JP5289061B2 - 新規なへテロアリール置換ベンゾチアゾール - Google Patents

新規なへテロアリール置換ベンゾチアゾール Download PDF

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Publication number
JP5289061B2
JP5289061B2 JP2008552268A JP2008552268A JP5289061B2 JP 5289061 B2 JP5289061 B2 JP 5289061B2 JP 2008552268 A JP2008552268 A JP 2008552268A JP 2008552268 A JP2008552268 A JP 2008552268A JP 5289061 B2 JP5289061 B2 JP 5289061B2
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Japan
Prior art keywords
benzothiazol
mmol
compound
pyridin
benzothiazole
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Expired - Fee Related
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JP2008552268A
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English (en)
Japanese (ja)
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JP2009528271A (ja
JP2009528271A5 (enExample
Inventor
イルヴァ・グラーヴェンフォシュ
カトリン・ヨーナソン
ヨーナス・マールムストレム
グンナール・ノードヴァル
ダーヴィド・ピリング
カン・スリーヴォ
ダニエル・ソーン
ペーテル・ストレム
ダーヴィド・ウェンスブー
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008552268A 2006-01-27 2007-01-25 新規なへテロアリール置換ベンゾチアゾール Expired - Fee Related JP5289061B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27
US60/762,654 2006-01-27
PCT/SE2007/000068 WO2007086800A1 (en) 2006-01-27 2007-01-25 Novel heteroaryl substituted benzothiazoles

Publications (3)

Publication Number Publication Date
JP2009528271A JP2009528271A (ja) 2009-08-06
JP2009528271A5 JP2009528271A5 (enExample) 2010-03-04
JP5289061B2 true JP5289061B2 (ja) 2013-09-11

Family

ID=38309497

Family Applications (1)

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JP2008552268A Expired - Fee Related JP5289061B2 (ja) 2006-01-27 2007-01-25 新規なへテロアリール置換ベンゾチアゾール

Country Status (20)

Country Link
US (2) US8163928B2 (enExample)
EP (1) EP1981883A4 (enExample)
JP (1) JP5289061B2 (enExample)
KR (1) KR101406248B1 (enExample)
CN (1) CN101410393B (enExample)
AR (1) AR059178A1 (enExample)
AU (1) AU2007207904C1 (enExample)
BR (1) BRPI0707283A2 (enExample)
CA (1) CA2640213A1 (enExample)
EC (1) ECSP088645A (enExample)
IL (1) IL192876A0 (enExample)
NO (1) NO20083394L (enExample)
NZ (1) NZ569667A (enExample)
RU (1) RU2448106C2 (enExample)
SA (1) SA07280009B1 (enExample)
TW (2) TW201018678A (enExample)
UA (1) UA95267C2 (enExample)
UY (1) UY30112A1 (enExample)
WO (1) WO2007086800A1 (enExample)
ZA (1) ZA200806075B (enExample)

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WO2012145169A2 (en) 2011-04-21 2012-10-26 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
US20140348748A1 (en) * 2011-09-16 2014-11-27 Lisheng Cai Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
CN102558091B (zh) * 2011-12-22 2014-10-08 合肥工业大学 一种苯并噻唑类衍生物及其用途
CN102659772B (zh) * 2012-05-03 2015-02-11 北京师范大学 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用
JP5422782B1 (ja) 2012-12-21 2014-02-19 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
EP2968296B1 (en) 2013-03-12 2020-09-02 The Regents of the University of California Gamma-secretase modulators
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KR102682408B1 (ko) * 2021-05-12 2024-07-05 에이치케이이노엔 주식회사 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도
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Also Published As

Publication number Publication date
US20120207679A1 (en) 2012-08-16
EP1981883A4 (en) 2010-10-06
AU2007207904A1 (en) 2007-08-02
US8163928B2 (en) 2012-04-24
CN101410393B (zh) 2012-01-25
TW200736252A (en) 2007-10-01
US8957215B2 (en) 2015-02-17
SA07280009B1 (ar) 2011-07-20
JP2009528271A (ja) 2009-08-06
BRPI0707283A2 (pt) 2011-04-26
WO2007086800A1 (en) 2007-08-02
KR101406248B1 (ko) 2014-06-19
AR059178A1 (es) 2008-03-12
ECSP088645A (es) 2008-08-29
CA2640213A1 (en) 2007-08-02
RU2448106C2 (ru) 2012-04-20
KR20080090542A (ko) 2008-10-08
RU2008130965A (ru) 2010-03-10
NZ569667A (en) 2011-09-30
IL192876A0 (en) 2009-02-11
AU2007207904C1 (en) 2011-10-13
UA95267C2 (en) 2011-07-25
ZA200806075B (en) 2012-12-27
UY30112A1 (es) 2007-08-31
CN101410393A (zh) 2009-04-15
AU2007207904B2 (en) 2011-03-10
NO20083394L (no) 2008-10-02
US20090028787A1 (en) 2009-01-29
EP1981883A1 (en) 2008-10-22
TW201018678A (en) 2010-05-16

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