JP2014523854A5 - - Google Patents
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- Publication number
- JP2014523854A5 JP2014523854A5 JP2014504057A JP2014504057A JP2014523854A5 JP 2014523854 A5 JP2014523854 A5 JP 2014523854A5 JP 2014504057 A JP2014504057 A JP 2014504057A JP 2014504057 A JP2014504057 A JP 2014504057A JP 2014523854 A5 JP2014523854 A5 JP 2014523854A5
- Authority
- JP
- Japan
- Prior art keywords
- phospholipid
- aromatic compound
- polymer
- liposome composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims 20
- 150000001491 aromatic compounds Chemical class 0.000 claims 13
- 150000003904 phospholipids Chemical class 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000002708 enhancing effect Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 230000002285 radioactive effect Effects 0.000 claims 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 208000037259 Amyloid Plaque Diseases 0.000 claims 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- -1 carboxy, sulfonyl Chemical group 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 125000003147 glycosyl group Chemical group 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims 2
- 229960004359 iodixanol Drugs 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 claims 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000002591 computed tomography Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472605P | 2011-04-06 | 2011-04-06 | |
| US61/472,605 | 2011-04-06 | ||
| PCT/US2012/032649 WO2012139080A2 (en) | 2011-04-06 | 2012-04-06 | Lipid-based nanoparticles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017176383A Division JP6533813B2 (ja) | 2011-04-06 | 2017-09-14 | 脂質ベースのナノ粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523854A JP2014523854A (ja) | 2014-09-18 |
| JP2014523854A5 true JP2014523854A5 (enExample) | 2014-10-30 |
| JP6212032B2 JP6212032B2 (ja) | 2017-10-18 |
Family
ID=46966277
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504057A Expired - Fee Related JP6212032B2 (ja) | 2011-04-06 | 2012-04-06 | 脂質ベースのナノ粒子 |
| JP2017176383A Expired - Fee Related JP6533813B2 (ja) | 2011-04-06 | 2017-09-14 | 脂質ベースのナノ粒子 |
| JP2019098174A Pending JP2019151664A (ja) | 2011-04-06 | 2019-05-27 | 脂質ベースのナノ粒子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017176383A Expired - Fee Related JP6533813B2 (ja) | 2011-04-06 | 2017-09-14 | 脂質ベースのナノ粒子 |
| JP2019098174A Pending JP2019151664A (ja) | 2011-04-06 | 2019-05-27 | 脂質ベースのナノ粒子 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9801957B2 (enExample) |
| EP (2) | EP2694116B1 (enExample) |
| JP (3) | JP6212032B2 (enExample) |
| KR (2) | KR101973063B1 (enExample) |
| CN (1) | CN104144708B (enExample) |
| AU (3) | AU2012239888B9 (enExample) |
| BR (1) | BR112013025633A2 (enExample) |
| CA (1) | CA2831480C (enExample) |
| DK (1) | DK2694116T3 (enExample) |
| ES (1) | ES2685824T3 (enExample) |
| MX (1) | MX357227B (enExample) |
| PL (1) | PL2694116T3 (enExample) |
| PT (1) | PT2694116T (enExample) |
| WO (1) | WO2012139080A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012139080A2 (en) | 2011-04-06 | 2012-10-11 | Board Of Regents Of The University Of Texas System | Lipid-based nanoparticles |
| CA2848994A1 (en) | 2012-01-20 | 2013-07-25 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| US9512092B2 (en) | 2013-12-12 | 2016-12-06 | Albert Einstein College Of Medicine, Inc. | Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof |
| EP3204051B1 (en) * | 2014-10-08 | 2019-05-29 | Texas Children's Hospital | Mri imaging of amyloid plaque using liposomes |
| GB201509934D0 (en) | 2015-06-08 | 2015-07-22 | King S College London | Nanoparticles |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| US11241510B2 (en) | 2016-11-30 | 2022-02-08 | Texas Children's Hospital | Hydrophilic fluorinated molecules for liposomal 19F MRI probes with unique MR signatures |
| JP7545393B2 (ja) * | 2019-01-24 | 2024-09-04 | アルゼカ バイオサイエンシズ、エルエルシー | 誤って折りたたまれたタンパク質を画像化するための機能化リポソーム |
| CN115916263B (zh) * | 2020-01-29 | 2025-10-03 | 德克萨斯儿童医院 | 用于淀粉样蛋白沉积mri的靶向对比剂 |
| US11779664B2 (en) | 2020-02-12 | 2023-10-10 | Texas Children's Hospital | Targeted contrast agents for MRI of alpha-synuclein deposition |
| CN115279424A (zh) * | 2020-02-12 | 2022-11-01 | 德克萨斯儿童医院 | 用于α-突触核蛋白沉积MRI的靶向对比剂 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331751A (en) * | 1980-11-17 | 1982-05-25 | Eastman Kodak Company | Electrically photosensitive materials and elements for photoelectrophoretic imaging processes |
| US5204085A (en) | 1985-01-08 | 1993-04-20 | Mallinckrodt Medical, Inc. | Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents |
| US5674468A (en) | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
| DE69527194T2 (de) | 1994-03-28 | 2003-02-06 | Daiichi Pharmaceutical Co., Ltd. | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
| US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| JP4829454B2 (ja) * | 1999-11-30 | 2011-12-07 | ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ | 放射線感受性リポソーム |
| AU2002211517A1 (en) | 2000-10-04 | 2002-04-15 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| WO2002094191A2 (en) * | 2001-05-23 | 2002-11-28 | New York University | Detection of alzheimer's amyloid by magnetic resonance imaging |
| JP2005519129A (ja) | 2002-03-05 | 2005-06-30 | クリーブランド ステート ユニバーシティー | エアロゾル薬物送達のための凝集粒子 |
| WO2004096120A2 (en) | 2003-05-01 | 2004-11-11 | Nst Neurosurvival Technologies Ltd. | Compounds that selectively bind to membranes of apoptotic cells |
| US7208174B2 (en) | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
| US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
| US7713517B2 (en) | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
| US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| US7803351B2 (en) * | 2004-08-20 | 2010-09-28 | Washington University | Blood brain barrier permeation peptides |
| US20070292354A1 (en) * | 2004-09-23 | 2007-12-20 | Guerbet | Contrast Agents Encapsulating Systems for Cest Imaging |
| US9943481B2 (en) * | 2005-05-26 | 2018-04-17 | Biorest Ltd. | Compositions and methods using same for delivering agents into a target organ protected by a blood barrier |
| WO2007048019A2 (en) * | 2005-10-20 | 2007-04-26 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| WO2008054498A2 (en) * | 2006-04-07 | 2008-05-08 | The Board Of Trustees Of The University Of Illinois | Hydrophilic polymer-conjugated lipids for peptide and protein folding disorders |
| US20090123047A1 (en) | 2007-03-21 | 2009-05-14 | Yfantis Spyros A | Method and system for characterizing prostate images |
| EP1982733A1 (en) | 2007-04-17 | 2008-10-22 | Bayer Schering Pharma Aktiengesellschaft | Use of a contrast agent for magnetic resonance imaging of endoleaks |
| WO2009015397A1 (en) | 2007-07-26 | 2009-01-29 | Nanoscan Imaging, Llc | Methods for imaging using improved nanoparticulate contrast agents |
| US8642013B2 (en) | 2007-12-05 | 2014-02-04 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| CA2711503A1 (en) | 2008-01-08 | 2009-07-16 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
| ITMI20081052A1 (it) * | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
| AU2009257279A1 (en) * | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
| WO2010017094A2 (en) | 2008-07-31 | 2010-02-11 | The General Hospital Corporation | CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING |
| AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| CN102438591A (zh) | 2009-03-19 | 2012-05-02 | 马维尔生物科学公司 | 用于增强成像对比度的组合物和方法 |
| US9334304B2 (en) * | 2009-04-02 | 2016-05-10 | The Johns Hopkins University | Self-assembling peptides bearing organic electronic functionality and applications employing the same |
| US20120263646A1 (en) | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| ES2526124T3 (es) | 2010-06-16 | 2015-01-07 | Cymabay Therapeutics, Inc. | Agonistas del receptor GPR120 y sus usos |
| CN103429226A (zh) | 2011-03-02 | 2013-12-04 | 森苏林公司 | 囊泡组合物 |
| WO2012139080A2 (en) * | 2011-04-06 | 2012-10-11 | Board Of Regents Of The University Of Texas System | Lipid-based nanoparticles |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| CA2848994A1 (en) | 2012-01-20 | 2013-07-25 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| US9377472B2 (en) | 2012-04-30 | 2016-06-28 | Amoneta Diagnostics | Biological complex specific for Alzheimer's disease detection in vitro and use thereof |
| CA2906035A1 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| EP3204051B1 (en) | 2014-10-08 | 2019-05-29 | Texas Children's Hospital | Mri imaging of amyloid plaque using liposomes |
-
2012
- 2012-04-06 WO PCT/US2012/032649 patent/WO2012139080A2/en not_active Ceased
- 2012-04-06 AU AU2012239888A patent/AU2012239888B9/en not_active Ceased
- 2012-04-06 KR KR1020137029510A patent/KR101973063B1/ko not_active Expired - Fee Related
- 2012-04-06 CA CA2831480A patent/CA2831480C/en not_active Expired - Fee Related
- 2012-04-06 BR BR112013025633A patent/BR112013025633A2/pt not_active Application Discontinuation
- 2012-04-06 ES ES12767275.6T patent/ES2685824T3/es active Active
- 2012-04-06 US US13/441,816 patent/US9801957B2/en not_active Expired - Fee Related
- 2012-04-06 EP EP12767275.6A patent/EP2694116B1/en not_active Not-in-force
- 2012-04-06 EP EP18167725.3A patent/EP3366313A1/en not_active Withdrawn
- 2012-04-06 PT PT12767275T patent/PT2694116T/pt unknown
- 2012-04-06 CN CN201280017548.6A patent/CN104144708B/zh not_active Expired - Fee Related
- 2012-04-06 PL PL12767275T patent/PL2694116T3/pl unknown
- 2012-04-06 MX MX2013011231A patent/MX357227B/es active IP Right Grant
- 2012-04-06 DK DK12767275.6T patent/DK2694116T3/en active
- 2012-04-06 KR KR1020197007384A patent/KR102035187B1/ko not_active Expired - Fee Related
- 2012-04-06 JP JP2014504057A patent/JP6212032B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-14 JP JP2017176383A patent/JP6533813B2/ja not_active Expired - Fee Related
- 2017-09-21 AU AU2017232156A patent/AU2017232156C1/en not_active Ceased
-
2019
- 2019-05-27 JP JP2019098174A patent/JP2019151664A/ja active Pending
- 2019-10-08 AU AU2019246775A patent/AU2019246775A1/en not_active Abandoned
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