JP2018514568A5 - - Google Patents
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- Publication number
- JP2018514568A5 JP2018514568A5 JP2017556988A JP2017556988A JP2018514568A5 JP 2018514568 A5 JP2018514568 A5 JP 2018514568A5 JP 2017556988 A JP2017556988 A JP 2017556988A JP 2017556988 A JP2017556988 A JP 2017556988A JP 2018514568 A5 JP2018514568 A5 JP 2018514568A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- carbon atom
- fibrosis
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 6
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 6
- 206010016654 Fibrosis Diseases 0.000 claims description 6
- 230000004761 fibrosis Effects 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 4
- -1 methoxy, ethoxy Chemical group 0.000 claims description 4
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 230000009787 cardiac fibrosis Effects 0.000 claims description 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 description 6
- UXHIBYLONSGIOH-UHFFFAOYSA-N Cc1ccc(CCC(N2)=O)c2n1 Chemical compound Cc1ccc(CCC(N2)=O)c2n1 UXHIBYLONSGIOH-UHFFFAOYSA-N 0.000 description 1
- HBWCJMBLUCNJIS-UHFFFAOYSA-N Cc1nc(NCCC2)c2cc1 Chemical compound Cc1nc(NCCC2)c2cc1 HBWCJMBLUCNJIS-UHFFFAOYSA-N 0.000 description 1
- FSWRUYCICUXURT-UHFFFAOYSA-N Cc1nc(nccc2)c2cc1 Chemical compound Cc1nc(nccc2)c2cc1 FSWRUYCICUXURT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154894P | 2015-04-30 | 2015-04-30 | |
| US62/154,894 | 2015-04-30 | ||
| PCT/US2016/029962 WO2016176532A1 (en) | 2015-04-30 | 2016-04-29 | Tetrahydronaphthyridinyl propionic acid derivatives and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018514568A JP2018514568A (ja) | 2018-06-07 |
| JP2018514568A5 true JP2018514568A5 (enExample) | 2019-05-30 |
Family
ID=56027176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556988A Withdrawn JP2018514568A (ja) | 2015-04-30 | 2016-04-29 | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9572801B2 (enExample) |
| EP (1) | EP3288555A1 (enExample) |
| JP (1) | JP2018514568A (enExample) |
| KR (1) | KR20170141757A (enExample) |
| CN (1) | CN108040467A (enExample) |
| AU (1) | AU2016255494A1 (enExample) |
| BR (1) | BR112017023432A2 (enExample) |
| CA (1) | CA2983312A1 (enExample) |
| IL (1) | IL255054A0 (enExample) |
| MX (1) | MX2017013880A (enExample) |
| RU (1) | RU2017141561A (enExample) |
| WO (1) | WO2016176532A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2953948T (lt) | 2013-02-07 | 2018-01-10 | Scifluor Life Sciences, Inc | Fluorinti integrino antagonistai |
| US8901144B2 (en) * | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| RU2017132433A (ru) | 2015-02-19 | 2019-03-19 | Сайфлуор Лайф Сайенсиз, Инк. | Фторированные производные тетрагидронафтиридинилнонановой кислоты и их применение |
| US10118929B2 (en) | 2016-04-27 | 2018-11-06 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
| AU2018229275B2 (en) | 2017-02-28 | 2021-12-23 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| CA3097656A1 (en) | 2018-04-27 | 2019-10-31 | Arrowhead Pharmaceuticals, Inc. | Integrin targeting ligands and uses thereof |
| TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
| WO2020081154A1 (en) | 2018-08-29 | 2020-04-23 | Morphic Therapeutic, Inc. | INHIBITORS OF ανβ6 INTEGRIN |
| CA3109534A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibiting .alpha.v .beta.6 integrin |
| KR20230049584A (ko) * | 2020-05-07 | 2023-04-13 | 플라이언트 테라퓨틱스, 인크. | 아미노산 화합물을 사용한 호흡기 질환의 치료 |
| JP7585564B2 (ja) * | 2020-09-24 | 2024-11-19 | 株式会社ファンケル | セラミド含有ニオソームを含む化粧料 |
| CN119255801A (zh) * | 2022-05-30 | 2025-01-03 | 赛诺哈勃药业（成都）有限公司 | 四氢萘啶衍生物在制备防治粘连相关疾病的药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1318254C (en) | 1988-01-06 | 1993-05-25 | Munehiro Tomikawa | Inhibitory agent of hepatic fibrosis containing pantethine |
| ATE153500T1 (de) | 1991-04-01 | 1997-06-15 | Univ Duke | Verfahren zur inhibierung der fibrose |
| JP3818322B2 (ja) | 1994-04-28 | 2006-09-06 | 敏一 中村 | コラーゲン分解促進剤 |
| US5645839A (en) | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
| WO1998008528A1 (en) | 1996-08-30 | 1998-03-05 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
| CN1284955A (zh) * | 1997-12-17 | 2001-02-21 | 麦克公司 | 整联蛋白受体拮抗剂 |
| US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6117445A (en) | 1998-01-28 | 2000-09-12 | Link Technology Inc. | Methods for the prevention and treatment of fibrosis and sclerosis |
| WO2001062292A1 (en) | 2000-02-22 | 2001-08-30 | Suntory Limited | Preventive or therapeutic drugs for fibrosis containing chymase inhibitors as the active ingredient |
| EP1319002A1 (en) * | 2000-09-14 | 2003-06-18 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| US6509347B2 (en) * | 2001-06-11 | 2003-01-21 | Merck & Co., Inc. | Crystalline forms of an integrin receptor antagonist |
| US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| LT2953948T (lt) | 2013-02-07 | 2018-01-10 | Scifluor Life Sciences, Inc | Fluorinti integrino antagonistai |
| RU2017132433A (ru) * | 2015-02-19 | 2019-03-19 | Сайфлуор Лайф Сайенсиз, Инк. | Фторированные производные тетрагидронафтиридинилнонановой кислоты и их применение |
| EP3273965A4 (en) * | 2015-03-26 | 2018-12-05 | Merck Sharp & Dohme Corp. | Composition and methods for treating chronic kidney disease |
-
2016
- 2016-04-29 JP JP2017556988A patent/JP2018514568A/ja not_active Withdrawn
- 2016-04-29 AU AU2016255494A patent/AU2016255494A1/en not_active Abandoned
- 2016-04-29 US US15/142,023 patent/US9572801B2/en not_active Expired - Fee Related
- 2016-04-29 EP EP16724172.8A patent/EP3288555A1/en not_active Withdrawn
- 2016-04-29 MX MX2017013880A patent/MX2017013880A/es unknown
- 2016-04-29 WO PCT/US2016/029962 patent/WO2016176532A1/en not_active Ceased
- 2016-04-29 KR KR1020177034091A patent/KR20170141757A/ko not_active Withdrawn
- 2016-04-29 CA CA2983312A patent/CA2983312A1/en not_active Abandoned
- 2016-04-29 RU RU2017141561A patent/RU2017141561A/ru not_active Application Discontinuation
- 2016-04-29 BR BR112017023432A patent/BR112017023432A2/pt not_active Application Discontinuation
- 2016-04-29 CN CN201680036759.2A patent/CN108040467A/zh active Pending
-
2017
- 2017-10-16 IL IL255054A patent/IL255054A0/en unknown
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