RU2448106C2 - Новые гетероарил-замещенные бензотиазолы - Google Patents

Новые гетероарил-замещенные бензотиазолы Download PDF

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Publication number
RU2448106C2
RU2448106C2 RU2008130965/04A RU2008130965A RU2448106C2 RU 2448106 C2 RU2448106 C2 RU 2448106C2 RU 2008130965/04 A RU2008130965/04 A RU 2008130965/04A RU 2008130965 A RU2008130965 A RU 2008130965A RU 2448106 C2 RU2448106 C2 RU 2448106C2
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compound according
disease
alzheimer
compound
atoms
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RU2008130965/04A
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English (en)
Russian (ru)
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RU2008130965A (ru
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Ильва ГРАВЕНФОРС (SE)
Ильва Гравенфорс
Катрин ЙОНАССОН (SE)
Катрин ЙОНАССОН
Йонас МАЛЬМСТРЁМ (SE)
Йонас МАЛЬМСТРЁМ
Гуннар НОРДВАЛЛЬ (SE)
Гуннар Нордвалль
Давид ПИРИНГ (SE)
Давид ПИРИНГ
Кан СЛИВО (SE)
Кан СЛИВО
Даниэль СОН (SE)
Даниэль Сон
Петер СТРЁМ (SE)
Петер СТРЁМ
Давид ВЕНСБО (SE)
Давид Венсбо
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Астразенека Аб
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2008130965/04A 2006-01-27 2007-01-25 Новые гетероарил-замещенные бензотиазолы RU2448106C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27
US60/762,654 2006-01-27

Publications (2)

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RU2008130965A RU2008130965A (ru) 2010-03-10
RU2448106C2 true RU2448106C2 (ru) 2012-04-20

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US (2) US8163928B2 (enExample)
EP (1) EP1981883A4 (enExample)
JP (1) JP5289061B2 (enExample)
KR (1) KR101406248B1 (enExample)
CN (1) CN101410393B (enExample)
AR (1) AR059178A1 (enExample)
AU (1) AU2007207904C1 (enExample)
BR (1) BRPI0707283A2 (enExample)
CA (1) CA2640213A1 (enExample)
EC (1) ECSP088645A (enExample)
IL (1) IL192876A0 (enExample)
NO (1) NO20083394L (enExample)
NZ (1) NZ569667A (enExample)
RU (1) RU2448106C2 (enExample)
SA (1) SA07280009B1 (enExample)
TW (2) TW200736252A (enExample)
UA (1) UA95267C2 (enExample)
UY (1) UY30112A1 (enExample)
WO (1) WO2007086800A1 (enExample)
ZA (1) ZA200806075B (enExample)

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JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
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US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
JP2012507534A (ja) * 2008-10-31 2012-03-29 メルク・シャープ・エンド・ドーム・コーポレイション 新規置換アザベンゾオキサゾール類
EP2501696B1 (en) * 2009-10-15 2016-12-28 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
EP2585455B1 (en) 2010-06-24 2019-08-07 The Regents of the University of California Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms
EP2699157B1 (en) * 2011-04-21 2018-03-14 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
WO2013040183A1 (en) * 2011-09-16 2013-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
CN102558091B (zh) * 2011-12-22 2014-10-08 合肥工业大学 一种苯并噻唑类衍生物及其用途
CN102659772B (zh) * 2012-05-03 2015-02-11 北京师范大学 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用
KR20190136125A (ko) * 2012-12-21 2019-12-09 국립연구개발법인 양자과학기술연구개발기구 뇌 안에 축적된 타우 단백질을 이미징하기 위한 신규한 화합물
EP2968296B1 (en) 2013-03-12 2020-09-02 The Regents of the University of California Gamma-secretase modulators
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
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GB201617339D0 (en) * 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
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JP7293343B2 (ja) 2018-05-09 2023-06-19 アプリノイア セラピューティクス リミテッド ヘテロアリール化合物及びその使用
CN112105393A (zh) * 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途
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CN114380731B (zh) * 2022-03-09 2024-07-02 台州学院 一种kcnq钾离子通道激动剂、药物组合物及其应用
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Publication number Publication date
JP2009528271A (ja) 2009-08-06
BRPI0707283A2 (pt) 2011-04-26
US20090028787A1 (en) 2009-01-29
CA2640213A1 (en) 2007-08-02
CN101410393A (zh) 2009-04-15
NO20083394L (no) 2008-10-02
ECSP088645A (es) 2008-08-29
EP1981883A1 (en) 2008-10-22
SA07280009B1 (ar) 2011-07-20
JP5289061B2 (ja) 2013-09-11
TW200736252A (en) 2007-10-01
WO2007086800A1 (en) 2007-08-02
AU2007207904C1 (en) 2011-10-13
NZ569667A (en) 2011-09-30
AU2007207904A1 (en) 2007-08-02
US20120207679A1 (en) 2012-08-16
RU2008130965A (ru) 2010-03-10
UA95267C2 (en) 2011-07-25
AU2007207904B2 (en) 2011-03-10
US8163928B2 (en) 2012-04-24
AR059178A1 (es) 2008-03-12
ZA200806075B (en) 2012-12-27
UY30112A1 (es) 2007-08-31
IL192876A0 (en) 2009-02-11
EP1981883A4 (en) 2010-10-06
CN101410393B (zh) 2012-01-25
TW201018678A (en) 2010-05-16
KR20080090542A (ko) 2008-10-08
KR101406248B1 (ko) 2014-06-19
US8957215B2 (en) 2015-02-17

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