JP2013537240A5 - - Google Patents
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- Publication number
- JP2013537240A5 JP2013537240A5 JP2013529411A JP2013529411A JP2013537240A5 JP 2013537240 A5 JP2013537240 A5 JP 2013537240A5 JP 2013529411 A JP2013529411 A JP 2013529411A JP 2013529411 A JP2013529411 A JP 2013529411A JP 2013537240 A5 JP2013537240 A5 JP 2013537240A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- hydroxy
- alkoxy
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 104
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 56
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 40
- 125000003545 alkoxy group Chemical group 0.000 claims description 36
- 125000004122 cyclic group Chemical group 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 24
- 150000002431 hydrogen Chemical class 0.000 claims description 24
- 150000001412 amines Chemical class 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 17
- 125000001188 haloalkyl group Chemical group 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 125000001931 aliphatic group Chemical group 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 125000000524 functional group Chemical group 0.000 claims description 12
- 125000005842 heteroatom Chemical group 0.000 claims description 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 206010012601 diabetes mellitus Diseases 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 3
- 206010022489 Insulin Resistance Diseases 0.000 claims description 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 3
- -1 tautomers Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
- 208000008589 Obesity Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38444610P | 2010-09-20 | 2010-09-20 | |
| US61/384,446 | 2010-09-20 | ||
| PCT/US2011/052318 WO2012040177A1 (en) | 2010-09-20 | 2011-09-20 | Methods and compositions for treatment of diabetes and dyslipidemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537240A JP2013537240A (ja) | 2013-09-30 |
| JP2013537240A5 true JP2013537240A5 (enExample) | 2014-10-23 |
Family
ID=45818296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529411A Pending JP2013537240A (ja) | 2010-09-20 | 2011-09-20 | 糖尿病および脂質異常症の処置のための方法および組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8623897B2 (enExample) |
| EP (1) | EP2618824A4 (enExample) |
| JP (1) | JP2013537240A (enExample) |
| KR (1) | KR20140009125A (enExample) |
| CN (1) | CN103327974A (enExample) |
| AU (1) | AU2011305610A1 (enExample) |
| BR (1) | BR112013008675A2 (enExample) |
| CA (1) | CA2812109A1 (enExample) |
| MX (1) | MX2013003078A (enExample) |
| RU (1) | RU2013118021A (enExample) |
| SG (1) | SG188996A1 (enExample) |
| WO (1) | WO2012040177A1 (enExample) |
| ZA (1) | ZA201301936B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013537240A (ja) * | 2010-09-20 | 2013-09-30 | カリウス セラピューティクス エスエー | 糖尿病および脂質異常症の処置のための方法および組成物 |
| US20140121267A1 (en) * | 2011-09-20 | 2014-05-01 | Kareus Therapeutics, Sa | Methods and compositions for treatment of diabetes and dyslipidemia |
| WO2014162320A2 (en) * | 2013-04-04 | 2014-10-09 | Sphaera Pharma Pvt. Ltd. | Novel analogues of epicatechin and related polyphenols |
| US9827222B2 (en) | 2013-07-01 | 2017-11-28 | Emory University | Treating or preventing nephrogenic diabetes insipidus |
| WO2015143276A1 (en) * | 2014-03-20 | 2015-09-24 | Esperion Therapeutics, Inc. | Carboxy-cyclopropyl undecanol compounds for treatment of liver disease and other medical disorders |
| SG10201908500UA (en) | 2015-03-13 | 2019-11-28 | Esperion Therapeutics Inc | Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| CN107118098B (zh) * | 2016-02-25 | 2020-07-14 | 中国科学院上海药物研究所 | 一类脂肪酸类化合物、其制备方法及其用途 |
| PL3618821T3 (pl) | 2017-01-31 | 2025-07-07 | Nephrodi Therapeutics, Inc. | Postępowanie w przypadku nerkopochodnej moczówki prostej |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3280169A (en) * | 1962-09-18 | 1966-10-18 | Union Carbide Corp | Sulfo-substituted aromatic dicarboxylic compounds |
| US3773946A (en) | 1969-09-02 | 1973-11-20 | Parke Davis & Co | Triglyceride-lowering compositions and methods |
| US3853951A (en) * | 1971-07-14 | 1974-12-10 | American Cyanamid Co | Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone |
| IL64542A0 (en) | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
| DE3423166A1 (de) | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US4739113A (en) * | 1986-05-30 | 1988-04-19 | Merck & Co., Inc. | Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors |
| JPS63246351A (ja) * | 1987-04-02 | 1988-10-13 | Rikagaku Kenkyusho | ポリケト−ル系化合物及びその合成法 |
| US5648387A (en) | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
| FR2740135B1 (fr) | 1995-10-20 | 1997-12-19 | Roussel Uclaf | Nouveaux derives de pyrazoles acides, leur procede de preparation, leur application a titre de medicaments, leur nouvelle utilisation et les compositions pharmaceutiques les renfermant |
| IL119971A (en) | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
| JPH10273469A (ja) * | 1997-02-03 | 1998-10-13 | Takeda Chem Ind Ltd | ２環性キノン誘導体、製造法および剤 |
| DE19837620A1 (de) | 1997-08-22 | 1999-02-25 | Novartis Ag | Organische Verbindungen |
| KR100643419B1 (ko) | 1998-03-27 | 2006-11-10 | 얀센 파마슈티카 엔.브이. | Ｈｉｖ를 억제하는 피리미딘 유도체 |
| ES2193660T3 (es) | 1998-03-27 | 2003-11-01 | Janssen Pharmaceutica Nv | Derivados de pirimidina inhibidores de vih. |
| US6387897B1 (en) | 1998-06-30 | 2002-05-14 | Neuromed Technologies, Inc. | Preferentially substituted calcium channel blockers |
| WO2000020390A1 (en) | 1998-10-07 | 2000-04-13 | Georgetown University | Monomeric and dimeric heterocycles, and therapeutic uses thereof |
| EP1130469A1 (en) | 2000-02-22 | 2001-09-05 | Lucent Technologies Inc. | A radiation-sensitive resist material and a process for device fabrication using the same |
| DE10010430A1 (de) | 2000-03-03 | 2001-09-06 | Bayer Ag | Substituierte 5-Ethyl-dihydropyridazinone und ihre Verwendung |
| IL155213A0 (en) | 2000-10-11 | 2003-11-23 | Esperion Therapeutics Inc | Ketone compounds and compositions for cholesterol management and related uses |
| US6540795B2 (en) | 2001-04-02 | 2003-04-01 | Ciba Specialty Chemicals Corporation | Candle wax stabilized with oxazolidines |
| US6547840B2 (en) | 2001-04-02 | 2003-04-15 | Ciba Specialty Chemicals Corporation | Candle wax stabilized with imidazolidines |
| JP2004523638A (ja) | 2001-04-02 | 2004-08-05 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | 安定化したロウソクのロウ |
| US6905525B2 (en) | 2001-04-02 | 2005-06-14 | Ciba Specialty Chemicals Corporation | Candle wax stabilized with piperazinones |
| US6562084B2 (en) | 2001-04-02 | 2003-05-13 | Ciba Specialty Chemicals Corporation | Candle wax stabilized with piperazindiones |
| US6544305B2 (en) | 2001-04-02 | 2003-04-08 | Ciba Specialty Chemicals Corporation | Candle wax stabilized with piperazinones |
| US6544304B2 (en) | 2001-04-02 | 2003-04-08 | Ciba Specialty Chemicals Corporation | Candle wax stabilized with morpholinones |
| JP4009251B2 (ja) * | 2001-10-09 | 2007-11-14 | 杏林製薬株式会社 | 新規な４−（２−フロイル）アミノピペリジン、その合成中間体、その製造方法および医薬としてのその用途 |
| US20040082641A1 (en) | 2002-10-28 | 2004-04-29 | Rytved Klaus Asger | Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases |
| DK2404890T3 (en) | 2003-01-23 | 2017-10-16 | Esperion Therapeutics Inc | Hydroxyl compounds and compositions for controlling cholesterol and related uses |
| US7705177B2 (en) * | 2003-12-24 | 2010-04-27 | Esperion Therapuetics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| AU2003300438A1 (en) | 2003-12-24 | 2005-08-03 | Esperion Therapeutics, Inc. | Ether compounds and compositions for cholesterol management and related uses |
| FR2903695B1 (fr) * | 2006-07-13 | 2008-10-24 | Merck Sante Soc Par Actions Si | Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| IL181577A0 (en) * | 2007-02-26 | 2007-07-04 | Jacob Bar Tana | Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders |
| JP5345293B2 (ja) | 2007-03-29 | 2013-11-20 | 株式会社Ａｄｅｋａ | 重合性化合物及び重合性組成物 |
| US8252389B2 (en) | 2007-09-25 | 2012-08-28 | MERCK Patent Gesellschaft mit beschränkter Haftung | Mesogenic dimers |
| JP2013537240A (ja) * | 2010-09-20 | 2013-09-30 | カリウス セラピューティクス エスエー | 糖尿病および脂質異常症の処置のための方法および組成物 |
-
2011
- 2011-09-20 JP JP2013529411A patent/JP2013537240A/ja active Pending
- 2011-09-20 CN CN2011800558120A patent/CN103327974A/zh active Pending
- 2011-09-20 BR BR112013008675A patent/BR112013008675A2/pt not_active IP Right Cessation
- 2011-09-20 SG SG2013018833A patent/SG188996A1/en unknown
- 2011-09-20 EP EP11827340.8A patent/EP2618824A4/en not_active Withdrawn
- 2011-09-20 KR KR1020137007110A patent/KR20140009125A/ko not_active Withdrawn
- 2011-09-20 WO PCT/US2011/052318 patent/WO2012040177A1/en not_active Ceased
- 2011-09-20 AU AU2011305610A patent/AU2011305610A1/en not_active Abandoned
- 2011-09-20 US US13/236,807 patent/US8623897B2/en active Active
- 2011-09-20 MX MX2013003078A patent/MX2013003078A/es not_active Application Discontinuation
- 2011-09-20 RU RU2013118021/15A patent/RU2013118021A/ru not_active Application Discontinuation
- 2011-09-20 CA CA2812109A patent/CA2812109A1/en not_active Abandoned
-
2013
- 2013-03-14 ZA ZA2013/01936A patent/ZA201301936B/en unknown
-
2014
- 2014-01-06 US US14/148,580 patent/US20140142178A1/en not_active Abandoned