CR20170112A - NUEVOS COMPUESTOS ANTAGONISTAS DE INTEGRINA avß6 - Google Patents

NUEVOS COMPUESTOS ANTAGONISTAS DE INTEGRINA avß6

Info

Publication number
CR20170112A
CR20170112A CR20170112A CR20170112A CR20170112A CR 20170112 A CR20170112 A CR 20170112A CR 20170112 A CR20170112 A CR 20170112A CR 20170112 A CR20170112 A CR 20170112A CR 20170112 A CR20170112 A CR 20170112A
Authority
CR
Costa Rica
Prior art keywords
avß6
integrina
new
antagonist compounds
acid
Prior art date
Application number
CR20170112A
Other languages
English (en)
Inventor
Matthew Howard James Campbell-Crawford
John Martin Pritchard
Niall Andrew Anderson
Ashley Paul Hancock
Joanna Mary Redmond
Original Assignee
Glaxosmithkline Intelectual Property Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intelectual Property Dev Ltd filed Critical Glaxosmithkline Intelectual Property Dev Ltd
Publication of CR20170112A publication Critical patent/CR20170112A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de fórmula (I): que es ácido 4-(3-fluoro-3-(2-(5,6,7,8-tetrahidro-1,8-naftiridin-2-il)etil)pirrolidin-1-il)-3-(3-(2-metoxietoxi)fenil)butanoico, o una sal del mismo.
CR20170112A 2014-09-26 2015-09-22 NUEVOS COMPUESTOS ANTAGONISTAS DE INTEGRINA avß6 CR20170112A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1417002.1A GB201417002D0 (en) 2014-09-26 2014-09-26 Novel compound
PCT/EP2015/071776 WO2016046225A1 (en) 2014-09-26 2015-09-22 Novel compounds

Publications (1)

Publication Number Publication Date
CR20170112A true CR20170112A (es) 2017-05-26

Family

ID=51901158

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170112A CR20170112A (es) 2014-09-26 2015-09-22 NUEVOS COMPUESTOS ANTAGONISTAS DE INTEGRINA avß6

Country Status (36)

Country Link
US (3) US9956209B2 (es)
EP (2) EP3428167A1 (es)
JP (1) JP6611799B2 (es)
KR (1) KR101998000B1 (es)
CN (1) CN107074848B (es)
AR (1) AR101994A1 (es)
AU (1) AU2015320858B2 (es)
BR (1) BR112017006251A2 (es)
CA (1) CA2962315A1 (es)
CL (1) CL2017000705A1 (es)
CO (1) CO2017002714A2 (es)
CR (1) CR20170112A (es)
CY (1) CY1121071T1 (es)
DK (1) DK3197892T3 (es)
DO (1) DOP2017000081A (es)
EA (1) EA031481B1 (es)
ES (1) ES2690748T3 (es)
GB (1) GB201417002D0 (es)
HR (1) HRP20181796T1 (es)
HU (1) HUE041827T2 (es)
IL (1) IL250592A0 (es)
JO (1) JO3413B1 (es)
LT (1) LT3197892T (es)
MA (1) MA40580B1 (es)
MX (1) MX2017003948A (es)
PE (1) PE20170502A1 (es)
PH (1) PH12017500361B1 (es)
PL (1) PL3197892T3 (es)
PT (1) PT3197892T (es)
RS (1) RS58000B1 (es)
SG (1) SG11201701183YA (es)
SI (1) SI3197892T1 (es)
TW (1) TW201629056A (es)
UA (1) UA119181C2 (es)
UY (1) UY36314A (es)
WO (1) WO2016046225A1 (es)

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GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201604589D0 (en) * 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604681D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
WO2018089360A1 (en) 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Pyrrole amides as alpha v integrin inhibitors
MX2019005244A (es) 2016-11-08 2019-08-05 Squibb Bristol Myers Co Acidos propionicos 3-sustituidos como inhibidores de la integrina alfa v.
US10851098B2 (en) 2016-11-08 2020-12-01 Bristol-Myers Squibb Company Azole amides and amines as alpha v integrin inhibitors
EP3538526B1 (en) 2016-11-08 2024-04-10 Bristol-Myers Squibb Company Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha v integrin inhibitors
AU2017359027A1 (en) 2016-11-08 2019-06-20 Bristol-Myers Squibb Company Indazole derivatives as αV integrin antagonists
EP3558303A4 (en) * 2016-12-23 2020-07-29 Pliant Therapeutics, Inc. AMINO ACID COMPOUNDS AND METHOD FOR USE
MA47692A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
EP3589627A4 (en) 2017-02-28 2020-08-05 Morphic Therapeutic, Inc. INHIBITORS OF (ALPHA-V) (BETA-6) -INTEGRIN
US11332498B2 (en) 2017-03-17 2022-05-17 Technische Universitat Munchen Ligands for integrin αVβ8, synthesis and uses thereof
JP7291696B2 (ja) 2017-11-07 2023-06-15 ブリストル－マイヤーズ スクイブ カンパニー アルファｖインテグリン阻害剤としてのピロロピラジン誘導体
CN108208177A (zh) * 2017-11-28 2018-06-29 上海交通大学医学院附属新华医院 含丁酸类化合物的组合物及其应用
WO2020047208A1 (en) * 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
UY38352A (es) * 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibidores de integrina alfavbeta6
EP3843728A4 (en) * 2018-08-29 2022-05-25 Morphic Therapeutic, Inc. INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
UY38353A (es) * 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibición de integrina alfavbeta6
WO2020074937A1 (en) * 2018-10-09 2020-04-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of alpha-v-integrin (cd51) inhibitors for the treatment of cardiac fibrosis
CA3119807A1 (en) * 2018-12-04 2020-06-11 Sumitomo Dainippon Pharma Oncology, Inc. Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound

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WO2011111880A1 (ko) 2010-03-08 2011-09-15 주식회사 메디젠텍 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
GB201305668D0 (en) * 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
AU2014324426A1 (en) 2013-09-30 2016-04-21 The Regents Of The University Of California Anti-alphavbeta1 integrin compounds and methods
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
KR102647026B1 (ko) 2015-02-19 2024-03-12 사이플루어 라이프 사이언시즈, 인크 플루오르화 테트라히드로나프티리디닐 노난산 유도체 및 이의 용도
US10214522B2 (en) 2015-03-10 2019-02-26 The Regents Of The University Of California Anti-alphavbeta1 integrin inhibitors and methods of use
GB201604589D0 (en) 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds

Also Published As

Publication number Publication date
EP3197892A1 (en) 2017-08-02
EP3197892B1 (en) 2018-09-05
HUE041827T2 (hu) 2019-05-28
CN107074848A (zh) 2017-08-18
DOP2017000081A (es) 2017-04-30
CO2017002714A2 (es) 2017-06-30
SG11201701183YA (en) 2017-04-27
CN107074848B (zh) 2019-11-01
UY36314A (es) 2016-04-29
PL3197892T3 (pl) 2019-05-31
CL2017000705A1 (es) 2017-11-03
JO3413B1 (ar) 2019-10-20
US20190275016A1 (en) 2019-09-12
TW201629056A (zh) 2016-08-16
AU2015320858A1 (en) 2017-03-09
KR101998000B1 (ko) 2019-07-08
AR101994A1 (es) 2017-01-25
EP3428167A1 (en) 2019-01-16
MX2017003948A (es) 2017-06-26
MA40580B1 (fr) 2018-09-28
PH12017500361A1 (en) 2017-07-17
BR112017006251A2 (pt) 2017-12-12
PE20170502A1 (es) 2017-04-27
WO2016046225A1 (en) 2016-03-31
CA2962315A1 (en) 2016-03-31
CY1121071T1 (el) 2019-12-11
UA119181C2 (uk) 2019-05-10
JP6611799B2 (ja) 2019-11-27
KR20170055489A (ko) 2017-05-19
GB201417002D0 (en) 2014-11-12
IL250592A0 (en) 2017-04-30
US10342783B2 (en) 2019-07-09
ES2690748T3 (es) 2018-11-22
US9956209B2 (en) 2018-05-01
DK3197892T3 (en) 2018-11-26
PH12017500361B1 (en) 2017-07-17
AU2015320858B2 (en) 2018-10-18
JP2017528507A (ja) 2017-09-28
HRP20181796T1 (hr) 2018-12-28
LT3197892T (lt) 2018-12-10
SI3197892T1 (sl) 2018-12-31
US20170290817A1 (en) 2017-10-12
PT3197892T (pt) 2018-12-12
US20180271845A1 (en) 2018-09-27
MA40580A (fr) 2017-08-02
RS58000B1 (sr) 2019-01-31
EA031481B1 (ru) 2019-01-31
EA201790715A1 (ru) 2017-07-31

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