JP2014523854A5 - - Google Patents
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- Publication number
- JP2014523854A5 JP2014523854A5 JP2014504057A JP2014504057A JP2014523854A5 JP 2014523854 A5 JP2014523854 A5 JP 2014523854A5 JP 2014504057 A JP2014504057 A JP 2014504057A JP 2014504057 A JP2014504057 A JP 2014504057A JP 2014523854 A5 JP2014523854 A5 JP 2014523854A5
- Authority
- JP
- Japan
- Prior art keywords
- phospholipid
- aromatic compound
- polymer
- liposome composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims 20
- 150000001491 aromatic compounds Chemical class 0.000 claims 13
- 150000003904 phospholipids Chemical class 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000002708 enhancing effect Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 230000002285 radioactive effect Effects 0.000 claims 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 208000037259 Amyloid Plaque Diseases 0.000 claims 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- -1 carboxy, sulfonyl Chemical group 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 125000003147 glycosyl group Chemical group 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims 2
- 229960004359 iodixanol Drugs 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 claims 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000002591 computed tomography Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472605P | 2011-04-06 | 2011-04-06 | |
| US61/472,605 | 2011-04-06 | ||
| PCT/US2012/032649 WO2012139080A2 (en) | 2011-04-06 | 2012-04-06 | Lipid-based nanoparticles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017176383A Division JP6533813B2 (ja) | 2011-04-06 | 2017-09-14 | 脂質ベースのナノ粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523854A JP2014523854A (ja) | 2014-09-18 |
| JP2014523854A5 true JP2014523854A5 (enExample) | 2014-10-30 |
| JP6212032B2 JP6212032B2 (ja) | 2017-10-18 |
Family
ID=46966277
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504057A Expired - Fee Related JP6212032B2 (ja) | 2011-04-06 | 2012-04-06 | 脂質ベースのナノ粒子 |
| JP2017176383A Expired - Fee Related JP6533813B2 (ja) | 2011-04-06 | 2017-09-14 | 脂質ベースのナノ粒子 |
| JP2019098174A Pending JP2019151664A (ja) | 2011-04-06 | 2019-05-27 | 脂質ベースのナノ粒子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017176383A Expired - Fee Related JP6533813B2 (ja) | 2011-04-06 | 2017-09-14 | 脂質ベースのナノ粒子 |
| JP2019098174A Pending JP2019151664A (ja) | 2011-04-06 | 2019-05-27 | 脂質ベースのナノ粒子 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9801957B2 (enExample) |
| EP (2) | EP2694116B1 (enExample) |
| JP (3) | JP6212032B2 (enExample) |
| KR (2) | KR102035187B1 (enExample) |
| CN (1) | CN104144708B (enExample) |
| AU (3) | AU2012239888B9 (enExample) |
| BR (1) | BR112013025633A2 (enExample) |
| CA (1) | CA2831480C (enExample) |
| DK (1) | DK2694116T3 (enExample) |
| ES (1) | ES2685824T3 (enExample) |
| MX (1) | MX357227B (enExample) |
| PL (1) | PL2694116T3 (enExample) |
| PT (1) | PT2694116T (enExample) |
| WO (1) | WO2012139080A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012239888B9 (en) * | 2011-04-06 | 2017-10-12 | Alzeca Biosciences, LLC | Lipid-based nanoparticles |
| JP6130401B2 (ja) | 2012-01-20 | 2017-05-17 | アンナプラガダ，アナンス | 医学画像を客観的に特徴付けるための方法および組成物 |
| US9512092B2 (en) * | 2013-12-12 | 2016-12-06 | Albert Einstein College Of Medicine, Inc. | Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof |
| KR102409017B1 (ko) * | 2014-10-08 | 2022-06-16 | 텍사스 칠드런스 하스피탈 | 리포좀을 이용한 아밀로이드 플라크의 mri 영상화 |
| GB201509934D0 (en) | 2015-06-08 | 2015-07-22 | King S College London | Nanoparticles |
| US20170354672A1 (en) * | 2016-05-16 | 2017-12-14 | The Board Of Regents Of The University Of Texas System | Compositions for the delivery of trna as nanoparticles and methods of use therewith |
| WO2018100540A1 (en) * | 2016-11-30 | 2018-06-07 | Texas Children's Hospital | Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures |
| WO2020154623A1 (en) * | 2019-01-24 | 2020-07-30 | Alzeca Biosciences, LLC | Functionalized liposomes for imaging misfolded proteins |
| US11116854B2 (en) * | 2020-01-29 | 2021-09-14 | Texas Children's Hospital | Targeted contrast agents for MRI of amyloid deposition |
| CN115279424A (zh) * | 2020-02-12 | 2022-11-01 | 德克萨斯儿童医院 | 用于α-突触核蛋白沉积MRI的靶向对比剂 |
| US11779664B2 (en) | 2020-02-12 | 2023-10-10 | Texas Children's Hospital | Targeted contrast agents for MRI of alpha-synuclein deposition |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331751A (en) * | 1980-11-17 | 1982-05-25 | Eastman Kodak Company | Electrically photosensitive materials and elements for photoelectrophoretic imaging processes |
| US5204085A (en) | 1985-01-08 | 1993-04-20 | Mallinckrodt Medical, Inc. | Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents |
| US5674468A (en) | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
| ZA952485B (en) | 1994-03-28 | 1995-12-15 | Nycomed Imaging As | Liposomes |
| US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| ATE287700T1 (de) * | 1999-11-30 | 2005-02-15 | Univ Arizona | Strahlung-sensitive liposomen |
| WO2002028441A2 (en) * | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| WO2002094191A2 (en) * | 2001-05-23 | 2002-11-28 | New York University | Detection of alzheimer's amyloid by magnetic resonance imaging |
| JP2005519129A (ja) | 2002-03-05 | 2005-06-30 | クリーブランド ステート ユニバーシティー | エアロゾル薬物送達のための凝集粒子 |
| WO2004096120A2 (en) | 2003-05-01 | 2004-11-11 | Nst Neurosurvival Technologies Ltd. | Compounds that selectively bind to membranes of apoptotic cells |
| US7208174B2 (en) | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
| US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
| US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| US7713517B2 (en) | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
| WO2006026184A2 (en) * | 2004-08-20 | 2006-03-09 | Washington University | Blood brain barrier permeation peptides |
| JP2008513533A (ja) * | 2004-09-23 | 2008-05-01 | ゲルベ | Ｃｅｓｔイメージング用の造影剤封入システム |
| US9943481B2 (en) * | 2005-05-26 | 2018-04-17 | Biorest Ltd. | Compositions and methods using same for delivering agents into a target organ protected by a blood barrier |
| US20070160658A1 (en) * | 2005-10-20 | 2007-07-12 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| EP2010223A2 (en) * | 2006-04-07 | 2009-01-07 | The Board Of Trustees Of The University Of Illinois | Hydrophilic polymer-conjugated lipids for peptide and protein folding disorders |
| US20090123047A1 (en) | 2007-03-21 | 2009-05-14 | Yfantis Spyros A | Method and system for characterizing prostate images |
| EP1982733A1 (en) | 2007-04-17 | 2008-10-22 | Bayer Schering Pharma Aktiengesellschaft | Use of a contrast agent for magnetic resonance imaging of endoleaks |
| US20110311457A1 (en) | 2007-07-26 | 2011-12-22 | Nanoscan Imaging, Llc | Methods for imaging vascular inflammation using improved nanoparticle contrast agents |
| JP2011506325A (ja) | 2007-12-05 | 2011-03-03 | マーバル バイオサイエンシーズ インコーポレイテッド | ナノスケールのコントラスト剤及びその使用方法 |
| JP5647899B2 (ja) | 2008-01-08 | 2015-01-07 | ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ | オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化 |
| ITMI20081052A1 (it) * | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
| US20090311191A1 (en) | 2008-06-13 | 2009-12-17 | Ananth Annapragada | Imaging of atherosclerotic plaques using liposomal imaging agents |
| WO2010017094A2 (en) | 2008-07-31 | 2010-02-11 | The General Hospital Corporation | CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING |
| AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| AU2010226566A1 (en) | 2009-03-19 | 2011-11-03 | Board Of Regents Of The University Of Texas System | Compositions and methods for enhancing contrast in imaging |
| WO2010115080A2 (en) * | 2009-04-02 | 2010-10-07 | The Johns Hopkins University | Self-assembling peptides bearing organic electronic functionality and applications employing the same |
| EP2501696B1 (en) | 2009-10-15 | 2016-12-28 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| CA2801182A1 (en) | 2010-06-16 | 2011-12-22 | Metabolex, Inc. | Gpr120 receptor agonists and uses thereof |
| ES2913069T3 (es) | 2011-03-02 | 2022-05-31 | Sensulin Llc | Composiciones de vesículas |
| AU2012239888B9 (en) | 2011-04-06 | 2017-10-12 | Alzeca Biosciences, LLC | Lipid-based nanoparticles |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| JP6130401B2 (ja) | 2012-01-20 | 2017-05-17 | アンナプラガダ，アナンス | 医学画像を客観的に特徴付けるための方法および組成物 |
| US9377472B2 (en) | 2012-04-30 | 2016-06-28 | Amoneta Diagnostics | Biological complex specific for Alzheimer's disease detection in vitro and use thereof |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| KR102409017B1 (ko) | 2014-10-08 | 2022-06-16 | 텍사스 칠드런스 하스피탈 | 리포좀을 이용한 아밀로이드 플라크의 mri 영상화 |
-
2012
- 2012-04-06 AU AU2012239888A patent/AU2012239888B9/en not_active Ceased
- 2012-04-06 CN CN201280017548.6A patent/CN104144708B/zh not_active Expired - Fee Related
- 2012-04-06 BR BR112013025633A patent/BR112013025633A2/pt not_active Application Discontinuation
- 2012-04-06 PL PL12767275T patent/PL2694116T3/pl unknown
- 2012-04-06 KR KR1020197007384A patent/KR102035187B1/ko not_active Expired - Fee Related
- 2012-04-06 CA CA2831480A patent/CA2831480C/en not_active Expired - Fee Related
- 2012-04-06 WO PCT/US2012/032649 patent/WO2012139080A2/en not_active Ceased
- 2012-04-06 PT PT12767275T patent/PT2694116T/pt unknown
- 2012-04-06 JP JP2014504057A patent/JP6212032B2/ja not_active Expired - Fee Related
- 2012-04-06 US US13/441,816 patent/US9801957B2/en not_active Expired - Fee Related
- 2012-04-06 ES ES12767275.6T patent/ES2685824T3/es active Active
- 2012-04-06 KR KR1020137029510A patent/KR101973063B1/ko not_active Expired - Fee Related
- 2012-04-06 DK DK12767275.6T patent/DK2694116T3/en active
- 2012-04-06 EP EP12767275.6A patent/EP2694116B1/en not_active Not-in-force
- 2012-04-06 MX MX2013011231A patent/MX357227B/es active IP Right Grant
- 2012-04-06 EP EP18167725.3A patent/EP3366313A1/en not_active Withdrawn
-
2017
- 2017-09-14 JP JP2017176383A patent/JP6533813B2/ja not_active Expired - Fee Related
- 2017-09-21 AU AU2017232156A patent/AU2017232156C1/en not_active Ceased
-
2019
- 2019-05-27 JP JP2019098174A patent/JP2019151664A/ja active Pending
- 2019-10-08 AU AU2019246775A patent/AU2019246775A1/en not_active Abandoned
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