IL192876A0 - Novel heteroaryl substituted benzothiazoles - Google Patents

Novel heteroaryl substituted benzothiazoles

Info

Publication number
IL192876A0
IL192876A0 IL192876A IL19287608A IL192876A0 IL 192876 A0 IL192876 A0 IL 192876A0 IL 192876 A IL192876 A IL 192876A IL 19287608 A IL19287608 A IL 19287608A IL 192876 A0 IL192876 A0 IL 192876A0
Authority
IL
Israel
Prior art keywords
heteroaryl substituted
novel heteroaryl
substituted benzothiazoles
benzothiazoles
novel
Prior art date
Application number
IL192876A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Sohn Daniel
Jonasson Catrin
Gunnar Nordvall
Gravenfors Ylva
Malmstrom Jonas
Pyring David
Slivo Can
Strom Peter
Wensbo David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38309497&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL192876(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Sohn Daniel, Jonasson Catrin, Gunnar Nordvall, Gravenfors Ylva, Malmstrom Jonas, Pyring David, Slivo Can, Strom Peter, Wensbo David filed Critical Astrazeneca Ab
Publication of IL192876A0 publication Critical patent/IL192876A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL192876A 2006-01-27 2008-07-17 Novel heteroaryl substituted benzothiazoles IL192876A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27
PCT/SE2007/000068 WO2007086800A1 (en) 2006-01-27 2007-01-25 Novel heteroaryl substituted benzothiazoles

Publications (1)

Publication Number Publication Date
IL192876A0 true IL192876A0 (en) 2009-02-11

Family

ID=38309497

Family Applications (1)

Application Number Title Priority Date Filing Date
IL192876A IL192876A0 (en) 2006-01-27 2008-07-17 Novel heteroaryl substituted benzothiazoles

Country Status (20)

Country Link
US (2) US8163928B2 (enExample)
EP (1) EP1981883A4 (enExample)
JP (1) JP5289061B2 (enExample)
KR (1) KR101406248B1 (enExample)
CN (1) CN101410393B (enExample)
AR (1) AR059178A1 (enExample)
AU (1) AU2007207904C1 (enExample)
BR (1) BRPI0707283A2 (enExample)
CA (1) CA2640213A1 (enExample)
EC (1) ECSP088645A (enExample)
IL (1) IL192876A0 (enExample)
NO (1) NO20083394L (enExample)
NZ (1) NZ569667A (enExample)
RU (1) RU2448106C2 (enExample)
SA (1) SA07280009B1 (enExample)
TW (2) TW201018678A (enExample)
UA (1) UA95267C2 (enExample)
UY (1) UY30112A1 (enExample)
WO (1) WO2007086800A1 (enExample)
ZA (1) ZA200806075B (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
EP2300481B1 (en) 2008-05-30 2015-09-30 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
AU2009309027A1 (en) * 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
US20120263646A1 (en) * 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JP6069661B2 (ja) * 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用
CN103491870B (zh) * 2011-04-21 2016-12-28 加利福尼亚大学董事会 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
WO2013040183A1 (en) * 2011-09-16 2013-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
CN102558091B (zh) * 2011-12-22 2014-10-08 合肥工业大学 一种苯并噻唑类衍生物及其用途
CN102659772B (zh) * 2012-05-03 2015-02-11 北京师范大学 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用
AU2012397435B2 (en) 2012-12-21 2017-03-30 National Institutes For Quantum And Radiological Science And Technology Novel compound for imaging TAU protein accumulated in the brain
WO2014165263A1 (en) 2013-03-12 2014-10-09 The Regents Of The University Of California, A California Corporation Gamma-secretase modulators
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
WO2015051188A1 (en) * 2013-10-02 2015-04-09 Washington University Heterocyclic molecules for biomedical imaging and therapeutic applications
WO2016004513A1 (en) * 2014-07-11 2016-01-14 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
JP6562361B2 (ja) * 2014-07-16 2019-08-21 国立研究開発法人科学技術振興機構 ベンゾチアゾール化合物及びこれを含有する医薬
JP6672296B2 (ja) 2014-10-31 2020-03-25 ザ ジェネラル ホスピタル コーポレイション 強力なγ−セクレターゼモジュレータ
EP3227287B1 (de) 2014-12-02 2019-08-07 Bayer Pharma Aktiengesellschaft Heteroaryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
JP2017537916A (ja) * 2014-12-02 2017-12-21 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての二環式化合物
JP6740239B2 (ja) * 2015-03-12 2020-08-12 エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ 複素環置換二環式アゾール殺有害生物剤
HRP20211156T1 (hr) * 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
GB201617339D0 (en) * 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
JP7168650B2 (ja) * 2017-08-02 2022-11-09 スピノジェニックス， インコーポレイテッド ベンゾチアゾールおよび関連化合物
CA3099318C (en) 2018-05-09 2024-02-13 Aprinoia Therapeutics Inc. Heteroaryl compounds and uses thereof
CN112105393A (zh) * 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途
RS67123B1 (sr) * 2019-01-31 2025-09-30 Spinogenix Inc Čvrsti oblici promotera spinogeneze
GB201914989D0 (en) * 2019-10-16 2019-11-27 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU Aggregates
EP4058065A4 (en) 2019-11-13 2023-05-03 Aprinoia Therapeutics Limited COMPOUNDS FOR DEGRADING TAU PROTEIN AGGREGATES AND USES THEREOF
KR102682408B1 (ko) * 2021-05-12 2024-07-05 에이치케이이노엔 주식회사 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도
CN114478431B (zh) * 2022-03-09 2024-07-02 台州学院 一种双取代苯并噻吩类钾离子通道激动剂的制备方法
CN114380731B (zh) * 2022-03-09 2024-07-02 台州学院 一种kcnq钾离子通道激动剂、药物组合物及其应用
CN120303267A (zh) 2022-11-03 2025-07-11 森托尼克思有限公司 针对tau聚集体的选择性配体
WO2025202955A1 (en) 2024-03-28 2025-10-02 Pi Industries Ltd. Fused bicyclic compounds and their use as pest control agents

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
GB8305245D0 (en) 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4556411A (en) * 1984-12-07 1985-12-03 Fmc Corporation Benzothiazole derivatives for plant growth and development modification
JPS6394248A (ja) 1986-10-08 1988-04-25 Canon Inc 電子写真感光体
CA2034309C (en) * 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
EP0735821A4 (en) 1993-12-21 1998-04-01 Lilly Co Eli METHODS FOR TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH AMYLO DOGEN PEPTIDES
US5518713A (en) * 1995-02-13 1996-05-21 3V Inc. Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them
JPH11116476A (ja) 1997-10-16 1999-04-27 Sankyo Co Ltd 縮合複素環化合物
BRPI0113470B8 (pt) * 2000-08-24 2021-05-25 Univ Pittsburgh composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal
WO2002051821A1 (en) * 2000-12-22 2002-07-04 Astrazeneca Ab Therapeutic compounds
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
CN100422180C (zh) 2001-04-23 2008-10-01 宾夕法尼亚州大学理事会 淀粉样斑块聚集抑制剂和诊断成像剂
WO2003045929A1 (en) * 2001-11-26 2003-06-05 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
TW200401194A (en) 2002-07-11 2004-01-16 Advanced Micro Devices Inc Method and apparatus for determining a processor state without interrupting processor operation
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
JP2004250411A (ja) 2003-02-21 2004-09-09 Bf Kenkyusho:Kk アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物
CA2438032C (en) 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US20060276433A1 (en) 2003-03-31 2006-12-07 Keiichi Kawagoe Hydrazone derivative
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
PL1636217T3 (pl) * 2003-05-13 2009-02-27 Hoffmann La Roche 1-Imidazobenzotiazole jako ligandy receptora adenozynowego
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
CA2609980C (en) 2005-05-27 2015-10-13 Queen's University At Kingston Treatment of protein folding disorders
WO2007033080A2 (en) 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
JP2009508863A (ja) 2005-09-16 2009-03-05 ユニバーシティー オブ ピッツバーグ 少なくとも１種のアミロイド形成タンパク質を含むアミロイド沈着物を検出するためのｉｎｖｉｖｏまたはｉｎｖｉｔｒｏ方法
DK1945622T3 (da) 2005-10-11 2012-04-02 Univ Pittsburgh Isotopisk-mærkede benzofuranforbindelser som billeddannelsesmidler til amyloidogene proteiner
ATE533485T1 (de) * 2005-10-31 2011-12-15 Merck Sharp & Dohme Cetp-inhibitoren
JP4738419B2 (ja) 2005-11-30 2011-08-03 富士フイルムＲｉファーマ株式会社 アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
US7700616B2 (en) * 2006-05-08 2010-04-20 Molecular Neuroimaging, Llc. Compounds and amyloid probes thereof for therapeutic and imaging uses
TW200813035A (en) * 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
KR20090101469A (ko) 2007-01-22 2009-09-28 아스트라제네카 아베 신규 헤테로아릴 치환된 이미다조〔１，２­ａ〕피리딘 유도체

Also Published As

Publication number Publication date
UY30112A1 (es) 2007-08-31
WO2007086800A1 (en) 2007-08-02
SA07280009B1 (ar) 2011-07-20
CN101410393B (zh) 2012-01-25
AU2007207904C1 (en) 2011-10-13
US20120207679A1 (en) 2012-08-16
TW200736252A (en) 2007-10-01
BRPI0707283A2 (pt) 2011-04-26
RU2008130965A (ru) 2010-03-10
AU2007207904A1 (en) 2007-08-02
CN101410393A (zh) 2009-04-15
ZA200806075B (en) 2012-12-27
US20090028787A1 (en) 2009-01-29
AU2007207904B2 (en) 2011-03-10
TW201018678A (en) 2010-05-16
CA2640213A1 (en) 2007-08-02
US8957215B2 (en) 2015-02-17
KR101406248B1 (ko) 2014-06-19
EP1981883A4 (en) 2010-10-06
UA95267C2 (en) 2011-07-25
ECSP088645A (es) 2008-08-29
JP2009528271A (ja) 2009-08-06
JP5289061B2 (ja) 2013-09-11
NZ569667A (en) 2011-09-30
RU2448106C2 (ru) 2012-04-20
NO20083394L (no) 2008-10-02
AR059178A1 (es) 2008-03-12
US8163928B2 (en) 2012-04-24
KR20080090542A (ko) 2008-10-08
EP1981883A1 (en) 2008-10-22

Similar Documents

Publication Publication Date Title
ZA200806075B (en) Novel heteroaryl substituted benzothiazoles
IL196527A0 (en) Substituted heteroaryl derivatives
ZA200903237B (en) Substituted heteroaryl pyridopyrimidone derivatives
IL195669A0 (en) Novel heteroaryl substituted benzoxazoles
IL195007A0 (en) Thiazole derivatives
EP2034838A4 (en) NOVEL CONNECTIONS
EP2032142A4 (en) NOVEL CONNECTIONS
EP1981596A4 (en) NEW CONNECTIONS
EP1973884A4 (en) NEW HETEROCYCLES
EP1981900A4 (en) NEW COMPOUNDS
GB0603550D0 (en) Novel compounds
IL194493A0 (en) Thiazolyl dihydro-indazoles
GB0602900D0 (en) Novel Compounds
GB0605462D0 (en) Novel compounds
EP2031965A4 (en) NEW COMPOUNDS
GB0614154D0 (en) Novel Pyriazine Derivatives
GB0600483D0 (en) Novel compounds
GB0607840D0 (en) Novel compounds
HK1122571A (en) Novel heteroaryl substituted benzothiazoles
GB0610722D0 (en) Novel aluminium-air barreries
GB0603899D0 (en) Novel compounds
GB0606527D0 (en) Novel compounds
GB0607529D0 (en) Novel compounds
GB0605677D0 (en) Novel compounds
GB0604897D0 (en) Novel compounds