PE20171259A1 - Compuestos - Google Patents
CompuestosInfo
- Publication number
- PE20171259A1 PE20171259A1 PE2017001084A PE2017001084A PE20171259A1 PE 20171259 A1 PE20171259 A1 PE 20171259A1 PE 2017001084 A PE2017001084 A PE 2017001084A PE 2017001084 A PE2017001084 A PE 2017001084A PE 20171259 A1 PE20171259 A1 PE 20171259A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- ethyl
- methyl
- refers
- kidney disease
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se refiere a un compuesto de formula (I) en la que R1 es heteroarilo opcionalmente sustituido con metilo, etilo, halo o =O; R2 es H, metilo o etilo, o una sal del mismo. Es un compuesto seleccionado el acido 3-(5-cloro-6-(1-(piridin-2-il)etoxi)benzo[d]isoxazol-3-il)propanoico; entre otros. Tambien se refiere a una composicion. Dicho compuesto es un inhibidor de KMO siendo util en el tratamiento de pancreatitis aguda, enfermedad renal cronica, enfermedad renal aguda, entre otros
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201422727 | 2014-12-19 | ||
GBGB1508866.9A GB201508866D0 (en) | 2015-05-22 | 2015-05-22 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20171259A1 true PE20171259A1 (es) | 2017-08-28 |
Family
ID=54850210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017001084A PE20171259A1 (es) | 2014-12-19 | 2015-12-17 | Compuestos |
Country Status (26)
Country | Link |
---|---|
US (2) | US9932328B2 (es) |
EP (1) | EP3233844B1 (es) |
JP (1) | JP6644790B2 (es) |
KR (1) | KR102557791B1 (es) |
CN (1) | CN107108594B (es) |
AU (1) | AU2015367396C1 (es) |
BR (1) | BR112017013193B1 (es) |
CA (1) | CA2969385C (es) |
CL (1) | CL2017001549A1 (es) |
CO (1) | CO2017005872A2 (es) |
CR (1) | CR20170261A (es) |
DO (1) | DOP2017000141A (es) |
EA (1) | EA033632B1 (es) |
ES (1) | ES2737893T3 (es) |
IL (1) | IL252155B (es) |
JO (1) | JO3656B1 (es) |
MX (1) | MX2017008069A (es) |
NZ (1) | NZ732002A (es) |
PE (1) | PE20171259A1 (es) |
PH (1) | PH12017500993A1 (es) |
SG (1) | SG11201703807VA (es) |
TW (1) | TWI698433B (es) |
UA (1) | UA120381C2 (es) |
UY (1) | UY36451A (es) |
WO (1) | WO2016097144A1 (es) |
ZA (1) | ZA201702918B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA033632B1 (ru) * | 2014-12-19 | 2019-11-12 | Glaxosmithkline Ip Dev Ltd | 3-(6-АЛКОКСИ-5-ХЛОРБЕНЗО[d]ИЗОКСАЗОЛ-3-ИЛ)ПРОПИОНОВАЯ КИСЛОТА, ПОЛЕЗНАЯ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНУРЕНИНМОНООКСИГЕНАЗЫ |
KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7622495B2 (en) * | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
EP2152679A1 (en) * | 2007-05-24 | 2010-02-17 | NeuroSearch A/S | Benzisoxazole derivatives as potassium channel modulators for the treatment of e.g. respiratory diseases, epilepsy and convulsions |
WO2010011302A1 (en) | 2008-07-22 | 2010-01-28 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
WO2010017132A1 (en) * | 2008-08-04 | 2010-02-11 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
KR20120131161A (ko) * | 2010-01-25 | 2012-12-04 | 씨에이치디아이 파운데이션, 인코포레이티드 | 특정 키뉴레닌-3-모노옥시게나제 억제제, 그의 제약 조성물 및 사용 방법 |
BR112014004845A2 (pt) * | 2011-08-30 | 2017-04-04 | Chdi Foundation Inc | pelo menos uma entidade química; pelo menos um composto; composição farmacêutica; uso de uma quantidade terapeuticamente eficaz de pelo menos uma entidade química; composição farmacêutica embalada |
GB201322512D0 (en) * | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
EA033632B1 (ru) * | 2014-12-19 | 2019-11-12 | Glaxosmithkline Ip Dev Ltd | 3-(6-АЛКОКСИ-5-ХЛОРБЕНЗО[d]ИЗОКСАЗОЛ-3-ИЛ)ПРОПИОНОВАЯ КИСЛОТА, ПОЛЕЗНАЯ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНУРЕНИНМОНООКСИГЕНАЗЫ |
-
2015
- 2015-12-17 EA EA201791402A patent/EA033632B1/ru not_active IP Right Cessation
- 2015-12-17 CA CA2969385A patent/CA2969385C/en active Active
- 2015-12-17 TW TW104142406A patent/TWI698433B/zh active
- 2015-12-17 WO PCT/EP2015/080221 patent/WO2016097144A1/en active Application Filing
- 2015-12-17 KR KR1020177016276A patent/KR102557791B1/ko active IP Right Grant
- 2015-12-17 NZ NZ732002A patent/NZ732002A/en unknown
- 2015-12-17 SG SG11201703807VA patent/SG11201703807VA/en unknown
- 2015-12-17 JP JP2017532625A patent/JP6644790B2/ja active Active
- 2015-12-17 AU AU2015367396A patent/AU2015367396C1/en active Active
- 2015-12-17 EP EP15810681.5A patent/EP3233844B1/en active Active
- 2015-12-17 CN CN201580068887.0A patent/CN107108594B/zh active Active
- 2015-12-17 UA UAA201707042A patent/UA120381C2/uk unknown
- 2015-12-17 ES ES15810681T patent/ES2737893T3/es active Active
- 2015-12-17 MX MX2017008069A patent/MX2017008069A/es active IP Right Grant
- 2015-12-17 UY UY0001036451A patent/UY36451A/es active IP Right Grant
- 2015-12-17 US US15/537,805 patent/US9932328B2/en active Active
- 2015-12-17 CR CR20170261A patent/CR20170261A/es unknown
- 2015-12-17 BR BR112017013193-5A patent/BR112017013193B1/pt active IP Right Grant
- 2015-12-17 PE PE2017001084A patent/PE20171259A1/es unknown
- 2015-12-17 JO JOP/2015/0324A patent/JO3656B1/ar active
-
2017
- 2017-04-26 ZA ZA2017/02918A patent/ZA201702918B/en unknown
- 2017-05-08 IL IL252155A patent/IL252155B/en active IP Right Grant
- 2017-05-29 PH PH12017500993A patent/PH12017500993A1/en unknown
- 2017-06-14 DO DO2017000141A patent/DOP2017000141A/es unknown
- 2017-06-14 CO CONC2017/0005872A patent/CO2017005872A2/es unknown
- 2017-06-15 CL CL2017001549A patent/CL2017001549A1/es unknown
-
2018
- 2018-02-20 US US15/900,043 patent/US10273232B2/en active Active
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