WO2008078424A1 - ベンゾキサゾール誘導体 - Google Patents

ベンゾキサゾール誘導体 Download PDF

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Publication number
WO2008078424A1
WO2008078424A1 PCT/JP2007/063350 JP2007063350W WO2008078424A1 WO 2008078424 A1 WO2008078424 A1 WO 2008078424A1 JP 2007063350 W JP2007063350 W JP 2007063350W WO 2008078424 A1 WO2008078424 A1 WO 2008078424A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzoxazole derivatives
conformation disease
composition
conformation
disease
Prior art date
Application number
PCT/JP2007/063350
Other languages
English (en)
French (fr)
Inventor
Yukitsuka Kudo
Syozo Furumoto
Nobuyuki Okamura
Original Assignee
Tohoku University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2006/325804 external-priority patent/WO2007074786A1/ja
Application filed by Tohoku University filed Critical Tohoku University
Priority to JP2008550970A priority Critical patent/JP5190893B2/ja
Priority to EP07768120A priority patent/EP2103611A4/en
Priority to US12/520,752 priority patent/US7910579B2/en
Publication of WO2008078424A1 publication Critical patent/WO2008078424A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Abstract

　コンフォーメーション病の早期診断に有用なベンゾキサゾール誘導体又はその薬学的に許容される塩もしくは溶媒和物、それを含むコンフォーメーション病診断用組成物及びキット、ならびにコンフォーメーション病治療及び／又は予防用医薬組成物などが本発明により提供される。
PCT/JP2007/063350 2006-12-25 2007-07-04 ベンゾキサゾール誘導体 WO2008078424A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008550970A JP5190893B2 (ja) 2006-12-25 2007-07-04 ベンゾキサゾール誘導体
EP07768120A EP2103611A4 (en) 2006-12-25 2007-07-04 benzoxazole
US12/520,752 US7910579B2 (en) 2006-12-25 2007-07-04 Benzoxazole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2006/325804 WO2007074786A1 (ja) 2005-12-26 2006-12-25 コンフォーメーション病診断プローブ
JPPCT/JP2006/325804 2006-12-25

Publications (1)

Publication Number Publication Date
WO2008078424A1 true WO2008078424A1 (ja) 2008-07-03

Family

ID=39562218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/063350 WO2008078424A1 (ja) 2006-12-25 2007-07-04 ベンゾキサゾール誘導体

Country Status (3)

Country Link
US (1) US7910579B2 (ja)
EP (1) EP2103611A4 (ja)
WO (1) WO2008078424A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5422782B1 (ja) * 2012-12-21 2014-02-19 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
WO2019054427A1 (ja) 2017-09-14 2019-03-21 第一三共株式会社 環状構造を有する化合物
JP2019123675A (ja) * 2018-01-12 2019-07-25 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
US11291732B1 (en) 2019-11-13 2022-04-05 Aprinoia Therapeutics Limited Compounds for degrading α-synuclein aggregates and uses thereof

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WO2013170858A1 (en) 2012-05-16 2013-11-21 Coloplast A/S Novel polymeric photoinitiators and photoinitiator monomers
CN102936228B (zh) * 2012-11-08 2015-03-11 江苏省原子医学研究所 6-(2-氟乙氧基)-2-甲基苯并噁唑的制备方法
US8951258B2 (en) 2013-03-01 2015-02-10 Warsaw Orthopedic, Inc. Spinal correction system and method
US10736672B2 (en) 2017-05-25 2020-08-11 Warsaw Orthopedic, Inc. Spinal implant system and method
GB201712567D0 (en) 2017-08-04 2017-09-20 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for tau aggregates

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5422782B1 (ja) * 2012-12-21 2014-02-19 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
WO2014097474A1 (ja) * 2012-12-21 2014-06-26 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
US11667628B2 (en) 2012-12-21 2023-06-06 National Institutes For Quantum And Radiological Science And Technology Compounds for imaging tau proteins that accumulate in brain
WO2019054427A1 (ja) 2017-09-14 2019-03-21 第一三共株式会社 環状構造を有する化合物
JP2019123675A (ja) * 2018-01-12 2019-07-25 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
CN111556868A (zh) * 2018-01-12 2020-08-18 上海富吉医疗器械有限公司 放射性核素标记化合物和含有该化合物的显影剂
KR20200109335A (ko) 2018-01-12 2020-09-22 상하이 차트웰 메디컬 인스트루먼트 컴퍼니 리미티드 방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제
CN111556868B (zh) * 2018-01-12 2023-03-28 上海富吉医疗科技有限公司 放射性核素标记化合物和含有该化合物的显影剂
US11291732B1 (en) 2019-11-13 2022-04-05 Aprinoia Therapeutics Limited Compounds for degrading α-synuclein aggregates and uses thereof
US11642413B2 (en) 2019-11-13 2023-05-09 Aprinoia Therapeutics Limited Compounds for degrading Tau protein aggregates and uses thereof

Also Published As

Publication number Publication date
US20100021385A1 (en) 2010-01-28
EP2103611A1 (en) 2009-09-23
US7910579B2 (en) 2011-03-22
EP2103611A4 (en) 2010-06-30

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