JP2010524857A5 - - Google Patents
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- Publication number
- JP2010524857A5 JP2010524857A5 JP2010503199A JP2010503199A JP2010524857A5 JP 2010524857 A5 JP2010524857 A5 JP 2010524857A5 JP 2010503199 A JP2010503199 A JP 2010503199A JP 2010503199 A JP2010503199 A JP 2010503199A JP 2010524857 A5 JP2010524857 A5 JP 2010524857A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxy
- hydrogen
- integer
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 53
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 41
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 32
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 23
- 230000002285 radioactive effect Effects 0.000 claims 15
- 229910052740 iodine Inorganic materials 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 9
- 208000037259 Amyloid Plaque Diseases 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- -1 benzoyloxy, phenyl Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 230000000536 complexating effect Effects 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 150000002366 halogen compounds Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 CC(C)(*)N(C)* Chemical compound CC(C)(*)N(C)* 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90759807P | 2007-04-10 | 2007-04-10 | |
| PCT/US2008/059864 WO2008124812A1 (en) | 2007-04-10 | 2008-04-10 | Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010524857A JP2010524857A (ja) | 2010-07-22 |
| JP2010524857A5 true JP2010524857A5 (enExample) | 2012-06-07 |
Family
ID=39831428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503199A Pending JP2010524857A (ja) | 2007-04-10 | 2008-04-10 | フェン−ナフタレン及びフェン−キノリン誘導体、及びアミロイドプラークに結合させ、そして造影するための使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100215579A1 (enExample) |
| EP (1) | EP2144916A4 (enExample) |
| JP (1) | JP2010524857A (enExample) |
| WO (1) | WO2008124812A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2247558T5 (pl) | 2008-02-14 | 2024-10-14 | Eli Lilly And Company | Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| US8420052B2 (en) | 2008-07-24 | 2013-04-16 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying AD pathology |
| EP2411057B1 (en) * | 2009-03-23 | 2020-05-06 | Eli Lilly and Company | Imaging agents for detecting neurological disorders |
| US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| ES2620177T3 (es) | 2009-10-15 | 2017-06-27 | Guerbet | Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas |
| JP2013532136A (ja) | 2010-06-04 | 2013-08-15 | ピラマル イメージング ソシエテ アノニム | Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法 |
| WO2019018562A1 (en) * | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| JOP20210243A1 (ar) | 2019-03-05 | 2023-01-30 | Bayer Ag | طريقة لتحضير 4-أمينو-5-مثيل بيريدون |
| CN118591373A (zh) | 2021-11-23 | 2024-09-03 | 恩福莱克逊治疗有限公司 | 吡咯并吡啶-苯胺化合物的制剂 |
| WO2024208542A1 (en) | 2023-04-05 | 2024-10-10 | Minascent Technologies Gmbh | Process for the production of 4-amino-5-methyl-(1h)-pyridin-2-one |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07165721A (ja) * | 1993-12-15 | 1995-06-27 | Sumitomo Chem Co Ltd | 放射性イソキノリンカルボキサミド誘導体 |
| FR2732019B1 (fr) * | 1995-03-24 | 1997-06-13 | Flamel Tech Sa | Spiropyrannes photochromiques, compositions et articles les contenant |
| IL118469A (en) * | 1995-06-15 | 2000-08-13 | Tanabe Seiyaku Co | Naphthalene derivatives their preparation and intermediates thereof |
| US5998624A (en) * | 1997-05-07 | 1999-12-07 | Emory University | Haloisoquinoline carboxamide |
| WO2000015629A1 (en) * | 1998-09-11 | 2000-03-23 | Ppg Industries Ohio, Inc. | Polymerizable polyalkoxylated naphthopyrans |
| JP2001072872A (ja) * | 1999-07-02 | 2001-03-21 | Konica Corp | 樹脂組成物および光学用レンズ |
| KR100947913B1 (ko) * | 2001-08-27 | 2010-03-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 스틸벤 유도체 및 이것을 아밀로이드 플라크의 결합 및영상화에 사용하는 용도 |
| TWI306450B (en) * | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
| TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| EP1574500A1 (en) * | 2002-12-16 | 2005-09-14 | BF Research Institute, Inc. | Quinoline derivative as diagnostic probe for disease with tau protein accumulation |
| US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
| US7666886B2 (en) * | 2005-07-15 | 2010-02-23 | The Regents Of The University Of California | Compounds and methods for the diagnosis and treatment of amyloid associated diseases |
| MX2008010668A (es) * | 2006-02-21 | 2008-10-01 | Amgen Inc | Derivados de cinolina como inhibidores de fosfodiesterasa 10. |
-
2008
- 2008-04-10 WO PCT/US2008/059864 patent/WO2008124812A1/en not_active Ceased
- 2008-04-10 US US12/595,111 patent/US20100215579A1/en not_active Abandoned
- 2008-04-10 EP EP08745465A patent/EP2144916A4/en not_active Withdrawn
- 2008-04-10 JP JP2010503199A patent/JP2010524857A/ja active Pending
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