JP2009120598A5 - - Google Patents
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- Publication number
- JP2009120598A5 JP2009120598A5 JP2008273676A JP2008273676A JP2009120598A5 JP 2009120598 A5 JP2009120598 A5 JP 2009120598A5 JP 2008273676 A JP2008273676 A JP 2008273676A JP 2008273676 A JP2008273676 A JP 2008273676A JP 2009120598 A5 JP2009120598 A5 JP 2009120598A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- solvate
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 38
- 239000012453 solvate Substances 0.000 claims 28
- 125000003003 spiro group Chemical group 0.000 claims 25
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 201000001421 hyperglycemia Diseases 0.000 claims 3
- DGENZVKCTGIDRZ-UHFFFAOYSA-N 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid Chemical compound C1=CC(CCC(=O)O)=CC=C1NCC1=CC=CC(OC=2C=CC=CC=2)=C1 DGENZVKCTGIDRZ-UHFFFAOYSA-N 0.000 claims 2
- 229940125827 GPR40 agonist Drugs 0.000 claims 2
- 208000002705 Glucose Intolerance Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940126904 hypoglycaemic agent Drugs 0.000 claims 2
- 230000003914 insulin secretion Effects 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 201000009104 prediabetes syndrome Diseases 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 claims 1
- 229940122199 Insulin secretagogue Drugs 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000010030 glucose lowering effect Effects 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008273676A JP4568779B2 (ja) | 2007-10-26 | 2008-10-24 | スピロ環化合物及びその医薬用途 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007279697 | 2007-10-26 | ||
| JP2008273676A JP4568779B2 (ja) | 2007-10-26 | 2008-10-24 | スピロ環化合物及びその医薬用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010165678A Division JP2010270137A (ja) | 2007-10-26 | 2010-07-23 | スピロ環化合物及びその医薬用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009120598A JP2009120598A (ja) | 2009-06-04 |
| JP2009120598A5 true JP2009120598A5 (enExample) | 2010-04-22 |
| JP4568779B2 JP4568779B2 (ja) | 2010-10-27 |
Family
ID=40579581
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008273676A Expired - Fee Related JP4568779B2 (ja) | 2007-10-26 | 2008-10-24 | スピロ環化合物及びその医薬用途 |
| JP2010165678A Pending JP2010270137A (ja) | 2007-10-26 | 2010-07-23 | スピロ環化合物及びその医薬用途 |
| JP2014158380A Pending JP2014221829A (ja) | 2007-10-26 | 2014-08-04 | スピロ環化合物及びその医薬用途 |
| JP2016001396A Ceased JP2016102130A (ja) | 2007-10-26 | 2016-01-06 | スピロ環化合物及びその医薬用途 |
| JP2017049246A Pending JP2017132787A (ja) | 2007-10-26 | 2017-03-14 | スピロ環化合物及びその医薬用途 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010165678A Pending JP2010270137A (ja) | 2007-10-26 | 2010-07-23 | スピロ環化合物及びその医薬用途 |
| JP2014158380A Pending JP2014221829A (ja) | 2007-10-26 | 2014-08-04 | スピロ環化合物及びその医薬用途 |
| JP2016001396A Ceased JP2016102130A (ja) | 2007-10-26 | 2016-01-06 | スピロ環化合物及びその医薬用途 |
| JP2017049246A Pending JP2017132787A (ja) | 2007-10-26 | 2017-03-14 | スピロ環化合物及びその医薬用途 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8299296B2 (enExample) |
| EP (3) | EP2202216B1 (enExample) |
| JP (5) | JP4568779B2 (enExample) |
| KR (1) | KR101565622B1 (enExample) |
| CN (1) | CN101835737B (enExample) |
| AR (1) | AR071055A1 (enExample) |
| AU (1) | AU2008314933B2 (enExample) |
| BR (1) | BRPI0818687A2 (enExample) |
| CA (1) | CA2704013C (enExample) |
| CL (1) | CL2008003153A1 (enExample) |
| CO (1) | CO6321230A2 (enExample) |
| CY (1) | CY1113352T1 (enExample) |
| DK (1) | DK2202216T3 (enExample) |
| ES (1) | ES2386596T3 (enExample) |
| HR (1) | HRP20120696T1 (enExample) |
| IL (1) | IL205283A (enExample) |
| ME (1) | ME02338B (enExample) |
| MX (1) | MX2010004435A (enExample) |
| MY (1) | MY148469A (enExample) |
| NZ (1) | NZ584161A (enExample) |
| PE (1) | PE20091014A1 (enExample) |
| PL (1) | PL2202216T3 (enExample) |
| PT (1) | PT2202216E (enExample) |
| RS (1) | RS52474B (enExample) |
| RU (1) | RU2490250C2 (enExample) |
| SI (1) | SI2202216T1 (enExample) |
| TW (1) | TWI421070B (enExample) |
| WO (1) | WO2009054479A1 (enExample) |
| ZA (1) | ZA201002305B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009012929A (es) * | 2007-06-11 | 2009-12-14 | Givaudan Sa | Compuestos organicos. |
| EP2202216B1 (en) * | 2007-10-26 | 2012-06-27 | Japan Tobacco Inc. | Spiro-ring compound and use thereof for medical purposes |
| WO2009157418A1 (ja) * | 2008-06-25 | 2009-12-30 | 第一三共株式会社 | カルボン酸化合物 |
| CA2765743A1 (en) | 2009-06-29 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane |
| PL2448910T3 (pl) * | 2009-06-29 | 2013-10-31 | Merz Pharma Gmbh & Co Kgaa | Sposób wytwarzania nerameksanu |
| WO2011000540A1 (en) * | 2009-06-29 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing 3,3,5,5-tetramethylcyclohexanone |
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| AR078522A1 (es) * | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
| AR078948A1 (es) * | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
| RU2567755C2 (ru) | 2009-12-25 | 2015-11-10 | Мотида Фармасьютикал Ко., Лтд. | Новое производное 3-гидрокси-5-арилизотиазола |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US9040525B2 (en) | 2010-10-08 | 2015-05-26 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
| WO2012104206A1 (de) | 2011-02-01 | 2012-08-09 | Boehringer Ingelheim International Gmbh | 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-chinazolin-6- yloxy]-1,4-diaza-spiro[5.5]undecan-5-on dimaleat, dessen verwendung als arzneimittel und dessen herstellung |
| US8557766B2 (en) | 2011-04-27 | 2013-10-15 | Mochida Pharmaceutical Co., Ltd. | 3-hydroxyisothiazole 1-oxide derivatives |
| WO2012147516A1 (ja) | 2011-04-28 | 2012-11-01 | 持田製薬株式会社 | 環状アミド誘導体 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2875020B1 (en) | 2012-07-19 | 2017-09-06 | Boehringer Ingelheim International GmbH | Process for the preparation of a fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| TWI692469B (zh) | 2012-11-09 | 2020-05-01 | 南韓商Ｌｇ化學股份有限公司 | Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
| CA2891574A1 (en) | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
| KR101569522B1 (ko) | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| WO2015084692A1 (en) | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| EP3102198B1 (en) | 2014-02-06 | 2020-08-26 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| DK3107901T3 (da) | 2014-02-19 | 2020-06-22 | Piramal Entpr Ltd | Forbindelser til brug som gpr120 agonister |
| CA2955919A1 (en) | 2014-07-25 | 2016-01-28 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof |
| AU2015313829B2 (en) | 2014-09-11 | 2020-07-23 | Piramal Enterprises Limited | Fused heterocyclic compounds as GPR120 agonists |
| EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
| US11186565B2 (en) | 2017-03-31 | 2021-11-30 | Takeda Pharmaceutical Company Limited | Aromatic compound |
| MY196582A (en) | 2018-02-13 | 2023-04-19 | Gilead Sciences Inc | PD-1/PD-L1 Inhibitors |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
| EP3870566A1 (en) | 2018-10-24 | 2021-09-01 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ，インク． | Ｇｐｒ４０アゴニスト |
| BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CN115181023B (zh) * | 2022-05-17 | 2023-07-28 | 东华理工大学 | 螺环活性增塑剂及其制备方法 |
| WO2025037230A1 (en) * | 2023-08-11 | 2025-02-20 | Life Code Limited | Compositions, agents and preparations for promoting hair growth and/or mitigating hair loss |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4331179A1 (de) * | 1993-09-14 | 1995-03-16 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| GB9927056D0 (en) | 1999-11-17 | 2000-01-12 | Karobio Ab | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders |
| ATE371008T1 (de) * | 2002-10-14 | 2007-09-15 | Firmenich & Cie | Spiroverbindungen als duftstoffe |
| CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| US7820837B2 (en) | 2003-05-30 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
| JP4922615B2 (ja) * | 2003-11-26 | 2012-04-25 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| RU2006126978A (ru) * | 2003-12-25 | 2008-01-27 | Такеда Фармасьютикал Компани Лимитед (Jp) | Производные 3-(4-бензилоксифенил)пропановой кислоты |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | ３−（４−ベンジルオキシフェニル）プロパン酸誘導体 |
| KR20070004769A (ko) | 2004-02-27 | 2007-01-09 | 암젠 인코포레이션 | 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법 |
| EP1731505B1 (en) * | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| JP2007284350A (ja) | 2004-07-27 | 2007-11-01 | Takeda Chem Ind Ltd | 糖尿病治療剤 |
| US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| EP1924546A1 (en) * | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| US7714008B2 (en) | 2006-09-07 | 2010-05-11 | Amgen Inc. | Heterocyclic GPR40 modulators |
| EP2061760A1 (en) | 2006-09-07 | 2009-05-27 | Amgen, Inc | Benzo-fused compounds for use in treating metabolic disorders |
| EP2202216B1 (en) * | 2007-10-26 | 2012-06-27 | Japan Tobacco Inc. | Spiro-ring compound and use thereof for medical purposes |
| WO2009157418A1 (ja) | 2008-06-25 | 2009-12-30 | 第一三共株式会社 | カルボン酸化合物 |
-
2008
- 2008-10-24 EP EP08841970A patent/EP2202216B1/en active Active
- 2008-10-24 BR BRPI0818687A patent/BRPI0818687A2/pt not_active IP Right Cessation
- 2008-10-24 RS RS20120400A patent/RS52474B/sr unknown
- 2008-10-24 EP EP13184140.5A patent/EP2684861A3/en not_active Withdrawn
- 2008-10-24 EP EP12173164A patent/EP2508503A1/en not_active Withdrawn
- 2008-10-24 SI SI200830752T patent/SI2202216T1/sl unknown
- 2008-10-24 TW TW097140805A patent/TWI421070B/zh not_active IP Right Cessation
- 2008-10-24 RU RU2010121160/04A patent/RU2490250C2/ru not_active IP Right Cessation
- 2008-10-24 KR KR1020107011427A patent/KR101565622B1/ko not_active Expired - Fee Related
- 2008-10-24 CL CL2008003153A patent/CL2008003153A1/es unknown
- 2008-10-24 MY MYPI2010001866A patent/MY148469A/en unknown
- 2008-10-24 CN CN2008801132388A patent/CN101835737B/zh not_active Expired - Fee Related
- 2008-10-24 MX MX2010004435A patent/MX2010004435A/es active IP Right Grant
- 2008-10-24 NZ NZ584161A patent/NZ584161A/en not_active IP Right Cessation
- 2008-10-24 AU AU2008314933A patent/AU2008314933B2/en not_active Ceased
- 2008-10-24 AR ARP080104642A patent/AR071055A1/es not_active Application Discontinuation
- 2008-10-24 ES ES08841970T patent/ES2386596T3/es active Active
- 2008-10-24 JP JP2008273676A patent/JP4568779B2/ja not_active Expired - Fee Related
- 2008-10-24 PT PT08841970T patent/PT2202216E/pt unknown
- 2008-10-24 PE PE2008001826A patent/PE20091014A1/es not_active Application Discontinuation
- 2008-10-24 WO PCT/JP2008/069296 patent/WO2009054479A1/ja not_active Ceased
- 2008-10-24 PL PL08841970T patent/PL2202216T3/pl unknown
- 2008-10-24 DK DK08841970.0T patent/DK2202216T3/da active
- 2008-10-24 CA CA2704013A patent/CA2704013C/en not_active Expired - Fee Related
- 2008-10-24 US US12/258,033 patent/US8299296B2/en not_active Expired - Fee Related
- 2008-10-24 ME MEP-2016-195A patent/ME02338B/me unknown
- 2008-10-24 HR HRP20120696AT patent/HRP20120696T1/hr unknown
-
2010
- 2010-03-31 ZA ZA2010/02305A patent/ZA201002305B/en unknown
- 2010-04-22 IL IL205283A patent/IL205283A/en not_active IP Right Cessation
- 2010-05-26 CO CO10062839A patent/CO6321230A2/es active IP Right Grant
- 2010-07-23 JP JP2010165678A patent/JP2010270137A/ja active Pending
-
2012
- 2012-08-22 CY CY20121100753T patent/CY1113352T1/el unknown
- 2012-09-14 US US13/616,389 patent/US20130109710A1/en not_active Abandoned
-
2014
- 2014-08-04 JP JP2014158380A patent/JP2014221829A/ja active Pending
- 2014-11-17 US US14/542,869 patent/US20150299090A1/en not_active Abandoned
-
2016
- 2016-01-06 JP JP2016001396A patent/JP2016102130A/ja not_active Ceased
-
2017
- 2017-03-14 JP JP2017049246A patent/JP2017132787A/ja active Pending
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