CN115697987A - 雌激素受体调节剂化合物及其用途 - Google Patents
雌激素受体调节剂化合物及其用途 Download PDFInfo
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- CN115697987A CN115697987A CN202180041694.1A CN202180041694A CN115697987A CN 115697987 A CN115697987 A CN 115697987A CN 202180041694 A CN202180041694 A CN 202180041694A CN 115697987 A CN115697987 A CN 115697987A
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- compound
- cycloalkyl
- pharmaceutically acceptable
- acceptable salt
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- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
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- 125000004434 sulfur atom Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BFHSUIWEPMCBQR-UHFFFAOYSA-N tert-butyl n-(3-methylazetidin-3-yl)carbamate Chemical group CC(C)(C)OC(=O)NC1(C)CNC1 BFHSUIWEPMCBQR-UHFFFAOYSA-N 0.000 description 1
- NZEPWAXJSWYEDV-VIFPVBQESA-N tert-butyl n-[(3s)-azepan-3-yl]carbamate Chemical group CC(C)(C)OC(=O)N[C@H]1CCCCNC1 NZEPWAXJSWYEDV-VIFPVBQESA-N 0.000 description 1
- UCBLMUMETZZNIZ-OAHLLOKOSA-N tert-butyl n-[(7s)-5-benzyl-5-azaspiro[2.4]heptan-7-yl]carbamate Chemical compound C([C@H](C1(CC1)C1)NC(=O)OC(C)(C)C)N1CC1=CC=CC=C1 UCBLMUMETZZNIZ-OAHLLOKOSA-N 0.000 description 1
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical group C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
本申请提供了一种具有雌激素受体调节活性或功能的化合物或其药学上可接受的盐，所述化合物具有式(I)结构且具有本申请所述取代基和结构特征。本申请还提供了包含式(I)化合物或其药学上可接受的盐的药物组合物，以及所述式(I)化合物或其药学上可接受的盐在制备预防或治疗雌激素受体相关性疾病的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010536528 | 2020-06-12 | ||
| CN2020105365286 | 2020-06-12 | ||
| CN2020105725135 | 2020-06-22 | ||
| CN202010572513 | 2020-06-22 | ||
| CN202110573837 | 2021-05-25 | ||
| CN2021105738375 | 2021-05-25 | ||
| PCT/CN2021/099653 WO2021249533A1 (zh) | 2020-06-12 | 2021-06-11 | 雌激素受体调节剂化合物及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115697987A true CN115697987A (zh) | 2023-02-03 |
Family
ID=78846890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180041694.1A Pending CN115697987A (zh) | 2020-06-12 | 2021-06-11 | 雌激素受体调节剂化合物及其用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN115697987A (zh) |
| TW (1) | TW202214626A (zh) |
| WO (1) | WO2021249533A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115872996A (zh) * | 2023-02-21 | 2023-03-31 | 山东绿叶制药有限公司 | 一种雌激素受体降解剂化合物及其制备方法和应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202327576A (zh) * | 2021-11-12 | 2023-07-16 | 大陸商先聲藥業有限公司 | 吡咯烷類化合物的鹽、晶型及其製備方法 |
| WO2024039861A1 (en) * | 2022-08-19 | 2024-02-22 | Olema Pharmaceuticals, Inc. | 2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole derivatives as estrogen receptor modulators for the treatment of cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10131663B2 (en) * | 2016-10-24 | 2018-11-20 | Astrazeneca Ab | Chemical compounds |
| WO2019002441A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| WO2019002442A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| TW202016084A (zh) * | 2018-05-30 | 2020-05-01 | 大陸商迪哲（江蘇）醫藥有限公司 | 選擇性雌激素受體下調劑和其用途 |
| CN111499614A (zh) * | 2019-01-31 | 2020-08-07 | 江苏恒瑞医药股份有限公司 | 四氢异喹啉类衍生物、其制备方法及其在医药上的应用 |
| CN111825613B (zh) * | 2020-08-17 | 2022-02-15 | 上海勋和医药科技有限公司 | 作为选择性雌激素受体下调剂的四氢异喹啉类化合物、合成方法及用途 |
-
2021
- 2021-06-11 CN CN202180041694.1A patent/CN115697987A/zh active Pending
- 2021-06-11 WO PCT/CN2021/099653 patent/WO2021249533A1/zh active Application Filing
- 2021-06-11 TW TW110121533A patent/TW202214626A/zh unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115872996A (zh) * | 2023-02-21 | 2023-03-31 | 山东绿叶制药有限公司 | 一种雌激素受体降解剂化合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021249533A1 (zh) | 2021-12-16 |
| TW202214626A (zh) | 2022-04-16 |
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Effective date of registration: 20230907 Address after: No. 20 Yaogu Yiheng Road, Xiuying District, Haikou City, Hainan Province, 570311 Applicant after: Xiansheng Zaiming Pharmaceutical Co.,Ltd. Address before: 210042 699 Xuanwu Road, Xuanwu District, Nanjing, Jiangsu -18 Applicant before: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. |
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Country or region after: China Address after: No. 20 Yaogu Yiheng Road, Xiuying District, Haikou City, Hainan Province, 570311 Applicant after: Hainan Xiansheng Zaiming Pharmaceutical Co.,Ltd. Address before: No. 20 Yaogu Yiheng Road, Xiuying District, Haikou City, Hainan Province, 570311 Applicant before: Xiansheng Zaiming Pharmaceutical Co.,Ltd. Country or region before: China |