PE20170502A1 - ACIDO 4-(3-FLUORO-3-(2-(5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-2-IL)ETIL)PIRROLIDIN-1-IL)-3-(3-(2-METOXIETOXI)FENIL)BUTANOICO COMO ANTAGONISTA DE INTEGRINA aVß6 - Google Patents

ACIDO 4-(3-FLUORO-3-(2-(5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-2-IL)ETIL)PIRROLIDIN-1-IL)-3-(3-(2-METOXIETOXI)FENIL)BUTANOICO COMO ANTAGONISTA DE INTEGRINA aVß6

Info

Publication number
PE20170502A1
PE20170502A1 PE2017000380A PE2017000380A PE20170502A1 PE 20170502 A1 PE20170502 A1 PE 20170502A1 PE 2017000380 A PE2017000380 A PE 2017000380A PE 2017000380 A PE2017000380 A PE 2017000380A PE 20170502 A1 PE20170502 A1 PE 20170502A1
Authority
PE
Peru
Prior art keywords
acid
avß6
naphthyridin
pyrrolidin
tetrahydro
Prior art date
Application number
PE2017000380A
Other languages
English (en)
Inventor
Niall Andrew Anderson
Matthew Howard James Campbell-Crawford
Ashley Paul Hancock
John Martin Pritchard
Joanna Mary Redmond
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of PE20170502A1 publication Critical patent/PE20170502A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se refiere a un compuesto de formula (I) que es el acido 4-(3-fluoro-3-(2-(5,6,7,8-tetrahidro-1,8-naftiridin-2-il)etil)pirrolidin-1-il)-3-(3-(2-metoxietoxi)fenil)butanoico que tiene actividad antagonista del receptor de integrina aVß6, siendo util para el tratamiento de fibrosis pulmonar; tambien se refiere a una composicion farmaceutica que lo comprende
PE2017000380A 2014-09-26 2015-09-22 ACIDO 4-(3-FLUORO-3-(2-(5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-2-IL)ETIL)PIRROLIDIN-1-IL)-3-(3-(2-METOXIETOXI)FENIL)BUTANOICO COMO ANTAGONISTA DE INTEGRINA aVß6 PE20170502A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1417002.1A GB201417002D0 (en) 2014-09-26 2014-09-26 Novel compound

Publications (1)

Publication Number Publication Date
PE20170502A1 true PE20170502A1 (es) 2017-04-27

Family

ID=51901158

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017000380A PE20170502A1 (es) 2014-09-26 2015-09-22 ACIDO 4-(3-FLUORO-3-(2-(5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-2-IL)ETIL)PIRROLIDIN-1-IL)-3-(3-(2-METOXIETOXI)FENIL)BUTANOICO COMO ANTAGONISTA DE INTEGRINA aVß6

Country Status (36)

Country Link
US (3) US9956209B2 (es)
EP (2) EP3197892B1 (es)
JP (1) JP6611799B2 (es)
KR (1) KR101998000B1 (es)
CN (1) CN107074848B (es)
AR (1) AR101994A1 (es)
AU (1) AU2015320858B2 (es)
BR (1) BR112017006251A2 (es)
CA (1) CA2962315A1 (es)
CL (1) CL2017000705A1 (es)
CO (1) CO2017002714A2 (es)
CR (1) CR20170112A (es)
CY (1) CY1121071T1 (es)
DK (1) DK3197892T3 (es)
DO (1) DOP2017000081A (es)
EA (1) EA031481B1 (es)
ES (1) ES2690748T3 (es)
GB (1) GB201417002D0 (es)
HR (1) HRP20181796T1 (es)
HU (1) HUE041827T2 (es)
IL (1) IL250592A0 (es)
JO (1) JO3413B1 (es)
LT (1) LT3197892T (es)
MA (1) MA40580B1 (es)
MX (1) MX2017003948A (es)
PE (1) PE20170502A1 (es)
PH (1) PH12017500361A1 (es)
PL (1) PL3197892T3 (es)
PT (1) PT3197892T (es)
RS (1) RS58000B1 (es)
SG (1) SG11201701183YA (es)
SI (1) SI3197892T1 (es)
TW (1) TW201629056A (es)
UA (1) UA119181C2 (es)
UY (1) UY36314A (es)
WO (1) WO2016046225A1 (es)

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GB201417002D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201604589D0 (en) * 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604680D0 (en) * 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604681D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
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AR110139A1 (es) 2016-11-08 2019-02-27 Bristol Myers Squibb Co COMPUESTOS MONO Y ESPIROCÍCLICOS QUE CONTIENEN CICLOBUTANO Y AZETIDINA COMO INHIBIDORES DE LA INTEGRINA aV
MA46746A (fr) 2016-11-08 2019-09-18 Bristol Myers Squibb Co Amides d'azole et amines en tant qu'inhibiteurs d'intégrine alpha v
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EP3843728A4 (en) * 2018-08-29 2022-05-25 Morphic Therapeutic, Inc. INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
JP2022512648A (ja) * 2018-10-09 2022-02-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 心筋線維化の処置のためのαＶ－インテグリン（ＣＤ５１）阻害剤の使用
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GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
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GB201604589D0 (en) 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds

Also Published As

Publication number Publication date
PT3197892T (pt) 2018-12-12
JO3413B1 (ar) 2019-10-20
GB201417002D0 (en) 2014-11-12
IL250592A0 (en) 2017-04-30
RS58000B1 (sr) 2019-01-31
DOP2017000081A (es) 2017-04-30
US10342783B2 (en) 2019-07-09
PL3197892T3 (pl) 2019-05-31
TW201629056A (zh) 2016-08-16
BR112017006251A2 (pt) 2017-12-12
JP2017528507A (ja) 2017-09-28
CR20170112A (es) 2017-05-26
EP3197892B1 (en) 2018-09-05
HUE041827T2 (hu) 2019-05-28
US20190275016A1 (en) 2019-09-12
LT3197892T (lt) 2018-12-10
SI3197892T1 (sl) 2018-12-31
CY1121071T1 (el) 2019-12-11
PH12017500361B1 (en) 2017-07-17
CA2962315A1 (en) 2016-03-31
JP6611799B2 (ja) 2019-11-27
UY36314A (es) 2016-04-29
AR101994A1 (es) 2017-01-25
KR101998000B1 (ko) 2019-07-08
KR20170055489A (ko) 2017-05-19
PH12017500361A1 (en) 2017-07-17
DK3197892T3 (en) 2018-11-26
EP3197892A1 (en) 2017-08-02
US20170290817A1 (en) 2017-10-12
SG11201701183YA (en) 2017-04-27
EA031481B1 (ru) 2019-01-31
AU2015320858B2 (en) 2018-10-18
ES2690748T3 (es) 2018-11-22
CO2017002714A2 (es) 2017-06-30
CL2017000705A1 (es) 2017-11-03
EP3428167A1 (en) 2019-01-16
US9956209B2 (en) 2018-05-01
CN107074848A (zh) 2017-08-18
EA201790715A1 (ru) 2017-07-31
MA40580B1 (fr) 2018-09-28
US20180271845A1 (en) 2018-09-27
UA119181C2 (uk) 2019-05-10
MX2017003948A (es) 2017-06-26
MA40580A (fr) 2017-08-02
HRP20181796T1 (hr) 2018-12-28
WO2016046225A1 (en) 2016-03-31
CN107074848B (zh) 2019-11-01
AU2015320858A1 (en) 2017-03-09

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