ECSP21013620A - Inhibición de la integrina alfa v beta 6 - Google Patents

Inhibición de la integrina alfa v beta 6

Info

Publication number
ECSP21013620A
ECSP21013620A ECSENADI202113620A ECDI202113620A ECSP21013620A EC SP21013620 A ECSP21013620 A EC SP21013620A EC SENADI202113620 A ECSENADI202113620 A EC SENADI202113620A EC DI202113620 A ECDI202113620 A EC DI202113620A EC SP21013620 A ECSP21013620 A EC SP21013620A
Authority
EC
Ecuador
Prior art keywords
beta
alpha
inhibition
assay
integrin
Prior art date
Application number
ECSENADI202113620A
Other languages
English (en)
Inventor
Bruce Rogers
Cheng Zhong
Kyle Konze
Blaise Lippa
Qi Qiao
Bryce A Harrison
Tyler Day
James Dowling
Aleksey I Gerasyuto;
Kristopher Hahn
Mats Svensson
Eugene Hickey
Byungchan Kim
fu-yang Lin
Dawn Troast
Matthew Bursavich
Brian Sosa
Andrea Bortolato
Original Assignee
Morphic Therapeutic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphic Therapeutic Inc filed Critical Morphic Therapeutic Inc
Publication of ECSP21013620A publication Critical patent/ECSP21013620A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen inhibidores de molécula pequeña de la integrina alfa V beta 6, y métodos para usarlos para tratar una serie de enfermedades y afecciones. Los solicitantes han descubierto nuevos compuestos inhibidores de la integrina alfa V beta 6 y han evaluado la posesión, el rendimiento y la utilidad de ejemplos representativos de tales compuestos, tanto para la potencia bioquímica (por ejemplo, mediante el uso del ensayo del Ejemplo 35 para evaluar los ensayos de polarización de fluorescencia de compuestos para la unión de alfa V beta 6) como las propiedades de permeabilidad in vitro (por ejemplo, mediante el uso del ensayo del Ejemplo 36 para evaluar la permeabilidad en MDCK).
ECSENADI202113620A 2018-08-29 2021-02-26 Inhibición de la integrina alfa v beta 6 ECSP21013620A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862724423P 2018-08-29 2018-08-29
US201962859457P 2019-06-10 2019-06-10

Publications (1)

Publication Number Publication Date
ECSP21013620A true ECSP21013620A (es) 2021-05-31

Family

ID=67809398

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202113620A ECSP21013620A (es) 2018-08-29 2021-02-26 Inhibición de la integrina alfa v beta 6

Country Status (22)

Country Link
US (4) US20200071322A1 (es)
EP (2) EP3617206A1 (es)
JP (1) JP2021535141A (es)
KR (1) KR20210065935A (es)
CN (1) CN112805001A (es)
AU (1) AU2019327475A1 (es)
BR (1) BR112021003859A2 (es)
CA (1) CA3109534A1 (es)
CL (1) CL2021000484A1 (es)
CO (1) CO2021002706A2 (es)
CR (1) CR20210109A (es)
DO (1) DOP2021000035A (es)
EC (1) ECSP21013620A (es)
IL (1) IL280782A (es)
MA (1) MA51066A (es)
MX (1) MX2021002181A (es)
PE (1) PE20211640A1 (es)
PH (1) PH12021550404A1 (es)
SG (1) SG11202101913PA (es)
TW (1) TW202035400A (es)
UY (1) UY38353A (es)
WO (1) WO2020047239A1 (es)

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DK3761980T3 (da) 2018-03-07 2024-01-29 Pliant Therapeutics Inc Aminosyreforbindelser og fremgangsmåder til anvendelse
CU24693B1 (es) 2018-06-27 2024-02-07 Pliant Therapeutics Inc Compuestos de aminoácido con enlazadores no ramificados como inhibidores de la integrina
PE20211640A1 (es) 2018-08-29 2021-08-24 Morphic Therapeutic Inc INHIBICION DE LA INTEGRINA xvß6
TW202028179A (zh) 2018-10-08 2020-08-01 美商普萊恩醫療公司 胺基酸化合物及使用方法
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Also Published As

Publication number Publication date
MA51066A (fr) 2020-10-14
BR112021003859A2 (pt) 2021-05-18
KR20210065935A (ko) 2021-06-04
PE20211640A1 (es) 2021-08-24
PH12021550404A1 (en) 2021-10-04
IL280782A (en) 2021-04-29
US11739087B2 (en) 2023-08-29
JP2021535141A (ja) 2021-12-16
TW202035400A (zh) 2020-10-01
EP3617206A1 (en) 2020-03-04
US11021480B2 (en) 2021-06-01
US20200071322A1 (en) 2020-03-05
US20200385384A1 (en) 2020-12-10
UY38353A (es) 2020-03-31
US20220073511A1 (en) 2022-03-10
AU2019327475A1 (en) 2021-03-11
CO2021002706A2 (es) 2021-05-20
CN112805001A (zh) 2021-05-14
EP4086254A1 (en) 2022-11-09
WO2020047239A1 (en) 2020-03-05
MX2021002181A (es) 2021-07-15
SG11202101913PA (en) 2021-03-30
US20200354359A1 (en) 2020-11-12
CR20210109A (es) 2021-06-24
CL2021000484A1 (es) 2021-09-03
DOP2021000035A (es) 2021-06-30
CA3109534A1 (en) 2020-03-05

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