TW200736252A - Novel heteroaryl substituted benzothiazoles - Google Patents

Novel heteroaryl substituted benzothiazoles

Info

Publication number
TW200736252A
TW200736252A TW096102118A TW96102118A TW200736252A TW 200736252 A TW200736252 A TW 200736252A TW 096102118 A TW096102118 A TW 096102118A TW 96102118 A TW96102118 A TW 96102118A TW 200736252 A TW200736252 A TW 200736252A
Authority
TW
Taiwan
Prior art keywords
heteroaryl substituted
novel heteroaryl
relates
alzheimer
compositions
Prior art date
Application number
TW096102118A
Other languages
English (en)
Inventor
David Wensbo
Peter Strom
Ylva Gravenfors
Catrin Jonasson
Gunnar Nordvall
Jonas Malmstrom
Can Slivo
David Pyring
Daniel Sohn
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38309497&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200736252(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TW200736252A publication Critical patent/TW200736252A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
TW096102118A 2006-01-27 2007-01-19 Novel heteroaryl substituted benzothiazoles TW200736252A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27

Publications (1)

Publication Number Publication Date
TW200736252A true TW200736252A (en) 2007-10-01

Family

ID=38309497

Family Applications (2)

Application Number Title Priority Date Filing Date
TW096102118A TW200736252A (en) 2006-01-27 2007-01-19 Novel heteroaryl substituted benzothiazoles
TW098145976A TW201018678A (en) 2006-01-27 2007-01-19 Novel heteroaryl substituted benzothiazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW098145976A TW201018678A (en) 2006-01-27 2007-01-19 Novel heteroaryl substituted benzothiazoles

Country Status (20)

Country Link
US (2) US8163928B2 (zh)
EP (1) EP1981883A4 (zh)
JP (1) JP5289061B2 (zh)
KR (1) KR101406248B1 (zh)
CN (1) CN101410393B (zh)
AR (1) AR059178A1 (zh)
AU (1) AU2007207904C1 (zh)
BR (1) BRPI0707283A2 (zh)
CA (1) CA2640213A1 (zh)
EC (1) ECSP088645A (zh)
IL (1) IL192876A0 (zh)
NO (1) NO20083394L (zh)
NZ (1) NZ569667A (zh)
RU (1) RU2448106C2 (zh)
SA (1) SA07280009B1 (zh)
TW (2) TW200736252A (zh)
UA (1) UA95267C2 (zh)
UY (1) UY30112A1 (zh)
WO (1) WO2007086800A1 (zh)
ZA (1) ZA200806075B (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200736252A (en) 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
US8557222B2 (en) 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
JP2011524864A (ja) 2008-05-30 2011-09-08 メルク・シャープ・エンド・ドーム・コーポレイション 新規な置換されたアザベンゾオキサゾール
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
EP2341909A4 (en) * 2008-10-31 2012-05-30 Merck Sharp & Dohme NEW SUBSTITUTED AZABENZOXAZOLE
US20120263646A1 (en) * 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JP6069661B2 (ja) 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用
CA2831331C (en) 2011-04-21 2019-10-15 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
WO2013040183A1 (en) * 2011-09-16 2013-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
CN102558091B (zh) * 2011-12-22 2014-10-08 合肥工业大学 一种苯并噻唑类衍生物及其用途
CN102659772B (zh) * 2012-05-03 2015-02-11 北京师范大学 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用
WO2014097474A1 (ja) 2012-12-21 2014-06-26 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
US9938263B2 (en) 2013-03-12 2018-04-10 The General Hospital Corporation Gamma-secretase modulators
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
WO2015051188A1 (en) 2013-10-02 2015-04-09 Washington University Heterocyclic molecules for biomedical imaging and therapeutic applications
WO2016004513A1 (en) * 2014-07-11 2016-01-14 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
EP3170820B1 (en) * 2014-07-16 2019-02-20 Japan Science and Technology Agency Benzothiazole compound and medicine containing same
WO2016070107A1 (en) 2014-10-31 2016-05-06 The General Hospital Corporation Potent gamma-secretase modulators
BR112017011661A2 (pt) * 2014-12-02 2018-03-06 Bayer Cropscience Aktiengesellschaft compostos bicíclicos como agentes de controle de pragas.
US10292970B2 (en) 2014-12-02 2019-05-21 Bayer Pharma Aktiengesellschaft Heteroaryl-substituted imidazo[1,2-A]pyridines and their use
KR102536024B1 (ko) * 2015-03-12 2023-05-24 에프엠씨 코포레이션 헤테로환-치환 이환 아졸 살충제
EP3340796B1 (en) 2015-08-28 2021-04-21 CHDI Foundation, Inc. Probes for imaging huntingtin protein
GB201617339D0 (en) * 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
CN111163773A (zh) * 2017-08-02 2020-05-15 斯皮诺吉尼克斯公司 苯并噻唑及相关化合物
CN112105393A (zh) * 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途
EP3917521A4 (en) * 2019-01-31 2022-10-26 Spinogenix, Inc. SOLID FORMS OF A PROMOTER OF SPINOGENESIS
GB201914989D0 (en) * 2019-10-16 2019-11-27 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU Aggregates
WO2021097243A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Inc. Compounds for degrading tau protein aggregates and uses thereof
KR20220153888A (ko) * 2021-05-12 2022-11-21 에이치케이이노엔 주식회사 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도
CN114478431A (zh) * 2022-03-09 2022-05-13 台州学院 一种双取代苯并噻吩类钾离子通道激动剂的制备方法
CN114380731A (zh) * 2022-03-09 2022-04-22 台州学院 一种kcnq钾离子通道激动剂、药物组合物及其应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU369122A1 (ru) * 1971-01-05 1973-02-08 А. К. Арен, П. П. Заринь, С. К. Германе, Э. С. Лавринович Институт органического синтеза Латвийской ССР Способ получения 4-(бензазолил-2)- 1,2,5,6-тетрагидропиридинов
AU523040B2 (en) 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
GB8305245D0 (en) 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4556411A (en) * 1984-12-07 1985-12-03 Fmc Corporation Benzothiazole derivatives for plant growth and development modification
JPS6394248A (ja) 1986-10-08 1988-04-25 Canon Inc 電子写真感光体
CA2034309C (en) * 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
JPH09507071A (ja) 1993-12-21 1997-07-15 イーライ・リリー・アンド・カンパニー アミロイド原性ペプチドに関連した状態を治療又は予防する方法
US5518713A (en) 1995-02-13 1996-05-21 3V Inc. Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them
JPH11116476A (ja) 1997-10-16 1999-04-27 Sankyo Co Ltd 縮合複素環化合物
ES2395721T3 (es) 2000-08-24 2013-02-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Derivados de tioflavina y su uso en diagnosis y terapia de la enfermedad de alzheimer
US7045539B2 (en) * 2000-12-22 2006-05-16 Astrazeneca Ab Therapeutic benzoxazole compounds
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
EP1381604B1 (en) 2001-04-23 2006-12-27 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
WO2003045929A1 (fr) 2001-11-26 2003-06-05 Takeda Chemical Industries, Ltd. Derive bicyclique, procede de production de ce derive et utilisation correspondante
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
TW200401194A (en) 2002-07-11 2004-01-16 Advanced Micro Devices Inc Method and apparatus for determining a processor state without interrupting processor operation
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
JP2004250411A (ja) 2003-02-21 2004-09-09 Bf Kenkyusho:Kk アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
JPWO2004087641A1 (ja) 2003-03-31 2006-06-29 第一製薬株式会社 ヒドラゾン誘導体
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1893576A4 (en) 2005-05-27 2010-03-17 Univ Kingston TREATMENT OF PROTEIN DISORDERING
WO2007033080A2 (en) 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
US20080305040A1 (en) 2005-09-16 2008-12-11 University Of Pittsburgh In Vivo or in Vitro Method For Detecting Amyloid Deposits Having at Least One Amyloidogenic Protein
ES2379987T3 (es) 2005-10-11 2012-05-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compuestos de benzofurano marcados isotópicamente como radiotrazadores para proteínas amiloidógenas
WO2007070173A2 (en) * 2005-10-31 2007-06-21 Merck & Co., Inc. Cetp inhibitors
EP1956013B1 (en) 2005-11-30 2016-04-13 Fujifilm RI Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
TW200736252A (en) 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
US7700616B2 (en) 2006-05-08 2010-04-20 Molecular Neuroimaging, Llc. Compounds and amyloid probes thereof for therapeutic and imaging uses
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
US20100092385A1 (en) 2007-01-22 2010-04-15 Astrazeneca Ab Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives

Also Published As

Publication number Publication date
ECSP088645A (es) 2008-08-29
RU2448106C2 (ru) 2012-04-20
EP1981883A1 (en) 2008-10-22
UY30112A1 (es) 2007-08-31
AU2007207904A1 (en) 2007-08-02
EP1981883A4 (en) 2010-10-06
CN101410393A (zh) 2009-04-15
BRPI0707283A2 (pt) 2011-04-26
ZA200806075B (en) 2012-12-27
JP5289061B2 (ja) 2013-09-11
JP2009528271A (ja) 2009-08-06
US8957215B2 (en) 2015-02-17
CN101410393B (zh) 2012-01-25
US20090028787A1 (en) 2009-01-29
AU2007207904C1 (en) 2011-10-13
TW201018678A (en) 2010-05-16
CA2640213A1 (en) 2007-08-02
AR059178A1 (es) 2008-03-12
AU2007207904B2 (en) 2011-03-10
US8163928B2 (en) 2012-04-24
RU2008130965A (ru) 2010-03-10
NO20083394L (no) 2008-10-02
SA07280009B1 (ar) 2011-07-20
KR20080090542A (ko) 2008-10-08
KR101406248B1 (ko) 2014-06-19
NZ569667A (en) 2011-09-30
WO2007086800A1 (en) 2007-08-02
IL192876A0 (en) 2009-02-11
US20120207679A1 (en) 2012-08-16
UA95267C2 (en) 2011-07-25

Similar Documents

Publication Publication Date Title
TW200736252A (en) Novel heteroaryl substituted benzothiazoles
WO2007149030A8 (en) Novel heteroaryl substituted benzoxazoles
WO2009155017A3 (en) Novel substituted azabenzoxazoles
MX2009007487A (es) Derivados de imidazo[1,2-a]piridina substituidos de heteroarilo novedosos.
MY147347A (en) Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
WO2015191506A3 (en) Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
MX2009005279A (es) Derivados de n-(metil)-1h-pirazol-3-amina, n-(metil)-piridin-2-ami na y n-(metil)-tiazol-2-amina para el tratamiento de enfermedades asociadas con proteinas amiloides o tipo amiloide, tal como por ejemplo alzheimer.
EA201101243A1 (ru) 3h-имидазо[4,5-c]пиридин-6-карбоксамиды в качестве противовоспалительных средств
NO20084853L (no) Forbindelser som er agonister av muscarinreseptorer og som kan vaere effektive i behandling av smerte, Alzheimers sykdom og/eller schizofreni
WO2011045415A3 (en) Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JO3265B1 (ar) مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
EA200971107A1 (ru) Катехоламиновые производные, полезные для лечения болезни паркинсона
EA200802173A1 (ru) Производные терфенила для лечения болезни альцгеймера
ZA200705018B (en) Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease
WO2007006534A3 (en) Piperidine derivatives useful in the diagnostic and therapeutic treatment of diseases depending on renin activity
NO20085323L (no) Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase
AR114029A2 (es) Compuestos adecuados como precursores de compuestos que son útiles para obtener imágenes de depósitos amiloides, usos y procesos
NO20064982L (no) 1,3,4-oksadiazol-2-oner som PPAR delta modulatorer og anvendelse derav
EP2378879A4 (en) TRIAZONE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
WO2010051196A8 (en) Novel substituted azabenzoxazoles
MX2009009113A (es) Nuevos indoles 2-heteroaril sustituidos 695.
DE60207612D1 (de) Verbindungen zur bilddarstellung der alzheimer-krankenheit
WO2008152068A3 (en) [1,10]-phenanthroline derivatives for the treatment of neurodegenerative or haematological diseases
WO2006020156A3 (en) Heterocyclic dye compounds for in vivo imaging and diagnosis of alzheimer’s disease
WO2008009655A3 (de) Medizinische verwendung von n-phenylpropenoyl-aminosäurederivaten und verwandten verbindungen