PE20211640A1 - INHIBICION DE LA INTEGRINA xvß6 - Google Patents
INHIBICION DE LA INTEGRINA xvß6Info
- Publication number
- PE20211640A1 PE20211640A1 PE2021000252A PE2021000252A PE20211640A1 PE 20211640 A1 PE20211640 A1 PE 20211640A1 PE 2021000252 A PE2021000252 A PE 2021000252A PE 2021000252 A PE2021000252 A PE 2021000252A PE 20211640 A1 PE20211640 A1 PE 20211640A1
- Authority
- PE
- Peru
- Prior art keywords
- integrin
- compounds
- cyclopropylphenyl
- naphthyridin
- pyrrolidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esta referido a compuestos de Formula I, en donde A, B y C son como se indica a continuacion. Entre los compuestos preferidos tenemos los siguientes: acido 2-(2-ciclopropilfenil)-2-((R)-3-(4-(5,6,7,8-tetrahidro-1,8- naftiridin-2-il)butoxi)pirrolidin-1-il)acetico; acido 2-(2-ciclopropilfenil)-2-((R)-3-(3-(5,6,7,8-tetrahidro-1,8-naftiridin-2-il)propoxi)pirrolidin-1-il)acetico; entre otros. Estos compuestos son inhibidores de molecula pequena de la integrina alfavbeta6 y son utiles para el tratamiento de fibrosis pulmonar idiopatica, nefropatia diabetica, glomeruloesclerosis focal segmentaria, enfermedad renal cronica, esteatohepatitis no alcoholica, entre otras afecciones.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862724423P | 2018-08-29 | 2018-08-29 | |
US201962859457P | 2019-06-10 | 2019-06-10 | |
PCT/US2019/048782 WO2020047239A1 (en) | 2018-08-29 | 2019-08-29 | INHIBITING αV β6 INTEGRIN |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20211640A1 true PE20211640A1 (es) | 2021-08-24 |
Family
ID=67809398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000252A PE20211640A1 (es) | 2018-08-29 | 2019-08-29 | INHIBICION DE LA INTEGRINA xvß6 |
Country Status (22)
Country | Link |
---|---|
US (4) | US20200071322A1 (es) |
EP (2) | EP3617206A1 (es) |
JP (1) | JP7540998B2 (es) |
KR (1) | KR20210065935A (es) |
CN (1) | CN112805001B (es) |
AU (1) | AU2019327475A1 (es) |
BR (1) | BR112021003859A2 (es) |
CA (1) | CA3109534A1 (es) |
CL (1) | CL2021000484A1 (es) |
CO (1) | CO2021002706A2 (es) |
CR (1) | CR20210109A (es) |
DO (1) | DOP2021000035A (es) |
EC (1) | ECSP21013620A (es) |
IL (1) | IL280782A (es) |
MA (1) | MA51066A (es) |
MX (1) | MX2021002181A (es) |
PE (1) | PE20211640A1 (es) |
PH (1) | PH12021550404A1 (es) |
SG (1) | SG11202101913PA (es) |
TW (1) | TW202035400A (es) |
UY (1) | UY38353A (es) |
WO (1) | WO2020047239A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018049068A1 (en) | 2016-09-07 | 2018-03-15 | Pliant Therapeutics, Inc. | N-acyl amino acid compounds and methods of use |
CA3054792A1 (en) | 2017-02-28 | 2018-09-07 | Morphic Therapeutic, Inc. | Inhibitors of .alpha.v.beta.6 integrin |
MA47697A (fr) | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'(alpha-v)(bêta-6) intégrine |
EP4328230A3 (en) | 2018-03-07 | 2024-04-24 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
JP7540998B2 (ja) | 2018-08-29 | 2024-08-27 | モーフィック セラピューティック,インコーポレイテッド | αvβ6インテグリンの阻害 |
TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
EP3873897B1 (en) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases |
EP3873900A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
WO2020092375A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
CN114222730B (zh) | 2019-08-14 | 2024-09-10 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
JP2023541427A (ja) * | 2020-09-11 | 2023-10-02 | アローヘッド ファーマシューティカルズ インコーポレイテッド | 骨格筋送達プラットフォーム及び使用方法 |
CN116710169A (zh) | 2020-11-19 | 2023-09-05 | 普利安特治疗公司 | 整合素抑制剂及其用途 |
WO2024173570A1 (en) * | 2023-02-14 | 2024-08-22 | Morphic Therapeutic, Inc. | INHIBITING αvβ8 INTEGRIN |
WO2024173572A1 (en) * | 2023-02-14 | 2024-08-22 | Morphic Therapeutic, Inc. | INHIBITING α vβ8 INTEGRIN |
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JP7540998B2 (ja) | 2018-08-29 | 2024-08-27 | モーフィック セラピューティック,インコーポレイテッド | αvβ6インテグリンの阻害 |
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-
2019
- 2019-08-29 JP JP2021510691A patent/JP7540998B2/ja active Active
- 2019-08-29 UY UY0001038353A patent/UY38353A/es not_active Application Discontinuation
- 2019-08-29 BR BR112021003859-0A patent/BR112021003859A2/pt unknown
- 2019-08-29 SG SG11202101913PA patent/SG11202101913PA/en unknown
- 2019-08-29 KR KR1020217006113A patent/KR20210065935A/ko not_active Application Discontinuation
- 2019-08-29 US US16/555,589 patent/US20200071322A1/en not_active Abandoned
- 2019-08-29 CA CA3109534A patent/CA3109534A1/en active Pending
- 2019-08-29 MA MA051066A patent/MA51066A/fr unknown
- 2019-08-29 CN CN201980056588.3A patent/CN112805001B/zh active Active
- 2019-08-29 TW TW108131114A patent/TW202035400A/zh unknown
- 2019-08-29 PE PE2021000252A patent/PE20211640A1/es unknown
- 2019-08-29 MX MX2021002181A patent/MX2021002181A/es unknown
- 2019-08-29 CR CR20210109A patent/CR20210109A/es unknown
- 2019-08-29 AU AU2019327475A patent/AU2019327475A1/en active Pending
- 2019-08-29 EP EP19194490.9A patent/EP3617206A1/en not_active Withdrawn
- 2019-08-29 WO PCT/US2019/048782 patent/WO2020047239A1/en active Application Filing
- 2019-08-29 EP EP22173105.2A patent/EP4086254A1/en active Pending
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2020
- 2020-07-27 US US16/939,848 patent/US20200354359A1/en not_active Abandoned
- 2020-08-24 US US17/001,086 patent/US11021480B2/en active Active
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2021
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- 2021-02-25 CL CL2021000484A patent/CL2021000484A1/es unknown
- 2021-02-25 DO DO2021000035A patent/DOP2021000035A/es unknown
- 2021-02-26 PH PH12021550404A patent/PH12021550404A1/en unknown
- 2021-02-26 EC ECSENADI202113620A patent/ECSP21013620A/es unknown
- 2021-02-26 CO CONC2021/0002706A patent/CO2021002706A2/es unknown
- 2021-04-23 US US17/239,045 patent/US11739087B2/en active Active
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WO2020047239A1 (en) | 2020-03-05 |
CL2021000484A1 (es) | 2021-09-03 |
US20200385384A1 (en) | 2020-12-10 |
US11739087B2 (en) | 2023-08-29 |
US11021480B2 (en) | 2021-06-01 |
MA51066A (fr) | 2020-10-14 |
US20220073511A1 (en) | 2022-03-10 |
TW202035400A (zh) | 2020-10-01 |
JP7540998B2 (ja) | 2024-08-27 |
EP4086254A1 (en) | 2022-11-09 |
CR20210109A (es) | 2021-06-24 |
EP3617206A1 (en) | 2020-03-04 |
US20200071322A1 (en) | 2020-03-05 |
UY38353A (es) | 2020-03-31 |
AU2019327475A1 (en) | 2021-03-11 |
SG11202101913PA (en) | 2021-03-30 |
JP2021535141A (ja) | 2021-12-16 |
CO2021002706A2 (es) | 2021-05-20 |
IL280782A (en) | 2021-04-29 |
BR112021003859A2 (pt) | 2021-05-18 |
DOP2021000035A (es) | 2021-06-30 |
PH12021550404A1 (en) | 2021-10-04 |
CN112805001B (zh) | 2024-07-23 |
CA3109534A1 (en) | 2020-03-05 |
ECSP21013620A (es) | 2021-05-31 |
MX2021002181A (es) | 2021-07-15 |
US20200354359A1 (en) | 2020-11-12 |
CN112805001A (zh) | 2021-05-14 |
KR20210065935A (ko) | 2021-06-04 |
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