UA95267C2 - Heteroaryl substituted benzothiazoles - Google Patents
Heteroaryl substituted benzothiazolesInfo
- Publication number
- UA95267C2 UA95267C2 UAA200809015A UAA200809015A UA95267C2 UA 95267 C2 UA95267 C2 UA 95267C2 UA A200809015 A UAA200809015 A UA A200809015A UA A200809015 A UAA200809015 A UA A200809015A UA 95267 C2 UA95267 C2 UA 95267C2
- Authority
- UA
- Ukraine
- Prior art keywords
- heteroaryl substituted
- relates
- alzheimer
- compositions
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Заявленное изобретение касается новых замещенных гетероарилом производных бензотиазола, их предшественников, терапевтического применения таких соединений, которые имеют структурную формулу (I):и их фармацевтически приемлемых солей, композиций и применения.Кроме того, изобретение касается новых замещенных гетероарилом производных бензотиазола, которые являются пригодными для отображения осаждений амилоида у живых пациентов, их композиций, применения и создания таких соединений.Конкретнее, заявленное изобретение касается способа отображения осаждений амилоида в мозге in vivo для предсмертного диагноза болезни Альцгеймера, а также определения клинической эффективности терапевтических агентов против болезни Альцгеймера.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76265406P | 2006-01-27 | 2006-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA95267C2 true UA95267C2 (en) | 2011-07-25 |
Family
ID=38309497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200809015A UA95267C2 (en) | 2006-01-27 | 2007-01-25 | Heteroaryl substituted benzothiazoles |
Country Status (20)
Country | Link |
---|---|
US (2) | US8163928B2 (ru) |
EP (1) | EP1981883A4 (ru) |
JP (1) | JP5289061B2 (ru) |
KR (1) | KR101406248B1 (ru) |
CN (1) | CN101410393B (ru) |
AR (1) | AR059178A1 (ru) |
AU (1) | AU2007207904C1 (ru) |
BR (1) | BRPI0707283A2 (ru) |
CA (1) | CA2640213A1 (ru) |
EC (1) | ECSP088645A (ru) |
IL (1) | IL192876A0 (ru) |
NO (1) | NO20083394L (ru) |
NZ (1) | NZ569667A (ru) |
RU (1) | RU2448106C2 (ru) |
SA (1) | SA07280009B1 (ru) |
TW (2) | TW200736252A (ru) |
UA (1) | UA95267C2 (ru) |
UY (1) | UY30112A1 (ru) |
WO (1) | WO2007086800A1 (ru) |
ZA (1) | ZA200806075B (ru) |
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TW200736252A (en) | 2006-01-27 | 2007-10-01 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
US8557222B2 (en) | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
JP2011524864A (ja) | 2008-05-30 | 2011-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な置換されたアザベンゾオキサゾール |
US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
EP2341909A4 (en) * | 2008-10-31 | 2012-05-30 | Merck Sharp & Dohme | NEW SUBSTITUTED AZABENZOXAZOLE |
US20120263646A1 (en) * | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
JP6069661B2 (ja) | 2010-06-24 | 2017-02-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用 |
CA2831331C (en) | 2011-04-21 | 2019-10-15 | The Regents Of The University Of California | Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles |
WO2013040183A1 (en) * | 2011-09-16 | 2013-03-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof |
CN102558091B (zh) * | 2011-12-22 | 2014-10-08 | 合肥工业大学 | 一种苯并噻唑类衍生物及其用途 |
CN102659772B (zh) * | 2012-05-03 | 2015-02-11 | 北京师范大学 | 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用 |
WO2014097474A1 (ja) | 2012-12-21 | 2014-06-26 | 独立行政法人放射線医学総合研究所 | 脳内に蓄積したタウタンパク質をイメージングするための新規化合物 |
US9938263B2 (en) | 2013-03-12 | 2018-04-10 | The General Hospital Corporation | Gamma-secretase modulators |
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WO2015051188A1 (en) | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
WO2016004513A1 (en) * | 2014-07-11 | 2016-01-14 | Simon Fraser University | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods |
EP3170820B1 (en) * | 2014-07-16 | 2019-02-20 | Japan Science and Technology Agency | Benzothiazole compound and medicine containing same |
WO2016070107A1 (en) | 2014-10-31 | 2016-05-06 | The General Hospital Corporation | Potent gamma-secretase modulators |
BR112017011661A2 (pt) * | 2014-12-02 | 2018-03-06 | Bayer Cropscience Aktiengesellschaft | compostos bicíclicos como agentes de controle de pragas. |
US10292970B2 (en) | 2014-12-02 | 2019-05-21 | Bayer Pharma Aktiengesellschaft | Heteroaryl-substituted imidazo[1,2-A]pyridines and their use |
KR102536024B1 (ko) * | 2015-03-12 | 2023-05-24 | 에프엠씨 코포레이션 | 헤테로환-치환 이환 아졸 살충제 |
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GB201617339D0 (en) * | 2016-10-12 | 2016-11-23 | Lytix Biopharma As | Therapeutic compounds |
CN111163773A (zh) * | 2017-08-02 | 2020-05-15 | 斯皮诺吉尼克斯公司 | 苯并噻唑及相关化合物 |
CN112105393A (zh) * | 2018-05-16 | 2020-12-18 | 爱默蕾大学 | 苯乙烯基苯并噻唑衍生物及在成像中的用途 |
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KR20220153888A (ko) * | 2021-05-12 | 2022-11-21 | 에이치케이이노엔 주식회사 | 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도 |
CN114478431A (zh) * | 2022-03-09 | 2022-05-13 | 台州学院 | 一种双取代苯并噻吩类钾离子通道激动剂的制备方法 |
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TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
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-
2007
- 2007-01-19 TW TW096102118A patent/TW200736252A/zh unknown
- 2007-01-19 TW TW098145976A patent/TW201018678A/zh unknown
- 2007-01-24 AR ARP070100305A patent/AR059178A1/es unknown
- 2007-01-24 SA SA7280009A patent/SA07280009B1/ar unknown
- 2007-01-25 UA UAA200809015A patent/UA95267C2/ru unknown
- 2007-01-25 NZ NZ569667A patent/NZ569667A/en not_active IP Right Cessation
- 2007-01-25 EP EP20070709290 patent/EP1981883A4/en not_active Withdrawn
- 2007-01-25 AU AU2007207904A patent/AU2007207904C1/en not_active Ceased
- 2007-01-25 CA CA002640213A patent/CA2640213A1/en not_active Abandoned
- 2007-01-25 WO PCT/SE2007/000068 patent/WO2007086800A1/en active Application Filing
- 2007-01-25 RU RU2008130965/04A patent/RU2448106C2/ru not_active IP Right Cessation
- 2007-01-25 CN CN2007800112344A patent/CN101410393B/zh not_active Expired - Fee Related
- 2007-01-25 BR BRPI0707283-0A patent/BRPI0707283A2/pt not_active IP Right Cessation
- 2007-01-25 KR KR1020087020871A patent/KR101406248B1/ko not_active IP Right Cessation
- 2007-01-25 US US12/162,255 patent/US8163928B2/en not_active Expired - Fee Related
- 2007-01-25 JP JP2008552268A patent/JP5289061B2/ja not_active Expired - Fee Related
- 2007-01-26 UY UY30112A patent/UY30112A1/es not_active Application Discontinuation
-
2008
- 2008-07-11 ZA ZA2008/06075A patent/ZA200806075B/en unknown
- 2008-07-17 IL IL192876A patent/IL192876A0/en unknown
- 2008-07-22 EC EC2008008645A patent/ECSP088645A/es unknown
- 2008-08-01 NO NO20083394A patent/NO20083394L/no not_active Application Discontinuation
-
2012
- 2012-04-23 US US13/453,579 patent/US8957215B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ECSP088645A (es) | 2008-08-29 |
RU2448106C2 (ru) | 2012-04-20 |
EP1981883A1 (en) | 2008-10-22 |
UY30112A1 (es) | 2007-08-31 |
AU2007207904A1 (en) | 2007-08-02 |
EP1981883A4 (en) | 2010-10-06 |
CN101410393A (zh) | 2009-04-15 |
BRPI0707283A2 (pt) | 2011-04-26 |
ZA200806075B (en) | 2012-12-27 |
JP5289061B2 (ja) | 2013-09-11 |
JP2009528271A (ja) | 2009-08-06 |
US8957215B2 (en) | 2015-02-17 |
CN101410393B (zh) | 2012-01-25 |
US20090028787A1 (en) | 2009-01-29 |
AU2007207904C1 (en) | 2011-10-13 |
TW201018678A (en) | 2010-05-16 |
CA2640213A1 (en) | 2007-08-02 |
AR059178A1 (es) | 2008-03-12 |
AU2007207904B2 (en) | 2011-03-10 |
US8163928B2 (en) | 2012-04-24 |
RU2008130965A (ru) | 2010-03-10 |
NO20083394L (no) | 2008-10-02 |
SA07280009B1 (ar) | 2011-07-20 |
KR20080090542A (ko) | 2008-10-08 |
KR101406248B1 (ko) | 2014-06-19 |
NZ569667A (en) | 2011-09-30 |
WO2007086800A1 (en) | 2007-08-02 |
IL192876A0 (en) | 2009-02-11 |
TW200736252A (en) | 2007-10-01 |
US20120207679A1 (en) | 2012-08-16 |
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