JP2013500342A5 - - Google Patents
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- Publication number
- JP2013500342A5 JP2013500342A5 JP2012522939A JP2012522939A JP2013500342A5 JP 2013500342 A5 JP2013500342 A5 JP 2013500342A5 JP 2012522939 A JP2012522939 A JP 2012522939A JP 2012522939 A JP2012522939 A JP 2012522939A JP 2013500342 A5 JP2013500342 A5 JP 2013500342A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkyl
- aralkyl
- compound according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 125000003710 aryl alkyl group Chemical group 0.000 claims 19
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 18
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 claims 2
- 229910052768 actinide Inorganic materials 0.000 claims 2
- 150000001255 actinides Chemical class 0.000 claims 2
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims 2
- 150000002602 lanthanoids Chemical class 0.000 claims 2
- 206010065973 Iron Overload Diseases 0.000 claims 1
- PLIUCYCUYQIBDZ-RMWYGNQTSA-N all-trans-4-oxoretinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C PLIUCYCUYQIBDZ-RMWYGNQTSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22869009P | 2009-07-27 | 2009-07-27 | |
| US61/228,690 | 2009-07-27 | ||
| PCT/US2010/043241 WO2011017054A2 (en) | 2009-07-27 | 2010-07-26 | Prodrugs of desazadesferrothiocin polyether analogues as metal chelation agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013500342A JP2013500342A (ja) | 2013-01-07 |
| JP2013500342A5 true JP2013500342A5 (enExample) | 2013-09-12 |
Family
ID=43544849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012522939A Pending JP2013500342A (ja) | 2009-07-27 | 2010-07-26 | 金属キレート化剤としてのデサザデスフェロチオシンポリエーテルアナログのプロドラッグ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110053993A1 (enExample) |
| EP (1) | EP2459544A4 (enExample) |
| JP (1) | JP2013500342A (enExample) |
| CN (1) | CN102648189A (enExample) |
| AU (1) | AU2010281452A1 (enExample) |
| BR (1) | BR112012001761A2 (enExample) |
| CA (1) | CA2768041A1 (enExample) |
| WO (1) | WO2011017054A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003270473A1 (en) | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| ES2732625T3 (es) | 2005-04-04 | 2019-11-25 | Univ Florida | Análogos de poliéter de desferritiocina |
| CN104003955A (zh) | 2007-03-15 | 2014-08-27 | 佛罗里达大学研究基金公司 | 去铁硫辛聚醚类似物 |
| CN102149700A (zh) | 2008-07-14 | 2011-08-10 | 法罗肯生物科学公司 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
| EP2566854A4 (en) * | 2010-05-04 | 2013-11-06 | Shire Llc | DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS |
| WO2012015154A1 (ko) * | 2010-07-26 | 2012-02-02 | 엘지전자 주식회사 | 다중 반송파 정합을 지원하는 무선 접속 시스템에서 비주기적 채널상태정보 피드백 방법 |
| CA2857990A1 (en) | 2011-12-09 | 2013-06-13 | Ferrokin Biosciences, Inc. | Oral formulations for treating metal overload |
| BR112014014544A2 (pt) | 2011-12-16 | 2017-06-13 | Univ Florida | usos de análogos de 4'-desferritiocina |
| WO2014089482A1 (en) * | 2012-12-07 | 2014-06-12 | Ferrokin Biosciences, Inc. | Polymorph forms of desazadesferrithiocin analogs |
| HK1220194A1 (zh) | 2013-03-15 | 2017-04-28 | Ferrokin Biosciences, Inc. | 去氮杂去铁硫代霉素(desazadesferrithiocin)类似物的多晶型形式 |
| US10010535B2 (en) | 2013-11-22 | 2018-07-03 | University Of Florida Research Foundation, Incorporated | Desferrithiocin analogs and uses thereof |
| WO2016176343A1 (en) * | 2015-04-27 | 2016-11-03 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
| WO2018139165A1 (ja) * | 2017-01-24 | 2018-08-02 | 住友ゴム工業株式会社 | タイヤ |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0214101A3 (de) * | 1985-09-03 | 1989-05-31 | Ciba-Geigy Ag | Verwendung von Eisen(III)-Chelatoren vom Typ Desferrioxamin B und Desferriferrithiocin zur Behandlung von Malaria |
| US5840739A (en) * | 1992-11-16 | 1998-11-24 | University Of Florida Research Foundation, Inc. | Thiazoline acid derivatives |
| AT500490A1 (de) * | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| JPWO2004031163A1 (ja) * | 2002-10-01 | 2006-02-02 | 株式会社カネカ | 光学活性α−置換システインまたはその塩の製造方法並びにその合成中間体及びその製造方法 |
| AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| ES2732625T3 (es) * | 2005-04-04 | 2019-11-25 | Univ Florida | Análogos de poliéter de desferritiocina |
| US20100137346A1 (en) * | 2006-12-12 | 2010-06-03 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogue actinide decorporation agents |
| CN104003955A (zh) * | 2007-03-15 | 2014-08-27 | 佛罗里达大学研究基金公司 | 去铁硫辛聚醚类似物 |
| CN102149700A (zh) * | 2008-07-14 | 2011-08-10 | 法罗肯生物科学公司 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
| CA2772212A1 (en) * | 2009-08-25 | 2011-03-10 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof |
| EP2566854A4 (en) * | 2010-05-04 | 2013-11-06 | Shire Llc | DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS |
-
2010
- 2010-07-26 BR BR112012001761A patent/BR112012001761A2/pt not_active IP Right Cessation
- 2010-07-26 JP JP2012522939A patent/JP2013500342A/ja active Pending
- 2010-07-26 US US12/843,483 patent/US20110053993A1/en not_active Abandoned
- 2010-07-26 CN CN2010800395082A patent/CN102648189A/zh active Pending
- 2010-07-26 AU AU2010281452A patent/AU2010281452A1/en not_active Abandoned
- 2010-07-26 CA CA2768041A patent/CA2768041A1/en not_active Abandoned
- 2010-07-26 WO PCT/US2010/043241 patent/WO2011017054A2/en not_active Ceased
- 2010-07-26 EP EP10806863A patent/EP2459544A4/en not_active Withdrawn
-
2012
- 2012-09-05 US US13/604,025 patent/US20130005781A1/en not_active Abandoned