NO20083394L - Nye heteroaryl substituerte benzotiasoler - Google Patents

Nye heteroaryl substituerte benzotiasoler

Info

Publication number
NO20083394L
NO20083394L NO20083394A NO20083394A NO20083394L NO 20083394 L NO20083394 L NO 20083394L NO 20083394 A NO20083394 A NO 20083394A NO 20083394 A NO20083394 A NO 20083394A NO 20083394 L NO20083394 L NO 20083394L
Authority
NO
Norway
Prior art keywords
relates
alzheimer
disease
compositions
heteroaryl substituted
Prior art date
Application number
NO20083394A
Other languages
English (en)
Norwegian (no)
Inventor
Gunnar Nordvall
Daniel Sohn
Catrin Jonasson
Ylva Gravenfors
Jonas Malmstrom
David Pyring
Can Slivo
Peter Strom
David Wensbo
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38309497&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083394(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20083394L publication Critical patent/NO20083394L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO20083394A 2006-01-27 2008-08-01 Nye heteroaryl substituerte benzotiasoler NO20083394L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27
PCT/SE2007/000068 WO2007086800A1 (en) 2006-01-27 2007-01-25 Novel heteroaryl substituted benzothiazoles

Publications (1)

Publication Number Publication Date
NO20083394L true NO20083394L (no) 2008-10-02

Family

ID=38309497

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083394A NO20083394L (no) 2006-01-27 2008-08-01 Nye heteroaryl substituerte benzotiasoler

Country Status (20)

Country Link
US (2) US8163928B2 (enExample)
EP (1) EP1981883A4 (enExample)
JP (1) JP5289061B2 (enExample)
KR (1) KR101406248B1 (enExample)
CN (1) CN101410393B (enExample)
AR (1) AR059178A1 (enExample)
AU (1) AU2007207904C1 (enExample)
BR (1) BRPI0707283A2 (enExample)
CA (1) CA2640213A1 (enExample)
EC (1) ECSP088645A (enExample)
IL (1) IL192876A0 (enExample)
NO (1) NO20083394L (enExample)
NZ (1) NZ569667A (enExample)
RU (1) RU2448106C2 (enExample)
SA (1) SA07280009B1 (enExample)
TW (2) TW201018678A (enExample)
UA (1) UA95267C2 (enExample)
UY (1) UY30112A1 (enExample)
WO (1) WO2007086800A1 (enExample)
ZA (1) ZA200806075B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
US8557222B2 (en) 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
US8530483B2 (en) 2008-05-30 2013-09-10 Merck Sharp & Dohme Corp. Substituted azabenzoxazoles
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
US20110212031A1 (en) * 2008-10-31 2011-09-01 Cyrille Sur Novel substituted azabenzoxazoles
US20120263646A1 (en) * 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JP6069661B2 (ja) * 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用
WO2012145169A2 (en) 2011-04-21 2012-10-26 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
US20140348748A1 (en) * 2011-09-16 2014-11-27 Lisheng Cai Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
CN102558091B (zh) * 2011-12-22 2014-10-08 合肥工业大学 一种苯并噻唑类衍生物及其用途
CN102659772B (zh) * 2012-05-03 2015-02-11 北京师范大学 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用
JP5422782B1 (ja) 2012-12-21 2014-02-19 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
EP2968296B1 (en) 2013-03-12 2020-09-02 The Regents of the University of California Gamma-secretase modulators
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
WO2015051188A1 (en) 2013-10-02 2015-04-09 Washington University Heterocyclic molecules for biomedical imaging and therapeutic applications
WO2016004513A1 (en) * 2014-07-11 2016-01-14 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
WO2016010092A1 (ja) 2014-07-16 2016-01-21 国立研究開発法人科学技術振興機構 ベンゾチアゾール化合物及びこれを含有する医薬
MX381224B (es) 2014-10-31 2025-03-12 Massachusetts Gen Hospital Potentes moduladores de gamma-secretasa.
CN107207490A (zh) * 2014-12-02 2017-09-26 拜耳作物科学股份公司 作为害虫防治剂的双环化合物
WO2016087343A1 (de) 2014-12-02 2016-06-09 Bayer Pharma Aktiengesellschaft Heteroaryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
KR102536024B1 (ko) * 2015-03-12 2023-05-24 에프엠씨 코포레이션 헤테로환-치환 이환 아졸 살충제
CA2995847C (en) * 2015-08-28 2024-05-28 Chdi Foundation, Inc. Probes for imaging huntingtin protein
GB201617339D0 (en) * 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
CA3071525A1 (en) 2017-08-02 2019-02-07 Spinogenix, Inc. Benzothiazole and related compounds
GB201806004D0 (en) 2018-04-11 2018-05-23 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU aggregates
CN112384517B (zh) 2018-05-09 2023-07-14 新旭生技股份有限公司 杂芳基化合物及其用途
CN112105393A (zh) * 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途
ES3032326T3 (en) * 2019-01-31 2025-07-17 Spinogenix Inc Solid forms of a promoter of spinogenesis
GB201914989D0 (en) * 2019-10-16 2019-11-27 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU Aggregates
CA3161455A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Limited Compounds for degrading tau protein aggregates and uses thereof
KR102682408B1 (ko) * 2021-05-12 2024-07-05 에이치케이이노엔 주식회사 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도
CN114478431B (zh) * 2022-03-09 2024-07-02 台州学院 一种双取代苯并噻吩类钾离子通道激动剂的制备方法
CN114380731B (zh) * 2022-03-09 2024-07-02 台州学院 一种kcnq钾离子通道激动剂、药物组合物及其应用
JP2025540931A (ja) 2022-11-03 2025-12-17 セントニックス インコーポレイテッド タウ凝集体に対する選択的リガンド
UY41082A (es) 2024-03-28 2025-08-29 Pi Industries Ltd Compuestos bicíclicos condensados y su uso como agentes de control de plagas

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
GB8305245D0 (en) 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4556411A (en) * 1984-12-07 1985-12-03 Fmc Corporation Benzothiazole derivatives for plant growth and development modification
JPS6394248A (ja) 1986-10-08 1988-04-25 Canon Inc 電子写真感光体
CA2034309C (en) * 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
JPH09507071A (ja) 1993-12-21 1997-07-15 イーライ・リリー・アンド・カンパニー アミロイド原性ペプチドに関連した状態を治療又は予防する方法
US5518713A (en) * 1995-02-13 1996-05-21 3V Inc. Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them
JPH11116476A (ja) 1997-10-16 1999-04-27 Sankyo Co Ltd 縮合複素環化合物
RU2324686C2 (ru) 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
WO2002051821A1 (en) * 2000-12-22 2002-07-04 Astrazeneca Ab Therapeutic compounds
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
CA2444214A1 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
WO2003045929A1 (en) * 2001-11-26 2003-06-05 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
TW200401194A (en) 2002-07-11 2004-01-16 Advanced Micro Devices Inc Method and apparatus for determining a processor state without interrupting processor operation
CA2494139A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
JP2004250411A (ja) 2003-02-21 2004-09-09 Bf Kenkyusho:Kk アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
CA2521056A1 (en) 2003-03-31 2004-10-14 Daiichi Pharmaceutical Co., Ltd. Hydrazone derivative
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
JP2008545663A (ja) 2005-05-27 2008-12-18 クイーンズ ユニバーシティ アット キングストン タンパク質フォールディング障害の治療
WO2007033080A2 (en) 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
EP1937260A2 (en) 2005-09-16 2008-07-02 University of Pittsburgh In-vivo and in-vitro method for detecting amyloid deposits having at least one amyloidogenic protein
US8138360B2 (en) 2005-10-11 2012-03-20 University of Pittsburgh—of the Commonwealth System of Higher Education Isotopically-labeled benzofuran compounds as imaging agents for amyloidogenic proteins
EP1954287B2 (en) * 2005-10-31 2016-02-24 Merck Sharp & Dohme Corp. Cetp inhibitors
US8022075B2 (en) 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
EP2023919A4 (en) * 2006-05-08 2010-12-22 Molecular Neuroimaging Llc COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES
TW200813035A (en) * 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
AU2008208091A1 (en) 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives

Also Published As

Publication number Publication date
US20120207679A1 (en) 2012-08-16
EP1981883A4 (en) 2010-10-06
JP5289061B2 (ja) 2013-09-11
AU2007207904A1 (en) 2007-08-02
US8163928B2 (en) 2012-04-24
CN101410393B (zh) 2012-01-25
TW200736252A (en) 2007-10-01
US8957215B2 (en) 2015-02-17
SA07280009B1 (ar) 2011-07-20
JP2009528271A (ja) 2009-08-06
BRPI0707283A2 (pt) 2011-04-26
WO2007086800A1 (en) 2007-08-02
KR101406248B1 (ko) 2014-06-19
AR059178A1 (es) 2008-03-12
ECSP088645A (es) 2008-08-29
CA2640213A1 (en) 2007-08-02
RU2448106C2 (ru) 2012-04-20
KR20080090542A (ko) 2008-10-08
RU2008130965A (ru) 2010-03-10
NZ569667A (en) 2011-09-30
IL192876A0 (en) 2009-02-11
AU2007207904C1 (en) 2011-10-13
UA95267C2 (en) 2011-07-25
ZA200806075B (en) 2012-12-27
UY30112A1 (es) 2007-08-31
CN101410393A (zh) 2009-04-15
AU2007207904B2 (en) 2011-03-10
US20090028787A1 (en) 2009-01-29
EP1981883A1 (en) 2008-10-22
TW201018678A (en) 2010-05-16

Similar Documents

Publication Publication Date Title
UA95267C2 (en) Heteroaryl substituted benzothiazoles
NO20090201L (no) Nye heteroarylsubstituerte benzoksazoler
WO2009155017A3 (en) Novel substituted azabenzoxazoles
UA98481C2 (en) 2-heteroaryl substituted benzothiophenes and benzofuranes
NO20092293L (no) Sulfonyl-fenyl-2H-[1,2,4]oksodiazol-5-onderivater, fremgangsmate for fremstilling derav og deres anvendelse som farmasoytiske midler
NO20064412L (no) Kondensert heterocykelderivat, medisinsk sammensetning inneholdende det samme og medisinsk anvendelse derav
NO20082673L (no) Nye 2-amino-imidazol-4-on forbindelser og deres anvendelse i fremstilling av et medikament som skal brukes til behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerasjon og demens
NO20090166L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
NO20090755L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
NO20085323L (no) Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase
NO20074615L (no) Dihydrotienopyrimidiner for behandling av inflamatoriske sykdommer
MA32898B1 (fr) Modulateurs allosteriques positifs du recepteur m1 d'arylmethylbenzoquinazolinone
MA33450B1 (fr) Dérivés d'oxazine et leur utilisation en tant qu'inhibiteurs de bace pour le traitement de troubles neurologiques
ATE515505T1 (de) Heterocyclische fxr-bindende verbindungen
NO20083197L (no) Substituert cinnolin-derivater som GABAA-reseptor modulatorer og metode for deres syntese
NO20076479L (no) Nye oksadiazolderivater og anvendelse derav som positive allosteriske metabotropiske modulatorer av glutamatreseptorer
EA200701745A1 (ru) Циклопропанкарбоксамидные производные
MX346101B (es) Sonda de formacion de imagen de tau.
NO20084516L (no) Terfenylderivater for behandling av alzheimers sykdom
US20160075731A1 (en) Uridine nucleoside derivatives, compositions and methods of use
NO20091782L (no) Fremgangsmate for syntese av derivater av 3-amino-tetrahydrofuran-3-karboxylsyre og deres anvendelse som medikamenter
EA201100267A1 (ru) Новые бензофураны, подходящие в качестве предшественников соединений, которые являются полезными для визуализации амилоидных отложений
WO2008078424A1 (ja) ベンゾキサゾール誘導体
WO2010051196A8 (en) Novel substituted azabenzoxazoles
NO20064659L (no) Nye kvarterniserte quinuklidin-estere

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application