRPI0813499 B8 BR PI0813499B8
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- preparation
- pharmaceutical composition
- same
- raf kinase
- Prior art date
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94729107P | 2007-06-29 | 2007-06-29 | |
| US60/947,291 | 2007-06-29 | ||
| PCT/US2008/068762 WO2009006389A2 (en) | 2007-06-29 | 2008-06-30 | Pyrimidine derivatives useful as raf kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0813499A2 BRPI0813499A2 (pt) | 2015-01-06 |
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| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| EP2167497A2 (en) | 2007-06-29 | 2010-03-31 | Sunesis Pharmaceuticals, Inc. | Heterocyclic compounds useful as raf kinase inhibitors |
| JP2012514044A (ja) | 2008-12-30 | 2012-06-21 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | Rafキナーゼ阻害剤として有用なヘテロアリール化合物 |
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